• Journal of the Korean Data and Information Science Society
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• 제21권6호
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• pp.1343-1351
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• 2010

Sample size determination is very important part in clinical trials because it influences the time and the cost of the experimental studies. In this article, we consider the Bayesian methods for sample size determination based on hypothesis testing. Specifically we compare the usual Bayesian method using Bayes factor with the decision theoretic method using Bayesian reference criterion in mean difference problem for the normal case with known variances. We illustrate two procedures numerically as well as graphically.

• 임상간호연구
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• 제30권1호
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• pp.11-23
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• 2024

Purpose: This study developed a scale of nurses' stress and examined the validity and reliability of the scale. Methods: The scale was developed according to DeVellis' scale development procedure. Based on the Nursing Work Environment Stress model and the results of focus group interviews, 43 preliminary items were generated. A survey was conducted with 208 clinical nurses to test the psychometric properties of the scale. Both exploratory factor analysis and confirmatory factor analysis were employed to figure out and confirm the scale's theoretical structure statistically. In addition, content, convergent, and discriminative validity were evaluated and Cronbach's α was calculated to test internal reliability. Results: The final scale consisted of 19 items and verified four-factor structures. The structure of the scale was confirmed using confirmatory factor analysis, and it showed moderate correlations with the Copenhagen Burnout Inventory and Korean Nurses Occupational Stress Scale. Cronbach's α was .87. Conclusion: A scale of nurses' stress to nursing work was developed to embrace a wide range of nurses' psychological responses to nursing work based on the theoretical model.

• Journal of Korean Biological Nursing Science
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• 제22권3호
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• pp.176-183
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• 2020

Purpose: : The purpose of this study was to evaluate the intrauterine insemination (IUI) success rate and to define the variables for predicting success. Methods: The secondary data analysis was used with data collected from infertile females who underwent IUI in Fertility and IVF (In Vitro Fertilization) clinics, who benefited from the 'National Medical-aid Program for ART (assisted reproductive technology) in 2016', in which the data of 34,920 IUI cases were retrospectively reviewed. The primary outcome measure was the clinical pregnancy rate in elderly and young infertile females. Data were analyzed by descriptive statistics, χ2 test and logistic regression. Results: The pregnancy rate was 12.1% (2,095 cases) in elderly infertile females and 15.6% in young infertile females (2,758 cases) (χ2 = 87.90, p< .001). Using the logistic regression analysis, clinical pregnancy was positively associated with the ovulatory factor (OR= 1.48, p< .001) and male factor (OR= 1.19, p< .05) in elderly infertile females. It was positively associated with the ovulatory factor (OR= 1.30, p= .001) and the peritoneal cavity factor (OR= 0.58, p< .05) in young infertile females. Conclusion: Our results indicate that the pregnancy rate in young infertile females was higher than that in old infertile females, and the IUI is the effective option in pregnancies in all ages with infertility due to the ovulatory factor. Additionally, further studies are necessary to fully describe pregnancy experiences for all the infertile females.

• 대한임상검사과학회지
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• 제37권3호
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• pp.197-206
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• 2005

To determine the correlation between mast cells(MCs) and neoangiogenesis in the growth and progression of cervical cancer, we investigated mast cell density(MCD), microvessel density(MVD) and the expression of vascular epithelial growth factor(VEGF) in cervical intraepithelial neoplasia and invasive suqamous cell carcinoma of the uterine cervix. Forty-five cervical intraepithelial neoplasia(CIN I, II and III), 15 microinvasive carcinomas, 15 invasive squamous cell carcinomas and 20 normal cervical epithelia were included in this study. MCs were stained with anti-c-Kit antibody and alcian blue, microvessels with anti-factor VIII antibody and VEGF with anti-VEGF antibody. The adjacent fields of both normal and neoplastic epithelium were used for counting MCs and microvessels. Computerized image analysis was used to evaluate MCD and MVD. MCD and MVD were the mean numbers per $1mm^2$ counted in 5-10 high and low power fields respectively. In both c-Kit and alcian blue stained sections, MCD progressively increased along the continuum from CIN I to invasive squamous cell carcinoma(p<0.001). MVD increased significantly with cervical neoplasia progression, from CIN to invasive squamous cell carcinoma (p<0.001). In double c-Kit and Factor VIII-stained sections, MCs were mainly present in the areas adjacent to newly formed blood vessels. However, there were no significant differences in MCD and MVD between normal epithelum and CIN I. A strong correlation was also observed between MCD and MVD. In double VEGF and alcian blue-stained sections, VEGF was expressed in only MCs. Strong VEGF-positive MCs were particularly abundant around the tumorous region. Our results suggest that MCs may upregulate neoangiogenesis by VGEF secretion in the development and progression of cervical neoplasia.

• Biomolecules & Therapeutics
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• 제21권5호
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• pp.323-331
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• 2013

TGF-${\beta}$ pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-${\beta}$ (TGF-${\beta}$) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-${\beta}$ related functional contexts. This review discusses the molecular mechanism of the TGF-${\beta}$ pathway and describes the different ways of tumor suppression and promotion by TGF-${\beta}$. In the last part of the review, the data on targeting TGF-${\beta}$ pathway for cancer treatment is assessed. The TGF-${\beta}$ inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.

• 한국임상보건과학회지
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• 제7권2호
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• pp.1257-1265
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• 2019

Purpose: This study was conducted to examine the correlations among nursing professionalism, clinical practice satisfaction of nursing students. Method: The subjects were 184 nursing students recruited from one college located in D city. Data were collected using structured questionnaire, and analyzed with the PASW 21.0 program. Results: The results indicate that nursing students have levels of nursing professionalism, and clinical practice satisfaction that are higher than the median. Nursing professionalism showed differences according to plans for academic performance, major satisfaction, personality, and personal relations. Nursing professionalism was significantly correlated with clinical practice satisfaction, major satisfaction. Conclusion: Clinical practice satisfaction, and academic performance were the most influential factor predicting greater nursing professionalism. Thus, these factors should be considered when developing a program for enhancing nursing professionalism.

• 간호행정학회지
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• 제21권3호
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• pp.233-242
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• 2015

Purpose: This was a correlational study to identify effects of perception of clinical ladder system on job satisfaction and intention to leave in perioperative nurses. Methods: Participants were 154 of perioperative nurses from larger general hospitals in Seoul. Data were collected from April, 16 to 22, 2013 using self-report questionnaires which included items on perception of clinical ladder system, job satisfaction, and intention to leave. Data were analyzed using frequency, t-test, ANOVA, $Scheff{{\acute{e}}$ test, Pearson correlation coefficients, and multiple stepwise regression. Results: The average mean score for perception of clinical ladder system was midline at 2.69 point out of 4 point. Perception of clinical ladder system correlated positively with job satisfaction (r=.38, p<.01) and negatively with intention to leave (r=-.88, p<.01). Perception of clinical ladder system was the factor which most influenced job satisfaction explaining 17.1% of the variance, also perception of clinical ladder system was the factor which most influenced intention to leave, explaining 12.7% of the variance. Conclusion: Results of this study suggest that there is a need to enhance the perception of the clinical ladder system and to find ways to fulfill the expected effects for improving perioperative nurses' job satisfaction and reducing the intention to leave.

• 융합정보논문지
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• 제10권5호
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• pp.51-59
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• 2020

본 연구의 목적은 간호대학생의 임상간호인성, 임상실습스트레스, 스트레스 대처 및 간호전문직관의 관련성을 파악하고, 간호전문직관에 영향을 미치는 요인을 규명하여 간호대학생의 올바른 간호전문직관을 증진시키기 위한 프로그램을 개발하는데 기초자료로 활용하기 위함이다. 본 연구는 2019년 5월에서 6월까지 G시 소재 대학에 재학 중인 4학년 학생 145명을 대상으로 하였다. 자료분석은 SPSS를 이용하여 t-test, ANOVA, 상관관계 분석, 단계적 다중회귀분석으로 실시하였다. 연구결과, 간호대학생의 임상간호인성, 임상실습스트레스, 스트레스 대처는 간호전문직관과 유의한 양의 상관관계를 나타냈다. 간호전문직관에 영향을 미치는 요인으로는 임상간호인성과 스트레스 대처로, 이들 요인은 간호전문직관을 38.2% 설명하였고(F=43.973, p=.000), 가장 영향을 미치는 요인은 스트레스 대처로 나타났다(β=.508, p=.000). 본 연구의 결과는 간호대학생의 긍정적인 간호전문직관을 위해서 임상간호인성을 증진시키고 다양한 스트레스 대처방법을 제공하는 것이 필요함을 보여준다.

• 한국간호교육학회지
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• 제17권2호
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• pp.218-225
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• 2011

Purpose: This study was to compare the influencing factors of clinical competence between associate and bachelor nursing students completing nursing courses. Method: The subjects were 429 students completing the nursing courses (172 bachelor course students, and 257 associate course students). The study design was cross sectional. Results: Bachelor students showed a significant higher score in clinical competence than associate students. There were significant influencing factors on clinical competence including critical thinking disposition, professional conduct, communication skill, theoretical education satisfaction, and practice education satisfaction. The strongest factor influencing clinical competence was critical thinking disposition. All the factors mentioned above explained 49% of clinical competence in associate courses, and 40.0% in bachelor courses excluding the factor of practice education satisfaction. The level of theoretical and practice education satisfaction of bachelor courses was significantly lower than associate. Conclusion: It is recommended that associate course nursing students should be encouraged in critical thinking disposition, professional conduct, and communication skill. Bachelor course nursing students should be encouraged in practical education including practical environments, instruction methods, and content for improving clinical competence.

• 한국산학기술학회논문지
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• 제18권8호
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• pp.135-144
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• 2017

본 연구는 2015년도에 개발된 임상간호사들의 병원폭력태도 측정도구인 HVAS-18의 타당도와 신뢰도를 재검증하기 위한 방법론적 연구이다. 본 연구의 대상자는 서울과 인천소재 3개 종합병원 간호사 150명을 대상으로 하였으며 자료수집기간은 2017년 3월 1일부터 4월 2일까지로 하였다. 연구결과 기존 HVAS-18의 18개 문항 중 각 문항들과 전체 문항 간의 수정된 상관계수(corrected item-total correlation coefficient) .30 이상, 요인 적재량 .50 이상 문항들만을 채택하여 최종 14개 문항 4개 영역을 추출하였다. 최종 HVAS-14는 기존 HVAS-18의 설명력 64.0% 보다 8.3% 증가한 71.4%의 높은 설명력을 보여주었다. HVAS-14의 제 1영역은 '인식' 3문항(20.3%), 제 2영역은 '반응' 4문항(20.2%), 제 3영역은 '대응' 3문항(15.5%), 제 4영역은 '결과' 4문항(15.4%)로 구성되어 있었다. HVAS-14의 전체 신뢰도는 Cronbach's alpha=.87 이었고, 도구의 안정성 평가를 위한 급내 상관계수 Cronbach's alpha=.87로 측정되었으며, 4개 하부영역의 Cronbach's alpha=.78~.86으로 측정되었다. HVAS-14는 재검증 과정을 통해 도구의 신뢰도와 타당도 및 도구의 안정성이 검증된 상태이므로 임상간호사의 병원폭력에 대한 태도 측정도구로 적합하고 의료기관외 다양한 영역에서도 쉽게 사용할 수 있을 것이다.