• Bulletin of the Korean Chemical Society
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• 제32권2호
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• pp.645-650
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• 2011

The 3D-QSAR study of 2-arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors was performed by comparative molecular field analysis (CoMFA), CoMFA region focusing (CoMFA-RF) for optimizing the region for the final PLS analysis, and comparative molecular similarity indices analysis (CoMSIA) methods to determine the factors required for the activity of these compounds. The best orientation was searched by all-orientation search strategy using AOS, to minimize the effect of the initial orientation of the structures. The predictive ability of CoMFARF and CoMSIA were determined using a test set of twelve compounds giving predictive correlation coefficients of 0.886, and 0.754 respectively indicating good predictive power. Further, the robustness and sensitivity to chance correlation of the models were verified by bootstrapping and progressive scrambling analyses respectively. Based upon the information derived from CoMFA(RF) and CoMSIA, identified some key features that may be used to design new inhibitors for cholesteryl ester transfer protein.

• 방사선산업학회지
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• 제9권1호
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• pp.37-46
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• 2015

This study examines mutual perceptions between general public and nuclear plant employees on understanding nuclear policy communication applying the co-orientation model. The total of 414 responses were analyzed including 211 of the general public and 203 of plant employees. Results indicate that agreement between general public and plant employees is relatively high, in that general public tends to have negative evaluation to nuclear policy communication, but plant employees tends to have positive one. In terms of congruence, general public perceive that plant employees might have more positive evaluation than themselves, and nuclear plant employees perceive that general public might have more negative evaluation than themselves. Finally, in terms of accuracy, general public accurately estimate how nuclear plant employees perceive on policy communication, whereas nuclear plant employees unaccurately estimate how general public perceive on policy communication.

• Bulletin of the Korean Chemical Society
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• 제34권3호
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• pp.899-906
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• 2013

Using generated conformations from docking analysis by Gold algorithm, some 3D-QSAR models; CoMFA and CoMSIA have been created on 39 N-benzoylated phenoxazines and phenothiazines, including their S-oxidized analogues. These molecules inhibit the polymerization of tubulin into microtubules and thus they have been studied for the development of antitumor drugs. Training set for the CoMFA and CoMSIA models using 30 docked conformations gives $q^2$ Leave one out (LOO) values of 0.756 and 0.617, and $r^2$ ncv values of 0.988 and 0.956, respectively. The ability of prediction and robustness of the models were evaluated by test set, cross validation (leave-one-out and leave-ten-out), bootstrapping, and progressive scrambling approaches. The all-orientation search (AOS) was used to achieve the best orientation to minimize the effect of initial orientation of the structures. The docking results confirmed CoMFA and CoMSIA contour maps. The docking and 3D-QSAR studies were thoroughly interpreted and discussed and confirmed the experimental $pIC_{50}$ values.

• 한국산학기술학회논문지
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• 제12권9호
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• pp.3924-3935
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• 2011

본 연구는 기업가지향성, 시장지향성, 혁신성, 고객지향성 간의 인과관계와 경영성과에 미치는 영향을 살펴보고자, 기업가 시장지향성과 조직유효성 경영성과 간에 나타나는 혁신성과 고객지향성의 매개효과를 실증 분석하였다. 중소기업 임직원들로부터 받은 설문지 419부를 분석한 결과, 첫째, 기업가지향성이 시장지향성의 선행변수임이 검정되었다. 둘째, 시장지향성이 기업가지향성과 혁신성 고객지향성 간에 매개역할을 하는 것으로 나타났다. 셋째, 기업가적 시장지향성이 혁신성과 고객지향성에 긍정적인 영향을 나타냈다. 넷째, 혁신성과 고객지향성이 조직유효성과 경영성과에 긍정적인 영향을 나타냈다. 다섯째, 본 연구의 핵심이라 할 수 있는 혁신성과 고객지향성이 기업가적 시장지향성과 조직유효성 경영성과 간에 매개효과를 보였다. 이와 같은 본 연구결과는 중소기업 경영에 있어서, 기업가지향성, 시장지향성, 혁신성, 고객지향성과 같은 조직특성의 중요성을 제기함으로써, 이러한 기업문화를 조성하고 이를 고조시킬 수 있는 경영진의 리더십이 중요함을 인식시킬 수 있는 시사점을 제공할 것이다.

• 한국의상디자인학회지
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• 제22권4호
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• pp.39-48
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• 2020

This study's research method was to investigate the effects of career development in the field of beauty on organizational commitment. A survey targeted 271 beauty workers living in Seoul and Gyeonggi-do. For data analysis, SPSS 21.0 was used for statistical processing. First, descriptive statistics were analyzed, followed by a factor analysis and reliability analysis, third, correlation analysis, and finally linear regression analysis. Detailed research results are as follows. First, the effect of career development of beauty workers and organizational commitment was investigated. The result is as follows. The independent variables, self-development, goal orientation, and career orientation, which are sub-variables of career development, were found to have a statistically significant positive effect. Second, the effect of career development of beauty workers on co-workers' organizational commitment was investigated. The result is as follows. By the independent variable, self-development, and career orientation, which are sub-variables of career development, are found to have a significant positive effect. However, goal orientation had no effect. Therefore, based on the results of this study, the implications are as follows. As beauty is a creative pursuit, it is often done in collaboration rather than alone, and therefore camaraderie plays an important part in the foundation of a commitment to a company. It is a field that goes after a goal after committing to a community mindset, instead of pursuing a goal alone.

• 한국산학기술학회논문지
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• 제18권7호
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• pp.569-578
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• 2017

본 연구는 정보다양성 수용 정도와 종업원 태도간의 관계에서 조직 내 대인간 소통의 긍정적인 조절효과를 규명하고자 하였다. 최근 전 세계적으로 조직 내 다양성이 증대되고 있는 상황에서 국내 조직에서도 인적구성의 다양성이 심화되고 있다. 따라서 조직 내 다양성 관리를 어떻게 하느냐에 따라 조직성과에 미치는 영향이 달라질 수 있다. 기존 다양성 연구들은 객관적인 다양성 특성의 분산에만 초점을 맞추고 있기 때문에 혼재된 연구결과들을 도출하고 있다. 본 연구는 기존 다양성 연구들의 불일치된 연구결과들을 극복하기 위해 구성원들이 다양성을 어떻게 지각하는지에 대해 관심을 두고자 하였으며, 이를 위해 정보다양성 수용 정도라는 변수를 활용하였다. 분석을 위해 국내기업에 종사하는 301명의 조직구성원들을 대상으로 위계적 회귀분석을 활용하여 가설을 검증하였다. 분석결과, 정보다양성 수용 정도는 직무만족과 조직몰입에 정(+)적인 영향을 미쳤다. 소통의 조절효과에서는 동료와의 소통에서만 긍정적인 조절효과가 검증되어 소통 유형에 따라 변수들에 미치는 영향력이 다름을 확인하였다. 연구결과를 토대로 연구의 시사점과 향후 연구방향을 제시하였다.

• International Journal of Advanced Culture Technology
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• 제8권1호
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• pp.44-55
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• 2020

The degree of mutual understanding between nursing students and instructors regarding simulation-based education remains unknown. The purpose of this study was to identify the subjectivity of nursing students and instructors about simulation-based learning, and was intended to expand the mutual understand by employing the co-orientation model. Q-methodology was used to identify the perspectives of 46 nursing students and 38 instructors. Perception types found among students in relation to simulation-based learning were developmental training seekers, instructor-dependent seekers, and learning achievement seekers. The instructors estimated the student perception types as passive and dependent, positive commitment, demanding role as facilitators, and psychological burden. Perception types found among instructors included nursing capacity enhancement seekers, self-reflection seekers, and reality seekers. The students classified the instructors' perception types as nursing competency seekers, learning reinforcement seekers, and debriefing-oriented seekers. As a result of the analysis of these relations in the co-orientation model, instructors identified psychological burden and passive and dependent cognitive frameworks among students; however, these were not reported in the students' perspectives. Likewise, the reality seekers type found among the perception types of instructors was not identified by the students. These findings can help develop and implement simulation-based curricula aimed at maximizing the learning effect of nursing students.

• 재활치료과학
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• 제11권4호
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• pp.7-22
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• 2022

목적 : 본 연구는 국내 CO-OP 중재 연구를 체계적으로 고찰하여 임상적 근거를 제공하고자 한다. 연구방법 : 본 연구는 2015년 1월부터 2021년 12월까지 학술연구정보서비스(RISS), 학술교육원(e-article) 데이터베이스에 게재된 문헌 중 선정기준에 적합한 13편의 논문을 최종적으로 선택하여 연구 방법의 내용에 따라 일반적 특성과 질적 수준으로 나누어 분석하였다. 결과 : 연구 내용을 분석한 결과, 2015년 이후 연구가 지속적으로 진행되었으며 CO-OP 중재 연구의 근거 수준은 개별대상연구가 주를 이루었다. 연구 대상은 아동과 성인 모두에게 적용되고 있었으며, CO-OP 중재의 목표 활동 영역으로 아동은 놀이와 여가, 성인은 수단적 일상생활 영역으로 나타났다. 중재의 효과를 살펴보기 위한 평가로는 COPM과 PQRS 평가를 많이 사용하였으며 구체화 전략으로는 아동은 자세, 집중하기, 과제변형, 언어적 상상을 많이 사용하였고 성인은 자세, 집중하기, 과제변형, 움직임에 대한 느낌, 언어적 상상, 과제 촉진 언어를 주로 사용한 것으로 나타났다. 결론 : 본 연구를 통해 국내 CO-OP 중재를 적용한 연구의 특성과 질적 수준을 확인할 수 있었다. CO-OP 중재가 작업치료 분야에서 지속해서 적용되고 있으며, 적용 연령과 진단군이 확대되고 있음을 알 수 있었다. 국내 CO-OP 중재 연구의 체계적 고찰을 통해 임상에서 CO-OP 중재를 실행하기 위한 근거 자료를 제공하였다는 데 의의가 있다.

• 유통과학연구
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• 제12권8호
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• pp.71-82
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• 2014

Purpose - This study is to examine the effect of environmental orientation on innovation, environmental and market performance in Korean franchise firms' context. This study also investigates how environmental orientation, innovation and environmental performance play mediating roles between environmental orientation and market performance. For these purposes, the authors developed a structural model which consists of several constructs. In the model, environmental orientation was proposed to affect innovation and environmental performance, while innovation and environmental performance influence market performance. Specifically, innovation and environmental performance were proposed as core mediators between franchise firms' environmental orientation and market performance. Research design, data, and methodology - The data were collected from 155 franchise firms in Korea during January 2012. The results of factor analysis with reliability test with Cronbach's α warranted unidimensionality of the measures for each construct. In addition, nomological validity of the measures of each construct was warranted from the result of correlation analysis. The data were analyzed with reliability analysis, and structural equation modeling with SPSS Win/PC 18.0 and AMOS 18.0. Results - The results of the overall model analysis appeared as follow: χ²=52.388(df=21), p=.000. GFI=.932, AGFI=.854, NFI=.964, CFI=.978, RMSEA=.099, RMR=.059. Since the result of the overall model analysis demonstrated a good fit, we further analyzed our data. The findings can be summarized as follows: Firstly, the environmental orientation had a positive effect on innovation and environmental performance, but had not a direct effect on market performance. Secondly, innovation had a positive effect on environmental performance, but had not a direct effect on market performance. Thirdly, environmental performance had a positive effect on market performance. Conclusions - The results of this study show that, in order to achieve competitive advantages and environmental and market performance in turbulent market situation, franchise firms should emphasize internal and external environmental orientation, and put through improvements in perspective of technology, organization, and product. Consequently, this research suggests that environmental orientation is a motive for franchise companies' innovation, environmental performance, and market performance. It also suggests theoretical and managerial implications, limitations, and further research directions.

• 한국표면공학회지
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• 제53권1호
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• pp.1-8
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• 2020

Sulfamate-chloride baths were fabricated to study the properties of the electrodeposited Ni and NiCo thin films. The dependences of current efficiency, deposit composition of Ni and Co, residual stress, surface morphology and microstructure of electrodeposited Ni and NiCo thin films on CoCl₂ concentration in sulfamate-chloride baths were investigated. The current efficiency was measured to be more than about 90%, independent of the changes of CoCl₂ concentration in the baths. Residual stress of Ni and NiCo thin films was increased from about 45 to about 250 MPa with varying CoCl₂ concentration from 0 to 0.210 M CoCl₂ in the baths and then reached to a plateau, about 250 MPa above 0.420 M CoCl₂ concentration. Nodular surface morphologies were observed at most CoCl₂ concentrations in the baths except 0.210 M. NiCo thin film electrodeposited from the bath with 0.210 M CoCl₂ concentration showed an acicular surface morphology. Pure Ni thin film consists of FCC(111), FCC(200), FCC(220), and FCC(311) peaks without any preferred orientation. On the other hand NiCo thin films make up of HCP(100), FCC(111), HCP(101), FCC(200), FCC(220) or HCP(110), FCC(311) or HCP(112) and FCC(222) peaks. It was revealed from the analysis of XRD result that FCC(111) peak at the NiCo thin film electrodeposited from the bath with 0.084 M CoCl₂ concentration can be regarded as the preferred orientation. However the peak of the preferred orientation was changed to FCC(220) or HCP(110) above 0.084 M CoCl₂ concentration in the baths. Then the intensity of FCC(220) or HCP(110) peak was gradually decreased with increasing CoCl₂ concentration further. The crystalline size of pure Ni thin film was observed to be about 53 ㎛ and those of NiCo thin films were in the range of 35~45 ㎛.