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http://dx.doi.org/10.5369/JSST.2009.18.1.042

Microfluidic chip for characterization of mechanical property of cell by using impedance measurement  

Kim, Dong-Il (Department of Electronic Engineering, Sogang University)
Choi, Eun-Pyo (Department of Mechanical Engineering, Sogang University)
Chio, Sung-Sik (School of Life Science and Biotechnology, Korea University)
Park, Jung-Yul (Department of Mechanical Engineering, Sogang University)
Lee, Sang-Ho (School of Life Science and Biotechnology, Korea University)
Yun, Kwang-Seok (Department of Electronic Engineering, Sogang University)
Publication Information
Journal of Sensor Science and Technology / v.18, no.1, 2009 , pp. 42-47 More about this Journal
Abstract
In this paper we propose a microfluidic chip that measures the mechanical stiffness of cell membrane using impedance measurement. The microfluidic chip is composed of PDMS channel and a glass substrate with electrode. The proposed device uses patch-clamp technique to capture and deform a target cell and measures impedance of deformed cells. We demonstrated that the impedance increased after the membrane stretched and blocked the channel.
Keywords
Microfluidic chip; cell stiffness; impedance measurement; Lab-on-a-chip;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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