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http://dx.doi.org/10.7732/kjpr.2015.28.6.752

Synergistic Anti-diabetic Effect of Cirsium setidens Combined with Other Plants in vitro and in vivo  

Huifang, Guo (Department of Medical Biotechnology, Kangwon National University)
Jiang, Yunyao (Department of Medical Biotechnology, Kangwon National University)
Wang, Myeong-Hyeon (Department of Medical Biotechnology, Kangwon National University)
Publication Information
Korean Journal of Plant Resources / v.28, no.6, 2015 , pp. 752-758 More about this Journal
Abstract
The anti-diabetic effect of Cirsium setidens water extract and the combinations with Bletilla striata, Cymbidium kanran, and Sparganium stoloniferum Buch.-Ham. ethanolic extracts had been studied. The combination of four extracts (3:1:1:1) showed larger anti-diabetic activity in vitro and in vivo. It is notable that the single water extract from C. setidens exhibited more effective anti-diabetic effect than most of the combinations. We also investigated whether fermentation process was promoted the anti-diabetic activity. The data suggested the fermentation product of combination of four extracts (3:1:1:1) exhibited the strongest activity both in vitro and in vivo, which was higher than the non-fermented group. The result indicated the fermentation and the appropriate combination of extracts enhanced the anti-diabetes activity.
Keywords
Anti-diabetes; Cirsium setidens; Hypoglycemic; Synergistic;
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