• Genomics & Informatics
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• v.16 no.4
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• pp.25.1-25.5
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• 2018

Coronary artery disease (CAD) is one of the leading causes of death and disability all around the world. Recent studies have revealed that aberrantly regulated long non-coding RNA (lncRNA) as one of the main classes of cellular transcript plays a key regulatory role in transcriptional and epigenetic pathways. Recent reports have demonstrated that circulating lncRNAs in the blood can be potential biomarkers for CAD. HOTAIR is one of the most cited lncRNAs with a critical role in the initiation and progression of the gene expression regulation. Recent research on the role of the HOTAIR in cardiovascular disease lays the basis for the development of new studies considering this lncRNA as a potential biomarker and therapeutic target in CAD. In this study, we aimed to compare the expression of HOTAIR lncRNA in the blood samples of patients with CAD and control samples. The expression level was examined by semi-quantitative reverse transcriptase polymerase chain reaction technique. Our data shows that expression of HOTAIR is up-regulated in blood samples of patients with CAD.

• BMB Reports
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• v.52 no.1
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• pp.86-108
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• 2019

In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and gene expression has been observed to be deregulated with aging. In this review, we discuss the current knowledge on the transcriptional alterations that have been described to occur with age in metazoans. First, we discuss age-related transcriptional changes in protein-coding genes, the expected functional impact of such changes, and how known pro-longevity interventions impact these changes. Second, we discuss the changes and impact of emerging aspects of transcription in aging, including age-related changes in splicing, lncRNAs and circRNAs. Third, we discuss the changes and potential impact of transcription of transposable elements with aging. Fourth, we highlight small ncRNAs and their potential impact on the regulation of aging phenotypes. Understanding the aging transcriptome will be key to identify important regulatory targets, and ultimately slow-down or reverse aging and extend healthy lifespan in humans.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.17 no.4
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• pp.97-102
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• 2007

In this paper, a new architecture for fast-serial $GF(2^m)$ multiplier with low hardware complexity is proposed. The fast-serial multiplier operates standard basis of $GF(2^m)$ and is faster than bit serial ones but with lower area complexity than bit parallel ones. The most significant feature of the fast-serial architecture is that a trade-off between hardware complexity and delay time can be achieved. But The traditional fast-serial architecture needs extra (t-1)m registers for achieving the t times speed. In this paper a new fast-serial multiplier without increasing the number of registers is presented.

• Women's Health Nursing
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• v.26 no.4
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• pp.274-284
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• 2020

Purpose: The purpose of this study was to investigate the effects and characteristics of health care programs for pregnant women with gestational diabetes mellitus (GDM) in Korea. Methods: This study was conducted according to the Cochrane Collaboration's systematic literature review handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guideline. We searched eight international and domestic electronic databases for relevant studies. Two reviewers independently selected the studies and extracted data. For each study, information on the research method, participants, characteristics of the program, and results were extracted using a previously established coding table. The National Evidence-based Healthcare Collaborating Agency's risk of bias assessment tool for non-randomized studies was used to assess the risk of bias of the included articles. A qualitative review of the selected studies was performed because the interventions differed considerably and the measured outcomes varied. Results: Out of 128 initially identified papers, seven were included in the final analysis. The risk of bias was evaluated as generally low. Health care programs for pregnant women with GDM showed positive effects on blood glucose control. Anxiety and depression were reduced, and self-management and self-care behavior, self-efficacy, and maternal identity improved. Conclusion: Our study provides clinical evidence for the effectiveness of health care programs for pregnant women with GDM, and its results can be used to support the development of health care programs for GDM. More well-designed research is needed on GDM, especially studies that deal with emotional stress and apply a family-oriented approach.

• Molecules and Cells
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• v.45 no.5
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• pp.343-352
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• 2022

The advent of the assay for transposase-accessible chromatin using sequencing (ATAC-seq) has shown great potential as a leading method for analyzing the genome-wide profiling of chromatin accessibility. A comprehensive reference to the ATAC-seq dataset for disease progression is important for understanding the regulatory specificity caused by genetic or epigenetic changes. In this study, we present a genome-wide chromatin accessibility profile of 44 liver samples spanning the full histological spectrum of nonalcoholic fatty liver disease (NAFLD). We analyzed the ATAC-seq signal enrichment, fragment size distribution, and correlation coefficients according to the histological severity of NAFLD (healthy control vs steatosis vs fibrotic nonalcoholic steatohepatitis), demonstrating the high quality of the dataset. Consequently, 112,303 merged regions (genomic regions containing one or multiple overlapping peak regions) were identified. Additionally, we found differentially accessible regions (DARs) and performed transcription factor binding motif enrichment analysis and de novo motif analysis to determine new biomarker candidates. These data revealed the gene-regulatory interactions and noncoding factors that can affect NAFLD progression. In summary, our study provides a valuable resource for the human epigenome by applying an advanced approach to facilitate diagnosis and treatment by understanding the non-coding genome of NAFLD.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.12
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• pp.4476-4491
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• 2021

Video service providers tend to face user network problems in the process of transmitting video streams. They strive to provide user with superior video quality in a limited bitrate environment. It is necessary to accurately determine the target bitrate range of the video under different quality requirements. Recently, several schemes have been proposed to meet this requirement. However, they do not take the impact of visual influence into account. In this paper, we propose a new multi-category model to accurately predict the target bitrate range with target visual quality by machine learning. Firstly, a dataset is constructed to generate multi-category models by machine learning. The quality score ladders and the corresponding bitrate-interval categories are defined in the dataset. Secondly, several types of spatial-temporal features related to VMAF evaluation metrics and visual factors are extracted and processed statistically for classification. Finally, bitrate prediction models trained on the dataset by RandomForest classifier can be used to accurately predict the target bitrate of the input videos with target video quality. The classification prediction accuracy of the model reaches 0.705 and the encoded video which is compressed by the bitrate predicted by the model can achieve the target perceptual quality.

• Proceedings of the Korea Information Processing Society Conference
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• 2010.11a
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• pp.291-294
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• 2010

표준 코딩 스타일은 개발 단계에서 오류 가능성이 있는 코드를 사전에 차단하고 코드의 가독성을 높여 소스코드의 품질을 높일 수 있는 대표적인 방법이다. 자동차 분야에서는 MISRA-C 와 같은 표준 코딩 스타일이 있으며 이를 검사하는 다수의 도구가 개발되었다. 본 논문에서는 소프트웨어의 안전성 및 신뢰성을 기반으로 국제 및 산업 표준 권고 사항과 경험적인 사례를 바탕으로 가전 기기 소프트웨어에 적합한 코딩 스타일 43 종을 정의했으며 이를 구현한 자동화 도구를 개발했다. 개발된 C 코딩 스타일 검사기를 이용하여 냉장고와 세탁기에 탑재된 소스코드에 대상으로 실험해 개발자들이 쉽게 위배하는 규칙에 대해서 살펴보았다. 위배한 코딩 스타일 중 주석관련 스타일이 각 소스코드 별로 64%, 24%로 가장 많이 차지하고 있으며, 제어문 관련 규칙이 12%, 17%, 코드 모양(Layout)관련 규칙이 4%, 11% 순으로 나타났다. 본 논문에서 개발한 코딩 스타일 검사 도구는 향후 양산되는 제품에 계속적으로 적용될 것이며 소프트웨어 품질 향상에 실질적인 도움이 될 것으로 기대된다.

• Convergence Security Journal
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• v.23 no.1
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• pp.63-68
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• 2023

In this study, in relation to blockchain protocol and network security, we study the configuration of blockchain and encryption key management methods on smart contracts so that we can have a strong level of response to MITM attacks and DoS/DDoS attacks. It is expected that the use of blockchain technology with enhanced security can be activated through respond to data security threats such as MITM through encryption communication protocols and enhanced authentication, node load balancing and distributed DDoS attack response, secure coding and vulnerability scanning, strengthen smart contract security with secure consensus algorithms, access control and authentication through enhanced user authentication and authorization, strengthen the security of cores and nodes, and monitoring system to update other blockchain protocols and enhance security.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.5
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• pp.1708-1734
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• 2022

In the development of logistics system, the breakthrough of important technologies such as technology platform for logistics information management and control is the key content of the study. Based on Javascript and JQuery, the logistics system realizes real-time monitoring, collection of historical status data, statistical analysis and display, intelligent recommendation and other functions. In order to strengthen the cooperation of warehouse storage, enhance the utilization rate of resources, and achieve the purpose of real-time and visual supervision of transportation equipment and cargo tracking, this paper studies the VNF dynamic deployment and SFC routing problem in the network load change scenario based on the logistics system. The BIP model is used to model the VNF dynamic deployment and routing problem. The optimization objective is to minimize the total cost overhead generated by each SFCR. Furthermore, the application of the SFC mapping algorithm in the routing topology solving problem is proposed. Based on the concept of relative cost and the idea of topology transformation, the SFC-map algorithm can efficiently complete the dynamic deployment of VNF and the routing calculation of SFC by using multi-layer graph. In the simulation platform based on the logistics system, the proposed algorithm is compared with VNF-DRA algorithm and Provision Traffic algorithm in the network receiving rate, throughput, path end-to-end delay, deployment number, running time and utilization rate. According to the test results, it is verified that the test results of the optimization algorithm in this paper are obviously improved compared with the comparison method, and it has higher practical application and promotion value.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.4A
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• pp.451-463
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• 2000

In this paper, we design the radio data link protocols with QoS provisioning for mobile multimedia such as voice, data, and video in CDMA-based ATM networks, and analyze the performance of the data link protocols. To support mobile multimedia traffic, the required QoS parameters and the characteristics are analyzed, and wireless protocol stacks are proposed for integrating the wireless access network and ATM transport networks, and radio data link protocols are designed for provisioning QoS Control. The data link protocols are analyzed assuming that the system is supporting voice and data traffic simultaneously. In case of data traffic, the delay and throughput of SREJ ARQ and Type-1 Hybrid ARQ scheme are compared, and in case of voice traffic, the packet loss rate of BCH coding is analyzed according to the varying data traffic loads. The results indicate that the adaptive radio link protocols are efficient to support QoS requirements while the complexities are increased.