• Archives of Pharmacal Research
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• v.9 no.3
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• pp.163-167
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• 1986

Twenty six urea analogues, most of which have already been approved for human use, were tested for their antiurease activity in vitro. Cell-free extracts obtained from a clinical isolate of Proteus mirabilis was used as the source of enzyme. Acetohydroxamic acid which is a proven potent urease inhibitor but not approved for human use was again shown to be the most active compound among the tested. Phenacemide, cycloserine, and deferoxamine were demonstrated to be moderate inhibitors. Oxtetracycline, trimethoprim, and cefamandole revealed a demonstrable antiruease activity, but only at very high concentrations. The antiurease activity of cycloserine, trimethoprim, and cefamandole was pH dependent-only active at acidic pH. The inhibitory activity of acetohydroxamic acid however was independent of change in pH. The inhibitory activity of acetohydroxamic acid however was independent of change in pH. Hydrogen ion concentration plays an important role in urease activity and acidification (pH 5. 5) alone eliminates approximately 65% of the enzymic activity. Adjustment of pH therefore appears to be an important adjunct in reducing unrease activity and should always be studied to maximize the effcacy of antiurease compounds under investigation.

• Health Policy and Management
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• v.27 no.2
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• pp.114-120
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• 2017

The hospital standardized mortality ratio (HSMR) is a widely used generic measure for assessing quality of hospital care in many countries. However, the validity of HSMR as a quality indicator is still controversial. We critically reviewed characteristics of HSMR and suggested how to use HSMR as a quality indicator in the Korean setting. The association between HSMR and other quality measures of hospital care is inconclusive. In addition current HSMR model has shortcomings in risk adjustment because of the lack of clinical data, accuracy of disease coding, coding variation among hospitals, end-of-life care issues, and so on. Therefore, HSMR should be used as an indicator for improvement, not for judgement such as public reporting and pay-for-performance. More efforts will be needed to tackle practical and methodological weaknesses of HSMR in the Korean setting.

• Journal of Korean Academy of Nursing
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• v.50 no.3
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• pp.419-430
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• 2020

Purpose: This study aimed to assess the effect of the emotional coaching program for hospital nurses. Methods: The study used a non-equivalent control group pretest-posttest design, and participants included 60 nurses (30 in the experimental group and 30 in the control group) who worked at a general hospital. The experimental group attended four sessions, one per week, with each session lasting two and a half hours. Collected data were analyzed using descriptive statistics, Fisher's exact test, χ² test, t-test, paired t-test, and repeated measures ANOVA using SPSS WIN 23.0 program. Results: Significant differences were shown between the experimental and the control groups regarding emotional labor (F=68.40, p<.001), resilience (F=48.77, p<.001), and self-efficacy (F=15.31, p<.001). Conclusion: The emotional coaching program for nurses is useful for enhancing nurses' emotional labor management, resilience, and self-efficacy. In addition, this program may serve as a basis for providing emotional coaching to nurses in the future.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.30 no.1
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• pp.49-55
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• 2004

The management of mandibular condylar fractures in children has long been a matter of controversy. The fracture, if not treated appropriately, may result in complications such as disturbance of mandibular growth and temporomandibular joint ankylosis. They are usually treated nonsurgically, which has been proved to be satisfactory in the long term results. Nineteen children with 25 condylar fractures experienced during their growth period (age at trauma from 10 months to 12 years, mean 7.0 years) were studied. All patients were treated by arch bars and intermaxillary fixation for $7{\sim}14$ days. They have been evaluated with clinical and radiographic examination. The maximum mouth opening and lateral movement of the mandible were within normal limits. There was no malocclusion or ankylosis. Beginning of remodelling was evident at postoperative $1{\sim}3$ months. Remodelling of the condyle was good in 21, while partial adjustment occured in the other 4 condyles. These results suggest that the conservative treatment of condylar fractures in growing children results in good functional results and good remodelling of the condyle.

• Health Policy and Management
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• v.30 no.3
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• pp.270-276
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• 2020

Entering the fourth industrial revolution era, health technology is rapidly developing and the people's needs for medical services are gradually increasing. Establishing a life cycle management of health technology has emerged as a new policy agenda to cope with these changes. However, the management of health technology have been conducted without continuity and with several problems pointed out. Therefore, we suggest the reform agendas by stages to establish system for a life cycle management of health technology in the fourth industrial revolution era as follows. In the stage of development, it is important not only to provide research funding, but also consulting by professional about whole cycle of health technologies. In the phase of market entry, there are needs for enhance the system that would expand the early adoption for innovative technology and increase its effectiveness. After the spread of health technology to clinical settings, a reassessment and post management system should be established that have an institutional framework with strong price adjustment and exit mechanism. Furthermore, we hope that discussions will be brisk in macro perspective on the balancing of development in healthcare industry, health of people and national health insurance finance.

• Clinical and Experimental Pediatrics
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• v.48 no.5
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• pp.476-480
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• 2005

Immunosuppressive therapy in pediatric renal transplant recipients is changing consequence of the increasing number of available immunosuppressive agents. The optimal use of immunosuppressive agents requires a thorough understanding of the pharmacokinetic characteristics, but the information on the pharmacokinetic characteristics of these drugs in pediatric transplant recipients is still limited. In general, patients younger than 5 years old show higher clearance rates, therefore the need for higher dosages in younger patients seems evident. By the therapeutic drug monitoring, trough($C_{min}$) and peak level($C_{max}$) are measured and the area under the blood concentration-time curve(AUC), which is taken as being representative of total systemic exposure can be calculated. Cyclosporine A (CSA) has poor bioavailability, which contributes to high inter- and intra-patient pharmacokinetic variability. CSA concentration measured 2 hours after administration($C_2$) has better correlation with the AUC than $C_{min}$ and is an alternative technique that predicts the AUC. Tacrolimus(Tac) has a great deal of inter-individual variability like CSA but intra-individual variability in systemic exposure is considered to be low. Both CSA and Tac are metabolized by a cytochrome P-450 enzyme isoform(CYP3A4). We should consider changing the dosages when CSA or Tac is used in combination with the medicines that inhibit or induce the CYP3A4. In case of steroid-free immunosuppressive therapy, the blood concentration of Tac should be frequently checked and dosage adjustment may be needed.

• The Journal of Korean Academic Society of Nursing Education
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• v.26 no.2
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• pp.132-145
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• 2020

Purpose: The purpose of this study was to examine the effects of a care promotion program based on nursing students' self-understanding. Methods: A quasi-experimental approach using a randomized clinical trial pre- and posttest design was used. Participants were assigned to an experiment group (n=29) or control group (n=30). Data were collected from June 23 to September 8, 2017. The experiment group participated in a care promotion program based on self-understanding for 24 hours through eight sessions covering eight different topics. The data were analyzed using t-test and repeated-measures ANOVA using SPSS/WIN 21.0. Results: Compared to the control group, the experiment group reported significant positive changes for college life adjustment (F=28.74, p<.001), emotional intelligence (F=15.66, p<.001), and interpersonal caring behavior (F=9.37, p=.003). Conclusion: Findings from this study indicate that care promotion based on a self-understanding improvement program with the application of group enneagram education is a useful intervention strategy to promote the care promotion program based on nursing students' self-understanding. Care promotion based on self-understanding will be utilized as an intervention program to form positive values of care and interpersonal relationship through care awareness, self-change, understanding of others and care experience in the group.

• Journal of information and communication convergence engineering
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• v.7 no.2
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• pp.223-230
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• 2009

For pulse trigger way and the energy injection rate according to PET ($Pause^{10-90}$ $Energy^{20-40}$ $Trigger^{1-7}$) function, indeed, human body condition, period of dormancy in this research about this back correctly adjustment possible and designed harmless micro carrying along style hair exclusion so that can design and manufacture and run special quality examination and Xenon flash lamp to crawl in human body. Because creating individual's skin model to do stable treatment by light transmission way by skin impedance and measure, must embody treatment special quality of most suitable that draw skin color, energy, wave length, approximately, transmission time, pulse delay etc. and want. Specially, saved standard of war treatment pulse modeling by skin impedance, and manufacture pulse modeling system of most suitable by skin subordinate, and embody suitable treatment pulse. Specially, embody as could do root of a hair exclusion being emitted in pulse form using multi wave length of 560nm, 590nm, 640nm, 755nm and embodied clinical data. If become research repletion furthermore little more, is seen that can approximate in commercialization.

• Biomedical Science Letters
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• v.16 no.4
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• pp.293-298
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• 2010

Several risk factors for osteoporosis are known relatively well. Some nutrients are directly or indirectly needed for metabolic processes related to bone. Recently, an increased prevalence of osteoporosis has been reported in patients with hemochromatosis, an iron overload disease. Thus, the aim of this study was to find out if there was any relationship between serum ferritin and T-score of bone mineral density in healthy women. We recruited 1,101 subjects females aged between 39 and 85 years. We measured serum ferritin, glucose tolerance indices, lipid profiles, inflammatory indices, hormones, calcium, alkaline phosphatase. Also, anthropometric, blood pressure, and bone mineral density measurements were performed. T-score was negatively correlated with age (r=-0.425; P<0.01), systolic (r=-0.109; P<0.01) and diastolic (r=-0.093; P<0.01) pressure, follicular stimulation hormone (r=-0.190; P<0.01), alkaline phosphatase (r=-0.235; P<0.01), and serum ferritin (r=-0.090; P<0.05) and positively with body mass index (r=0.050; P=0.01), HDL-cholesterol (r=0.314; P<0.01), and estradiol (r=0.200; P<0.01). After adjustment for age, alkaline phosphatase, body mass index, HDL-cholesterol, estradiol, and follicular stimulation hormone, serum ferritin was independently inversely correlated with T-score (${\beta}$=-0.001; P<0.05). It is possible that an increase of serum ferritin in females be risk to osteoporosis.

• The Korean Journal of Applied Statistics
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• v.27 no.2
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• pp.331-343
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• 2014

We propose two estimating procedures to analyze clustered interval-censored data with an informative cluster size based on a marginal model and investigate their asymptotic properties. One is an extension of Cong et al. (2007) to interval-censored data and the other uses the within-cluster resampling method proposed by Hoffman et al. (2001). Simulation results imply that the proposed estimators have a better performance in terms of bias and coverage rate of true value than an estimator with no adjustment of informative cluster size when the cluster size is related with survival time. Finally, they are applied to lymphatic filariasis data adopted from Williamson et al. (2008).