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http://dx.doi.org/10.5012/bkcs.2011.32.4.1293

Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A3 and B Viruses  

Yong, Jian-Ping (School of Public Health in Ningxia Medical University)
Aisa, Haji Akber (Xinjiang Technical Institute of Physics and Chemistry, The Key Laboratory of Plant Resources and Natural Products Chemistry, Chinese Academy of Sciences)
Publication Information
Bulletin of the Korean Chemical Society / v.32, no.4, 2011 , pp. 1293-1297 More about this Journal
Abstract
To improve the biological activities of rupestonic acid, 21 new rupestonic acid fatty ester derivatives (2a-2h) and aromatic ester derivatives (2i-2u) were synthesized and preliminarily evaluated for their anti-influenza activity in vitro by the national center for drug screening of China, using the Oseltamivir and Ribavirin as reference drugs. The results showed that 2l ($IC_{50}=0.5{\mu}mol/L$) exhibited potent anti-influenza $A_3$ viral activity among the synthesized compounds and was 10-fold more potent than that of the reference drug Oseltamivir ($IC_{50}=5.1{\mu}mol/L$).
Keywords
Synthesis; Rupestonic acid ester derivatives; Anti-influenza virus;
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