• Journal of Pharmaceutical Investigation
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• v.27 no.4
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• pp.287-293
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• 1997

To make a stable o/w emulsion, the effects of egg lecithin as an emulsifier and polyvinylpyrrolidone (PVP) as an auxiliary emulsifier on the physical stability of emulsion were investigated. The oil-in-water emulsion system was manufactured by microfluidizer and evaluated the physical stability. Average particle size and size distribution of emulsion was measured by dynamic light scattering analyzer and interfacial tension was measured. From the interfacial tension tested, critical micelle concentration of the egg lecithin was 0.1 %w/v and optimal concentration for the preparation of emulsion was 1.0 %w/v. The mean particle size was about $0.2\;{\mu}m$ which was suitable for injections. The short-term accelerated stability studies were conducted by centrifugation, freeze-thaw method and shaking of the emulsion samples. The addition of PVP was caused the reduction in the particle size and improved the physical stability of emulsion. These results suggested that a mixed interfacial film comprising the egg lecithin and PVP was formed at the o/w interface and it was effective in preventing phase separation under thermic or mechanical stress. We used antineoplaston A10 (A10) as a model drug which is peptide and amino acid derivative having a action to the living organism against the development of neoplastic growth by a nonimmunological progress. It has a poor solubility in water and there may be a difficulty in formulation of A10. Emulsion formulation study about A10 was performed. Solubility of A10 in emulsion was about five times as high as that in water. From the results of solubility and partition coefficient, almost A10 molecules in o/w emulsion exist in the interface between oil and water.

• Journal of the Korean Society for Marine Environment & Energy
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• v.15 no.2
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• pp.118-125
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• 2012

World population has increased rapidly following the industrial revolution, reaching 7 billion in 2012. Several forecasts estimate that this number will rise to about 8 billion in 2025. Improvements of living standards in developing nations have also raised resource and energy demands worldwide. In consequences, human beings have faced many global and urgent problems, such as global warming, water and food shortages, resource and energy crises, and so on. Many ocean utilization technologies for avoiding or reducing such big problems have been developed, for examples $CO_2$ ocean sequestration, seawater desalination, artificial upwelling, deepwater mining, and ocean energies. It is important, however, to assess such technologies from the viewpoints of sustainability and public acceptancy, since the aims of those technologies are to develop sustainable social systems rather than conventional ones based on fossil resources. Inclusive Marine Pressure Assessment and Classification Technology Research Committee (generally called IMPACT Research Committee) of Japan Society of Naval Architects and Ocean Engineers, has proposed Inclusive Impact Index "Triple I" as an indicator, which can predict both environmental sustainability and economical feasibility, in order to assess the ocean utilization technologies from the viewpoints of sustainability and public acceptancy. This index was considered by combining Ecological Footprint and Environmental Risk Assessment. The Ecological Footprint and the Environmental Risk Assessment are introduced in the first part of this paper. Then the concept and the structure of the Triple I are explained in the second part of this paper. Finally, the economy-ecology conversion factor in Triple I accounting is considered.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.16 no.5
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• pp.121-133
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• 2017

Since the mid 1990s, policies have been actively promoted to improve safety and pedestrian environment around the school such as the improvement of School zone. However, the prevention of accidents was not effective because it did not extend to the school road where the main transportation route for children's commuting takes place. In addition, due to the rapid increase of automobiles, trunk road traffic in the peak time bypasses the back roads, which threatens children's safety and the environment by invading the school area, which is the main living space of children. In this study, the characteristics of domestic children's traffic accidents were investigated and the problems were analyzed by conducting a field survey on Yeouido Secondary School in Seoul and Unjung Elementary School in Gyeonggi Province. In addition, Variable speed limit signs and Beacons were installed in the pedestrian road of comunity including School zone, and the effects of facilities on the speed of vehicles were analyzed. As a result of the analysis, the Variable speed limit sign showed a deceleration effect of about 8.3km/h, and the Beacon showed a phenomenon in which the traveling speed of 0.8km/h increased only slightly. In addition, the traffic violation rate of passenger cars, buses, and lorries decreased by about 3% as a result of investigating the number of traffic violation vehicles before and after installation.

• Journal of the Korean Society of Food Science and Nutrition
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• v.37 no.9
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• pp.1214-1221
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• 2008

The aim of this study is to propose suggestions for establishing Korean regulatory standards of infant formula. Accordingly, the regulatory standards for food contaminants and additives in Korean infant formulas were compared and analyzed with those in CODEX, EU, Australia and New Zealand. Several suggestions for regulations were found from different countries. Firstly, it is advisable that additives for nutrient supplement of infant formula be classified as types of nutrients. Secondly, it is proposed that guidelines should be set on the maximum amount of additives in infant formula. Thirdly, pathogens such as Staphylococci and Salmonella of infant formula should be regulated. Finally, present regulations need to establish the maximum permissible levels of some pesticides, Pb and Al, that other countries are already regulating. These proposed recommendations would broaden the scope of infant formula regulatory standards needed for infants' health.

• Journal of Korean Home Economics Education Association
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• v.23 no.1
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• pp.1-17
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• 2011

The purpose of this paper was to explore the materials in the Korean and Japanese Home Economics textbooks in middle school with the perspective of green life education. Home Economics is one of the relevant subjects to green growth education. Therefore, home economics teachers need to teach green life based on the low $CO_2$-green growth in the class. Sustainable living at home has been emphasized as one of the main importance of Home Economics since the first curriculum period. However, it is required to reinforce in the 2009 revised curriculum. The content analyses had been done to explore the materials of five areas in the 8 Korean and 2 Japanese junior highschool Home Economics textbooks through two checking steps. Each subject area of Home Economics had various form of materials such as terminology, table figure pictures, reading, and activity, related to green life related to environmental, economic, and social sustenance. The forms and the quantity of materials were some what differ by subject areas as well as textbooks. The levels of material contents were ranged from the knowledge, recognition, to intention to practicum of green life. The green life materials were more likely practical in Japanese textbooks rather than Korean ones. It is recommended teachers to choose the valuable materials over the textbooks and practical green life should clearly mentioned in home economics curriculum to be showed in textbooks.

• Journal of Global Scholars of Marketing Science
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• v.15 no.1
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• pp.41-60
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• 2005

The purposes of this study were 1)to examine the conceptual structure of purchasing motives and information seeking of beauty service, 2)to find out the effects of purchasing motives on information seeking, and 3)to investigate the differences of purchasing motives and information seeking according to the demographic variables. The questionnaire was developed based on pretest and previous studies, and completed by 331 female consumers living in Seoul and Busan. Data were analyzed by factor analysis, Cronbach's a, regression analysis, Pearson's correlation, ANOVA, and Duncan test. The results are as follows; First, factor analysis showed that the purchasing motives of beauty services consisted of five factors, such as Fashionableness, Impulse purchase, Special event, Mood & Recreation, and Practical purchasing needs. And the information seeking for beauty services consisted of four factors, such as Mass media, Opinions of neighbors, Experience & Observation, and Sales hook. Second, mass media was effected by fashionableness, impulse purchase, special event, and mood & recreation. Experience & Observation was effected by fashionableness, special event, and mood & recreation. Sales hook was effected by fashionableness, and impulse purchase. Third, the dimensions of purchasing motives and information seeking of beauty service were significantly different according to age, marriage or unmarried, and duties.

• Journal of Digital Convergence
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• v.15 no.5
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• pp.207-215
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• 2017

With rapid development of IT technology and biotechnology, human lifespan is extended rapidly, and we are living in the era where aging becomes the social issue. Due to this aging problem, manpower is mainly replaced by Automated Guided Vehicles (AGV) in manufacturing factories or warehouse logistics transportation. Rate of AGV use increases sharply every year. AGVs, which were used only in Smart Factories, extends its usage into indoor and outdoor operation by changing their usages to container transportation that can carry huge containers in the harbor. With the expansion of AGVs usage, the importance of RCS (Remote Control System) is also increased. In this study, we surveyed and analyzed the characteristics and technology trends of technical features of AGV's RCS that are developing in various ways to establish quality evaluation system of AGV RCS. Based on this, and by referring to international quality assessment standards, ISO/IEC 25000 series, we derived evaluation items on functional suitability and usability to secure reliability of AGV RCS. Also, it is our intention to develop evaluation model using those derived usability and reliability evaluation items.

• Korean Journal of Environmental Biology
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• v.17 no.1
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• pp.1-9
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• 1999

Numerous observations revealed strong evidence of increased middle ultraviolet radiation or UV-B (280 ~ 320 nm) at the earth's surface resulting from stratospheric ozone depletion. UV is the waveband of electromagnetic radiation which is strongly absorbed by nucleic acids and proteins, thus causing damage to living systems. It has been recorded in the East Sea, Korea that solar UV-B impinging on the ocean surface penetrates seawater to significant depths. Recent researches showed that exposure to UV-B for as short as 2h at the ambient level (2.0 Wm$^{-2}$) decreased macroalgal growth and photosynthesis and destroyed photosynthetic pigments. These may suggest that UV-B could be an important environmental factor to determine algal survival and distribution. Some adaptive mechanisms to protect macroalgae from UV-damage have been found, which include photoreactivation and formation of UV-absorbing pigments. Post-illumination of visible light mitigated UV-induced damage in laminarian young sporophytes with blue the most effective waveband. The existence of UV-B absorbing pigments has been recognized in the green alga, Ulva pertusa and the red alga, Pachymeniopsis sp., which is likely to exert protective function for photosynthetic pigments inside the thalli from UV-damage. Further studies are however needed to confirm that these mechanisms are of general occurrence in seaweeds. Macroalgae together with phytoplankton are the primary producers to incorporate about 100 Gt of carbons per year, and provide half of the total biomass on the earth. UV-driven reduction in macroalgal biomass, if any, would therefore cause deleterious effects on marine ecosystem. The ultimate impacts of increasing UV-B flux due to ozone destruction are still unknown, but the impression from UV studies made so far seems to highlight the importance of setting up long-term monitoring system for us to be able to predict and detect the onset of large -scale deterioration in aquatic ecosystem.

• Radiation Oncology Journal
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• v.13 no.4
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• pp.385-390
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• 1995

Purpose : To assess the efficacy of craniospinal radiotherapy in patients with acute lymphoblastic leukemia (ALL) experiencing the CNS relapse. Materials and Methods: Thirty ALL patients with relapse in the central nervous system (CNS) were treated with radiotherapy and intrathecal chemotherapy. Age ranged 2 to 46. The number of males and females were all 15. Twenty-two cases were previously treated with presymptomatic radiotherapy to the whole brain. The extent of radiotherapy was the whole brain (18-24 Gy) and the whole spine (12 Gy) in 21 cases but the whole brain only in the 9 cases with poor performance. Results : The complete remission rate in the CNS was $100{\%}$. Among the 12 cases ($40{\%}$) who had secondary relapse, 9 cases had the bone marrow relapse alone, 2 cases had the CNS and bone marrow relapse, 1 cases had the CNS relapse alone. Higher CNS remission rate was observed when the initial remission duration was longer than 24 months or radiation was delivered to the whole brain and the whole spine. Survival rate at 2 year was $31.6{\%}$. Remission duration in the 10 living patients ragned from 9 to 87 months (median; 58 months).

• Analytical Science and Technology
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• v.27 no.5
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• pp.223-227
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• 2014

${\delta}$-Aminolevulinic acid (ALA) is a compound which is widely present in the biosphere and plays an important role in the living body as an intermediate of the tetrapyrrole compound biosynthesis pathway that leads to heme in mammals and chlorophyll in plants. ALA is of interest as a biodegradable mediator, a growth regulator, a precursor of heme proteins, and an effective agent used in therapy of cancer. It has been recently reported that ALA is commonly used in dermatology, due to good effects of skin therapy. Although for the last few decades a substantial amount of research has been focused on the elucidation of the mechanism of ALA and the improvement of its therapeutic activity, it's effect on the cell functions and growth was not cleared. Here, we identified that ALA treatment could attenuate cell proliferation of HEK293T and HaCaT cells. In addition, ALA treatement could induce apoptosis of HeLa cells. These results suggest that apoptosis induced by ALA treatment might be responsible for inhibition of cell proliferation. These results propose the possibility of the improved therapeutic strategy making ALA one of the effective drugs used in human cancers.