• Proceedings of the PSK Conference
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• 2002.10a
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• pp.387.2-387.2
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• 2002

The rhizomes of Cnidium ollicinale Makino (Umbelliferae) has been used as sedatives and analgesics in the Traditional Medicine in Korea. The essential oil of this rhizomes has been reported to possess CNS depressant activity. however, its analgesic activity has not yet been investigated. (omitted)

• Smart Media Journal
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• v.12 no.10
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• pp.102-109
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• 2023

This study aimed to investigate the growth parameters and antioxidant activity of Cnidium officinale under controlled temperature and carbon dioxide levels during the cultivation period. The plants were cultivated for four months, each group being set at the average temperature of the cultivation area +1.8℃/445ppm(SSP1), +3.6℃/872ppm(SSP3), and +4.4℃/1,142ppm(SSP5), respectively. During the cultivation period, the growth, Top/Root ratio, and leaf weight ratio(LWR) of C. officinale slightly decreased in SSP3 and SSP5 compared to SSP1, while the root weight ratio(RWR) increased. The antioxidant activity and related phenolic compound content in the aerial parts of C. officinale increased proportionally with temperature and CO₂ concentration. However, an adverse effect was observed in the high-concentration SSP5 group. Conversely, in the roots, the SSP5 group exhibited the highest antioxidant activity. This study suggests that it can be utilized as fundamental data necessary for understanding the correlation between environmental conditions and the growth as well as physiological activities of medicinal plants.

• Proceedings of the Korean Society of Life Science Conference
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• 2002.09a
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• pp.49-49
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• 2002

• Current Research on Agriculture and Life Sciences
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• v.15
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• pp.109-114
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• 1997

This studies were conducted to improve the root formation of plantlet derived from shoot tip culture and to evaluate the optium transplanting date of Cnidium officinale Makino in field. The rooting rate of shoot-tip derived plantlets was 81% on media containing 1.0 mg/L IBA and 0.05 mg/L BA within 30 days after culture. Upon transfer into potting soil, the seedling grown well under 75% shading. Optimal transplanting date on taking roots and rhizome growth was May 5 in field.

• Smart Media Journal
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• v.12 no.10
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• pp.93-101
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• 2023

Climate change has emerged as a global problem, with frequent temperature increases, droughts, and floods, and it is predicted that it will have a great impact on the characteristics and productivity of crops. Cnidium officinale is used not only as traditionally used herbal medicines, but also as various industrial raw materials such as health functional foods, natural medicines, and living materials, but productivity is decreasing due to threats such as continuous crop damage and climate change. Therefore, this paper proposes a model that can predict the physiologically active ingredient index according to the climate change scenario of Cnidium officinale, a representative medicinal crop vulnerable to climate change. In this paper, data was first augmented using the CTGAN algorithm to solve the problem of data imbalance in the collection of environment information, physiological reactions, and physiological active ingredient information. Column Shape and Column Pair Trends were used to measure augmented data quality, and overall quality of 88% was achieved on average. In addition, five models RF, SVR, XGBoost, AdaBoost, and LightBGM were used to predict phenol and flavonoid content by dividing them into ground and underground using augmented data. As a result of model evaluation, the XGBoost model showed the best performance in predicting the physiological active ingredients of the sacrum, and it was confirmed to be about twice as accurate as the SVR model.

• The Korea Journal of Herbology
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• v.21 no.3
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• pp.1-6
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• 2006

Objectives : In this report, we were studied the current status and future about cultivation of medicinal plants in Japan. Methods : To analysis the management and production of medicinal crops in Japan, variation of importation and cultivation of four medicinal crops such as Angelica acutiloba Kitagawa, Cnidium officinale Makino, Paeonia lactiflora Pallas and Rehmannia glutinosa Liboschitz var. purpurea Makino within 22 years ($1981{\sim}2002$) were investigated. Also we analyzed the herbal drug market in Japan using literature. Results : In the results, cultivated area and amount of Angelica acutiloba Kitagawa and Paeonia lactiflora Pallas reduced more than 50% within 22 years ($1981{\sim}2002$). Production decrease of medicinal crops is alloting through contract production in China. The cultivation of Rehmannia glutinosa Liboschitz var. purpurea Makino is enforcing minimum procluction for seed security. Conclusion : We hope that this report stimulates research to investigate for the establishment of cultural practices in Korea.

• Proceedings of the Korean Society of Life Science Conference
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• 2002.09a
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• pp.48-48
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• 2002

• 한국약용작물학회:학술대회논문집
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• 2012.05a
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• pp.53-54
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• 2012

• Journal of Korean Medical classics
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• v.25 no.1
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• pp.173-196
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• 2012

Object : From the ancient times, the importance of childbirth has been well recognized by Korean Traditional Medicine. Numeral methods have been developed to ease the labor process and keep the mother and child healthy from conception to labor. Bulsusan(佛手散) is one of the main remedies to healthy labor in KTM, both widely known and applied as well. Method : This paper examines the labor theory and practice of KTM focused on Bulsusan which is composed of Angelica gigas Nakai(當歸) and Cnidium officinale MAKINO(川芎). Result : 1. From the ancient times until the Q$\bar{i}$ng period, much attention was placed to the handling of the placenta, as it was conceived as bearing much relation to the health of the mother and her fate, and thus included in the labor process. 2. There was a recognition of the 'birth pulse[離經脈]', an intense change in the pulse that presents itself prior to somatic signs of labor. 3. There were numerous prescriptions that were administered beforehand to ease the process. They are mostly constituted with medicinals that nurture Gi(氣) and stimulate its flow, which in turn makes the fetus firm and reduces the volume, easing the labor process. 4. The medical practice of labor-induction was called 'Choesaeng(催生)'. The prescriptions which functioned as such were mostly constituted with blood medicinals such as Angelica gigas Nakai and Cnidium officinale MAKINO, those which nurture both Gi(氣) and blood, and medicinals that physically lubricate the labor pathway such as honey, oil and Talcum(滑石). Conclusion : Bulsusan can be used in most problems concerning pregnancy and labor, and cases of emergency blood loss due to injury. The term 'bulsu(佛手)' infers to the medical ability of the great doctor who takes care of major blood-loss situations resulting from discharge of dead fetus, cesarean delivery, etc. The prescription name takes after this meaning, as it deals with similar conditions in its effect.

• Korean Journal of Medicinal Crop Science
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• v.23 no.2
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• pp.109-116
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• 2015

The HWND_G02 (Salvia miltiorrhiza Bunge, Crataegus pinnatifida, Polygonum multiflorum Thunberg, Cnidium officinale Makino) and HWND_G03 (Cinnamonum cassia Blume, Salvia miltiorrhiza Bunge, Crataegus pinnatifida, Polygonum multiflorum Thunberg, Cnidium officinale Makino, Allium macrostemon Bunge) are new natural mixture composed with several oriental herbs. The aim of the present study was to investigate the effects of HWND extracts on high cholesterol diet (HCD)-induced hyperlipidemic rats. Male Sprague-Dawley rats were divided into five groups: control, HCD, atorvastatin (5 mg/kg, po), ethanolic extracts of HWND_G02 (1,000 mg/kg, po) and HWND_G03 (1,000 mg/kg, po) were administered to the HCD-induced hyperlipidemic rats for 4 weeks to evaluate their anti-hyperlipidemic activities. HWND extracts markedly decreased body and liver wight gain, and recovered serum lipid levels, such as total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) in the HCD-induced hyperlipidemic rats. Furthermore, the lipid levels (TC and TG) and the lipid accumulation were significantly lowered in the liver tissue of HWND-administrated rats. After a HCD, each group had a lower atherogenic index (AI) compared to the HCD group. In conclusion, these data suggest that HWND extracts could be the candidate for the material to prevent hyperlipidemia.