The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
권호 표지

Comparative Study on Effects of WPH and WPHCR on the anticonvulsive action and Accumulation of Hg & AS in Organ of ICR Mice

우황포용환(牛黃抱龍丸)과 우황포용환(牛黃抱龍丸) 거(去) 주사석웅황(朱砂石雄黃)의 항경련작용(抗痙攣作用) 및 Hg, As의 간(肝).신장(腎臟)에의 축적(蓄積)에 대(對)한 비교연구(比較硏究)

  • 김윤희 (대전대 부속한방병원 소아과) ;
  • 이한철 (대전대 한의과대학)
  • Published : 1994.12.05
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Abstract

The Study was performed on the anticonvulsive effects of Woohwangporyonghwan(WPH) and Woohwangporyonghwan except CINNABARIS and REALGAR(WPHCR) in ICR mice pretreated with strychnine, picrotoxin, and caffeine as convulsive agents, and also was done on the accumulation of Hg & AS in organs of ICR mice by ICP hydride generation method. The results were obtained as follows: 1. WPH and WPHCR group showed significant effect in delaying the onset of convulsion induced by strichine, but time to death was effective only in WPHCR group. 2. WPH and WPHCR group were significantly effective in delaying convulsion induced by picrotoxin, and time to death. 3. The anticonvulsive effect of WPH and WPHCR group was not found convulsion induced by caffeine. 4. The accumulation of Hg, AS in liver and kidney of ICR mice was not determined below 50ng/g and below 80ng/g respectively. From the above results it could be concluded that WPH and WPHCR group were effective in the convulsions induced by strychnine and picrotoxin, although the accumulation of Hg & As in liver and kidney was not proved, further study might be necessary to prove the drug safety of WPH included CINNABARIS and REALGAR.

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References

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