• Title/Summary/Keyword: Cha-il

Search Result 1,185, Processing Time 0.028 seconds

Anti-inflammatory Effect of the Extract of Gynostemma pentaphyllum cell from Ullengdo Island as Korean Endemic Plant (한국 고유 식물 울릉도 돌외 식물 세포 배양추출물의 항염증 효과)

  • Mok, Bo-Ram;Kim, Soo-Yun;Paek, Seung hye;Jang, Young-su;Shin, Jung U;Moh, Sang Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.22 no.2
    • /
    • pp.745-754
    • /
    • 2021

  • The purpose of this study was to evaluate and verify the effectiveness of sustainable cosmetic raw materials developed from Gynostemma pentaphyllum, a plant native to Ulleungdo, in improving the skin barrier function and treating atopic dermatitis. Cells were derived from adult Gynostemma pentaphyllum plants, and suitable conditions for mass culture of the cells were established in a bioreactor. DNA components and amino acids extracted from this mass culture were identified from the HPLC fraction. In the in vitro efficacy evaluation results, changes in the expression levels of skin barrier-related proteins such as filaggrin (FLG) and Zonula occludens-1 (Zo-1) were insignificant. It was confirmed that the expression levels of the proteins thymic stromal lymphopoietin (TSLP) and interleukin-33 (IL-33) were significantly reduced. These results lead to the conclusion that Gynostemma pentaphyllum cell extracts have significant anti-inflammatory effects and that these extracts can be widely used as sustainable, nature-friendly active material in cosmetics with anti-inflammatory effects and targeted at improving atopic dermatitis.They may find use in anti-aging cosmetic products as well.

  • https://doi.org/10.5762/KAIS.2021.22.2.745 인용 PDF KSCI

Characterization of Single Nucleotide Polymorphisms in 55 Disease-Associated Genes in a Korean Population

  • Lee, Seung-Ku;Kim, Hyoun-Geun;Kang, Jason-J.;Oh, Won-Il;Oh, Berm-Seok;Kwack, Kyu-Bum
    • Genomics & Informatics
    • /
    • v.5 no.4
    • /
    • pp.152-160
    • /
    • 2007

  • Most common diseases are caused by multiple genetic and environmental factors. Among the genetic factors, single nucleotide polymorphisms (SNPs) are common DNA sequence variations in individuals and can serve as important genetic markers. Recently, investigations of gene-based and whole genome-based SNPs have been applied to association studies for marker discovery. However, SNPs are so population-specific that the association needs to be verified. Fifty-five genes and 384 SNPs were selected based on association with disease. Genotypes of 337 SNPs in candidate genes were determined using Illumina Sentrix Array Matrix (SAM) chips by an allele-specific extension method in 364 unrelated Korean individuals. Allelic frequencies of SNPs were compared with those of other populations obtained from the International HapMap database. Minor allele frequencies, linkage disequilibrium blocks, tagSNPs, and haplotypes of functional candidate SNPs in 55 genetic disease-associated genes were provided. Our data may provide useful information for the selection of genetic markers for gene-based genetic disease-association studies of the Korean population.

  • PDF KSCI

A Clinical Study on Patients with Hysterocele (자궁탈(子宮脫) 환자 치험 3례)

  • Seo, Bu-Il;Yun, Jumg-Mi;Cha, Eon-Myung
    • The Korea Journal of Herbology
    • /
    • v.23 no.1
    • /
    • pp.127-130
    • /
    • 2008

  • The hysterocele means the descent state of uterus than a normal position. We had medical treatments 3 patients with hysterocele (grade 1, 2 or 3) by invigorating qi and tonifying the kidney. And we had significant effects on patients with hysterocele grade 1, 2 by Soeuminbojungikgitang and Gamibojungikgitang. But we didn't cure a patient with hysterocele grade 3.

  • PDF