Browse > Article
http://dx.doi.org/10.5808/GI.2018.16.e25

Circulating HOTAIR LncRNA Is Potentially Up-regulated in Coronary Artery Disease  

Avazpour, Niloofar (Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz)
Hajjari, Mohammadreza (Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz)
Yazdankhah, Saeed (Department of Cardiology, Ahvaz Jundishapur University of Medical Sciences, Imam Khomeini Hospital)
Sahni, Azita (Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz)
Foroughmand, Ali Mohammad (Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz)
Publication Information
Genomics & Informatics / v.16, no.4, 2018 , pp. 25.1-25.5 More about this Journal
Abstract
Coronary artery disease (CAD) is one of the leading causes of death and disability all around the world. Recent studies have revealed that aberrantly regulated long non-coding RNA (lncRNA) as one of the main classes of cellular transcript plays a key regulatory role in transcriptional and epigenetic pathways. Recent reports have demonstrated that circulating lncRNAs in the blood can be potential biomarkers for CAD. HOTAIR is one of the most cited lncRNAs with a critical role in the initiation and progression of the gene expression regulation. Recent research on the role of the HOTAIR in cardiovascular disease lays the basis for the development of new studies considering this lncRNA as a potential biomarker and therapeutic target in CAD. In this study, we aimed to compare the expression of HOTAIR lncRNA in the blood samples of patients with CAD and control samples. The expression level was examined by semi-quantitative reverse transcriptase polymerase chain reaction technique. Our data shows that expression of HOTAIR is up-regulated in blood samples of patients with CAD.
Keywords
coronary artery disease; gene expression; HOTAIR; long noncoding RNA;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001;104:2673-2678.   DOI
2 Wong ND. Epidemiological studies of CHD and the evolution of preventive cardiology. Nat Rev Cardiol 2014;11:276-289.   DOI
3 Viereck J, Thum T. Circulating Noncoding RNAs as biomarkers of cardiovascular disease and injury. Circ Res 2017;120:381-399.   DOI
4 Fang Y, Fullwood MJ. Roles, functions, and mechanisms of long non-coding RNAs in cancer. Genomics Proteomics Bioinformatics 2016;14:42-54.   DOI
5 Hajjari M, Salavaty A. HOTAIR: an oncogenic long non-coding RNA in different cancers. Cancer Biol Med 2015;12:1-9.
6 Cai Y, Yang Y, Chen X, Wu G, Zhang X, Liu Y, et al. Circulating 'lncRNA OTTHUMT00000387022' from monocytes as a novel biomarker for coronary artery disease. Cardiovasc Res 2016;112:714-724.   DOI
7 Cao J. The functional role of long non-coding RNAs and epigenetics. Biol Proced Online 2014;16:11.
8 Tsai MC, Manor O, Wan Y, Mosammaparast N, Wang JK, Lan F, et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science 2010;329:689-693.   DOI
9 Rizki G, Boyer LA. Lncing epigenetic control of transcription to cardiovascular development and disease. Circ Res 2015;117:192-206.   DOI
10 Li D, Chen G, Yang J, Fan X, Gong Y, Xu G, et al. Transcriptome analysis reveals distinct patterns of long noncoding RNAs in heart and plasma of mice with heart failure. PLoS One 2013;8:e77938.   DOI
11 Kadar A, Glasz T. Development of atherosclerosis and plaque biology. Cardiovasc Surg 2001;9:109-121.   DOI
12 Libby P. Vascular biology of atherosclerosis: overview and state of the art. Am J Cardiol 2003;91:3A-6A.
13 Greco S, Gorospe M, Martelli F. Noncoding RNA in age-related cardiovascular diseases. J Mol Cell Cardiol 2015;83:142-155.   DOI
14 Taft RJ, Pang KC, Mercer TR, Dinger M, Mattick JS. Non-coding RNAs: regulators of disease. J Pathol 2010;220:126-139.   DOI
15 Shi X, Sun M, Liu H, Yao Y, Song Y. Long non-coding RNAs: a new frontier in the study of human diseases. Cancer Lett 2013;339:159-166.   DOI
16 Zhou T, Ding JW, Wang XA, Zheng XX. Long noncoding RNAs and atherosclerosis. Atherosclerosis 2016;248:51-61.   DOI
17 Thum T, Condorelli G. Long noncoding RNAs and microRNAs in cardiovascular pathophysiology. Circ Res 2015;116:751-762.   DOI
18 Archer K, Broskova Z, Bayoumi AS, Teoh JP, Davila A, Tang Y, et al. Long non-coding RNAs as master regulators in cardiovascular diseases. Int J Mol Sci 2015;16:23651-23667. www.genominfo.org 5/5 Genomics & Informatics Vol. 16, No. 4, 2018   DOI
19 Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 2007;129:1311-1323.   DOI
20 Carrion K, Dyo J, Patel V, Sasik R, Mohamed SA, Hardiman G, et al. The long non-coding HOTAIR is modulated by cyclic stretch and WNT/beta-CATENIN in human aortic valve cells and is a novel repressor of calcification genes. PLoS One 2014;9:e96577.   DOI
21 Yang L, Froberg JE, Lee JT. Long noncoding RNAs: fresh perspectives into the RNA world. Trends Biochem Sci 2014;39:35-43.   DOI
22 Greco S, Zaccagnini G, Perfetti A, Fuschi P, Valaperta R, Voellenkle C, et al. Long noncoding RNA dysregulation in ischemic heart failure. J Transl Med 2016;14:183.   DOI
23 Liu Y, Zheng L, Wang Q, Hu YW. Emerging roles and mechanisms of long noncoding RNAs in atherosclerosis. Int J Cardiol 2017;228:570-582.   DOI
24 GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015;385:117-171.   DOI
25 Davidson EH, Erwin DH. Gene regulatory networks and the evolution of animal body plans. Science 2006;311:796-800.   DOI
26 Gangwar RS, Rajagopalan S, Natarajan R, Deiuliis JA. Noncoding RNAs in cardiovascular disease: pathological relevance and emerging role as biomarkers and therapeutics. Am J Hypertens 2018;31:150-165.   DOI
27 ENCODE Project Consortium, Birney E, Stamatoyannopoulos JA, Dutta A, Guigo R, Gingeras TR, et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 2007;447:799-816.   DOI
28 Hajjari M, Khoshnevisan A, Shin YK. Molecular function and regulation of long non-coding RNAs: paradigms with potential roles in cancer. Tumour Biol 2014;35:10645-10663.   DOI
29 Ma Y, Ma W, Huang L, Feng D, Cai B. Long non-coding RNAs, a new important regulator of cardiovascular physiology and pathology. Int J Cardiol 2015;188:105-110.   DOI
30 Ounzain S, Burdet F, Ibberson M, Pedrazzini T. Discovery and functional characterization of cardiovascular long noncoding RNAs. J Mol Cell Cardiol 2015;89:17-26.   DOI
31 Gao L, Liu Y, Guo S, Yao R, Wu L, Xiao L, et al. Circulating long noncoding RNA HOTAIR is an essential mediator of acute myocardial infarction. Cell Physiol Biochem 2017;44:1497-1508.
32 Haemmig S, Simion V, Feinberg MW. Long non-coding RNAs in vascular inflammation. Front Cardiovasc Med 2018;5:22.   DOI