• Journal of KIISE:Information Networking
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• v.29 no.4
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• pp.412-427
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• 2002

This paper proposes a restoration scheme based on mobility learning and prediction in the presence of the failure of mobility databases in mobile communication systems. In mobile communication systems, mobility databases must maintain the current location information of users to provide a fast connection for them. However, the failure of mobility databases may cause some location information to be lost. As a result, without an explicit restoration procedure, incoming calls to users may be rejected. Therefore, an explicit restoration scheme against the failure of mobility databases is needed to guarantee continuous service availability to users. Introducing mobility learning and prediction into the restoration process allows systems to locate users after a failure of mobility databases. In failure-free operations, the movement patterns of users are learned by a Neuro-Fuzzy Inference System (NFIS). After a failure, an inference process of the NFIS is initiated and the users' future location is predicted. This is used to locate lost users after a failure. This proposal differs from previous approaches using checkpoint because it does not need a backup process nor additional storage space to store checkpoint information. In addition, simulations show that our proposal can reduce the cost needed to restore the location records of lost users after a failure when compared to the checkpointing scheme

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.35 no.3
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• pp.175-186
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• 2017

In this study was to survey method of national/public land actual condition survey to utilization of UAV, in order to evaluate the economic and accuracy. we carried out the comparative evaluation of the cadastral status surveying in terms of accuracy of parcel checkpoint, economical costs. The results are summarized as follows. First, average position error of the orthoimage was 0.033m in X error, 0.023m in Y error when the RMSE average calculated 0.046m from the intersection of plane distance connections. Secondly, it was appeared the accuracy of the orthophotograph is 0.076m at the maximum RMSE of the UAV orthoimage check point and 0.042m at the minimum RMSE compared with the VRS-GNSS survey results. Thirdly, when the allowable error specified in the implementing regulation of the current cadastral survey is applied, all of the checkpoint of 0.360m tolerance corresponding to the scale of 1/1,200 is satisfied. Finally, UAV utilization method in national/public land actual condition survey is 26,497,436(KRW) cheaper than cadastral survey method for In the economic evaluation of national/public land actual condition survey. Therefore, as a result of this study shows that the method of utilizing UAV in the national/public land actual condition survey satisfies legal standards in terms of accuracy and economical aspect is a way to further reduce the local government budget.

• Journal of Korean Neurosurgical Society
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• v.64 no.2
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• pp.271-281
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• 2021

Objective : Immune checkpoint inhibitors (ICIs) are approved for treating non-small-cell lung cancer (NSCLC); however, the safety and efficacy of combined ICI and Gamma Knife radiosurgery (GKS) treatment remain undefined. In this study, we retrospectively analyzed patients treated with ICIs with or without GKS at our institute to manage patients with brain metastases from NSCLC. Methods : We retrospectively reviewed medical records of patients with brain metastases from NSCLC treated with ICIs between January 2015 and December 2017. Of 134 patients, 77 were assessable for brain responses and categorized into three groups as follows : group A, ICI alone (n=26); group B, ICI with concurrent GKS within 14 days (n=24); and group C, ICI with non-concurrent GKS (n=27). Results : The median follow-up duration after brain metastasis diagnosis was 19.1 months (range, 1-77). At the last follow-up, 53 patients (68.8%) died, 20 were alive, and four were lost to follow-up. The estimated median overall survival (OS) of all patients from the date of brain metastasis diagnosis was 20.0 months (95% confidence interval, 12.5-27.7) (10.0, 22.5, and 42.1 months in groups A, B, and C, respectively). The OS was shorter in group A than in group C (p=0.001). The intracranial disease progression-free survival (p=0.569), local progression-free survival (p=0.457), and complication rates did not significantly differ among the groups. Twelve patients showed leptomeningeal seeding (LMS) during follow-up. The 1-year LMS-free rate in treated with ICI alone group (69.1%) was significantly lower than that in treated with GKS before ICI treatment or within 14 days group (93.2%) (p=0.004). Conclusion : GKS with ICI showed no favorable OS outcome in treating brain metastasis from NSCLC. However, GKS with ICI did not increase the risk of complications. Furthermore, compared with ICI alone, GKS with ICI may be associated with a reduced incidence of LMS. Further understanding of the mechanism, which remains unknown, may help improve the quality of life of patients with brain metastasis.

• IMMUNE NETWORK
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• v.23 no.4
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• pp.35.1-35.16
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• 2023

Defining the molecular dynamics associated with T cell differentiation enhances our understanding of T cell biology and opens up new possibilities for clinical implications. In this study, we investigated the dynamics of CD5 expression in CD8⁺ T cell differentiation and explored its potential clinical uses. Using PBMCs from 29 healthy donors, we observed a stepwise decrease in CD5 expression as CD8⁺ T cells progressed through the differentiation stages. Interestingly, we found that CD5 expression was initially upregulated in response to T cell receptor stimulation, but diminished as the cells underwent proliferation, potentially explaining the differentiation-associated CD5 downregulation. Based on the proliferation-dependent downregulation of CD5, we hypothesized that relative CD5 expression could serve as a marker to distinguish the heterogeneous CD8⁺ T cell population based on their proliferation history. In support of this, we demonstrated that effector memory CD8⁺ T cells with higher CD5 expression exhibited phenotypic and functional characteristics resembling less differentiated cells compared to those with lower CD5 expression. Furthermore, in the retrospective analysis of PBMCs from 30 non-small cell lung cancer patients, we found that patients with higher CD5 expression in effector memory T cells displayed CD8⁺ T cells with a phenotype closer to the less differentiated cells, leading to favorable clinical outcomes in response to immune checkpoint inhibitor (ICI) therapy. These findings highlight the dynamics of CD5 expression as an indicator of CD8⁺ T cell differentiation status, and have implications for the development of predictive biomarker for ICI therapy.

• IMMUNE NETWORK
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• v.15 no.2
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• pp.58-65
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• 2015

Melanoma is the most aggressive skin cancer and its incidence is gradually increasing worldwide. Patients with metastatic melanoma have a very poor prognosis (estimated 5-year survival rate of <16%). In the last few years, several drugs have been approved for malignant melanoma, such as tyrosine kinase inhibitors and immune checkpoint blockades. Although new therapeutic agents have improved progression-free and overall survival, their use is limited by drug resistance and drug-related toxicity. At the same time, adoptive cell therapy of metastatic melanoma with tumor-infiltrating lymphocytes has shown promising results in preclinical and clinical studies. In this review, we summarize the currently available drugs for treatment of malignant melanoma. In addition, we suggest cytokine-induced killer (CIK) cells as another candidate approach for adoptive cell therapy of melanoma. Our preclinical study and several previous studies have shown that CIK cells have potent anti-tumor activity against melanomas in vitro and in an in vivo human tumor xenograft model without any toxicity.

• Journal of Microbiology and Biotechnology
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• v.30 no.3
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• pp.469-475
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• 2020

During meiosis I, programmed DNA double-strand breaks (DSBs) occur to promote chromosome pairing and recombination between homologs. In Saccharomyces cerevisiae, Mec1 and Tel1, the orthologs of human ATR and ATM, respectively, regulate events upstream of the cell cycle checkpoint to initiate DNA repair. Tel1^ATM and Mec1^ATR are required for phosphorylating various meiotic proteins during recombination. This study aimed to investigate the role of Tel1^ATM and Mec1^ATR in meiotic prophase via physical analysis of recombination. Tel1^ATM cooperated with Mec1^ATR to mediate DSB-to-single end invasion transition, but negatively regulated DSB formation. Furthermore, Mec1^ATR was required for the formation of interhomolog joint molecules from early prophase, thus establishing a recombination partner choice. Moreover, Mec1^ATR specifically promoted crossover-fated DSB repair. Together, these results suggest that Tel1^ATM and Mec1^ATR function redundantly or independently in all post-DSB stages.

• Natural Product Sciences
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• v.19 no.2
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• pp.155-159
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• 2013

Honokiol, a naturally occurring neolignan mainly found in Magnolia species, has exhibited a potential anti-proliferative activity in human cancer cells. However, the growth inhibitory activity against hepatocellular carcinoma cells and the underlying molecular mechanisms has been poorly determined. The present study was designed to examine the anti-proliferative effect of honokiol in SK-HEP-1 human hepatocellular cancer cells. Honokiol exerted anti-proliferative activity with cell-cycle arrest at the G0/G1 phase and sequential induction of apoptotic cell death. The cell-cycle arrest was well correlated with the down-regulation of checkpoint proteins including cyclin D1, cyclin A, cyclin E, CDK4, PCNA, retinoblastoma protein (Rb), and c-Myc. The increase of sub-G1 peak by the higher concentration of honokiol ($75{\mu}M$) was closely related to the induction of apoptosis, which was evidenced by decreased expression of Bcl-2, Bid, and caspase-9. Hohokiol was also found to attenuate the activation of signaling proteins in the Akt/mTOR and ERK pathways. These findings suggest that the anti-proliferative effect of honokiol was associated in part with the induction of cell-cycle arrest, apoptosis, and dow-nregulation of Akt/mTOR signaling pathways in human hepatocellular cancer cells.

• The Transactions of the Korea Information Processing Society
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• v.7 no.6
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• pp.1753-1765
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• 2000

As the areas of computer application are expanded, real-time application environments that must process as many transactions as possible within their deadlines, such as a stock transaction systems, ATM switching systems etc, have been increased recently. The reason why the conventional database systems can't process soft real-time applications is the lack of prediction and poor performance on processing transaction's deadline. If transactions want to access data stored at the secondary storage, they can not satisfy requirements of real-time applications because of the disk delay time. This paper designs a main-memory database prototype systems to be suitable to real-time applications and then this system can produce rapid results without disk i/o as all of the information are loaded in main memory database. In thesis proposed the improved techniques with respect to logging, checkpointing, and recovering in our environment. In order to improve the performance of the system, a) the frequency of log analysis and redo processing is reduced by the proposed redo technique at system failure, b) database consistency is maintained by improved fuzzy checkpointing. The performance model is proposed which consists of two parts. The first part evaluates log processing time for recovery and compares with other research activities. The second part examines checkpointing behavior.

• Journal of KIISE:Software and Applications
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• v.26 no.5
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• pp.621-638
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• 1999

재시작 회복시 수행해야 할 작업략을 줄이기 위하여 주기적으로 수행되는 검사점 중 퍼지 검사점은 정상적인 트랜잭션들의 수행과 병행하여 수행된다. 트랜잭션들과 퍼지 검사점의 수행시, 로그 레코드 기록의 순서화를 위한 로그 래취를 획득한 상태에서 로그 레코드를 기록할수있으며, 트랜잭션 엔트리의 무결성을 보장하기 위한 트랜잭션 래취를 획득한 상태에서 트랜잭션은 로그 레코드의 기록과 관련된 트랜잭션 상태를 변경할수 있으며 검사점 프로세스는 트랜잭션의 상태를 검사할 수 있다. 퍼지 검사점과 트랜잭션들이 수행이 비동기로 수행되는 상황에서 로그래취와 트랜잭션 래취의 획득 및 해제 방법이 적절하지 못한 경우, 퍼지 검사점이 어떤 트랜잭션의 트랜잭션 상태를 검사하기 전에 그 트랜잭션에 의하여 기록된 로그 레코드이지만 그 퍼지 검사점이 그 트랜잭션 상태를 검사할때까지 그 로그 레코드의 기록상황이 그 트랜잭션의 트랜잭션 상태에 반영되지 않은 경우가 발생할수 있다. 이 경우, 기록 상황이 트랜잭션 상태에 반영되지 않은 그 로그 레코드를 그 퍼지 검사점에 대한 그 트랜잭션의 상태미방영 로그 레코드라고 한다. 본 논문은 상태미반영 로그 레코드를 발생시키는 상황들을 분석하고, 상태미반영 로그 레코드의 발생에 따른 문제점들을 기술하며, 상태미반영 로그 레코드의 발생에 대하여 전면 방지 기법, 일부 방지 기법 그리고 전면 허용하지만 회복시 이를 해결하는 기법등 세가지 해결책을 제시한다.

• The Transactions of the Korea Information Processing Society
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• v.3 no.2
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• pp.327-338
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• 1996

In this paper, we present a new checkpointing algorithm to preserve the consistency of resources in distributed transaction processing systems, and the error recovery algorithms to recover form the failure. In comparison with the existed algorithms, the checkpointing algorithm proposed in this paper can minimize the interference of the distributed transaction and the stroage cost during checkpointing, and does not need the extra message to make th checkpoint. Also we show that the error recovery algorithms prevent the distributed transaction with a partial fault from spreading the fault, which calls domnio-effect and prevent them from restarting cyclically. And we describe the correctness and the performane of the proposed algorithms.