• Journal of Microbiology and Biotechnology
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• 제16권1호
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• pp.158-162
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• 2006

Cyclic dipeptides isolated from Streptomyces sp. have been shown to have antimicrobial activity as well as other potentially useful biological activities. The purpose of this study was to compare the in vitro activity of two cyclic dipeptides combined against anaerobic bacteria with the activity of other antimicrobial agents. Specifically, the in vitro activity of the combination of two cyclic dipeptides was investigated against 140 clinical isolates of anaerobic bacteria by the agar dilution method and was compared with that of erythromycin, cefoxitin, imipenem, clindamycin, and metronidazole. The cyclic dipeptide combination and imipenem were the most active antimicrobial agents tested. In addition, the cyclic dipeptide combination had a radioprotective effect on five normal human lung fibroblast cells, showing survival rates higher $(>90\%)$ than either of the two cyclic dipeptides alone $(<80\%)$.

• Communications for Statistical Applications and Methods
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• 제19권6호
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• pp.799-808
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• 2012

It is known that human disease and the economic traits of livestock are significantly affected by a gene combination effect rather than a single gene effect. Existing methods to study this gene combination effect have disadvantages such as heavy computing, cost and time; therefore, to overcome those drawbacks, the SNPHarvester was developed to find the main gene combinations. In this paper, we looked for gene combinations using an adjusted linear regression model. This research finds that superior gene combinations which are related to the quality of the Korean beef cattle among sets of SNPs using SNPHarvester. We also identify the superior genotypes using a decision tree that can enhance the various qualities of Korean beef among selected a SNP combination.

• 한국자원식물학회지
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• 제28권6호
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• pp.752-758
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• 2015

The anti-diabetic effect of Cirsium setidens water extract and the combinations with Bletilla striata, Cymbidium kanran, and Sparganium stoloniferum Buch.-Ham. ethanolic extracts had been studied. The combination of four extracts (3:1:1:1) showed larger anti-diabetic activity in vitro and in vivo. It is notable that the single water extract from C. setidens exhibited more effective anti-diabetic effect than most of the combinations. We also investigated whether fermentation process was promoted the anti-diabetic activity. The data suggested the fermentation product of combination of four extracts (3:1:1:1) exhibited the strongest activity both in vitro and in vivo, which was higher than the non-fermented group. The result indicated the fermentation and the appropriate combination of extracts enhanced the anti-diabetes activity.

• 셀메드
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• 제12권3호
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• pp.13.1-13.3
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• 2022

The aim of this study was to evaluate the synergistic effect of Samulnori and Ajaeng combination in music therapy. Samulnori is the Korea's most successful traditional music. The Ajaeng, Korean traditional string instrument, generally plays the bass part in ensemble music. However, we have tried a new kind of musical style. (As you can see in the Youtube, https://youtu.be/QHIciJTTY0w). Samulnori and Ajaeng combination of our style have not been tried by any other musicians in Korea. Results from this study showed that Samulnori-induced excitation and Ajaeng-induced dynamics probably contributed to the synergistic effect of Samulnori and Ajaeng.

• 대한수의학회지
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• 제50권4호
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• pp.279-284
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• 2010

Combination therapy of antibiotics is leading to improved efficacy or safety profiles with decrease emergence of bacterial resistance. Because of this benefit, many of antibacterial combinations have been used in veterinary practice for the past few decades. The purpose of this study was to examine the in vitro activity of an amoxicillin alone and in combination with other antibiotics against pathogenic bacteria of fish origin. Based on the fractional inhibitory concentration (FIC) index (FIC $$\leq_-$$ 0.5), a synergistic interaction was shown in combination of florfenicol with amoxicillin or cefuroxime. The combination of florfenicol and amoxillin showed higher antibacterial activity than that of florfenicol and cefuroxime. Ratio of amoxicillin and florfenicol in combination was 1 : 1, which showed the antibacterial activity against bacterial isolates of fish as compared with other ratios. A synergetic effect of the combination (amoxicillin and florfenicol) was further confirmed in the time-kill curve study. The study showed a better in vitro antibacterial activity of a 1 : 1 combination of amoxicillin and florfenicol than the individual antibacterial against bacterial isolates of fish. In conclusion, the combination of florfenicol and amoxicillin may serve as a potential antibacterial therapy in fishes infected pathogenic bacteria.

• 대한한방내과학회지
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• 제38권6호
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• pp.891-901
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• 2017

Objectives: The aim of the study was to evaluate the anti-asthmatic effect of alismatis rhizoma and alisol acetate B combination therapy in a murine asthma model. Methods: C57BL/6 mice were sensitized to and challenged with a mixture of ragweed, dust mite, and aspergillus to induce an asthma animal model. Alismatis rhizoma extract and alisol acetate B combination therapy was co-administered only in the experimental group. To evaluate the anti-asthmatic effect of the combination therapy, inflammatory cell counts in bronchoalveolar lavage (BAL) fluid were determined, and tissue was examined histologically with hematoxylin and eosin (H & E) and periodic acid-Schiff (PAS) stains, by enzyme-linked immunosorbent assay (ELISA) of IgE, IL-4, and IL-5, and with reverse transcription polymerase chain reaction (RT-PCR) of IL-5, IL-33, MUC5AC. Results: Alismatis rhizoma and alisol acetate B combination therapy reduced the number of inflammatory cells, alleviated histologic features, and down-regulated all the investigated asthma mediators, IgE, IL-4, IL-5, IL-33, and MUC5AC. Conclusions: According to the above results, alismatis rhizoma and alisol acetate B combination therapy may have therapeutic potential for asthma.

• 문화기술의 융합
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• 제6권1호
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• pp.99-104
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• 2020

본 논문은 기업의 인사관리와 사업전략 간의 결합패턴에 따른 성과에 대해 분석하였다. 사업전략은 Miles & Snow의 혁신자, 방어자, 분석자 전략으로 구분하였으며, 각 전략 하에서 인사관리가 성과에 미치는 효과를 분석하였다. 자료는 한국노동연구원(KLI)이 2015년까지 진행한 사업체패널조사에 모두 응답한 업체들 중 사업전략에 대해 응답한 465개 기업의 자료를 사용하였다. 분석은 구조방정식모형을 활용하였다. 먼저 전체 표본을 대상으로 몰입형 인사관리와 성과에 대한 관계를 분석하였으며, 다음으로 사업전략 유형에 따라 나눈 개별 자료에서 인사관리가 성과에 미치는 모형을 분석하여 각 모형에서의 변수 간 관계와 모형적합도를 비교하였다. 먼저 전체 표본을 대상으로 한 분석결과에서 몰입형 인사관리가 성과에 유의한 영향을 미쳤고, 모형적합도도 양호하였다. 다음으로 개별 전략 하에서의 모형을 분석하였는데, 몰입형 인사관리는 혁신자 전략에서 성과에 유의한 영향을 미쳤으며, 모형적합도도 양호하였다. 그러나 방어자 및 분석자 전략과 몰입형 인사관리 간의 결합은 성과에 유의하지 않았고 모형적합도도 낮게 나타났다.

• 한국생활과학회지
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• 제16권2호
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• pp.407-419
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• 2007

The purpose of this study was to identify the effect of four clothing cues dot pattern size and ground field of color area ratio on dress's wearer image. The experimental materials developed for this study are a set of stimuli and response scales(The 7-point semantic). The stimuli were 30 color pictures manipulated with the combination of dot pattern size, dot pattern on background of color area ratio and neutral dress's using computer simulation. The subjects were 180 female undergraduates living students in Gyeong-nam. The result of this study are as follows: Image factor of the stimulus was composed of 5 different components (visibility, gracefulness, attractiveness, cuteness, womanly). Especially, Neutral color combination independently influenced the every components. In regarding the effect of interaction between each variable, the combination of dot pattern on background of color area ratio, dot pattern size on the combination had cuteness, womanly.

• 대한통합의학회지
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• 제6권2호
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• pp.117-123
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• 2018

Purpose : The purpose of this study was to investigate the effect of increased brain activity on the muscle endurance and the effect of brain activation through the combination of transcranial direct current stimulation and aerobic exercise on elderly woman. Methods : To investigate the effect of the muscle endurance on right leg, muscle endurance was evaluated by measuring the surface EMG of the muscles of the rectus femoris, biceps femoris, tibialis anterior, and gastrocnemius muscle. Results : There was a significant difference in the pre and post comparisons of muscle endurance on rectus femoris, biceps femoris, tibialis anterior muscle (p<.05). Difference of Combination of transcranial direct current stimulation and aerobic exercise group median frequency was smaller than control group (p<.05). There was not a significant difference in the pre and post comparisons of muscle endurance on biceps femoris, and gastrocnemius muscle. Difference of Combination of transcranial direct current stimulation and aerobic exercise group median frequency was showed a similar pattern. Conclusion : Through these results, It was found that increasing the brain activity by the transcranial direct current stimulation improves the exercise capacity on the elderly women. Combination of transcranial direct current stimulation and aerobic exercise maybe applied as an effective treatment for improving muscular endurance.

• Biomolecules & Therapeutics
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• 제7권3호
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• pp.216-220
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• 1999

A chemosensitivity assay with small replicate Mm5mt/cl C3H mammary tumor cell cultures was developed to determine whether changes in viral antigen expression and release into culture fluids could be utilized as an in vitro measure of modulating drug effect. The 52,000 MW viral envelope glycoprotein (gp52) of the mouse mammary tumor virus (MMTV) was measured in culture fluids of control and drug-treated cultures while cell density was simultaneously determined by cell staining and OD 664 nm determination. While extra-cellular gp52 levels and cell density progressively increased over 72 hours for control cultures, declines in both parameters provided dual measures of effect for combination [N(phophonacetyl-L-aspartic acid)+5-fluorouracil], combination 〔N(phophonacetyl-L-aspartic acid )+5-fluoro-5'-deoxyuridine〕and single component treatment of this combination. At each treated time point, thesecombinations begin to produce a greater decline in both cell density and gp52 levels as compared to single drug treatments. These results indicate that N(phopho-nacetyl-L-aspartic acid) in combination can enhance the effectiveness of single drug.