• Biomolecules & Therapeutics
• /
• v.6 no.3
• /
• pp.328-336
• /
• 1998

The subacute oral toxicity study of DWP-311 was carried out in Sprague-Dawley rats of both sexes. We daily examined clinical signs, body weights, hematological and biochemical parameters, and histopathological examinations for 30 days after administration of DWP-311 with different dose levels (0, 0.04, 0.2, and 1.0 g/kg). There were no clinical signs and pathological changes compared with control group except slight decreases in spontaneous motor activities and locomotions at high dose group of DWP-311. Body weights were not significantly changed in animals treated with DWP-311, In histopathological examinations, there were 2 cases of pneumonia in control group for one male and one female, but it was not directly related to DWP-311. These results indicate that subacute oral toxicities of DWP-311 were low and the no-observed a dverse effect level (NOAEL) was considered to be 1.0 g/kg in rats.

• Biomolecules & Therapeutics
• /
• v.10 no.1
• /
• pp.7-11
• /
• 2002

A single administration toxicity of (R)-JG-381 was studied in Sprague-Dawley rats of both sexes. In this study, rats were administered orally with dose of 50, 100, 200, 400 and 800 mg／kg of(R)-JG-381. We daily examined number of deaths, clinical signs, body weights and gross findings fur 14 days after (R)-JG-381 administration. When we administered different doses of 100, 200, 400 and 800 mg／kg, we found 5, 3, 5 and 5 male rats and 1, 4, 4 and 5 female rats dead within 1 day after administration, respectively. Some clinical signs(decrease of locomotor activity, decreased respiration rate, lacrimation, prone position) were observed during the experimental period. Our findings suggest that oral $LD_{50}s$(95% confidence limit) for male and female rats are 93.8mg／kg (28.8~161.6mg／kg) and 166.3mg／kg (89. I~284.8mg／kg), respectively.

• Biomolecules & Therapeutics
• /
• v.4 no.4
• /
• pp.330-333
• /
• 1996

Acute intravenous toxicities of rHu-EPO (recombinant human erythropoietin) were investigated in Sprague-Dawley rats. Seven days after administration of rHu-EPO, we examined the clinical signs, mortalities, body weight and etc. No clinical signs and mortalities of toxicity were observed in animals. Also, a significant change of body weights was not observed. These results suggest that LD$_{50}$ value was >25,000 unit/ kg in Sprague-Dawley rats and the acute intravenous toxicities of rHu-EPO were not significant.t.

• Korean Journal of Veterinary Research
• /
• v.24 no.1
• /
• pp.110-119
• /
• 1984

Effects on the healing process of the wound was compared between acupuncture and medicament anesthesia. Ten adult dogs were used and far medicament anesthesia thiopental sodium (Ravonal (R)) was injected. Incisions were made under anesthesia and thereafter clinical signs were observed and histopathological examinations were performed. Experimental results were summanized as following; No differences were found in the clinical signs between the two groups. Macroscopically and microscopically, the healing process was a little faster in the wounds under acupuncture anesthesia than under medicament anesthesia.

• Korean Journal of Veterinary Research
• /
• v.46 no.4
• /
• pp.405-408
• /
• 2006

A 4-year-old male Miniature Pinscher was referred because of head tilt, nystagmus, and ataxia. The hemogram revealed a moderate neutrophilic leukocytosis. On magnetic resonance imaging, cerebellar inflammation was detected. And cerebrospinal fluid analysis indicated marked neutrophilic pleocytosis. Based on these results, bacterial meningoencephalitis was suspected. The clinical signs were well controlled by a combination antibiotics therapy of the third generation cephalosporins (cefotaxime and cefixime) and metronidazole. We tentatively diagnosed this case as a bacterial meningoencephalitis because clinical signs were improved after only antibiotics therapy and relapsed when stopped antibiotics administrations, even though the result of bacterial culture on communication of cerebrospinal fluid (CSF) was negative.

• Archives of Plastic Surgery
• /
• v.44 no.6
• /
• pp.559-563
• /
• 2017

Supported by recent literature on the signs of aging of the middle and lower face, our clinical research has documented a loss of volume of the deep structural components of the central face and a progressive descent of the nasolabial fat and the jowl fat, leading to facial fragmentation. The signs that appear around the age of 45 to 50 years are well targeted by the mini-invasive technique described here. We focused on refitting the jowl fat and the nasolabial fat associated with cutaneous tightening. The use of absorbable barbed sutures (Quill) led to significant improvements, enabling the fitting of fat on fat. In the past 4 years, 167 operations were performed using this technique. The clinical results were very satisfactory, yielding a natural effect caused by the mobilization and strong fixation of the nasolabial fat and the jowl fat in the direction opposite to their displacement.

• Journal of Veterinary Clinics
• /
• v.18 no.3
• /
• pp.279-283
• /
• 2001

Eleven years old cocker spaniel referred to Veterianry Medical Teaching Hospital, Seoul National University was diagnosed as pheochromocytoma. The patient was transferred to the hospital after hit by car and the main clinical signs were tachypnea, tachycardia, edema of hindlimb and lethargy. On ultrasonographic examination, hyperechoic foci was detected and it was invaded into the caudal vena cava. Venography showed the filling defect and local dilation of the caudal vena. The diagnosis of pheochromocytoma is challenging due to the nonspecific clinical signs and severe concurrent disease in dogs. This report describes one dog with invasive pheochromocytoma in which radiography, ultrasonography and venacavography were key diagnositc tools. Ultrasonography was a usuful method for assessment of size, shape and margination of the tumor and invasiveness to the major vessels.

• Journal of Veterinary Clinics
• /
• v.14 no.2
• /
• pp.268-272
• /
• 1997

This study was performed to estimate the clinical signs and biochemical para meters of indicator on acute hepatic injury induced by the administration of CCl$_{4}$ in rats. Minor behavioral changer brittleness of skin hair and decreased volume of water and food intake were observed in rats after 2 hours of $CCl_{4}$ administration compared to control group. Concentration of serum albumin has shown lower than that of control group. However concentration of total bilirubin has shown higher than that of control group. As times go onto serum LDH activity was significantly increased compared to control Broup. Serum CPK activity hasn't shown change compared to control group. Passive hemagglutination that of afetoprotein was shown negative reaction in all the treatment groups and control group.

• Journal of Veterinary Clinics
• /
• v.15 no.1
• /
• pp.75-78
• /
• 1998

This study was performed to estimate the clinical signs and changes of biochemical parameters in rats with hepatic injury induced by the administration of 2, 2'-azobis(2- amidinopropane)dihydrochloride (AAPH) . Minor behavioral change, brittleness of skin hair and decreased volume of water and feed intake were observed in ra% 2 hours after AAPH administration compared to control group. Concentration of serum albumin showed lower than that of control group. However, concentration of total bilirubin has shown higher than that of control group. As time goes on, . serum LDH activity increased significantly compared to control group, but senun CPK activity did not change compared to control group. Passive hemanglutination of $\alpha $-fetoprotein was negative in all the treaDent groups and control group.

• Journal of Veterinary Clinics
• /
• v.25 no.6
• /
• pp.523-525
• /
• 2008

11 year old male Yorkshire terrier was referred to Haemaru Referral Animal Hospital with signs of hematuria, petechia, and gynecomastia. Blood works revealed severe leukopenia, moderate anemia and severe thrombocytopenia. On ultrasonography and radiography, mixed echo texture mass was found in abdomen. The abdominal mass was surgically removed, and submitted for histopathology. Histopathologic features of the tissues were consistent with malignant Sertoli cell tumor. Bone marrow aspirates were hypocellular. Serum estrogen concentration was 72.80 pg/ml (normal range for females <15 pg/ml) after surgery. Clinical signs of feminization and hemorrhagic diathesis were attributed to hyperestrinism caused by the tumor. The dog was put on fluid therapy, antibiotics and palliative drugs and survived 2 more weeks after surgery without clinical improvement.