Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Antihyperlipidemic Effect of Complex of Medicinal Plant Products on Hyperlipidemic Rats Induced by High Cholesterol Diet

약용식물 혼합물의 고지혈증 개선 효과

  • 이광호 ((주)하원제약 중앙연구소) ;
  • 박현수 ((주)하원제약 중앙연구소) ;
  • 윤용한 ((주)하원제약 중앙연구소) ;
  • 신용봉 ((주)하원제약 중앙연구소) ;
  • 백영찬 ((주)하원제약 중앙연구소) ;
  • 구대호 ((주)하원제약 중앙연구소) ;
  • 김성규 ((주)하원제약 중앙연구소) ;
  • 김명석 ((주)하원제약 중앙연구소)
  • Received : 2015.01.02
  • Accepted : 2015.02.16
  • Published : 2015.04.28
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Abstract

The HWND_G02 (Salvia miltiorrhiza Bunge, Crataegus pinnatifida, Polygonum multiflorum Thunberg, Cnidium officinale Makino) and HWND_G03 (Cinnamonum cassia Blume, Salvia miltiorrhiza Bunge, Crataegus pinnatifida, Polygonum multiflorum Thunberg, Cnidium officinale Makino, Allium macrostemon Bunge) are new natural mixture composed with several oriental herbs. The aim of the present study was to investigate the effects of HWND extracts on high cholesterol diet (HCD)-induced hyperlipidemic rats. Male Sprague-Dawley rats were divided into five groups: control, HCD, atorvastatin (5 mg/kg, po), ethanolic extracts of HWND_G02 (1,000 mg/kg, po) and HWND_G03 (1,000 mg/kg, po) were administered to the HCD-induced hyperlipidemic rats for 4 weeks to evaluate their anti-hyperlipidemic activities. HWND extracts markedly decreased body and liver wight gain, and recovered serum lipid levels, such as total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) in the HCD-induced hyperlipidemic rats. Furthermore, the lipid levels (TC and TG) and the lipid accumulation were significantly lowered in the liver tissue of HWND-administrated rats. After a HCD, each group had a lower atherogenic index (AI) compared to the HCD group. In conclusion, these data suggest that HWND extracts could be the candidate for the material to prevent hyperlipidemia.

Keywords

References

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