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http://dx.doi.org/10.7783/KJMCS.2015.23.2.109

Antihyperlipidemic Effect of Complex of Medicinal Plant Products on Hyperlipidemic Rats Induced by High Cholesterol Diet  

Lee, Kwang Ho (Central Research Institute of Hawon Pharmaceutical)
Park, Hyun Soo (Central Research Institute of Hawon Pharmaceutical)
Yun, Yong Han (Central Research Institute of Hawon Pharmaceutical)
Shin, Young Bong (Central Research Institute of Hawon Pharmaceutical)
Baik, Young Chan (Central Research Institute of Hawon Pharmaceutical)
Kooh, Dae Ho (Central Research Institute of Hawon Pharmaceutical)
Kim, Sung Kew (Central Research Institute of Hawon Pharmaceutical)
Kim, Myoung Seok (Central Research Institute of Hawon Pharmaceutical)
Publication Information
Korean Journal of Medicinal Crop Science / v.23, no.2, 2015 , pp. 109-116 More about this Journal
Abstract
The HWND_G02 (Salvia miltiorrhiza Bunge, Crataegus pinnatifida, Polygonum multiflorum Thunberg, Cnidium officinale Makino) and HWND_G03 (Cinnamonum cassia Blume, Salvia miltiorrhiza Bunge, Crataegus pinnatifida, Polygonum multiflorum Thunberg, Cnidium officinale Makino, Allium macrostemon Bunge) are new natural mixture composed with several oriental herbs. The aim of the present study was to investigate the effects of HWND extracts on high cholesterol diet (HCD)-induced hyperlipidemic rats. Male Sprague-Dawley rats were divided into five groups: control, HCD, atorvastatin (5 mg/kg, po), ethanolic extracts of HWND_G02 (1,000 mg/kg, po) and HWND_G03 (1,000 mg/kg, po) were administered to the HCD-induced hyperlipidemic rats for 4 weeks to evaluate their anti-hyperlipidemic activities. HWND extracts markedly decreased body and liver wight gain, and recovered serum lipid levels, such as total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) in the HCD-induced hyperlipidemic rats. Furthermore, the lipid levels (TC and TG) and the lipid accumulation were significantly lowered in the liver tissue of HWND-administrated rats. After a HCD, each group had a lower atherogenic index (AI) compared to the HCD group. In conclusion, these data suggest that HWND extracts could be the candidate for the material to prevent hyperlipidemia.
Keywords
HWND_G02; HWND_G03; Hyperlipidemia; Triglyceride; High Cholesterol Diet; Natural Product;
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Times Cited By KSCI : 12  (Citation Analysis)
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