• 대한장애인치과학회지
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• 제3권1호
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• pp.17-21
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• 2007

Allagille 증후군은 담즙분비의 감소로 인한 간의 손상, 황달, 황색종, 소양증 등의 다양한 문제들을 가진다. 구강영역의 문제점으로는 출혈 및 감염, 치아의 변색을 들 수 있다. 또한 증례의 환아와 같이 간이식을 할 경우 지속적인 면역억제제의 사용으로 인한 감염의 위험성은 평생 동안 계속되게 된다. 따라서, Alagille 증후군 환자에 있어서는 다음과 같은 사항들이 치과치료에서 필요하다고 생각된다. 의과 및 치과병력을 정확히 파악하고, 내원마다 전 치아들에 대한 평가를 철저히 실시하며, 발견되는 우식은 더 이상 진행이 되지않도록 즉시 치료해야 한다. 예방적 항생제를 투여하더라도 감염과 출혈을 예방하기위해 치료 시 최소한의 외상이 가해지도록 하며, 치료 후에도 감염의 소지가 있을 수 있는 치아는 제거하는 편이 유리하다. 성장이 끝난 후에는 심미적 기능적인 문제를 해결하기 위해 전 치열에 대한 재건이 필요하며 환자 스스로 구강위생에 신경을 쓸 수 있도록 예방 교육에 힘써야 할 것으로 생각한다.

• 대한임상전기생리학회지
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• 제10권2호
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• pp.43-49
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• 2012

Purpose : This study is to supply basal data need to development of First-Aid education program for female college students of non-health department that we surveyed safety awareness practice, First-Aid knowledge, educational requirement and necessity of the female college students of health and non-health department. Methods : This date was collected from September 1th in 2012 until October 5th by 5 person selected of which explain to purpose and method of the writing. We distributed the subject questionnaire of total 410 and analyzed questionnaire 385 only. Results : The results of this study are follows. First, the health group was higher than non-health group in conductive score of safety awareness and score of First-Aid knowledge in female students and there was statistically significant difference. Second, There was significant difference in Economical state, Educational state of the Safety awareness Practice score and First-Aid knowledge score about the general characteristic of the female college students of health department. Third, there wasn't significant difference in most of all item of the Safety awareness Practice score and First-Aid knowledge score about the general characteristic of the female college students of non-health department. Conclusion : Finally, We found that the female college students of health department lower than the female college students of non-health department in First-Aid knowledge level and surveyed that they felt the needs of First-Aid education. Therefore, there are able to need the opening of a course in order to raise the quality of safety awareness and First-Aid knowledge or to needs construction of educational system in continuously.

• Clinical and Experimental Pediatrics
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• 제59권sup1호
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• pp.14-18
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• 2016

Pediatric epilepsy can be caused by various conditions, including specific syndromes. 1p36 deletion syndrome is reported in 1 in 5,000-10,000 newborns, and its characteristic clinical features include developmental delay, mental retardation, hypotonia, congenital heart defects, seizure, and facial dysmorphism. However, detection of the terminal deletion in chromosome 1p by conventional G-banded karyotyping is difficult. Here we present a case of epilepsy with profound developmental delay and characteristic phenotypes. A 7-year-and 6-month-old boy experienced afebrile generalized seizure at the age of 5 years and 3 months. He had recurrent febrile seizures since 12 months of age and showed severe global developmental delay, remarkable hypotonia, short stature, and dysmorphic features such as microcephaly; small, low-set ears; dark, straight eyebrows; deep-set eyes; flat nasal bridge; midface hypoplasia; and a small, pointed chin. Previous diagnostic work-up, including conventional chromosomal analysis, revealed no definite causes. However, array-comparative genomic hybridization analysis revealed 1p36 deletion syndrome with a 9.15-Mb copy loss of the 1p36.33-1p36.22 region, and fluorescence in situ hybridization analysis (FISH) confirmed this diagnosis. This case highlights the need to consider detailed chromosomal study for patients with delayed development and epilepsy. Furthermore, 1p36 deletion syndrome should be considered for patients presenting seizure and moderate-to-severe developmental delay, particularly if the patient exhibits dysmorphic features, short stature, and hypotonia.

• 한국임상수의학회지
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• 제26권6호
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• pp.603-605
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• 2009

7연령의 암컷 미니어처 슈나우저견이 갑작스런 발작과 근육 떨림 증상을 주증으로 내원하였다. 내원 당시 발열과 헐떡임이 두드러졌으며, 신체검사 상에서 현저한 앞다리 근육 강직증상, 근육부분수축과 뻣뻣한 걸음걸이가 관찰되었다. 실험실 검사에서 심각한 저칼슘혈증과 함께 고인혈증이 특징적으로 관찰되었다. 이와 더불어 관찰된 낮은 농도의 부갑상선 호르몬과 이온화된 칼슘농도, 뇨중 칼슘과 인의 배설 량 측정을 통하여 원발성 부갑상선기능저하증이 진단되었다. 이 환축은 10% 글루콘산칼슘 투여를 통한 초기 치료에 반응이 좋았으며, 비타민 D 유사체와 칼슘 보조제를 통한 유지 치료에 의해 잘 관리 되고 있다. 부작용으로 일시적인 고인혈증이 나타났으나, 이 역시 경구용인 흡착제인 sevelamer hydrochloride를 이용한 치료에 의해 안정화 되었다. 결론적으로 본 증례의 경우 개에서 나타나는 원발성 부갑상선기능저하증의 임상증상과 특징적인 실험실 검사 결과 그리고, 치료 반응에 대한 국내 첫 증례보고이다.

• 대한화장품학회지
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• 제49권4호
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• pp.341-348
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• 2023

본 연구에서는 20 ~ 50 대 한국 여성을 대상으로 일시적 고온건조 환경 조성 전후 피부 수분량, 피부 유분량, 피부 멜라닌, 피부 붉은기, 피부 붉은기 이미지 분석, 경피수분손실량, 피부 각질량을 측정하여 기초 피부 특성 데이터를 수집하였으며, 측정시기 별 각질 채취를 진행하여 피부 바이오마커 중 총단백질량, 카르보닐화 단백질, 중성 지질, 지질 과산화를 분석하였다. 해당 결과를 기반으로 고온건조 환경 조성 전후의 차이를 확인하고, 피부 특성과 피부 바이오마커의 상관성을 확인하였으며, 이를 기반으로 신규 피부 지수를 만들었다. 신규 피부 지수는 제품 효능평가에 반영이 가능하며 추가연구를 통한 신규 인체적용시험법 구성 및 피부 바이오마커 발굴 연구 활용 가능성을 확인하였다.

• Korean Journal of Radiology
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• 제21권4호
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• pp.413-421
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• 2020

Objective: A widely applicable, non-invasive screening method for non-alcoholic fatty liver disease (NAFLD) is needed. We aimed to develop and validate an index combining computed tomography (CT) and routine clinical data for screening for NAFLD in a large cohort of adults with pathologically proven NAFLD. Materials and Methods: This retrospective study included 2218 living liver donors who had undergone liver biopsy and CT within a span of 3 days. Donors were randomized 2:1 into development and test cohorts. CTL-S was measured by subtracting splenic attenuation from hepatic attenuation on non-enhanced CT. Multivariable logistic regression analysis of the development cohort was utilized to develop a clinical-CT index predicting pathologically proven NAFLD. The diagnostic performance was evaluated by analyzing the areas under the receiver operating characteristic curve (AUC). The cutoffs for the clinical-CT index were determined for 90% sensitivity and 90% specificity in the development cohort, and their diagnostic performance was evaluated in the test cohort. Results: The clinical-CT index included CTL-S, body mass index, and aspartate transaminase and triglyceride concentrations. In the test cohort, the clinical-CT index (AUC, 0.81) outperformed CTL-S (0.74; p < 0.001) and clinical indices (0.73-0.75; p < 0.001) in diagnosing NAFLD. A cutoff of ≥ 46 had a sensitivity of 89% and a specificity of 41%, whereas a cutoff of ≥ 56.5 had a sensitivity of 57% and a specificity of 89%. Conclusion: The clinical-CT index is more accurate than CTL-S and clinical indices alone for the diagnosis of NAFLD and may be clinically useful in screening for NAFLD.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7575-7581
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• 2014

MicroRNAs (miRNAs) play an essential role in the development and progression of nasopharyngeal carcinomas (NPC). Despite advances in the field of cancer molecular biology and biomarker discovery, the development of clinically validated biomarkers for primary NPC has remained elusive. In this study, we investigated the expression and clinical significance of miRNAs as novel primary NPC diagnostic biomarkers. We used an array containing 2, 500 miRNAs to identify 22 significant miRNAs, and these candidate miRNAs were validated using 67 fresh NPC and 25 normal control tissues via quantitative real-time PCR (qRT-PCR). Expression and correlation analyses were performed with various statistical approaches, in addition to logistic regression and receiver operating characteristic curve analyses to evaluate diagnostic efficacy. qRT-PCR revealed five differentially expressed miRNAs (miR-93-5p, miR-135b-5p, miR-205-5p and miR-183-5p) in NPC tissue samples relative to control samples (p<0.05), with miR-135b-5p and miR-205-5p being of significant diagnostic value (p<0.01). Moreover, comparison of NPC patient clinicopathologic data revealed a negative correlation between miR-93-5p and miR-183-5p expression levels and lymph node status (p<0.05). These findings display an altered expression of many miRNAs in NPC tissues, thus providing information pertinent to pathophysiological and diagnostic research. Ultimately, miR-135b-5p and miR-205-5p may be implicated as novel NPC candidate biomarkers, while miR-93-5p, miR-650 and miR-183-5p may find application as relevant clinical pathology and diagnostic candidate biomarkers.

• Archives of Plastic Surgery
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• 제34권5호
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• pp.557-561
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• 2007

Purpose: Malignant melanoma is a fatal tumor arising in the melanocytic systems of the skin. The incidence of malignant melanoma, formerly considered a rare tumor in Korea, is observed to increase. The aim of this study is to analyze the clinical and histopathological pattern of malignant melanoma in one institute. Methods: Thirty patients with ages ranging from 33 to 80 years, diagnosed as malignant melanoma at our skin tumor department, were enrolled in a retrospective study over a 6 year period(2000. 9-2006. 7). The analyzed data included age, sex, location, duration before diagnosis, clinical type, level of invasion, and stage. Results: The cases were identified and analyzed by clinical and histopathologic study. The male to female ratio was 1:1.7. Lower extremities(especially, feet) were favored sites. The majority of cases were acral lentiginous melanoma(40%), followed by nodular melanoma (36.7%), superficial spreading melanoma(20%) in this study. Clark level IV was predominant in histopathologic study. There was merely narrow gap among each stage by AJCC. Conclusion: The clinicopathological characteristic of melanoma in our patients is quite different with that in the West. In this retrospective study, primary lesions of the foot were predominant with melanoma, and a high percentage of these were classified pathologically as acral lentiginous melanomas. Patients had a more advanced stage of disease at first presentation and a more deeply invasive primary lesion than Western patients. These suggest that malignant melanoma has a worse prognosis in our patients than in the West. So, further organized prospective studies are needed to approach the prudent and accurate diagnosis and management of melanoma in Korea.

• Annals of Clinical Neurophysiology
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• 제2권2호
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• pp.89-94
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• 2000

Purpose : Carpal tunnel syndrome (CTS) is a disorder of median nerve at wrist. It is usually diagnosed through clinical manifestation and nerve conduction study (NCS). However, sometimes, NCS does not provide a reliable evidence to reach the diagnosis. Thus, authors performed this study to determine whether NCS was correlated with specific parameters measured on magnetic resonance imaging (MRI) which might become a potential complemental diagnostic tool. Methods : We performed MRI in 34 wrists of 18 patients with clinical manifestations of CTS and pathologic nerve conduction values and analyzed them at levels of the distal radioulnar joint, pisiform and hook of hamate, Results : Increase in the cross-sectional area of the median nerve at the pisiform level and flattening, increased signal intensity, and contrast enhancement of the median nerve at levels of the pisiform and hook of hamate were statistically significant. Change in cross sectional areas between the distal radioulnar joint and hamate and the signal intensities at levels of pisiform and hamate were well correlated with the median nerve conduction velocity. Conclusions : Characteristic MRI findings in CTS reported previously were well demonstrated and some of MRI parameters are well correlated with nerve conduction study. MRI, despite cost, may help in evaluating CTS.

• Clinical and Experimental Pediatrics
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• 제50권9호
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• pp.901-904
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• 2007

목 적 : 가역성 후두부 백질 뇌증 증후군은 두정-후두엽의 백질 혹은 회질을 침범하는 특징을 가지는 복합 증후군이다. 이번 연구에서는 이 증후군의 임상적, 방사선학적 특징을 분석하였다. 방 법 : 총 15명의 환아를 대상으로 하였으며. 각 환아에서 급성기 동안의 평균 동맥압을 측정하고 신경학적 사건이 발생하기 수일에서 수주 전 안정 상태의 평균 동맥압을 조사하여 비교하였다. 그리고 이들의 뇌자기 공명 영상을 분석 비교하였으며 모든 연구는 후향적으로 이루어졌다. 결 과 : 15명의 환아(남아 : 9명, 여아 : 6명)의 연령은 2-20세(평균 연령:10세)였다. 뇌 자기공명 영상은 두정-후두엽의 백질 및 피질에 T2-weighted image에서 신호 강도의 증가를 보였다. 대개의 경우에서 스테로이드나 싸이클로스포린 복용 혹은 급격하게 혈압이 증가하는 사건과 관련성을 보였다. 결 론 : 가역성 후두부 백질 뇌증 증후군은 복합적인 신경학적 질환으로 이 복합 증후군에 대한 더 많은 연구를 함으로써 불필요한 검사를 줄이고 즉각적이고 합당한 치료를 환아에게 행할 수 있을 것으로 생각한다.