Acute Toxicity Study of Recombinant Human Erythropoietin(rHu-EPO) in Rats

랫드에서 인체 재조합 적혈구 조혈인자, rHu-EPO의 급성정맥독성시험

  • Published : 1996.12.01

Abstract

Acute intravenous toxicities of rHu-EPO (recombinant human erythropoietin) were investigated in Sprague-Dawley rats. Seven days after administration of rHu-EPO, we examined the clinical signs, mortalities, body weight and etc. No clinical signs and mortalities of toxicity were observed in animals. Also, a significant change of body weights was not observed. These results suggest that LD$_{50}$ value was >25,000 unit/ kg in Sprague-Dawley rats and the acute intravenous toxicities of rHu-EPO were not significant.t.

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