• Title/Summary/Keyword: Cell mechanical stiffness

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A Study on the Stiffness Characteristic of Repeated Unit Cell Structure (반복되는 구조물의 강성특성 연구)

  • Park, Soo;Seon, Kwang-Sang;Koo, Jae-Mean;Seok, Chang-Sung;Park, Tae-Jung
    • Journal of the Korean Society for Precision Engineering
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    • v.27 no.3
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    • pp.111-117
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    • 2010
  • The repeated unit cell structure is applied to the composite, the carbon nano tube and sandwich panel. In this paper, a study on the stiffness of unit cell structure has been performed with the tube support plate of the steam generator. For this, repeated unit cell structure's equivalent elastic constant and poisson's ratio was evaluated through FEA and tests under the elastic range load. Also we evaluated the effect on the specimen size from results.

Design and Implementation of Flexible Sensor to Measure Mechanical Stiffness of Soft Particles (Soft Particle의 강성 측정을 위한 단순한 구조의 유연 물질 센서의 개발)

  • Ihn, Yong Seok;Yang, Minho;Koo, Ja Choon
    • The Journal of Korea Robotics Society
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    • v.11 no.3
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    • pp.133-139
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    • 2016
  • Increasing interest of human health, building bio-database (Bio DB) has been become a hot issue in life science. Consequently, Single Cell Analysis (SCA) which can explain biodiversity of lives has been a significant factor for building Bio DB. In numerous studies from these analyses, they have been showed that mechanical properties of cells can serve explanation of biological heterogeneity and criterion of disease states. Therefore, measuring mechanical properties of cells have great potential to be used in bio-medical applications. However, traditionally, many researchers have undergone difficult and time consuming work because handling small sized cells usually requires high-skilled technique. Thus, this paper shows robotized stiffness measurement technique using fixed ended beam sensor, precision motorized stage and substrate which have wall structure.

A Nanoindentation Based Study of Mechanical Properties of Al-Si-Cu-Mg Alloy Foam Cell Wall (나노인덴테이션에 의한 Al-Si-Cu-Mg 합금 폼 셀 벽의 기계적 물성 연구)

  • Ha, San;Kim, Am-Kee;Lee, Chang-Hun;Lee, Hak-Joo;Ko, Soon-Gyu;Cho, Seong-Seock
    • Proceedings of the KSME Conference
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    • 2004.04a
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    • pp.382-387
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    • 2004
  • Nanoindentation technique has been used to measure the mechanical properties of aluminium alloy foam cell walls. Al-Si-Cu-Mg alloy foams of different compositions and different cell morphologies were produced using powder metallurgical method. Cell morphology of the foam was controlled during production by varying foaming time and temperature. Mechanical properties such as hardness and Young's modulus were calculated using two different methods: a continuous stiffness measurement (CSM) and an unloading stiffness measurement (USM) method. Experimental results showed that hardness and Young's modulus of Al-5%(wt.)Si-4%Cu-4%Mg (544 alloy) precursor and foam walls are higher than those of Al-3%Si-2%Cu-2%Mg (322 alloy) precursor and foam walls. It was noticed that mechanical properties of cell wall are different from those of precursor materials.

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Microfluidic chip for characterization of mechanical property of cell by using impedance measurement (임피던스 측정을 이용한 세포의 변형성 분석용 미소유체 칩)

  • Kim, Dong-Il;Choi, Eun-Pyo;Chio, Sung-Sik;Park, Jung-Yul;Lee, Sang-Ho;Yun, Kwang-Seok
    • Journal of Sensor Science and Technology
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    • v.18 no.1
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    • pp.42-47
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    • 2009
  • In this paper we propose a microfluidic chip that measures the mechanical stiffness of cell membrane using impedance measurement. The microfluidic chip is composed of PDMS channel and a glass substrate with electrode. The proposed device uses patch-clamp technique to capture and deform a target cell and measures impedance of deformed cells. We demonstrated that the impedance increased after the membrane stretched and blocked the channel.

A Simple Mixed-Based Approach for Thin-Walled Composite Blades with Two-Cell Sections

  • Jung Sung Nam;Park Il-Ju
    • Journal of Mechanical Science and Technology
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    • v.19 no.11
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    • pp.2016-2024
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    • 2005
  • In this work, a mixed beam approach that combines both the stiffness and the flexibility methods has been performed to analyze the coupled composite blades with closed, two-cell cross-sections. The Reissner's semi-complementary energy functional is used to derive the beam force-displacement relations. Only the membrane part of the shell wall is taken into account to make the analysis simple and also to deliver a clear picture of the mixed method. All the cross section stiffness coefficients as well as the distribution of shear across the section are evaluated in a closed-form through the beam formulation. The theory is validated against experimental test data, detailed finite element analysis results, and other analytical results for coupled composite blades with a two-cell airfoil section. Despite the simple kinematic model adopted in the theory, an accuracy comparable to that of two-dimensional finite element analysis has been obtained for cases considered in this study.

Modeling Negative Stiffness Mechanism of Vestibular Hair Cell by Applying Gating Spring Hypothesis to Inverted Pendulum Array (게이팅 스프링 가설을 적용한 전정기관 유모세포의 반강성 메커니즘 모델)

  • Lim, Ko-Eun;Park, Su-Kyung
    • Proceedings of the KSME Conference
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    • 2007.05a
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    • pp.405-408
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    • 2007
  • Vestibular hair cells, the sensory receptors of vestibular organs, selectively amplify miniscule stimuli to attain high sensitivity. Such selective amplification results in compressive nonlinear sensitivity, which plays an important role in expanding dynamic range while ensuring robustness of the system. In this study, negative stiffness mechanism, a mechanism responsible for the selective amplification by vestibular hair cells, is applied to a simple mechanical system consisting of an array of inverted pendulums. The structure and working principle of the system have been inspired by gating spring hypothesis proposing that opening and closing of transduction channels contributes to the global stiffness of vestibular hair bundle. Parameter study was carried out to analyze the effect of each parameter on the compressive nonlinearity of suggested model.

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Haircell-inspired Micromechanical Active Amplifiers Using the Mechanical Resonance Modulated by Variable Stiffness Springs (청각 유모세포를 모사한 미소기계적 능동 증폭기)

  • Heo, Yun-Jung;Lee, Won-Chul;Kim, Tae-Yoon;Cho, Young-Ho
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.31 no.11
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    • pp.1077-1082
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    • 2007
  • We present a micromechanical active amplifier, inspired from the principle of the outer hair cells in cochlea, amplifying both displacement and force. The present micromechanical active amplifier modulates the resonant carrier motion using the variable stiffness spring whose stiffness changes proportionally to the input motion. We design, fabricate, and characterize two types of the amplifiers A and B, each having the variable stiffness spring fur the maximum displacement gain and force gain, respectively. In the experimental study, the amplifier A shows the displacement gain of 5.62, which is 2.15 times larger than that of the amplifier 3. The amplifier B shows the force gain of 10.0, resulting in 1.26 times larger value compared to that of the amplifier A. We experimentally verify that the haircell-inspired micromechanical amplifiers are capable to amplify both displacement and force.

Effect of the Mechanical Properties of Cell-Interactive Hydrogels on a Control of Cell Phenotype (세포친화적 하이드로젤의 기계적 물성이 세포 표현형 제어에 미치는 영향)

  • Kim, Do Yun;Park, Honghyun;Lee, Kuen Yong
    • Polymer(Korea)
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    • v.39 no.3
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    • pp.412-417
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    • 2015
  • A critical element in tissue engineering approaches is a control of the mechanical properties of polymer scaffolds to regulate cell phenotype, which may lead to clinically successful tissue regeneration. In this study, we hypothesized that gel stiffness could be a key factor to manipulate adhesion and proliferation of different types of cells. RGD-modified alginate gels with various mechanical properties were prepared and used as a substrate for MC3T3-E1 and H9C2 cells. Adhesion and growth rate of MC3T3-E1 cells in vitro were increased in parallel with an increase of gel stiffness. In contrast, those of H9C2 cells were decreased. This approach to control the mechanical properties of polymer scaffolds depending on the cell types may find useful applications in the tissue engineering.

Stiffness and Fatigue Strength Analysis of Fuel Cell Vehicle Body Frame (연료전지차량 차체프레임 강성 및 내구해석)

  • Choi, Bok-Lok;Kang, Sung-Jong
    • Transactions of the Korean Society of Automotive Engineers
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    • v.19 no.4
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    • pp.47-53
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    • 2011
  • Firstly, FEM model for the body frame of a fuel cell vehicle was built up and design optimization results based on different schemes were exhibited. One scheme was to minimize weight while maintaining the normal mode frequencies and the other was to increase the frequencies without weight change. Next, for a rear frame model, shape parameter study on collapse characteristics such as peak resistance load and absorbed energy was carried out. Also, the stiffness of frame mounting brackets was predicted using inertance calculation and the durability of those mounting brackets for vehicle system loads was evaluated. Finally, for a representative mounting model, the influence on durability due to thickness change was analyzed.

Elastic Analysis of Honeycomb Materials Considering Cell Size and Cell Wall Thickness (셀 크기와 셀벽 두께를 고려한 하니컴 재료의 탄성 해석)

  • 김형구;최낙삼
    • Proceedings of the Korean Society For Composite Materials Conference
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    • 2003.04a
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    • pp.157-160
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    • 2003
  • Honeycomb sandwich composite structures have been widely used in aircraft and military industry because of light weight and high stiffness. Accurate mechanical properties of honeycomb materials are needed for analysis of sandwich composites. In this study, theoretical formula for elastic modulus of honeycomb materials was established considering bending and axial deformations of their walls. Finite-element analysis results were compared with theoretical ones of the longitudinal and transverse moduli of honeycomb materials. Consequently, the mechanical properties of honeycomb materials could be analytically predicted.

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