• YAKHAK HOEJI
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• v.49 no.5
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• pp.392-398
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• 2005

In this study, we evaluated the stability of amoxicillin (AMX) and clavulanic acid (CLA) in aqueous solution, and compared the stability of AMX and CLA in commercial combination products. In aqueous solutions, the degradation of AMX ($t_{90}=8.88\;day\;at\;10^{circ}C$) and CLA ($t_{90}=3.53\;day\;at\;10^{circ}C$) occurred rapidly. From the pH-rate profile, AMX and CLA were the most stable at the range of pH 5.5 and 6.0. After reconstitution of commercial dry syrups, the contents of AMX and CLA in suspensions were gradually decreased for 7 days. However, AMX and CLA in dispersible tablet were not changed at all. The contents of CLA in the dispersible tablet ($87.92\%$) and dry syrups (2.16 and $3.91\%$) were remained in the accel­erated stability test ($75\%\;RH,\;at\;40^{circ}C$) after 10 hours. And the colors of the dry syrups were rapidly changed from white to yellow. From these results, we concluded that the dispersible tablet could overcome the stability problems of dry syrups.

• Korean Journal of Pharmacognosy
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• v.42 no.1
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• pp.9-14
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• 2011

The fruit body of Forsythiae Fructus (Oleaceae), a common Korean medical herb, is widely used in the treatment of cold and inflammation. In order to elucidate the action mechanism and the active principles from the plant against anti-influenza virus, the influenza virus hemagglutinin (HA) and neuraminidase (NA) gene RT-PCR and Viral Screening & Identification (VSI) assay were conducted, and the activity against viral replication was also investigated. Consequently, one active constituent, namely pinoresinol showed the in vitro antiviral principle using a cytopathic effect (CPE) reduction method, indicating pinoresinol possessed anti-influenza viral activity. Furthermore, combination of pinoresinol and Tamiflu exhibited higher activities than Tamiflu alone against influenza virus (H3N2) infection. The results suggested that combination of pinoresinol with Tamiflu could be a better candidate for an ant-H3N2 viral agent in the treatment of the influenza.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2008.10a
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• pp.78-81
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• 2008

The purpose of this research is to verify whether presentation order has an effect on the evaluation of products. In the empirical study, three types of humidifier and those of toaster were used. These products have 6 different sets of combination (3! = 3${\times}$2${\times}$1), and each set was evaluated by 15 subjects who were provided with two sets of images from humidifier and toaster in empirical study (N=90). Subjects completed measures assessing the five aspects: attractiveness, convenience, hygiene, efficiency and durability of the product. Each of the dependent measures was assessed on Likert-scale ranging 1 to 7. The ratings to the five aspects were added individually. Three types of humidifier and those of toaster were divided into 3 classes in terms of 'class A' which consists of the highest rated product, 'class C' which consists of the lowest rated product, and 'class B' which consists of the rest. Two main findings were discovered: First, the presentation order of both class A and class C influences the product evaluation whereas that of class B does not. As class A was presented as the last one, the subjects evaluated it the most positive. In the case of class C, on the contrary, when it is presented as the first is the best for itself; Secondly, the result shows that presented C-B-A sequence combination has a greater effect on entire evaluation than all other conditions in this study.

• Korean Journal of Weed Science
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• v.15 no.2
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• pp.160-165
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• 1995

Anthocyanin formation in callus cultures using Populus alba ${\times}$ Populus glandulosa was evaluated on basal MS medium supplemented with various levels of growth regulators, sucrose and nitrate concentrations. The highest yield of anthocyanin from cultured cells was produced under 5% sucrose, 1/8 strength of nitrate(12.5% of basic concentration) and combination of 1.0 mg/l IAA with 2 mg/l BAP, respectively. The high anthocyanin producing cell line no. 11 was selected among 15 cell lines, showing over 80% cells contained anthocyanin producing cells. From these cells, the highly productive red protoplast was isolated and the highest protoplast yield, $6.7{\times}10^6$ was obtained in enzyme combination IV which is composed of 2.0% cellulase, 0.5% macerozyme and 0.1% pectolyase.

• Journal of the Korean Wood Science and Technology
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• v.50 no.1
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• pp.12-30
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• 2022

Many studies on plant extracts have been reported for the treatment of candidiasis caused by Candida albicans, a representative fungal infection. This study demonstrates the synergistic antifungal activity of the combination of Phellodendri Cortex and Magnoliae Cortex, previously reported to have antifungal efficacy. Considering the antifungal efficacy and the separation of the active constituents, berberine and magnolol, hot water extraction and carbon dioxide supercritical extraction were selected for Phellodendri Cortex and Magnoliae Cortex, respectively. A combination of 0.55 g/L hot water extract of Phellodendri Cortex and 0.59 g/L carbon dioxide supercritical extract of Magnoliae Cortex showed synergistic antifungal activity. The synergistic antifungal activity of 160 μM berberine and 100 μM magnolol, which are representative antifungal compounds of Phellodendri Cortex and Magnoliae Cortex, respectively, contributes to the synergistic antifungal effect of their extracts. The additive decrease in cellular ergosterol level and the increased antifungal efficacy by extracellular ergosterol suggest that disruption of the biological function of ergosterol in the cell membrane is not responsible for the synergistic antifungal activity of berberine and magnolol. Synergistic cellular release of chromosomal DNA upon mixing berberine and magnolol indicates that disruption of the cellular structure is responsible for the synergistic antifungal effect of berberine and magnolol.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.4
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• pp.391-401
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• 2011

Purpose: In the present study, the actual management state of trial contact lenses and lens care products in local optical shops was surveyed and analyzed to reduce the risk of lens complication possibly induced by neglecting lens care. Methods: The feeling of contact lens wearers during the wear of trial contact lenses was surveyed. Futhermore, the actual management state of trial contact lenses such as cosmetic lens and RGP lens and lens care products was also investigated by surveying opticians who trade contact lenses in local optical shops. Results: It was found that consumers trusted the sanitary conditions of the lens since trial cosmetic contact lens and RGP lens were cleaned before and after trails by over 98% of opticians in local optical shops. For trial cosmetic lens, cleaning with normal saline, multipurpose solution for soft lens and combination of saline and multipurpose solution were 38.5%, 40.5% and 21%, respectively, before trials. After trials, cosmetic lenses were cleaned with normal saline, multipurpose solution for soft lens and a combination of saline and multipurpose solution were 13%, 75%, and 12%, respectively. On the other hand, cleaning with normal saline, multipurpose solution for RGP lens and combination of saline and multipurpose solution were 28.5%, 38.5% and 33%, respectively, before trying trial RGP lens. After trials, RGP lenses were cleaned with normal saline, multipurpose solution for RGP lens and a combination of saline and multipurpose solution were 2.5%, 70%, and 27.5%, respectively, indicating that relatively many opticians followed the lens cleaning regimen. In local optical shops, the cleaning trial cosmetic lens was mainly conducted at every 10 days or a month and the washing cycle of cosmetic lens case was in a month or 2~3 months. The cleaning interval of trial RGP lens was primarily in a month or 2~3 months. For those lens cases, more than 75% of opticians washed them with a surfactant and then rinsed with cold water. The storing periods of lens care products were primarily in a week for saline and in a month and 2~3 months indicating that storing period of lens care products was relatively well-kept in local optical shops. Conclusions: It is thought that the concern about any microbial infection is not that high since trial contact lenses and lens care products were generally well-managed by opticians in local optical shops from the results above. However, better public eye health and better public confidence in opticians may be possible if further strengthen in avoidance of lens cleaning with saline, keep of cleaning cycles within 2 weeks and rinsing of lens cases with hot water happens.

• Journal of Food Hygiene and Safety
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• v.30 no.1
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• pp.1-12
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• 2015

This study was performed to determine risk ranking of the combination of pathogen-livestock or livestock products to identify the most significant public health risks and to prioritize risk management strategies. First, we reviewed foodborne outbreak data related to livestock products and determined main vehicles and pathogens according to the number of outbreak and case. Second, expert's opinion about management priority of pathogen-livestock product pairing was surveyed with 19 livestock experts in the university, research center, and government agency. Lastly, we used the outcome of Risk Ranger (semi-quantitative risk ranking tool) of 14 combinations of pathogen and livestock or livestock products. We have classified the combination of pathogen-livestock products into group I (high risk), II (medium risk), and III (low risk) according to their risk levels and management priority. Group I, which is the highest risk for foodborne outbreak, includes Salmonella spp./egg and egg products, Campylobacter spp./poultry, pathogenic E. coli/meat and processed ground meat. In conclusion, the results of this study will provide the specific guideline of mid- and long-term planning for risk assessment and risk management prioritization of the combination of pathogen and livestock, or livestock product.

• Archives of design research
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• v.6 no.1
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• pp.23-46
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• 1993

The development of technology in modern industrial world which grows and changes every day is shortening the cycle of life span of products, so there is a flood of products around us. It is enough to say that this phenomenon leads to further emphasis on the aspect of design for human being. It is not a new fact that to design for the rational function and the modeling from to make a combination and to satisfy consumers' desire is a short cut to gain competitive superiority in developing new products for MIS security. Therefore the design which plays a leading role in the activity of creating more convenient, more aesthetic, and more econemical products is called 'NEW CORPORATE WEAPON'. The amount of effort made for developing products is different in each company, but recently the plan to develope new products and its process arouse more interest. This thesis purports to improve objective understanding about the development of design by investigating products development research and the process of analysis and designing as a case study on developing a domestic supersonic humidifier. This thesis consists of five chapters in all. In chapter one as a preface, the purpose the method and the scope of the study is described. Chapter two contains my effort to grasp the background of study on the design and the basic structure of supersonic humidifier. Chapter three is an examination into the present conditions of supersonic humidifier used in domestic and foreign area, and the shape of design. In chapter four, a guide for the development of design is established. The idea sketch based on a fundamental shape and the drawing are added to this. In chapter five on the basis of the result of analysis in the preceding research I describe the development of design of products on the premise that marketing gives proof for them but the products oriented by manufacturer are not included in this case. In this thesis, I try to recognize the process of the develpment of design and the importance of the plan for design in developing products by examining an investigative and analytic study on the design of products.

• Asian-Australasian Journal of Animal Sciences
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• v.4 no.1
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• pp.21-24
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• 1991

A mixed infection of Haemophilus paragallinarum (Hpg), Mycoplasma gallisepticum (MG) and M. synoviae (Ms) was detected in layers of a poultry farm in Iwate prefecture in Japan by pathological, serological and bacteriological investigation. Hpg strains were isolated from three of five birds investigated and all strains were identified to be type C. The Hpg isolates were more susceptible in vitro to a combination of sulfamonomethoxine and ormetoprim (Ektecin) than each of sulfamethoxasol, sulfamonomethoxine, oxytetracycline, tetracycline, streptomycin, erythromycin and thianphinicol. After a total of six days' medication of 1% feed additive Ektecin, symptoms of infectious coryza of hens in the farm almost disappeared and no Hpg was detected even from birds showing nasal discharge.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.26 no.4
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• pp.1-5
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• 2012

By using LED optical devices and improving the efficiency of optical devices as well as lighting apparatus for humans, LED lighting industry puts the purpose of manufacturing the main products related with information, electric, large-sized LCD BLU, automobile, shipbuilding, agriculture, medical treatment, environment, and telecommunications, etc. Moreover, the main products and the industrial lighting products are manufactured with fusion, as the result, LED lighting industry provides various effects as well as sources of technology based on practical use of LED technology in order to develop the industry from the perspective of the lower price, the higher efficiency, the higher function, the deeper reliance. In the future, not only the development of new LED technology but also the fusion and combination of digital IT technologies using wire-wireless communication, sensor, controller, and artificial intelligence will be expected to create new industrial fields.