• 제목/요약/키워드: Clinical analysis

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A Comparison of the Ability of Fungal Internal Transcribed Spacers and D1/D2 Domain Regions to Accurately Identify Candida glabrata Clinical Isolates Using Sequence Analysis

  • Kang, Min-Ji;Choi, Yoon-Sung;Kim, Sunghyun
    • 대한의생명과학회지
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    • 제24권4호
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    • pp.430-434
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    • 2018
  • Candida glabrata is the second most prevalent causative agent for candidiasis following C. albicans. The opportunistic yeast, C. glabrata, is able to cause the critical bloodstream infections in hospitalized patients. Conventional identification methods for yeasts are often time consuming and labor intensive. Therefore, recent studies on sequence-based identification have been conducted. Recently, sequencing the D1/D2 domain of the large subunit ribosomal RNA gene and the internal transcribed spacers (ITS) 1 and ITS2 regions of the ribosomal DNA has proven useful for DNA-based identification of most species of fungi. In the present study, therefore, fungal ITS and D1/D2 domain regions were targeted and analyzed by DNA sequencing for the accurate identification of C. glabrata clinical isolates. A total of 102 C. glabrata clinical isolates from various clinical samples including bloodstream, catheterized urine, bile and other body fluids were used in the study. The results of the DNA sequence analysis showed that the mean standard deviation of species identity percent score between ITS and D1/D2 domain regions was $97.8%{\pm}2.9$ and $99.7%{\pm}0.46$, respectively. These results revealed that the D1/D2 domain region might be a better target for identifying C. glabrata clinical isolates based on DNA sequences than the ITS1 and ITS2 regions. However, in order to evaluate the usefulness of D1/D2 domain region for species identification of all Candida species, other Candida species such as C. albicans, C. tropicalis, C. dubliniensis, and C. krusei should be verified in further studies additionally.

혼종모형을 이용한 신규간호사 임상간호교육의 질에 대한 개념분석 (Quality of clinical nursing education for new graduate nurses: A concept analysis with a hybrid model)

  • 최희화;신수진
    • 한국간호교육학회지
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    • 제29권1호
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    • pp.27-40
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    • 2023
  • Purpose: The study aimed to examine the concept and attributes of the quality of clinical nursing education for new graduate nurses. Methods: This study adopted a hybrid model introduced by Schwartz-Barcott and Kim. In the theoretical stage, the meaning and attributes of the quality of clinical nursing education for new graduate nurses were determined by analyzing eight articles. In the fieldwork stage, data were collected using semi-structured interviews with five new graduate nurses and seven experienced nurses. The data were analyzed by qualitative content analysis methods developed by Elo and Kyngӓs. In the final analysis, a final result was arrived at comparing, contrasting, and integrating the attributes of the concepts derived in the theoretical and field-work stages. Results: The quality of clinical nursing education for new graduate nurses was identified as excellence or the standard of education for new graduate nurses that would support them in adapting to clinical settings and transitioning to professional nurses. The attributes of the quality of clinical nursing education were founded to possess three dimensions, six categories, and 18 attributes. The multidimensional attributes of the quality of clinical nursing education for new graduate nurses were confirmed as education resources, design, method, content, evaluation, interaction, and outcome under the three dimensions of input, process, and output. Conclusion: The concept and nature of the quality of clinical nursing education observed in this study can be utilized as a basis for the future development, evaluation, and improvement of clinical nursing education for new graduate nurses in healthcare organizations.

사물인터넷에서 치위생과 학생의 임상실습관련 무력감과 진로정체감과의 관계에서 자아존중감의 매개효과 (Mediating effect of self-Esteem in the Relationship between Dental Hygiene Students' Powerlessness and Career Identity in the IoT)

  • 김해선
    • 사물인터넷융복합논문지
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    • 제10권2호
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    • pp.115-124
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    • 2024
  • 본 연구는 사물인터넷에서 치위생과 학생을 대상으로 자아존중감이 임상실습관련 무력감과 진로정체감 사이의 관계에 영향을 주는지 확인하고자 하였다. 충청지역에 소재한 대학에 재학 중인 치위생과 학생 172명을 대상으로 설문조사를 실시하였다. 임상실습관련 무력감과 자아존중감 그리고 진로정체감 간의 상관관계를 확인하기 위해 피어슨의 상관관계분석을 시행하였고, 위계적 회귀분석을 이용하여 임상실습관련 무력감과 진로정체감 관계에서 자아존중감의 매개효과를 확인하였다. 연구결과 임상실습관련 무력감은 자아존중감과 진로정체감에 유의한 부적 상관관계가 있고 자아존중감과 진로정체감은 정적 상관관계가 있다는 것을 확인하였다. 또한 자아존중감은 임상실습관련 무력감과 진로정체감 사이의 관계에서 부분적인 영향을 미치는 것으로 나타났다. 따라서 임상실습에 참여하기 전 치위생과 학생들에게 자아존중감 향상을 위한 다양한 온라인 기반 자아존중감 향상 프로그램 마련이 필요하다.

내러티브 탐구를 통한 일 대학 간호학생들의 보건소실습 경험 연구 (A Study on Nursing Students' Experience during Clinical Practice at a Public Health Center)

  • 최혜정
    • 한국보건간호학회지
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    • 제19권2호
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    • pp.217-228
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    • 2005
  • Purpose: The purpose of this study is to understand nursing students' experiences during clinical practice at a public health center. Method: This research used narrative inquiry far data collection. From April 2005 to June 2006, data collection was conducted by open-ended interview, questionnaire and close observation. The participants, who were student nurses, were willing to take part in this study. Results: On the basis of these data, the experiences of clinical practice at public health center were: 1) when the student nurses begin clinical practice at public health centers for the first time, most of the students feel fearful, nervous and stressed. They also mentioned having a hard time being polite to clients and the staff. 2) The students had new experiences at the health public center compared with clinical practice. Especially, the student nurses who were determined to be good nurses were doing home visiting care service. Not only did they have the opportunity to confirm their identity as nurses, but also the students change their career course from clinical nursing to public health nursing. 4) They reflected on themselves after home visiting care service. Conclusion: On the basis of these findings, the following recommendations are made. 1) Data collection and analysis are needed, net only through the narrative method, but also through other various qualitative methods. 2) Comparative study is necessary to enhance clinical experiences through the analysis of the interfering factors and the original experiences.

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Association between the Learning Styles with Personalities of Medical Students and Their Clinical Performance Examination Achievements

  • Bae, Soo Jin;Hong, Sun Yeun
    • International Journal of Internet, Broadcasting and Communication
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    • 제13권1호
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    • pp.219-228
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    • 2021
  • The aim of this study was to investigate the learning styles with personalities of medical students which may affect the efficiency of teaching-learning system of clinical education to determine the association with the clinical performance examination achievement of the students. The learning styles and personality traits of 147 students of medical college were investigated. The obtained data were analyzed by statistical analysis including independent t-test and correlation analysis. The results of the analyses are as follows: there was significant difference in the participation model in the different genders; of the personality traits, there was significant difference in self-transcendence in the different genders, whereas there was significant difference in the persistence for past failure experiences; and there was significant association between the 6 sub-learning models(Independent vs. Dependent, Collaborative vs. Competitive, and Participant vs. Avoidant learning styles) and the personality traits(Novelty Seeking, Harm Avoidance, Reward Dependence, Persistence, Self-directedness, Cooperativeness and Self-transcendence). In addition, the participant type of students had higher scholastic achievements in clinical performance, and the students who scored high in self-transcendence and persistence also had higher clinical performance. In conclusion, the student's learning style and personalities affected the clinical scholastic performance. We believe that considering this current study, it would be possible to improve the quality of clinical education of medical teaching as well as helping medical students to choose career paths that are suitable for their personalities.

적극적 스트레스 대처매개 중재가 임상실습 스트레스와 만족도에 미치는 영향 (Effects of Aggressive Stress Response Mediation on Clinical Practice Stress and Satisfaction)

  • 이정윤;황혜경
    • 한국임상보건과학회지
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    • 제7권2호
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    • pp.1345-1354
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    • 2019
  • Purpose: This study aimed to determine the mediating effects of aggressive stress response on the association between clinical practice stress and clinical practice satisfaction in ophthalmic optics majors and provide basic data that could help form opticians' professionalism and make clinical practice more effective. Methods: This study was conducted in 236 sophomores and juniors in Daegu and North Gyeongsang Province who had finished clinical practice. Hierarchical regression analysis and mediating effect testing were performed to determine the associations among clinical practice stress, clinical practice satisfaction, and aggressive stress response and determine the mediating effects of aggressive stress response on the association between clinical practice stress and clinical practice satisfaction. Results: Clinical practice stress was significantly negatively correlated with clinical practice satisfaction and aggressive stress response (p<0.01), and aggressive stress response was significantly positively correlated with clinical practice satisfaction (p<0.01). The association between clinical practice stress and clinical practice satisfaction was more likely to be explained by the addition of clinical practice stress than by being aggressive stress response controlled, which statistically significantly met the criteria for mediating effects (p<0.001). Conclusions: It is necessary to pay more attention to program development and teaching methods within the department of ophthalmic optics so that ophthalmic optics majors can utilize aggressive stress response to overcome clinical practice stress effectively and improve clinical practice satisfaction.

High Resolution Melting Analysis for Epidermal Growth Factor Receptor Mutations in Formalin-fixed Paraffin-embedded Tissue and Plasma Free DNA from Non-small Cell Lung Cancer Patients

  • Jing, Chang-Wen;Wang, Zhuo;Cao, Hai-Xia;Ma, Rong;Wu, Jian-Zhong
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권11호
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    • pp.6619-6623
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    • 2013
  • Background:The aim of the research was to explore a cost effective, fast, easy to perform, and sensitive method for epidermal growth factor receptor (EGFR) mutation testing. Methods: High resolution melting analysis (HRM) was introduced to evaluate the efficacy of the analysis for dectecting EGFR mutations in exons 18 to 21 using formalin-fixed paraffin-embedded (FFPE) tissues and plasma free DNA from 120 patients. Results: The total EGFR mutation rate was 37.5% (45/120) detected by direct sequencing. There were 48 mutations in 120 FFPE tissues assessed by HRM. For plasma free DNA, the EGFR mutation rate was 25.8% (31/120). The sensitivity of HRM assays in FFPE samples was 100% by HRM. There was a low false-positive mutation rate but a high false-negative rate in plasma free DNA detected by HRM. Conclusions: Our results show that HRM analysis has the advantage of small tumor sample need. HRM applied with plasma free DNA showed a high false-negative rate but a low false-positive rate. Further research into appropriate methods and analysis needs to be performed before HRM for plasma free DNA could be accepted as an option in diagnostic or screening settings.

진료협력간호사의 역할규명을 위한 직무분석 - 교육상담간호사와 진료코디네이터간호사 중심 - (Job Analysis for Role Identification of Clinical Nurses with Expanded Role - Clinical Nurse with Education and Clinical Nurse with Coordination -)

  • 성영희;임난영;박광옥;정정희;권인각;김을순;황문숙
    • 임상간호연구
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    • 제15권2호
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    • pp.139-155
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    • 2009
  • Purpose: The purpose of this study was to identify role through job analysis (duties and tasks) of nurses who work as clinical nurses with education and clinical nurse with patient coordination within the hospital. Methods: The DACUM committee was organized with 8 nurses each, clinical nurses with education and clinical nurses with coordination. The committee derived the duties and tasks of the two groups of clinical nurses from their actual work in the hospital through a DACUM workshop. Validity of the derived duties and tasks was tested by 12 nurses at each of 3 hospital. Results: For clinical nurse with education, 8 duties and 45 tasks were identified, which included patient education and consultation, patient advocacy, management of the therapeutic process, direct nursing care, activities work directed at improvement, management of health promotion events, administration work, and self-improvement. For clinical nurse with coordination, 10 duties and 54 tasks were identified, and included client consultation, client education, direct nursing care, coordination of therapeutic flow, employee education, public relations with the community, planning and operation of meetings, administration work, work directed at improvement, and self-improvement. Conclusion: The results of this study contribute to not only the work of the participants but also basic data for human resource management in the hospital.

뇌질환 환자에서 전산화 인지치료의 임상적 유용성 : 체계적 고찰 및 메타분석 (Clinical Benefit of Computerized Cognitive Therapy in Patients with Brain Disease : A Systematic Review and Meta-Analysis)

  • 송승일;박소원
    • 대한통합의학회지
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    • 제8권4호
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    • pp.277-289
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    • 2020
  • Purpose : This study aims to confirm the clinical usefulness of computerized cognitive therapy program for patients with brain diseases in Korea and to present basic data that can confirm the effectiveness of computerized cognitive therapy program to experts related to rehabilitation in the future. Methods : A systematic review and meta-analysis research method was used to confirm the clinical effectiveness of computerized cognitive therapy applied to patients with brain diseases in Korea. Based on the national institute of health and medical colleges association (NECA) systematic literature manual and preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines for conducting research through systematic review and meta-analysis methods. Systematic review was PICOST-SD was used to research and select papers. For meta-analysis, the data was input and analyzed separately by literature result using the revman manager 5.3 program and the results were presented visually through tables and forest, funnel plot figure. Results : As a result of comprehensive analysis of the contents of the finally selected literature, it as found that studies on stroke and dementia were mainly conducted. In addition, through the evaluation of the quality of the literature, most of the existing computerized cognitive therapy studies were identified as high-quality studies, but the results were insufficient for randomization and blinding. And through meta-analysis, the clinical effectiveness of computerized cognitive therapy on cognitive function, activities of daily living, and visual perception function of patients with brain disease was found. Conclusion : The research literature that applied computerized cognitive therapy to brain disease subjects was comprehensively analyzed and identified. It is thought that this could be used as basic data on the characteristics of cognitive therapy that should be applied to patients with brain diseases in the future and the usefulness of computerized cognitive therapy program in actual clinical practice.

간호학생에 대한 인턴쉽과 임상실습지도자 활용 모델의 임상실습 만족도 비교 (A Comparison of the Effect of Internship and Preceptorship on Clinical Practice Education of Nursing Students)

  • 김혜순;윤혜상;김옥화
    • 한국간호교육학회지
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    • 제7권2호
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    • pp.217-228
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    • 2001
  • This study was designed to compare the effect of internship and preceptorship on satisfaction of clinical practice in nursing students. A total of 46 third grade students were assigned to 2 groups; 23 to inturnship group, 23 to preceptorship group. Satisfaction scores of clinical practice instruction and practice environment in internship group were higher than satisfactory scores of preceptorship group. There were no difference between satisfactory scores of clinical practice contents, clinical practice hour and clinical practice environment in internship and preceptorship. Satisfaction scores on clinical practice weren't significantly correlated with school credits. There were significant correlations among clinical practice contents, practice environment, practice instruction and clinical practice hour. There were significant correlations among clinical practice instruction, practice environment and clinical practice evaluation. Clinical practice instruction was the highest factor predicting satisfaction of clinical practice. In stepwise multiple regression analysis, 100% of the variance in satisfaction of clinical practice was accounted for by clinical practice instruction(59.1%), clinical practice contents(14.9%), clinical practice environment(12.3), clinical practice hour(8.8%), and clinical practice evaluation(5.5%).

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