Browse > Article

Clinical and Radiological Analysis of Reversible Posterior Leukoencephalopathy Syndrome in Children  

Lim, Hae-Ri (Department of Pediatrics, college of Medicine, Kyungpook National University)
Seo, Hye-Eun (Department of Pediatrics, college of Medicine, Kyungpook National University)
Kwon, Sun-Hak (Department of Pediatrics, college of Medicine, Kyungpook National University)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.9, 2007 , pp. 901-904 More about this Journal
Abstract
Purpose : Reversible posterior leukoencephalopathy syndrome is a complex disorder with characteristic clinical and radiologic findings that mainly involve the white/gray matter of the parieto-occipital lobes. The purpose of this study was to determine its clinical and radiological characteristics. Methods : A total of 15 pateints were involved in the study. Their medical records and radiological features of brain MRI were retrospectively reviewed and analyzed. Results : Fifteen pateints were involved. (9 males and 5 females). The patients' ages ranged from 2-20 years (mean age : 10 years). The brain MRI revealed fairly symmetric areas of increased T2 signal involving both white and gray matter of parieto-occipital regions. The condition seemed to be associated with cyclosporin A and steroid therapy or a variety of other conditions in which blood pressure rises acutely. Conclusion : Reversible posterior leukoencephalopathy syndrome is a complicated neurological condition, but a better understanding of this complex syndrome may obviate unnecessary investigations and lead to prompt and appropriate management of the associated problems.
Keywords
Leukoencephalopathy; Seizure; Cyclosporin; Steroid;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Yokobori S, Yokota H, Yamamoto Y. Pediatric Posterior Reversible Leukoencephalopathy Syndrome and NSAID-induced acute tubular intersitial nephritis. Pediatr Neurol 2006; 34:245-7   DOI   ScienceOn
2 Antunes NL, Small TN, George D, Boulad F, Lis E. Posterior leukoence- phalopathy syndrome may not be reversible. Pediatr Neurol 1999;20:241-3   DOI   ScienceOn
3 Schwarz RB, Mulkern RV, Gudbjartsson H, Jolesz F. Diffusion- weighted MR imaging in hypertensive encephalopathy: Clues to pathogenesis. Am J Neuroradiol 1998;19:859-62
4 Wright RR, Mathews HD. Hypertensive encephalopathy in childhood. J Child Neurol 1996;11:193-6   DOI
5 Taylor MB, Jackson A, Weller JM. Dynamic susceptibility contrast enhanced MRI in reversible posterior leukoencephalopathy syndrome associated hemolytic uremic syndrome. Br J radiol 2000;73:438-42   DOI
6 Mathy I, Gille M, Van Raemdonck F, Delbecq J, Depre A. Neurological complication of intravenous immunoglobulin (IVIg) therapy: An illustrative case of acute encephalopathy following IVIg therapy and and review fo the literature. Acta neurol Bleg 1998;98:347-51
7 Laguna P, Martin T, Marchena MJ, Moya M. Posterior leukoencephalopathy reversible sydrome secondary to panarteritis nodosa. Med Clin(Barc) 1997;37:64-6
8 Arai M, Shigeno K, Wada M. A reversible posterior leukoencephalopathy sydrome in a patient with classical polyateritis nodosa. Rinsho Shinkeigaku 1997;37:64-6
9 Delanty N, Vaughan C, Frucht S, Stubgen P. Erythropoietin associated hypertensive posterior leukoencephalopathy. Neurology 1997;49:636-9
10 Phillips DJ, Davies AH, Bliss BP. Hypertensive encephalopathy secondary to pheochromocytoma: The cause of death after carotid endarterectomy. J Cardiovasc Surg(torino) 1994;35:533-5
11 Pavlakis SG, frank Y, Kalina P, Chandra M, Lu D. Occipital- parietal encephalopathy: A new name for an old syndrome. Pediatr Neurol 1997;16:145-8   DOI   ScienceOn
12 Pavlaskis SG, Frank Y, Chusid R. Hypertensive encephalopathy, reversible occipitoparietal encephalopathy, or reversible posterior leukoencephalopathy: Three names for an old syndrome J Child Neurol 1999;14:277-81   DOI
13 Jones BV, Egelhoff JC, Petterson J. Hypertensive encephalopathy in children. Am J Neuroradiol 1997;18:101-6
14 Sanders TG, Clayman DA, Sanchez-Ramos L, Vines FS, Russo L. Brain in eclampsia: MR imaging with clinical correlation. Radiology 1991;180:475-8   DOI
15 Ito Y, Niwa H, lida T, Nagamatsu M, Yasuda T, Uanagi T, et al. Post-transfusion reversible posterior leukoencephalopathy syndrome with cerebral vasoconstriction. Neurology 1997;49:1174-5   DOI   ScienceOn
16 Cooney MJ. Bradley WG, Symko SC, Patel ST, Groncy PK. Hypertensive encephalopathy: Complication in children treated for myeloproliperative disorders-report of three cases. Radiology 2000;214:711-6   DOI
17 Kwon S, Koo J, Lee S. Clnical spectrum of reversible posterior leukoencephalopathy syndrome. Pediatr Neurol 2001; 24:361-4   DOI   ScienceOn
18 Ito Y, Arahata Y, Goto Y, M Hirayama, M Nagamutsu, T Yasuda, et al. Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome. Am J Neuroradiol 1998;19:415-7
19 Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med 1996;334:494-500   DOI   ScienceOn
20 Maryam P, Iris D, Jeannie Y, Katrina J, Paul R. Posterior reversible leukoencephalopathy in a case of postpartum eclampsia. Am J of Obsterics and Gynecology 2000:193;885-6
21 Truwit CL, Denarco CP, Lake JR, Demarco T. MR imaging of reversible cyclospoline A induced neurotoxicity. Am J Neuroradiol 1991;12:651-9
22 Ishikura K, Ikeda M, Hamasaki Y, Hataya H, Shishido S, Asanuma H, et al. Posterior reversible encephalopathy syndrome in children: Its high prevalance and more extensive imaging findings. Am J of Kidney Dis 2006:48;231-8   DOI   ScienceOn
23 Henderson RD, Rajah T, Nicol AJ, Read SJ. Posterior leukoencephalopathy following intrachecal chemotherapy with MRA documented vasospasm. Neurology 2003;60:326-8   DOI   ScienceOn
24 Gleeson JG, Duplessis AJ, Marnes PD, Riviello JJ Jr. Cyclosporin A acute encephalopathy and seizure syndrome in childhood: Clinical features and risk of seizure recurrence. J Child Neurol 1998;13:336-44   DOI
25 Catherine M, David A, Manoj K, James M. Tacrolimus leukoencephalopathy: A neuropathologic confirmation. Neurology 2004:63;1132-3   DOI   ScienceOn
26 Schwartz RB, Bravo SM, Klufas RA, et al. Cyclosporine neurotoxicity and its relationship to hypertensive encephalopathy: CT and MR findings in 16 cases. Am J Radiol 1995;165:627-31