• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.2
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• pp.327-340
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• 2015

General Circulation Models (GCMs) are the basic tool used for modelling climate. However, the spatio-temporal discrepancy between GCM and observed value, therefore, the models deliver output that are generally required calibration for applied studies. Which is generally done by Multi-Model Ensemble (MME) approach. Stochastic downscaling methods have been used extensively to generate long-term weather sequences from finite observed records. A primary objective of this study is to develop a forecasting scheme which is able to make use of a MME of different GCMs. This study employed a Nonstationary Hidden Markov Chain Model (NHMM) as a main tool for downscaling seasonal ensemble forecasts over 3 month period, providing daily forecasts. Our results showed that the proposed downscaling scheme can provide the skillful forecasts as inputs for hydrologic modeling, which in turn may improve water resources management. An application to the Nakdong watershed in South Korea illustrates how the proposed approach can lead to potentially reliable information for water resources management.

• BMB Reports
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• v.38 no.3
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• pp.307-313
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• 2005

Thiobacillus ferrooxidans is one of the most important bacterium used in bioleaching, and can utilize $Fe^{2+}$ or sulphide as energy source. Growth curves for Thiobacillus ferrooxidans have been tested, which show lag, logarithmic, stationary and aging phases as seen in other bacteria. The logarithmic phases were from 10 to 32 hours for Thiobacillus ferrooxidans cultivated with $Fe^{2+}$ and from 4 to 12 days for Thiobacillus ferrooxidans cultivated with elemental sulphur. Differences of protein patterns of Thiobacillus ferrooxidans growing on elemental sulphur and $Fe^{2+}$ separately were investigated after cultivation at $30^{\circ}C$ by the analysis of two-dimensional gel electrophoresis (2-DE), matrix-assisted laser desorption/ ionization (MALDI)-Mass spectrometry and ESI-MS/MS. From the 7 identified protein spots, 11 spots were found more abundant when growing on elemental sulphur. By contrast 6 protein spots were found decreased at elemental cultivation condition. Among the proteins identified, cytochrome C have been previously identified as necessary elements of electron-transfering pathway for Thiobacillus ferrooxidans to oxidize $Fe^{2+}$; ATP synthase alpha chain and beta are expressed increased when Thiobacillus ferrooxidans cultivated with $Fe^{2+}$ as energy source. ATP synthase Beta chain is the catalytic subunit, and ATP synthase alpha chain is a regulatory subunit. The function of ATPase produces ATP from ADP in the presence of a proton gradient across the membrane.

• Economic and Environmental Geology
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• v.56 no.2
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• pp.155-166
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• 2023

Through COVID-19, the importance of supply chain management of raw material minerals has been maximized. In particular, supply chain management is important for rare metals, which are difficult to manage demand and supply, in order to secure raw materials for the parts and materials industry that Korea is actively promoting. In this study, a system was established and evaluated to select Critical minerals that need to respond to Korea's industrial structure and global risks by quantifying tangible and intangible risk factors. Global Supply Concentration, Supplying country risk, Policy Social Environment Regulation, Domestic Import Instability, Risk responsiveness, Market Scale, Demand Fluctuation and Economic Importance were evaluated as evaluation indicators. The degree of risk and risk impact were quantitatively measured using the criticality matrix-criticality level. After evaluating 40 types of minerals used in domestic new growth businesses, 15 types of Critical minerals(Li, Pt, Co, V, REE, Mg, Mo, Cr, Ti, W, C, Ni, Al, Mn, Si) in Korea were selected. The results are expected to be used to establish policies to strengthen resource security and to make decisions to form a company's raw material portfolio.

• Polymer(Korea)
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• v.31 no.6
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• pp.461-468
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• 2007

In order to understand the structure of the existing aggregate in the nanocomposite, which has been prepared with polyester and trisilanolisobutyl polyhedral oligomeric silsesquioxane(TBPOSS), laser light scattering(LLS) and SEM-EDS were applied to its 1,1,1,3,3,3-hexafluoro-2-propanol solution and original sample, respectively. Although aggregate particles appeared as spherical shape of the average diameter of 120 nm in SEM image, they were not microgels but almost linear copolymer chains ($M_w=2.3{\times}10^6\;g/mol$) alternating 320 molecules of TBPOSS with polyester subchains. It has been microphase-separated from the matrix polyester due to the difference of chemical composition. As the matrix, polyester chain of $M_w=4.0{\times}10^4\;g/mol$ had averagely 2.5 molecules of TBPOSS per chain. It is also found that about 93% of total TBPOSS molecules existed in matrix phase and the residual 7% in spherically aggregated phase.

• BMB Reports
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• v.51 no.4
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• pp.182-187
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• 2018

In carcinoma, cancer-associated fibroblasts participate in force-mediated extracellular matrix (ECM) remodeling, consequently leading to invasion of cancer cells. Likewise, the ECM remodeling actively occurs in glioblastoma (GBM) and the consequent microenvironmental stiffness is strongly linked to migration behavior of GBM cells. However, in GBM the stromal cells responsible for force-mediated ECM remodeling remain unidentified. We show that tumor-associated mesenchymal stem-like cells (tMSLCs) provide a proinvasive matrix condition in GBM by force-mediated ECM remodeling. Importantly, CCL2-mediated Janus kinase 1 (JAK1) activation increased phosphorylation of myosin light chain 2 in tMSLCs and led to collagen assembly and actomyosin contractility. Collectively, our findings implicate tMSLCs as stromal cells providing force-mediated proinvasive ECM remodeling in the GBM microenvironment, and reminiscent of fibroblasts in carcinoma.

• Journal of the Optical Society of Korea
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• v.6 no.3
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• pp.121-127
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• 2002

The operating principal of a ring laser gyroscope depends on the phase difference for the counter-propagating waves within a closed path. The reflecting mirrors mounted on the monoblock form the traveling waves. The manufacturing accuracy of the monoblock influences the traveling path of ray, the sensitivity of laser resonator for misalignments, and diffraction losses. A 3 $\times$ 3 ray transfer matrix was derived for optical components with centering and squaring errors in a ring resonator. The matrix can be utilized to predict the optical ray paths on the basis of the manufacturing errors of the monoblock as well as the misalignment of mirrors. Then the distance and orientation (o. slope) at the arbitrary plane inside the resonator along the ideal optical path can be calculated from the chain multiplication of the ray transfer matrix for each optical component in one round trip. We also show that the counter-propagating rays In a ring resonator with errors does not coincide in each round trip, which results in gain difference between two beams, and how these errors can be adjusted through the alignment procedure. Finally this 3 $\times$ 3 ray matrix formalism can be used to calculate the beam size and its displacement from the optical axis and the deviation at the diaphragm.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.29 no.4
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• pp.212-218
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• 2003

Matrix metalloproteinases (MMPs) play an important role in the normal morphogenesis, maintenance, and repair of matrix and also have important functions in pathologic conditions characterized by excessive degradation of extracellular matrix, such as rheumatoid arthritis, osteoarthritis, periodontitis and in tumor invasion and metastasis. In this study, expression of MMP-1 and -2 mRNA in retrodiscal tissue of the temporomandibular joint (TMJ) was examined and compared with magnetic resonance imaging (MRI) and surgical findings. MMP mRNAs in the retrodiscal tissue samples were detected by reverse transcription - polymerase chain reaction. TMJ internal derangement (ID) was categorized as normal disc position, disc displacement with reduction, early stage of disc displacement without reduction (DDsR) and late stage of DDsR. TMJ osteoarthrosis (OA) was classified with normal, mild and advanced OA. The amount of synovial fluid collection was divided into not detected, small, large and extremely large amount on MR T2-weighted imaging. Perforation and adhesion were examined during open surgery of the TMJ. Six out of 37 samples were excluded because of little amount of extracted total mRNA. MMP-2 mRNA was detected whole joints, and so the MMP-2 mRNA seems to be expressed normally in retrodiscal tissue. However, MMP-1 mRNA was expressed in 8 of 31 joints. Frequencies of MMP-1 mRNA expression according to the TMJ IDs, amount of synovial fluid and surgical findings made no significant difference. MMP-1 mRNA was detected more frequently in OA groups (7/16 joints, 43.8%) than in normal bony structure group (1/15 joints, 6.7%). Expression of MMP-1 mRNA in retrodiscal tissue might be related with OA of the TMJ.

• Molecular & Cellular Toxicology
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• v.4 no.3
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• pp.253-259
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• 2008

Human follicular fluid (HFF) is the in vivo microenvironment for oocyte maturation and includes a variety of proteins that could be involved in oocyte development and fertilization. We therefore used a proteomic approach to identify new HFF proteins. HFF from mature human follicles was obtained from five women following oocyte collection for in vitro fertilization (IVF). Ethanol-precipitated HFF run on two-dimensional gel electrophoresis (2DE) produced approximately 250 Coomassie brilliant blue-stained spots, 64 of which were identified using matrix-assisted laser desorption/ionization-mass spectrometry (MALDIMS). In this study, several proteins including complement factor H, inter-${\alpha}$ (globulin) inhibitor H4, inter-${\alpha}$-trypsin inhibitor heavy chain H4 precursor, human zinc-${\alpha}$-2-glycoprotein chain B, PRO2619, PRO02044, and complex-forming glycoprotein HC were new proteins that have not been previously reported in HFF using proteomic methods. Additionally, we identified alloalbumin venezia for the first time from trichloroacetic acid (TCA)-precipitated HFF. These HFF proteins could serve as new biomarkers for important human reproductive processes.

• Journal of applied mathematics & informatics
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• v.28 no.1_2
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• pp.153-162
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• 2010

The finite buffer GI/G/1/K system is set up by using an unconventional arrangement of the state space, in which the remaining interarrival time or service time is chosen as the level. The stationary distributions of resulting Markov chain can be explicitly determined, and the chain is positive recurrent without any restriction. This is an advantage of this method, compared with that using the elapsed time approach [2].

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.3
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• pp.269-275
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• 2009

This paper represents a study on the conceptual design of new automatic bicycle transmission. The gear change in a commercial bicycle is carried out by moving the chain between sprockets. By the use of a multiple sprocket for speed change the power loss and transmission shock may occur. To solve the problem of bicycle transmission, the improved solution was derived by the technical contradiction matrix of TRIZ. The conceptual solution is one sprocket which replaces the function of multiple sprockets and adapts actively to the pitch of chain. And it was confirmed to be an adequate design through the Independence Axiom of design axiom.