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Clinical and Radiological Analysis of Reversible Posterior Leukoencephalopathy Syndrome in Children  

Lim, Hae-Ri (Department of Pediatrics, college of Medicine, Kyungpook National University)
Seo, Hye-Eun (Department of Pediatrics, college of Medicine, Kyungpook National University)
Kwon, Sun-Hak (Department of Pediatrics, college of Medicine, Kyungpook National University)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.9, 2007 , pp. 901-904 More about this Journal
Abstract
Purpose : Reversible posterior leukoencephalopathy syndrome is a complex disorder with characteristic clinical and radiologic findings that mainly involve the white/gray matter of the parieto-occipital lobes. The purpose of this study was to determine its clinical and radiological characteristics. Methods : A total of 15 pateints were involved in the study. Their medical records and radiological features of brain MRI were retrospectively reviewed and analyzed. Results : Fifteen pateints were involved. (9 males and 5 females). The patients' ages ranged from 2-20 years (mean age : 10 years). The brain MRI revealed fairly symmetric areas of increased T2 signal involving both white and gray matter of parieto-occipital regions. The condition seemed to be associated with cyclosporin A and steroid therapy or a variety of other conditions in which blood pressure rises acutely. Conclusion : Reversible posterior leukoencephalopathy syndrome is a complicated neurological condition, but a better understanding of this complex syndrome may obviate unnecessary investigations and lead to prompt and appropriate management of the associated problems.
Keywords
Leukoencephalopathy; Seizure; Cyclosporin; Steroid;
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