• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.8 no.4
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• pp.53-58
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• 2008

This paper designs sigma-delta D/A Converter with a high resolution and low power consumption. It reorganizes the input data along LJ, RJ, I2S mode and bit mode to the output data of A/D converter. The D/A converter decodes the original analog signal through HBF, Hold and 5th CIFB(Cascaded Integrators with distributed Feedback as well as distributed input coupling) sigma-delta modulation blocks. It uses repeatedly the addition operation in instead of the multiply operation for the chip area and the performance. Also, the half band filters of similar architecture composed the one block and it used the sample-hold block instead of the sinc filter. We supposed simple D/A Converter decreased in area. The filters of the block analyzed using the matlab tool. The top block designed using the top-down method by verilog language. The designed block is fabricated using Samsung 0.35um CMOS standard cell library. The chip area is 1500*1500um.

• JSTS:Journal of Semiconductor Technology and Science
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• v.14 no.3
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• pp.322-330
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• 2014

New effective techniques to repair "small" design errors in integrated circuits are presented. As semiconductor chip complexity increases and the design period becomes tight, errors frequently remain in a fabricated chip making revisions required. Full mask revision significantly increases the cost and time-to-market. However, since many "small" errors can be repaired by modifying several connections among the circuit blocks and spare cells, errors can frequently be repaired by revising metal layers. Metal only revision takes significantly less time and involves less cost when compared to full mask revision, since mask revision costs multi-million dollars while metal revision costs tens of thousand dollars. In our research, new techniques are developed to further reduce the number of metal layers to be revised. Specifically, we partition the circuit blocks with higher error probabilities and extend the terminals of the signals crossing the partition boundaries to the preselected metal repair layers. Our partitioning and pin extension to repair layers can significantly improve the repairability by revising only the metal repair layers. Since pin extension may increase delay slightly, this method can be used for non-timing-critical parts of circuits. Experimental results by using academia and industrial circuits show that the revision of the two metal layers can repair many "small" errors at low-cost and with short revision time. On the average, when 11.64% of the spare cell area and 24.72% of the extended pins are added to the original circuits, 83.74% of the single errors (and 72.22% of the double errors) can be corrected by using two metal revision. We also suggest methods to use our repair techniques with normal commercial vender tools.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.5 no.5
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• pp.1049-1068
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• 2011

In this paper a simple and effective call admission control (CAC) scheme is proposed for the emerging interleave-division multiple-access (IDMA) systems, supporting a variety of traffic types and offering different quality of service (QoS) requirements and priority levels. The proposed scheme is signal-to-interference-plus-noise ratio (SINR) evolution based CAC (SE-CAC). The key idea behind the scheme is to take advantage of the SINR evolution technique in the process of making admission decisions, which is developed from the effective chip-by-chip (CBC) multi-user detection (MUD) process in IDMA systems. By virtue of this semi-analytical technique, the MUD efficiency can be estimated accurately. Additionally, the computational complexity can be considerably reduced. These features make the scheme highly suitable for IDMA systems, which can combat intra-cell interference efficiently with simple CBC MUD. Analysis and simulation results show that compared to the traditional CAC scheme considering MUD efficiency as a constant, the proposed SE-CAC scheme can guarantee high power efficiency and throughput for multimedia traffic even in heavy load conditions, illustrating the high efficiency of CBC MUD. Furthermore, based on the SINR evolution, the SE-CAC can make accurate estimation of available resource considering the effect of MUD, leading to low outage probability as well as low blocking and dropping probability.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.5
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• pp.1073-1081
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• 2005

This paper describes a 3.3 V 10 bit CMOS digital-to-analog converter with a divided architecture of a 7 MSB and a 3 LSB, which uses an optimal Thermal-to-Binary Decoding method. Most of Dfh converters with hiか speed current drive are an architecture choosing current switch cell, column, row decoding method but this decoding circuit is complicated, occupies a large chip area. For these problems, this paper describes a D/A converter using an optimal Thermal-to-Binary Decoding method. The designed D/A converter with an active chip area of $0.953\;mm^2$ is fabricated by using a 0.35um process. The simulation data shows that the rise/fall time, settling time, and INL/DNL are 1.92/2.1 ns, 12.71 ns, and a less than ${\pm}2.3/{\pm}58$ LSB, respectively. The power dissipation of the D/A converter with a single power supply of 3.3 V is about 224 mW.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.6
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• pp.1585-1593
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• 2005

The genetic effects of restraint stress challenge on HPA axis and the therapeutic effect of Boshimgeonbi-tang on the stress were studied with cDNA microarray analyses, RT-PCR on hypothalamus using an immobilization-stress mice as an animal model. Male CD-1 mice were restrained in a tightly fitted and ventilated vinyl holder for 2hrs once a day, and this challenge was repeated for seven· consecutive days. In the change of body weight it showed that the Boshimgeonbi-tang is effected recovery on weight loss caused by the immobilization-stress. Seven days later, total RNA was extracted from the organs of the mouse, body-labeled with $CyDye^{TM}$ fluorescence dyes and then hybridized to CDNA microarray chip. Scanning and analyzing the array slides were carried out using GenePix4000 series scanner and GenePix $Pro^{TM}$ analyzing program, respectively. The expression profiles of 109 genes out of 6000 genes on the chip were significantly modulated in hypothalamus by the immobilization stress. Energy metabolism-, lipid metabolism-, apoptosis-, stress protein, transcriptional factor, and signal transduction-related genes were transcriptionally activated whereas DNA repair-, protein biosysthesis-, and structure integrity-related genes were down-regulated in hypothalamus. The 58 genes were up-regulated by the mRNA expression folds of 1.5 to 7.9. and the 51 genes were down-regulated by 1.5 - 5.5 fold. The 11 genes among them were selected to confirm the expression profiles by RT-PCR. The mRNA expression levels of Tnfrsf1a (apoptosis), Calm2 (cell cycle), Bag3 (apoptosis), Ogg1 (DNA repair), Aatk (apoptosis), Dffa (apoptosis), Fkbp5 (protein folding) were restored to the normal one by the treatment of Boshimgeonbi-tang.

• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.1
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• pp.54-60
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• 2006

In this paper, we describe a bio-fluidic device for adaptive sample pretreatment, in order to optimize the conditions under which absorbance assays can be conducted. This device can be successfully applied to the measurement of Escherichia coli (E. coli) concentrations using adaptive dilution, with which the dilution ratio can be adjusted during the dilution. Although many attempts have been previously made to miniaturize complex biochemical analyses at the chip scale, very few sample pretreatment processes have actually been miniaturized or automated at this point. Due to the lack of currently available on-chip pretreatments, analytical instruments tend to suffer from a limited range of analysis. This occasionally hinders the direct and quantitative analysis of specific analyses obtained from real samples. In order to overcome these issues, we exploit two novel strategies: dilution with a programmable ratio, and to-and-fro mixing. The bio-fluidic device consists of a rectangular chamber constructed of poly(dimethylsiloxane) (PDMS). This chamber has four openings, an inlet, an outlet, an air control, and an air vent. Each of the dilution cycles is comprised of four steps: detection, liquid drain, buffer injection, and to-and-fro mixing. When using adaptive sample pretreatment, the range in which E. coli concentrations can be measured is broadened, to an optical density (O.D.) range of $0.3{\sim}30$. This device may prove useful in the on-line monitoring of cell concentrations, in both fermenter and aqueous environments.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.37 no.9
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• pp.47-54
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• 2000

We designed asynchronous event logic library with 0.25um CMOS technology and interface chip for heterogeneous system with high-speed asynchronous FIFO operating at 1.6GHz. Optimized asynchronous standard cell layouts and Verilog models are designed for top-down design methodology. A Method for mitigating a design bottleneck when it comes to tolerate clock skew is described. This communication scheme using clock control circuits, which is used for the free of synchronization failures, is analyzed and implemented. With clock control circuit and FIFO, high-speed communication between synchronous modules operating at different clock frequencies or with asynchronous modules is performed. The core size of implemented high-speed 32bit-interface chip for heterogeneous system is about $1.1mm{\times}1.1mm$.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.6A
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• pp.640-647
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• 2006

This paper describes a design of AES-based CCMP(Counter mode with CBC-MAC Protocol) core for IEEE 802.11i wireless LAN security. To maximize the performance of CCMP core, two AES cores are used, one is the counter mode for data confidentiality and the other is the CBC node for authentication and data integrity. The S-box that requires the largest hardware in ARS core is implemented using composite field arithmetic, and the gate count is reduced by about 27% compared with conventional LUT(Lookup Table)-based design. The CCMP core was verified using Excalibur SoC kit, and a MPW chip is fabricated using a 0.35-um CMOS standard cell technology. The test results show that all the function of the fabricated chip works correctly. The CCMP processor has 17,000 gates, and the estimated throughput is about 353-Mbps at 116-MHz@3.3V, satisfying 54-Mbps data rate of the IEEE 802.11a and 802.11g specifications.

• Journal of Veterinary Science
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• v.21 no.5
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• pp.78.1-78.15
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• 2020

Background: Enteritis is one of the most frequently reported symptoms in piglets infected with porcine circovirus type 2 (PCV2), but the immunopathogenesis has not been reported. Objectives: This study examined the effect of a PCV2 infection on the intestinal mucosal immune function through morphological observations and immune-related molecular detection. Methods: Morphological changes within the ileum of piglets during a PCV2 infection were observed. The expression of the related-molecules was analyzed using a gene chip. The immunocyte subsets were analyzed by flow cytometry. The secretory immunoglobulin A (SIgA) content was analyzed by enzyme-linked immunosorbent assay. Results: The PCV2 infection caused ileal villus damage, intestinal epithelial cells exfoliation, and an increase in lymphocytes in the lamina propria at 21 days post-infection. Differentially expressed genes occurred in the defense response, inflammatory response, and the complement and coagulation cascade reactions. Most of them were downregulated significantly at the induction site and upregulated at the effector site. The genes associated with SIgA production were downregulated significantly at the induction site. In contrast, the expression of the Toll-like receptor-related genes was upregulated significantly at the effector site. The frequencies of dendritic cells, B cells, and CD8⁺T cells were upregulated at the 2 sites. The SIgA content decreased significantly in the ileal mucosa. Conclusions: PCV2 infections can cause damage to the ileum that is associated with changes in immune-related gene expression, immune-related cell subsets, and SIgA production. These findings elucidated the molecular changes in the ileum after a PCV2 infection from the perspective of intestinal mucosal immunity, which provides insights into a further study for PCV2-induced enteritis.

• Journal of Animal Reproduction and Biotechnology
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• v.38 no.3
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• pp.177-187
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• 2023

Background: The grading of Hanwoo (Korean native cattle) is based on four economic traits, and efforts have been continuously made to improve the genetic traits associated with these traits. There is a technology to predict the expected grade based on the 4 economic genetic SNP characteristics of Korean cattle calves using single nucleotide polymorphism (SNP) technology. Selection of highly proliferative, self-renewing, and differentiating satellite cells from cattle is a key technology in the cultured meat industry. Methods: We selected the Hanwoo with high and low-scored of genomic estimated breeding value (GEBV) by using the Hanwoo 50K SNP bead chip. We then isolated the bovine satellite cells from the chuck mass. We then conducted comparative analyses of cell proliferation, immunocytochemistry, qRT-PCR at short- and long-term culture. We also analyzed the differentiation capability at short term culture. Results: Our result showed that the proliferation was significantly high at High scored GEBV (Hs-GEBV) compared to Low scored GEBV (Ls-GEBV) at short- and long-term culture. The expression levels of Pax3 were significantly higher in Hs-GEBV bovine satellite cells at long-term culture. However, there were no significant differences in the expression levels of Pax7 between Hs- and Ls-GEBV bovine satellite cells at short- and long- term culture. The expression levels of MyoG and MyHC were significantly high at Ls-GEBV bovine satellite cells. Conclusions: Our results indicated that selection of bovine satellite cells by Hanwoo 50K SNP bead chip could be effective selection methods for massive producing of satellite cells.