• The Korean Nurse
• /
• v.36 no.3
• /
• pp.49-69
• /
• 1997

The urgent needs to establish hospice care systems in Korea arise from the following reasons: 0) a drastic increase in chronically ill patients with the increase of aged population: (2) rapid changes in living environment from the traditional habitation (e. g., Many Koreans living in apartment complexes, which is the most popular form of modern residence in recent years, prefer to die in the hospital.): the overall increase in patients with advanced cancer: (4) recent trends in early discharge of terminally ill patients from the limited hospital facilities to accomodate other medical insurance beneficiaries; (5) easy acceptance of euthanasia owing to the recent social atmosphere that belittles the dignity of human life; (6) medical and nursing care of AIDS patient in terminal stage; (7) and the problem associated with inhumane medical care system, overtreatment, and groundless fears against narcotics. Terminally ill patients were used to be treated in the hospital in the past. In these days, however, they are forced to have home cares with little assistance from the qualified medical personnel because of insufficient hospital facilities, which are even short for the need of emergency patients and provide priority cares to medical insurance beneficiaries with other acute problems. And yet, neither are there any administrative organizations nor systematic medical studies that deal with the level of terminally ill patient's need, their family's problems and resources of hospice care systems in Korea. Thus, most patients are not able to get appropriate medical care at the terminal stage of their lives. The objective of this study is to make comprehensive database for various hospice care organization currently in operation, link them through medical information system, and develop an easily accessible hospice care model that meets the need of most Korean people. Our survey results may be summarized as follows: Nationally there are 40 organizations that provide partial or full hospice care. However, these organizations are not linked to any formal medical service network. Furthermore, the objective of hospice care, care principles, personnel with appropriate training, educational programs, standard for care, costs, consulting service to patients' family members, the extent of medical care from professional staff members, status of hospice facility, and management of those institutions are neither clearly defined nor organized compared to the international hospice care standards. The surveys on patients of terminal stage. grouped in hospice and non-hospice care patients. reveal what they want visiting nursing care to help their pain control. psychological. social and spiritual demands. While the more than 90% of hospice care patients want to reduce their pains. the non-hospice care patients. in addition to their desire for pain control. demanded more psychological. social and spiritual helps as well. The results of this research could be utilized to 0) define the standard of hospice care. (2) provide the guidance for hospice medical care costs. (3) establish the database of hospice care systems. (4) develop softwares. (5) build communication network through Medinet. and (6) provide an organized visiting home nursing care system. These information should be a valuable resource to many medical staffs who are involved in cancer therapy. nursing care. and social welfare programs.

• Research in Community and Public Health Nursing
• /
• v.32 no.2
• /
• pp.162-174
• /
• 2021

Purpose: The purpose of this qualitative study is to explore the changed parenting experiences of mothers of elementary school kids living in the aftermath of the COVID-19 outbreak in Korea. Methods: From July to August in 2020, 10 mothers parenting elementary school students under the COVID-19 were interviewed in depth. For data analysis, a phenomenological research methodology suggested by Colaizzi was used. Results: According to the analysis, the experiences of mothers consisted of four categories: the 'pain from the uncontrollable COVID-19', 'the problem of family relations due to the COVID-19 pandemic situation', 'standing firm against the drastic changes', and 'accepting the world changed by the COVID-19'. Conclusion: The findings in this study vividly represent the parenting experiences of mothers of elementary school students after the outbreak of COVID-19. As the pandemic persists, mothers parenting elementary school students feel complex emotions and experience exhaustion, but in the process, they found family members growing positively and trying to adjust to each other to overcome the crisis. To support positive adaptation to catastrophic situations, an institutional and political foundation is needed to develop a systematic crisis management program customized for mothers and families of elementary school students. The results of this study can be used as basic data when establishing national policies and support systems so that mothers parenting elementary school students can better adapt to and overcome crisis situations.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.4
• /
• pp.2525-2528
• /
• 2013

The Homer protein family, also known as the family of cytoplasmic scaffolding proteins, which include three subtypes (Homer1, Homer2, Homer3). Homer3 can regulate transcription and play a very important role in the differentiation and development for some tissues (e.g. muscle and nervous systems). The current studies showed that Homer3 abnormal expression changes in acute myeloid leukemia (AML). Forced expression of Homer3 in transfected K562 cells inhibited proliferation, influenced the cell cycle profile, affected apoptosis induced by $As_2O_3$ through inhibition of Bcl2 expression, and also promoted cell differentiation induced by 12-O-tetra decanoylphorbol-acetate (TPA). These results showed that Homer3 is a novel gene which plays a certain role in the occurrence and development of AML.

• CELLMED
• /
• v.8 no.3
• /
• pp.14.1-14.6
• /
• 2018

Santalum album Linn. [Family: Santalaceae] is commonly known as white sandalwood, sandal safaid and safed chandan. It is one of the most valuable trees and second costliest wood in the world. Sandalwood and its oil is extensively used in the Unani and other traditional systems of medicine as it has blood purifier, anti-inflammatory, analgesic, exhilarant, cardiotonic, antiseptic, nervine tonic and expectorant properties. It is used in skin, cardiac, liver, gastrointestinal, respiratory, integument and urogenital disorders. These uses are supported and proven by many in vitro or in vivo studies. The proven pharmacological activities of S. album are antimicrobial, anti-oxidant, anti-inflammatory, antimutagenic and anti-fatigue. The research has proven that sandal oil or its constituents have anti-microbial activity. Sandalwood oil showed skin cancer preventive effect in mice and its constituent alpha santalol showed the anticancer property. The methanolic extract of wood was confirmed for antioxidant, free radical scavenging, analgesic and anti-inflammatory activities. ${\alpha}$ and ${\beta}$ santalols present in sandal oil showed sedative effects. Sandalwood tea had a significant effect on heart muscles of frog and showed increased myocardial contractility. Its oil showed significant changes in hepatic xenobiotic metabolizing enzymes. Sandalwood oil and its major constituents showed less acute oral and dermal toxicity in laboratory animals. Hence, the aforementioned studies justify the uses of sandalwood and its oil mentioned in the classical Unani literature. However, further clinical trials are suggested to confirm its efficacy and safety in humans.

• Journal of the Korean Home Economics Association
• /
• v.43 no.11 s.213
• /
• pp.165-183
• /
• 2005

Total fertility rate in South Korea is the lowest in the world. A fertility rate below replacement fertility level will result in serious social problems in the long term. Therefore, it is worthwhile to study a general understanding about the low fertility rate phenomenon and to investigate the effectiveness of fertility policies in order to ameliorate the resulting social problems due to the low fertility rate. This research was a descriptive examination into the low fertility rate phenomenon and an investigation of the needs for fertility potties and their effectiveness. The study subjects were consisted of 769 unmarried people aged from 18 to 40 years old. Data were collected from June to August 2004 and were analyzed by frequencies, mean, and standard deviation. The following results were revealed. First, unmarried people in general had positive perspectives about getting marriaged, giving birth, and being a parent. In addition, the primary cause of low fertility rate was economical difficulties for raising a child. Third, unmarried people thought that the low fertility rate phenomenon resoled in both positive and negative changes in a society. Fourth, policies for economical supports for raising children, establishing social atmosphere for gender equality, and trustful public educational systems were the political alternatives that people really wanted for having a child in the future. Effective alternatives for policies and strategies to address the low fertility rate problems are suggested in the discussion section.

• Journal of Microbiology and Biotechnology
• /
• v.21 no.1
• /
• pp.14-19
• /
• 2011

A cyclic undecapeptide-family natural product, cyclosporin A (CyA), which is one of the most valuable immunosuppressive drugs, is produced nonribosomally by a multifunctional cyclosporin synthetase enzyme complex in a filamentous fungal strain named Tolypocladium niveum. Previously, structural modifications of cyclosporins such as a regionspecific hydroxylation at the $4^{th}$ N-methyl leucine in a rare actinomycetes called Sebekia benihana were reported to lead to dramatic changes in their bioactive spectra. However, the reason behind this change could not be determined since a system to genetically manipulate S. benihana has not yet been developed. To address this limitation, in this study, we utilized the most commonly practiced gene manipulation techniques including conjugation-based foreign gene transfer-and-expression as well as targeted gene disruption to genetically manipulate S. benihana. Using these optimized genetic manipulation systems, a putative cytochrome P450 hydroxylase (CYP) gene named CYP506, which is involved in CyA hydroxylation in S. benihana, was specifically disrupted and genetically complemented. The S. benihana${\Delta}$CYP506 exhibited a significantly reduced CyA hydroxylation yield as well as considerable yield restoration by functional complementation of the S. benihana CYP506 gene, suggesting that the genetically manipulated S. benihana CYP mutant strains may serve as a more efficient bioconversion host for various valuable metabolites including CyA.

• Molecules and Cells
• /
• v.43 no.8
• /
• pp.671-685
• /
• 2020

The regulator of calcineurin (RCAN) was first reported as a novel gene called DSCR1, encoded in a region termed the Down syndrome critical region (DSCR) of human chromosome 21. Genome sequence comparisons across species using bioinformatics revealed three members of the RCAN gene family, RCAN1, RCAN2, and RCAN3, present in most jawed vertebrates, with one member observed in most invertebrates and fungi. RCAN is most highly expressed in brain and striated muscles, but expression has been reported in many other tissues, as well, including the heart and kidneys. Expression levels of RCAN homologs are responsive to external stressors such as reactive oxygen species, Ca²⁺, amyloid β, and hormonal changes and upregulated in pathological conditions, including Alzheimer's disease, cardiac hypertrophy, diabetes, and degenerative neuropathy. RCAN binding to calcineurin, a Ca²⁺/calmodulin-dependent phosphatase, inhibits calcineurin activity, thereby regulating different physiological events via dephosphorylation of important substrates. Novel functions of RCANs have recently emerged, indicating involvement in mitochondria homeostasis, RNA binding, circadian rhythms, obesity, and thermogenesis, some of which are calcineurin-independent. These developments suggest that besides significant contributions to DS pathologies and calcineurin regulation, RCAN is an important participant across physiological systems, suggesting it as a favorable therapeutic target.

• Korean Journal of Family Social Work
• /
• no.54
• /
• pp.263-296
• /
• 2016

This study aimed to understand the child rearing burden of mothers of youth with developmental disabilities and mothers' inner growth through their rearing experiences. The researchers conducted focus group interviews using the 'photovoice' method and individual interviews with a mothers' group of an orchestra whose members are youth with developmental disabilities. The data were qualitatively analyzed applying systematic content analysis. The results revealed that the lives of mothers of children with developmental disabilities were framed as 'keeping walking, even it's invisible', and their experiences were summed up by the phrase 'coming together and growing with their children.' Although the mothers of children with developmental disabilities experienced distress and difficulties, they also experienced joy and growth while parenting their children. Their children's participation in the orchestra were associated with changes in the mothers' perceptions of their children as well as their self-perceptions as caregivers, and the relationships with the support systems. Based on these findings, the implications of this study for social welfare practice were discussed.

• Journal of Families and Better Life
• /
• v.31 no.6
• /
• pp.97-112
• /
• 2013

This study was conducted to investigate the effect of sandplay therapy for couples on the self-differentiation, and heterosexual relationship satisfaction, of couples who are college students'. The subjects were four couples who are college students living in Seoul with low self-differentiation and heterosexual relationship satisfaction. I carried out sandplay therapy on four couples for once a week for 10 weeks, and each session was 70 minutes long. In this study, the self-differentiation scale was modified for Korea on the basis of Bowen's family systems theory (1976), and it was used as a research tool. Yu (2000) and Lee (2000) made a scale to measure heterosexual relationship satisfaction after they adjusted the Korea Marital Satisfaction Inventory (K-MSI). The scale was also used in order to compare pre-therapy and post-therapy traits and identify any changes. In addition, the group's behavior and interactions were observed and recorded in each session throughout the process of sandplay therapy with the couples, and the behanior and interactions were analyzed along with the change flow in the sand trays. The study's outcomes are summed up as follows. First, sandplay therapy with couples advances the level of self-differentiation in college students. Second, sandplay therapy with couples improves the heterosexual relationship satisfaction on college students. Third, the trays used in sandplay therapy with couples showed positive changes as the therapy progressed. As the sessions continued, negative factors in the trays decreased and the trays converged into one. As the sessions proceeded, it was observed that the couples became closer, felt more comfortable with each other, compromised and reflected on their relationship. The study's results show that sandplay therapy with couples increased the level of self-differentiation in college students and heterosexual relationship satisfaction, thus proving the therapy's effectiveness.

• Journal of Families and Better Life
• /
• v.22 no.1
• /
• pp.103-114
• /
• 2004

This study was performed by the literature review on housing of the aged in Korea with social constructionism perspective. This kind of research may be utilized as a theoretical framework for performance of any systems of housing for the aged. In terms of structural context, the value of conventional custom of filial piety thoughts and duty for family are being collapsed, which nay be suitable to the change of society, should be considered for positive acceptance of changes in ideology. In terms of institutional context, a method to grope for housing for the aged should be established through amicable cooperation between organizations of legalization concerned. In terms of organizational context, there is no organization that exclusively concern housing for the aged until now, thus, development of concrete manual is required for jobs of service in current department of policy for the aged. In terms of operational context, the service may include the understanding of characteristics of the aged and design of housing may also change the service of administration, and as cooperation in the local community care systems may change the service to the aged in the field. Connection of these services and operation of these organizations nay be required in the field to manage housing. Finally in terms of intersubjective context, as the form and method of housing management service is important, with understanding of the social meaning and importance on the role of manager.