• 대한한의학원전학회지
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• 제25권3호
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• pp.79-116
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• 2012

Objective : Zhao Xian-Ke(趙獻可) was a doctor in the Ming(明) Dynasty. His representing book is "Yiguan(醫貫)". It is considered as a requirement to study the Mingmen academy(命門學說). "Xuanyuanfulun(玄元膚論)", volume I of "Yiguan" intensively mentions his medical viewpoint. The study investigates Zhao's medical perspectives by studying "Xuanyuanfulun". Method : "Xuanyuanfulun" is translated. "Yiguan" published by Chinese Medicine(中國中醫藥) Publish was used as basis. "Yiguan" published by Xuexiao(學苑) Publish was used for reference. I checked and researched for several parts shown in "Suwen(素問)" and "Lingshu(靈樞)". I researched for 'Master(主)' of a human being. Result : 1. 'Master' of a human being is intangible Huo(火) in Mingmen. 2. It may be hard for me to assent to the opinion of Zhao Xian-Ke that the inferior twelve organs should be regarded as inferior eleven organs naturally. 3. Yinyang(陰陽) is to relatively cope with a situation and its wonders are within Wu(無). 4. The study emphasizes the importance of Yang, Huo and Qi(氣). 5. The study separates the date (year, month, date and time) into yin and yang and the causes of an illness are found based on the concept and its treatment shall be performed. 6. Among Wuxing(五行), Shui(水) and Huo are especially important. 7. There are intangible Shenshui(腎水) and intangible Xianghuo(相火) separately from the Shui and huo of Xinshen(心腎). Conclusion : The medical philosophy of Zhao Xian-Ke has been deeper. In addition, it will provide much help while understanding volumes 2 - 6 of "Yiguan" and apply to the clinical tests. I think it is not the problem, which is the right meaning of 'Master' in the "Xin is monarch of the organs" of "Suwen Linglanmidianlun(靈蘭秘典論)" or 'Master' that concerned by Zhao Xian-Ke, but it is just the different sight of the human being.

• 대한간호학회지
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• 제44권1호
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• pp.86-96
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• 2014

Purpose: This study was conducted to examine and compare satisfaction with Korean health care services for Americans, Chinese and Russians who resided in Korea. Methods: A questionnaire was distributed to 252 participants (81 Americans, 89 Chinese, 82 Russians). Three focus group interviews were subsequently conducted in order to obtain a greater understanding of participants' experience and perspectives. Results: The average satisfaction score was 3.09, with Americans and Russians showing significantly higher scores than Chinese. Overall, participants reported higher satisfaction in 'Facility', 'Quality of care' and 'Nursing services' as opposed to 'Information/education'. 'Care with cultural respect' as well as communication related services. Data from the focus group interviews were categorized into 12 sub-categories, 7 categories and 2 themes. The two themes were common experience and contrasting experience. Common experience included 4 categories, 'Quality of care', 'Hospital facility and health care system', 'Language barrier' and 'Information and education'. Contrasting experience included 3 categories, 'Medical cost', 'Health care personnel' and 'Accessibility'. Conclusion: Results of this study provide basic knowledge on foreign residents' satisfaction and experience with Korean health care services. Further research is needed with foreigners from different cultural backgrounds. Administrative and educational efforts are required to improve communication skills and cultural competency.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7805-7809
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• 2014

Objective: To explore the clinical efficacy and prognostic factors of chemoreduction combined with topical treatment of advanced intraocular retinoblastoma (RB). Materials and Methods: A total of 22 eyes from 17 children with RB were selected for the study and treated with chemoreduction combined with topical cryotherapy, transpupillary thermotherapy (TTT) or episcleral plaque brachytherapy. Clinical and follow-up data were retrospectively analyzed. Results: All children received 2~6 courses of chemoreduction treatment, ($4.5{\pm}0.8$ courses on average); 17 eyes from 13 children were treated by chemoreduction combined with cryotherapy or TTT and 5 eyes from 4 children with chemoreduction combined with $^{125}I$ episcleral plaque brachytherapy. The eye retention rate was 81.8% (18/22), among which 38.9% (7/18) featured restored or maintained good vision. Postoperative follow-up period was 7 to 34 months, ($18.6{\pm}5.2$ months on average). The recurrence rate was 41.2% (7/17), among which 57.1% (4/7) were controlled by supplementing or appending cryotherapy or TTT treatment during the follow-up period. The tumor basal diameter and thickness were significantly reduced (P<0.05 or P<0.01) after treatment. All children demonstrated different degrees of hair loss, 70.6% (12/17) with different degrees of gastrointestinal reactions, 5.88% (1/17) with neutropenia and 11.8% (2/17) being seriously infected during the chemotherapeutic treatment. Univariate and logistic regression analysis showed that tumor basal diameter before treatment had a significant effect on the prognosis (P<0.01). Conclusions: Chemoreduction combined with topical therapy can effectively control RB in the short term, and tumor basal diameter before treatment is an independent risk factor for prognosis.

• 한국조리학회지
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• 제16권5호
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• pp.193-207
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• 2010

본 연구는 메디컬 에스테틱 관광과 한류 인식이 관광 이미지, 한국음식 인식, 관광 만족, 행동 의도에 미치는 영향을 확인하는 것을 목적으로 하였다. 연구의 목적을 달성하기 위해 한국을 방문한 중국인과 일본인을 대상으로 서울과 부산 지역 특급 호텔과 성형외과를 방문하여 설문지 조사법으로 수행되었다. 가설의 검증을 위해 선형회귀분석을 실시한 결과, 메디컬 에스테틱 관광과 한류인식은 관광 이미지, 한국음식 인식, 관광 만족, 행동 의도에 각각 유의적인 정(+)의 영향을 미치는 것을 확인하였다(p<0.001). 특히 관광이란 볼거리 먹을거리 등 다양한 요인 중에서 메디컬 에스테틱 관광과 한류 인식이 먹을거리에 중요한 요인으로 작용한다는 점을 본 연구를 통해서 확인하였다. 따라서 지속적인 한류 인식의 고양을 위한 노력은 물론 최근 지속적인 상승세를 나타내고 있는 메디컬 에스테틱 관광 활성화 방안과 한식의 세계화에 이바지할 수 있는 정책 개발이 요구된다.

• Bulletin of the Korean Chemical Society
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• 제32권4호
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• pp.1293-1297
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• 2011

To improve the biological activities of rupestonic acid, 21 new rupestonic acid fatty ester derivatives (2a-2h) and aromatic ester derivatives (2i-2u) were synthesized and preliminarily evaluated for their anti-influenza activity in vitro by the national center for drug screening of China, using the Oseltamivir and Ribavirin as reference drugs. The results showed that 2l ($IC_{50}=0.5{\mu}mol/L$) exhibited potent anti-influenza $A_3$ viral activity among the synthesized compounds and was 10-fold more potent than that of the reference drug Oseltamivir ($IC_{50}=5.1{\mu}mol/L$).

• 한국잠사학회:학술대회논문집
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• 한국잠사학회 2004년도 International Conference of Sericultural and Entomological Sciences
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• pp.42-42
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• 2004

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3675-3680
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• 2012

Objective: To investigate the expression of endogenous hypoxia-related markers identified as being involved in vulvar squamous cell carcinoma (VSCC). Methods: We performed immunohistochemical staining of hypoxia-inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$), glucose transporter-1 (GLUT-1), carbonic anhydrase 9 (CA-9) and vascular endothelial growth factor (VEGF), on tissue sections of 25 VSCC patients, 10 vulvar intraepithelial neoplasia (VIN) patients and 12 healthy controls. Results: HIF-$1{\alpha}$ expression was found in all sections, with no significant difference between controls, VIN and VSCC sections (all P<0.05). Glut-1 expression was found in 25% of control, 90% of VIN and 100% of VSCC sections. A significant difference between control and VIN or VSCC was observed (all P<0.05), while no difference was found between VIN and VSCC sections (P>0.05). CA-9 expression was negative in control sections, but it was found in 30% of VIN sections and 52% of VSCC sections with strong staining. Similarly, CA-9 expression also showed obvious differences between controls and VIN or VSCC sections (all P<0.05). However, there was no significant difference between VIN and VSCC (P>0.05). There were only 25% of control sections with weak VEGF expression, while strong staining was found in about 60% of VIN sections and 25% of VSCC sections (all P<0.05). In addition, a difference was also found between VIN and VSCC sections (P<0.05). Conclusion: Expression of endogenous hypoxia markers (HIF-$1{\alpha}$, GLUT-1, CA-9 and VEGF) might be involved in the malignant progression of VSCC.

• Journal of Neurogastroenterology and Motility
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• 제25권3호
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• pp.343-362
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• 2019

Background/Aims There has been major progress in our understanding of the irritable bowel syndrome (IBS), and novel treatment classes have emerged. The Rome IV guidelines were published in 2016 and together with the growing body of Asian data on IBS, we felt it is timely to update the Asian IBS Consensus. Methods Key opinion leaders from Asian countries were organized into 4 teams to review 4 themes: symptoms and epidemiology, pathophysiology, diagnosis and investigations, and lifestyle modifications and treatments. The consensus development process was carried out by using a modified Delphi method. Results Thirty-seven statements were developed. Asian data substantiate the current global viewpoint that IBS is a disorder of gut-brain interaction. Socio-cultural and environmental factors in Asia appear to influence the greater overlap between IBS and upper gastrointestinal symptoms. New classes of treatments comprising low fermentable oligo-, di-, monosacharides, and polyols diet, probiotics, non-absorbable antibiotics, and secretagogues have good evidence base for their efficacy. Conclusions Our consensus is that all patients with functional gastrointestinal disorders should be evaluated comprehensively with a view to holistic management. Physicians should be encouraged to take a positive attitude to the treatment outcomes for IBS patients.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권8호
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• pp.2016-2029
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• 2023

Accurate prediction of critical illness is significant for ensuring the lives and health of patients. The selection of indicators affects the real-time capability and accuracy of the prediction for critical illness. However, the diversity and complexity of these indicators make it difficult to find potential connections between them and critical illnesses. For the first time, this study proposes an indicator analysis model to extract key indicators from the preoperative and intraoperative clinical indicators and laboratory results of critical illnesses. In this study, preoperative and intraoperative data of heart failure and respiratory failure are used to verify the model. The proposed model processes the datum and extracts key indicators through four parts. To test the effectiveness of the proposed model, the key indicators are used to predict the two critical illnesses. The classifiers used in the prediction are light gradient boosting machine (LightGBM) and eXtreme Gradient Boosting (XGBoost). The predictive performance using key indicators is better than that using all indicators. In the prediction of heart failure, LightGBM and XGBoost have sensitivities of 0.889 and 0.892, and specificities of 0.939 and 0.937, respectively. For respiratory failure, LightGBM and XGBoost have sensitivities of 0.709 and 0.689, and specificity of 0.936 and 0.940, respectively. The proposed model can effectively analyze the correlation between indicators and postoperative critical illness. The analytical results make it possible to find the key indicators for postoperative critical illnesses. This model is meaningful to assist doctors in extracting key indicators in time and improving the reliability and efficiency of prediction.

• 대한치과보철학회지
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• 제46권2호
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• pp.175-184
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• 2008

연구목적: 본 연구는 가변형 트레이 개발의 일환으로 그 시제품을 제작하고 비가역성 수성 콜로이드 인상재를 사용하여 중국인과 일본인에서 인상채득 시 트레이의 구강 내 적합성를 알아보고자 하였다. 연구재료 및 방법: 가변형 트레이는 한국 성인 악궁의 크기 분석결과를 기본으로 하여 설계하였으며, 먼저 CAD-CAM 작업을 통하여 견본 모형을 제작한 후, 이를 똑같이 복제한 실리콘 간이금형을 만들었다. 그리고 이 금형에 polyurethane을 주입하여 다수의 시제품을 완성하였다. 시제품을 이용하여 중국인으로는 상해 제2의과대학교 구강의학원 학생 60명 (남자 30명, 여자 30명)을 대상으로 하였고, 일본인으로는 일본 구마모토 고등학교 졸업생 60명 (남자 30명, 여자 30명)을 대상으로 인상채득을 실시하고, 측정부위별로 인상체의 두께와 길이를 측정한 후 통계처리를 하여 그 적합성을 평가하였다. 결과: 1. 중국인과 일본인 모두 스탑과 경사면에 의해 트레이의 폭이 적절히 조절되어 대체적으로 3-6mm의 균일한 인상체의 두께를 얻을 수 있었다. 2. 중국인의 상악 트레이에서는 전치 순측 변연부에서 두께가 6.2mm, 견치 순측 변연부에서 두께가 5.9mm, 구개부 중앙은 10.5 mm, 구개부 후방은 9.7mm 높이로 비교적 인상체의 두께가 크게 측정되었다. 3. 중국인의 하악 트레이에서는 제1, 2소구치 접촉점 설측 변연부에서 인상체의 길이가 8.9mm, 전치 설측 변연부에서 7.2mm로 길게 나타났으며, 견치 순측 6.8mm, 소구치 순측 7.0mm로 인상체의 두께가 크게 측정되었다. 4. 일본인의 상악 트레이에서는 전치 순측 변연부에서 두께가 7.4mm, 견치 순측 변연부에서 7.7mm, 구개부 중앙은 9.1mm 높이로 인상체의 두께가 비교적 크게 측정되었다. 5. 일본인의 하악 트레이에서는 견치 순측 7.4mm, 제1, 2소구치 접촉점 순측 변연부 8.4mm로 인상체의 두께가 크게 측정되었다. 결론: 본 가변형 치과 인상용 트레이는 한국인 모형 계측치를 바탕으로 설계되어 한국인에서 적합성이 우수하며, 본 실험의 결과 중국인과 일본인에서도 적합성이 좋아 본 트레이를 범용하여 쉽고 정확한 인상채득을 할 수 있을 것이다.