• The Journal of Pediatrics of Korean Medicine
• /
• v.7 no.1
• /
• pp.1-16
• /
• 1993

Experimental studies were done to research the clinical effect of Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang on the Anti-allergie effect in rats and mice. The results obtained as follows: 1. (1) In the effects of Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang on vascular permeability responses to intradermal histamin in rats, Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang revealed significant effect. (2) In the effects of Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang on vascular permeability responses to intradermal serotonin in rats, Woohwangporhyonghwan(minus REALGAR and CINNABARIS) revealed significant effect. 2. In the 48 hour homologous passive cutaneous anaphylaxis in rats provoked by the Ig E-like antibody against egg albumin, Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang revealed significant effect. 3. In the delayed type hypersensitivity responses to picryl chloride in mice, Woohwangporhyonghwan(minus REALGAR and CINNABARIS) revealed significant effect. 4. In the delayed type hypersensitivity responses to SRBC(Sheep Red Blood cell) in mice, Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang revealed significant effect. According to above-stated results, Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang were concluded to be effective as anti-allergic regimen and recommended to be used for treatment of allergic diseases.

• Journal of Oriental Neuropsychiatry
• /
• v.10 no.1
• /
• pp.159-177
• /
• 1999

In the study on the mineral substance used in Dong Eu Bo Gam(range of 'Sin') and the recent prescription of china, the results were as follows. 1. According to Dong Eu Bo Gam, Realgar was used for Sa-Su most often and Gold-leaf, Succinum, especially Cinnabaris were used for amnesia, epilepsy, a general term of manic-depressive psychosis too. The most kinds of mineral substance used for epilepsy. 2. According to recent prescription of china, Fossilia Ossis Mastodi got the most, and Succinum, Cinnabaris, Lapis Chloriti, Haematitum, Magnetitum, Gypsum Fibrosum, Fossilia Dentis Mastodi, iron powder were used frequently. For external application, Sulfur was too. And most kinds of mineral substance were used for epilepsy and schizophrenia. 3. Realgar, Gold-leaf, Succinum, Cinnabaris, Lapis Chloriti, Haematitum, Magnetitum, Gypsum Fibrosum, Fossilia Dentis Mastodi, iron powder have drug effect for mental disease, especially for epilepsy induced by terror. 4. For Application of mineral substance, it should be considered that the chemical elements of mineral substance act on human body. 5. For drug effect, it is important to make clear of original prescription.

• The Journal of Pediatrics of Korean Medicine
• /
• v.8 no.1
• /
• pp.59-74
• /
• 1994

The Study was performed on the anticonvulsive effects of Woohwangporyonghwan(WPH) and Woohwangporyonghwan except CINNABARIS and REALGAR(WPHCR) in ICR mice pretreated with strychnine, picrotoxin, and caffeine as convulsive agents, and also was done on the accumulation of Hg & AS in organs of ICR mice by ICP hydride generation method. The results were obtained as follows: 1. WPH and WPHCR group showed significant effect in delaying the onset of convulsion induced by strichine, but time to death was effective only in WPHCR group. 2. WPH and WPHCR group were significantly effective in delaying convulsion induced by picrotoxin, and time to death. 3. The anticonvulsive effect of WPH and WPHCR group was not found convulsion induced by caffeine. 4. The accumulation of Hg, AS in liver and kidney of ICR mice was not determined below 50ng/g and below 80ng/g respectively. From the above results it could be concluded that WPH and WPHCR group were effective in the convulsions induced by strychnine and picrotoxin, although the accumulation of Hg & As in liver and kidney was not proved, further study might be necessary to prove the drug safety of WPH included CINNABARIS and REALGAR.

• Journal of Haehwa Medicine
• /
• v.10 no.2
• /
• pp.73-81
• /
• 2002

In the literal study of anti-tumor effects of Jakeumjung. the results were as follows. 1. Jakeumjung is a traditional oriental medical prescription which is composed of Cremastare appeniculatae tuber, Euphorbiae pekinensis radix, Toosendan fructus, Chinensis galla, Moschus, Realgar and Cinnabaris. 2. Jakeumjung is applied to patients by administering or external application. When it is administered for patients, pertinent dose is 0.6~1.5g twice or three times per one day. When it is applied by external application, we melt it by water or vinegar and apply it to patients. 3. Effects of Jakeumjung are expelling toxin and pestilence, counteracting pathogen and relieving stagnation, detumescence and stopping pain. So it is used for detoxification from ancient. In recent, it is often used for cancer such as breast cancer, pancreatic cancer, epigastric cancer, acute leukemia, lymphoma, thymus cancer and skin cancer. 4. From the various experiments, Jakeumjung has been proved to have antifungal and antitumor effects. It inhibits and kills L7212, L1210 cells of leukemia. Especially, it acts in S stage of cell period. 5. Jakeumjung includes mineral medicines such as Realgar, Cinnabaris. So if we execute progressive study for anticancer effects and safety, the boundary of oriental medicine of using mineral medicines for cancer therapy will magnify in the future.

• Korean Journal of Oriental Medicine
• /
• v.16 no.1
• /
• pp.19-27
• /
• 2010

Objectives & Method : We investigated toxicity, poisoning symptoms, poisoning treatment and prevention against poisoning of mind-tranquilizing herbal medicines(安神藥) in order to use herbal medicines accurately. Result : Cinnabaris(朱砂), Zizyphi Spinosae Semen(酸棗仁), Polygalae Radix(遠志), Ganoderma(靈芝) and Polygoni Multiflori Ramulus(夜交藤) may give rise to some side effects or toxic symptoms in mind-tranquilizing herbal medicines(安神藥). The representative methods of poisoning treatment in western medicines are washing out the stomach, promotion of vomiting, causing diarrhea, supplies of grape sugar and symptomatic treatment, etc. The representative methods of poisoning treatment in oriental medicine take advantage of herbs. And Oriental medical doctor should meet symptoms as patients call for attention. In order to prevent against poisoning of mind-tranquilizing herbal medicines(安神藥), the patients should keep usage, dosage and notes and oriental medical doctors should do processing drugs. Conclusion : We should pay attention to clinical using of Cinnabaris(朱砂), Zizyphi Spinosae Semen(酸棗仁), Polygalae Radix(遠志), Ganoderma(靈芝) and Polygoni Multiflori Ramulus(夜交藤) in mind-tranquilizing herbal medicines(安神藥).

• The Journal of Internal Korean Medicine
• /
• v.41 no.6
• /
• pp.1282-1288
• /
• 2020

Objective: The case study assessed the possibility of improving symptoms by external treatment in a patient complaining of night sweats who could not take oral herbal medicine. Methods: Chinensis galla, Ostreae concha, and Cinnabaris were mixed in a 2:1:1 ratio and applied to CV8 before the patient went to bed. The treatment was removed upon waking and repeated every night. If itchiness and skin redness occurred, the position was changed to 2-3 cm up or down from the navel or application was changed to once every two days. Results: The external treatment eliminated the symptoms of sweating in the arms, legs, chest, and abdomen and reduced sweating in the occipital and neck areas. The sweating was improved to the extent that it no longer interfered with daily life. Conclusions: This case study shows the possibility of using external treatments rather than herbal medicine to treat night sweats.

• Analytical Science and Technology
• /
• v.21 no.6
• /
• pp.480-486
• /
• 2008

This paper reports on the monitoring results of some heavy metals (Pb, Cd, As and Hg) in oriental mineral medicines. Levels of Pb, Cd and As were determined using the acid digestion method and ICP-MS. Hg levels were determined using the gold amalgamation method and Automatic mercury analyzer (AMA). The results indicated that, in the case of Pb, 25.81% (24 cases) of the samples were over MRL (5 mg/kg). Pb levels in Calamina, Pumex, and Cinnabaris exceeded MRL (5 mg/kg). In the case of Cd, 9.68% (17cases) of the samples were over MRL (0.3 mg/kg). Cd levels in Calamina, Pumex and Cinnabaris were exceeded MRL (0.3 mg/kg). In case of As, 24.73% (23 cases) of samples exceeded MRL (3 mg/kg). As levels in Calamina, Lithargyrum, Vermilionum, Cinnabaris and Chalcocitum exceeded MRL (3 mg/kg). In the case of Hg, it was shown that the 76.34% (78 cases) of the samples exceeded MRL (0.2 mg/kg). Hg levels in almost all the samples exceeded MRL (0.2 mg/kg). These results led us to recommend that the domestic commercial law to be legislated to ensure the quality estimation and safety of oriental mineral medicines.

• Journal of Pharmacopuncture
• /
• v.6 no.2
• /
• pp.113-118
• /
• 2003

Results : 1. Vermilionum is made from the mixture of mercury and sulfur, resulting in reddish mercuric sulfide(Hg2S). 2. The characteristics for Vermilionum are pungent and sweet, has warm temperature, and enters heart, lung, and stomach meridians. 3. The efficacies of Vermilionum are to eliminate parasites, expels phlegm and dampness, and sedate heart and calm spirit. 4. Long-term intake make results in mercuric toxication. 5. Further researches on the administration methods and dosages are required to reduce side effects.

• The Journal of Pediatrics of Korean Medicine
• /
• v.17 no.1
• /
• pp.29-51
• /
• 2003

This study was progressed for oriental medical care of neonates by fetal toxicosis removal therapy, and the results as follows: 1. The purpose of fetal toxicosis removal therapy : It removes dirty blood in neonatal mouth and prevents diseases. 2. Kinds of fetal toxicosis removal therapy : Radix Glycyrrhizae(甘草), Rhizoma Coptidis(黃連), Cinnabaris-Mel(朱蜜), Calculus Bovis(牛黃), Sojae Semen Praepartum, Juice of Semen Allii Tuberosi(非汁) and mercury(汞粉). 3. A period of fetal toxicosis removal therapy : At birth, 3rd day or so, one week or so, after umbilical omission. 4. Methods of fetal toxicosis removal therapy: Purgative therapy(下法) and Emetic therapy(吐法).

• Herbal Formula Science
• /
• v.9 no.1
• /
• pp.83-103
• /
• 2001

I studied conductant drug(使藥) in a prescription. As results of these studies, conductant drug(使藥) with meaning of medicinal guide(引經) were Achyranthis Bidentatae Radix(牛膝), Platycodi Radix(桔梗), Cinnabaris(朱砂), Sal Maritimus(食鹽), alcoholic drink(酒,) Cimicifugae Rhizoma(升麻) and Bupleuri Radix(柴胡). Conductant drugs with meaning of harmonizing medicines in a prescription were almost Glycyrrhizae Radix(甘草). And sometimes Mel(蜂蜜) was used with meaning of harmonizing medicines in pill. And Jujubae Fructus was used with meaning of harmonizing medicines in purgation medicines.