• 대한한의학원전학회지
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• 제24권5호
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• pp.99-105
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• 2011

The medical treatment is process of collecting symptoms, making a diagnosis and treatment for the diagnosis. The remedy and the efficacy are the important hinge that links the diagnosis to the means of medical treatment. Lots of medical data are stored on database or saved as files in these days. The preferential way to find the efficacy related to the remedy is search all efficacy terms match up to the remedy term. To increase the rate of matching remedy terms with efficacy terms, we study the relation between efficacy terms and remedy terms and research the conversion way of the terms into the representative terms. The rate of matching the raw remedy terms with the raw efficacy terms is below 30%. The rate of matching the disaggregate remedy terms with the disaggregate efficacy terms is about 50%. The rate of matching the representative remedy terms with the representative efficacy terms is almost 70%.

• Molecules and Cells
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• 제44권7호
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• pp.517-528
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• 2021

A recent genetic study with Brucella abortus revealed the secretion activator gene A (SagA) as an autolysin component creating pores in the peptidoglycan (PGN) layer for the type IV secretion system (T4SS) and peptidoglycan hydrolase inhibitor A (PhiA) as an inhibitor of SagA. In this study, we determined the crystal structures of both SagA and PhiA. Notably, the SagA structure contained a PGN fragment in a space between the N- and C-terminal domains, showing the substrate-dependent hinge motion of the domains. The purified SagA fully hydrolyzed the meso-diaminopimelic acid (DAP)-type PGN, showing a higher activity than hen egg-white lysozyme. The PhiA protein exhibiting tetrameric assembly failed to inhibit SagA activity in our experiments. Our findings provide implications for the molecular basis of the SagA-PhiA system of B. abortus. The development of inhibitors of SagA would further contribute to controlling brucellosis by attenuating the function of T4SS, the major virulence factor of Brucella.

• 한국생산제조학회지
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• 제21권2호
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• pp.214-220
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• 2012

About 12 million people of the mobility handicapped were increased by the end of 2009 year. Universal design concept has been implemented in developed countries. Since 2004 low-floor buses are in Korea. In this study, there is no provision for mobility handicapped and small buses that can be comfortable riding car ramp design presented. The gate of a small buses lowered height of 200mm. Install the ramp in the center of the ramp by an air cylinder moves from side to side. The slope of the ramp was controlled by a hinge. Air cylinder thin type applicable in the narrow space of the slide cylinder was used.

• 대한기계학회논문집A
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• 제27권12호
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• pp.2011-2018
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• 2003

To analyze the bending collapse behavior of an aluminum square tube beam under a bending load, a finite element simulation for the four-point bending test has been performed. Using an aluminum tube beam specimen partly inserted with two steel bars, the local buckling deformation near the center of the tube beam was induced. The maximum bending load and the bending collapse behavior obtained from the numerical simulation were in good agreement with experimental results. Using a combination of the four-point bending test and its finite element simulation, analysis of the local buckling and the accompanied bending collapse behavior of aluminum tube beam could be quantitative accomplished.

• BMB Reports
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• 제46권5호
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• pp.282-287
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• 2013

Cecropin A and papiliocin are novel 37-residue cecropin-like antimicrobial peptides isolated from insect. We have confirmed that papiliocin possess high bacterial cell selectivity and has an ${\alpha}$-helical structure from $Lys^3$ to $Lys^{21}$ and from $Ala^{25}$ to $Val^{35}$, linked by a hinge region. In this study, we demonstrated that both peptides showed high antimicrobial activities against multi-drug resistant Gram negative bacteria as well as fungi. Interactions between these cecropin-like peptides and phospholipid membrane were studied using CD, dye leakage experiments, and NMR experiments, showing that both peptides have strong permeabilizing activities against bacterial cell membranes and fungal membranes as well as $Trp^2$ and $Phe^5$ at the N-terminal helix play an important role in attracting cecropin-like peptides to the negatively charged bacterial cell membrane. Cecropin-like peptides can be potent peptide antibiotics against multi-drug resistant Gram negative bacteria and fungi.

• Journal of Chest Surgery
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• 제24권7호
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• pp.663-668
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• 1991

To evaluate risks, complications and mortality of reoperations on heart valve prosthesis, we reviewed clinical records of 53 patients who underwent reoperation because of prosthetic valve failure[PVF], from Jan 1959 through Jun. 1991. They had undergone 48 mitral, 10 aortic valve rereplacement Primary tissue failure was the main cause of reoperation : it occurred in 51 valves at a mean postoperative interval of 58 months. Calcification and collagen disruption of prosthesis were main causes of primary tissue failure in macro and micropathology, In 3 failing mechanical prostheses, paravalvular leak was in 2 cases, another one case had the thrombi at the hinge portion. If conditions such as emergency operation with or without endocarditis, thromboembolism and advanced NYHA functional class are prevented, we think that reoperative valve replacement has similar morbidity and mortality to initial valve replacement surgery. But our sturdy represents higher mortality [22.6%] because of late surgical intervention failing the prevention of conditions leading to myocardial damage. In conclusion if the tearing, calcification, and a new murmur were detected the early reoperation should be considered to increase late survival.

• 한국정밀공학회지
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• 제26권2호
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• pp.35-44
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• 2009

Long stroke Fast Tool Servo (LFTS) with maximum stroke of $432{\mu}m$ is designed, manufactured and tested for fabrication of optical free-form surfaces. The large amount of stroke in LFTS has been realized by utilizing the hinge and lever mechanisms which enable the displacement amplification ratio of 4.3. In this mechanism the peculiar shape was devised for maximizing the displacement of end tip in LFTS and special mechanical spring has been mounted to provide the sufficient preload to the piezoelectric actuator. Also, its longitudinal motion of tool tip can be measured by capacitive type displacement sensor and closed-loop controlled to overcome the nonlinear hysteresis. In order to verify the static and dynamic characteristics of designed LFTS, several features including step response, frequency response and cut-off frequency in closed-loop mode were experimentally examined. Also, basic machining result shows that the proposed LFTS is capable of generating the optical free-form surface as an additional axis in diamond turning machine.

• 한국가스학회지
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• 제10권1호
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• pp.56-60
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• 2006

지하식 LNG 저장탱크의 Bottom Slab와 Side Wall의 연결부(코벨)는 응력집중을 완화하기 위하여 앵커바를 사용하여 부분적으로 고정되는 힌지 조건을 갖는다. 그러므로 LNG저장탱크 하중 조건인 LNG온도, 지하수압 등에 의해 방사 방향과 수직 방향으로 변형된다. 멤브레인 설계 관점에도 이러한 변형값이 직접 전달되어 중첩되므로 중요한 부분이다. 본 논문에서는 코벨부의 실제 거동을 조사하기 위하여 센서를 설치하여 온도, 하중 그리고 변위를 측정하였다. 또한 FEM 해석으로 예측한 하중조건에 대한 설계 값과 비교하여 합리적인 설계를 제시하고자 하였다.

• 항공우주시스템공학회지
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• 제12권4호
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• pp.75-80
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• 2018

위성용 카메라의 경우 광학계의 초점을 제어하기 위한 포커싱 메커니즘이 필수적이다. 그러나 국내의 위성용 광학계 포커싱 메커니즘 관련 연구는 시작 단계이며, 관련 보유 기술 또한 열제어형에 국한되어있다. 따라서 본 논문에서는 소형위성용 광학계에 적용 가능한 모터 구동형 포커싱 메커니즘을 제안하였다. 제안된 메커니즘은 모터 구동에 의해 secondary mirror에 z축 변위를 발생시키도록 설계하였다. 또한 서포터에 flexure hinge를 설치하여 사전하중을 가하도록 하여 메커니즘내 부품간 제작공차 및 조립공차로 인한 정렬도 오차를 최소화하도록 하였다. 메커니즘 제작 후 LVDT 센서(linear variable differential transformer sensor)와 레이저 변위측정기로 정렬도(de-space, de-center, tilt)를 측정한 결과 소형위성광학계에 적용 가능한 수준의 정렬도를 갖는 것을 확인하였다.

• Smart Structures and Systems
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• 제15권6호
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• pp.1393-1410
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• 2015

An original sensor system based on Fiber Bragg Gratings (FBG) for the strain monitoring of an adaptive wing element is presented in this paper. One of the main aims of the SARISTU project is in fact to measure the shape of a deformable wing for performance optimization. In detail, an Adaptive Trailing Edge (ATE) is monitored chord- and span-wise in order to estimate the deviation between the actual and the desired shape and, then, to allow attaining a prediction of the real aerodynamic behavior with respect to the expected one. The integration of a sensor system is not trivial: it has to fit inside the available room and to comply with the primary issue of the FBG protection. Moreover, dealing with morphing structures, large deformations are expected and a certain modulation is necessary to keep the measured strain inside the permissible measure range. In what follows, the mathematical model of an original FBG-based structural sensor system is presented, designed to evaluate the chord-wise strain of an Adaptive Trailing Edge device. Numerical and experimental results are compared, using a proof-of-concept setup. Further investigations aimed at improving the sensor capabilities, were finally addressed. The elasticity of the sensor structure was exploited to enlarge both the measurement and the linearity range. An optimisation process was then implemented to find out an optimal thickness distribution of the sensor system in order to alleviate the strain level within the referred component.