• The Korean Journal of Physiology and Pharmacology
• /
• 제8권4호
• /
• pp.173-179
• /
• 2004

Amyloid ${\beta}-peptide\;(A{\beta})$ contributes to the pathogenesis of Alzheimer's disease (AD), causing neuronal death through apoptosis. In this study, the neuroprotective role of BF-7, extracted form sericultural product, was examined against $A{\beta}-induced$ toxicity in cultured human neuronal cell SKN-SH. In order to know if the BF-7 has positive role on the cognition and memory in human, the mixture of BF-7, DHA and EPA (BDE) was examined using Rey Kim and K-WAIS test with 50 healthy high school student. We report here that BDE significantly attenuated $A{\beta}-induced$ apoptosis through the reduction of ROS accumulation, and diminished caspase-like protease activity. Moreover, the memory index and memory preservation, and attentative concentration of BDE treated group for 1 month were significantly improved, in contrast to the case of placebo control treated with DHA and EPA. This result represent that the BF-7 play significant positive role on learning memory. Taken together, our result suggested the natural product BF-7 is a good substance for the brain functionally and physiologically.

• 한국도서관정보학회지
• /
• 제8권
• /
• pp.69-96
• /
• 1981

We all know that we can not keep a proper social life without language. Yet language is so much a part of our environment that we hardly realize it is there. The purpose of this study is to provide an understanding of the linguistical aspect of communication process in order to carry out a successful human relations in the operation of libraries. Human development rests upon man's capacity to digest large quantities of knowledge and it is language which allows facts to be communicated, stored, and disseminated. An attempt was made in this study to illustrate the elementary meaning-of-words aspect of communication. In order to share the most commonly agreed meanings in interpersonal communication, a careful study of semantic noises is important. In a constant struggle to meet client needs, staff and administrators, librarian must understand communication dialogues, their messages and be able to read all level of meanings. In order to perform a successful function of the librarian, to act as a link-man or communicator and to cope with its ever growing information, it is suggested that the deep understanding of the following linguistical aspect of communication elements is essential. 1. Characteristics of Language: (1) Words have different meanings to different people. (2) Words vary in the degree of abstraction. (3) Language is incomplete by its nature. (4) Language reflects not only the personality of the individual but also the culture of man's society. 2. Noises in transmitting meanings: (1) Mechanical or Technical noises. (2) Semantic Noises (3) Noises caused by the psychological factors a. attention b. perception, sensation, cognition and perceptual field. 3. Linguistic Stratum Languages differ considerably in vocabulary by the physical and cultural environment setting as well as situation of individual living. There are seven different language stratum which reflects different region, sex, age, profession, special social stratum, academic and tabooed words.

• 한국산학기술학회논문지
• /
• 제8권2호
• /
• pp.354-361
• /
• 2007

아동 관련 시설의 계획에서 의사소통 능력이 부족한 아동들은 주사용자인 자신들의 의견을 시설계획에 적극적으로 반영하는데 현실적인 어려움을 갖는다. 따라서 이러한 문제에 대한 보완장치로 환경 행태 연구 분야에서의 연구 결과들을 아동들을 위한 시설계획에 적극적으로 반영하려는 시도가 요구된다. 이에 본 연구는 아동기의 환경행태 관련 연구 결과들을 분석 정리하여 아동들을 위한 시설계획에 참고할 수 있는 계획 자료를 축적하는 것을 목적으로 한다. 이를 위해 다양한 주제로 연구되어 온 아동기 관련 환경 행태 이론들을 개인적 차원과 사회적 차원의 두 가지 특성으로 나누어 고찰하였다. 개인적 차원의 특성에서는 지각과 환경인지 2가지 영역에서의 발달 양상을 고찰하였다. 그리고 사회적 차원의 특성에서는 프라이버시, 개인공간, 영역성, 밀도 등의 4가지 영역에서 각 특성의 기능 및 정의, 그리고 아동관련 시설 및 물리적 환경에서의 적용양상 등을 고찰하였다.

• 대한정형도수물리치료학회지
• /
• 제8권2호
• /
• pp.57-71
• /
• 2002

Cervical pain is a rapid increase that is owing to a flexion-extension whiplash injury, unappropriated posture, chronical repetition injury from abdominal position of head and neck, excessive repeating work, chronical deficiency of excercise. Because of that is bring about muscle unbalance, tightness of cervical extensor muscle, weakness of cervical deep flexor muscles, instability of cervical region and reduction of proprioceptive sensor. Recent the role of muscle is more emphasized for preservation of sine stabilization. And cognition of integrated muscular system, importance for the operation and relation is increased to maintain stability of the motor system and pertinent function. Therefore we are going to introduce the sling exercise and stabilization exercise method for advanced efficient of cervical and upper limb and for the muscle strengthening to importance cervical stabilization through neurological program as control the reaction of cervical stabilization. Sling exercise therapy(SET) concept consists of a system of diagnosis and treatment. The system of diagnosis involves testing the muscle's tolerance through progressive loading in open and close kinetic chains. The SET system contains elements such as relaxation, increasing the range of movement, traction, training the stabilizing musculature, sensory-motor exercises, training in open and close kinetic chains, dynamic training of the mobilizing musculature, cardiovascular exercise, group exercise, personal exercise at home Sensory-motor training is an essential element of the SET concept. The emphasis is on closed kinetic chain exercise on an unstable surface, there by achieving optimum stimulation of the sensory-motor apparatus.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제18권2호
• /
• pp.145-153
• /
• 2007

Objectives: This study was focused on the influence of chronic aircraft noise exposure on children's continuous performance, intelligence and reading skill. Methods: We enrolled 586 children in 4-6th grade of 7 primary schools near air base in Korea. Continuous performance was measured using the computerized ADS program. We analyzed 477-512 children on the visual continuous performance test, auditory continuous performance test, intelligence test, and reading and the vocabulary test. Intelligence was measured using vocabulary, digit span, block design, and digit symbol tests of K-WISC-III. Results: The commission error and variability deviation of auditory continuous performance test and reading test were significantly higher among children in schools with the helicopter noise and the fighting plane noise compared to children in the low noised schools. Conclusion: There was a possibility that chronic aircraft noise exposure was associated with impairment of the school performance. The result of our study also shows chronic aircraft noise was associated with reading ability.

• 간호행정학회지
• /
• 제14권3호
• /
• pp.229-240
• /
• 2008

Purpose: To develop the patient classification system based on the resource utilization for reimbursement of long-term care hospitals in Korea. Method: Health Insurance Review & Assessment Service (HIRA) conducted a survey in July 2006 that included 2,899 patients from 35 long-term care hospitals. To calculate resource utilization, we measured care time of direct care staff (physicians, nursing personnel, physical and occupational therapists, social workers). The survey of patient characteristics included ADL, cognitive and behavioral status, diseases and treatments. Major category criteria was developed by modified delphi method from 9 experts. Each category was divided into 2-3 groups by ADL using tree regression. Relative resource use was expressed as a case mix index (CMI) calculated as a proportion of mean resource use. Result: This patient classification system composed of 6 major categories (ultra high medical care, high medical care, medium medical care, behavioral problem, impaired cognition and reduced physical function) and 11 subgroups by ADL score. The differences of CMI between groups were statistically significant (p<.0001). Homogeneity of groups was examined by total coefficient of variation (CV) of CMI. The range of CV was 29.68-40.77%. Conclusions: This patient classification system is feasible for reimbursement of long-term care hospitals.

• 대한장애인치과학회지
• /
• 제6권1호
• /
• pp.19-22
• /
• 2010

1. 뇌성마비 환자는 질환의 특성상 전치부 개교를 동반한2급 부정교합. 이갈이 및 강한 폐구습관, 반복적인 간질 발작을 가지는 경우가 많다. 2. 이와 같은 특성은 전치부 외상 및 재외상 빈도를 높일뿐 아니라 전치부 수복물의 예후를 불량하게 한다. 3. 뇌성마비 환자의 전치부 수복시 일반적인 보철치료 외에도 인공치나 자연치를 포함한 Nance holding arch를 고려할 수 있으며 환자의 병력과 습관, 교합관계를 정확히 파악하여 적절한 수복물을 선택하여야 한다.

• 한국주거학회:학술대회논문집
• /
• 한국주거학회 2008년 추계학술발표대회 논문집
• /
• pp.425-430
• /
• 2008

Residential architecture was a lot more changed due to adopting modern residential type since 1960s. But people in farm houses are still living in a space of their past life causing a discrepancy. For this reason, the paper will identify the changed use for farm houses focusing on their plane views, and reason for the changed use as well. The result of this paper is expected to play a role for practical data to reasonably change and re-model farm houses located in back of cities such as Hyunpoong area. Targeted area for this paper, in order to survey change in residential environment due to industrialization and modernization, has narrowed down to 42 farm houses which are located Yuga-Myun, Hyunpoong-Gun, Dalsung-Gun where tradition and modern characteristics are harmonized being built before 1960s Researching relied on both documentary records and survey on the site, and survey on documentary records was performed in a way that preceding research for changed use of residential area was to be compared with people's farm houses in Kyeongsang-Do area, and survey on the site was carried out by photographing and land surveying and interview and analysis for them, and finally we acquired the result by analyzing use of interior for houses and plane view and relations between culture and social environment. From the result of this paper, there was a trend that farm houses had been improved function of a specific space by enlarging space and enlarged construction for inner rooms. And among spaces, kitchen and bath room was mostly enlarged its left side, and inner room had mostly enlarged its rear side, and kitchen was frequently enlarged in its side space. These kinds of variation in space is believed to be result of change of life style and house facilities

• Molecules and Cells
• /
• 제39권8호
• /
• pp.603-610
• /
• 2016

Recently, an increasing number of studies have focused on the effects of CD4+ T cell on cognitive function. However, the changes of Th2 cytokines in restricted CD4+ T cell receptor (TCR) repertoire model and their effects on the adult hippocampal neurogenesis and memory are not fully understood. Here, we investigated whether and how the mice with restricted CD4+ repertoire TCR exhibit learning and memory impairment by using OT-II mice. OT-II mice showed decreased adult neurogenesis in hippocampus and short- and long- term memory impairment. Moreover, Th2 cytokines in OT-II mice are significantly increased in peripheral organs and IL-4 is significantly increased in brain. Finally, IL-4 treatment significantly inhibited the proliferation of cultured adult rat hippocampal neural stem cells. Taken together, abnormal level of Th2 cytokines can lead memory dysfunction via impaired adult neurogenesis in OT-II transgenic.

• Journal of mucopolysaccharidosis and rare diseases
• /
• 제1권2호
• /
• pp.54-59
• /
• 2015

Purpose: Growth hormone (GH) therapy substantially improves several cognitive functions in PWS. However, the molecular mechanisms underlying the beneficial effects of GH on cognition remain unclear in PWS. In this study, we investigated the effects of recombinant human GH on the gene expression of GABAB receptor subunits and GH/insulin-like growth factor (IGF) axis genes in the brain regions of PWS-mimicking mice (Snord116del). Methods: Snord116del mice were injected subcutaneously with 1.0 mg/kg GH or saline, once daily for 7 days. The collected brain tissues were analyzed for mRNA content using quantitative PCR (qPCR) in the cerebellum, hippocampus, and cerebral cortex. Results: GH increased the mRNA expression level of the $GABA_{B1}$ receptor subunit ($GABA_{BR1}$) and IGF-1R in the cerebellum. Furthermore, a significant positive correlation was found between the level of $GABA_{BR1}$ mRNA and the expression of the IGF-1R transcript. GH also induced an increase in the mRNA expression of IGF-2 and IGF-2R in the cerebellum. Conclusion: These data indicate that GH may provide beneficial effects on cognitive function through its influences on the expression of $GABA_{BR1}$ and GH/IGF-1 axis genes in PWS patients.