• BMB Reports
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• v.49 no.12
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• pp.655-661
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• 2016

Polymer brush is a soft material unit tethered covalently on the surface of scaffolds. It can induce functional and structural modification of a substrate's properties. Such surface coating approach has attracted special attentions in the fields of stem cell biology, tissue engineering, and regenerative medicine due to facile fabrication, usability of various polymers, extracellular matrix (ECM)-like structural features, and in vivo stability. Here, we summarized polymer brush-based grafting approaches comparing self-assembled monolayer (SAM)-based coating method, in addition to physico-chemical characterization techniques for surfaces such as wettability, stiffness/elasticity, roughness, and chemical composition that can affect cell adhesion, differentiation, and proliferation. We also reviewed recent advancements in cell biological applications of polymer brushes by focusing on stem cell differentiation and 3D supports/implants for tissue formation. Understanding cell behaviors on polymer brushes in the scale of nanometer length can contribute to systematic understandings of cellular responses at the interface of polymers and scaffolds and their simultaneous effects on cell behaviors for promising platform designs.

• Human Ecology Research
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• v.52 no.5
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• pp.519-528
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• 2014

This study explores how the main variables of youth going through a transition period (parents' nurturing behavior, the youth's self-esteem and ego resilience, the peer group relationships) affect the youth's school adjustment. It also analyzes the effects of theses variables on the youth's dependence on cell phones, which are considered a necessity in modern society. This research is verified by using a structure model verification method based on data from the Korean Children Youth Panel Study. According to the research, first, 1st-year students in middle school show better adjustment to their school life and less dependence on cell phones when they have a stronger sense of self-esteem and ego resilience; further, it is revealed that cell phone dependence has an indirect influence on the school life of these children. Second, they tend to show better adjustment to their school life and less dependence on cell phones when their parents' nurturing behaviors are more positive. Third, these children tend to depend more on cell phones when they have a positive peer group relationship, Moreover, cell phone dependence has an indirect influence on their school life. When considering the impact of cell phone to youth in modern society, need to prepare proper training program for correct uses and preventing from addiction.

• Journal of Hydrogen and New Energy
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• v.23 no.1
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• pp.8-18
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• 2012

This paper presents a three-dimensional, transient cold-start polymer electrolyte fuel cell (PEFC) model to numerically evaluate the effects of membrane electrode assembly (MEA) design and cell location in a PEFC stack on PEFC cold start behaviors. The cold-start simulations show that the end cell experiences significant heat loss to the sub-freezing ambient and thus finally cold-start failure due to considerable ice filling in the cathode catalyst layer. On the other hand, the middle cells in the stack successfully start from $-30^{\circ}C$ sub-freezing temperature due to rapid cell temperature rise owing to the efficient use of waste heat generated during the cold-start. In addition, the simulation results clearly indicate that the cathode catalyst layer (CL) composition and thickness have an substantial influence on PEFC cold-start behaviors while membrane thickness has limited effect mainly due to inefficient water absorption and transport capability at subzero temperatures.

• 한국방재학회:학술대회논문집
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• 2007.02a
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• pp.71-74
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• 2007

Thin-walled multicell box girders subjected to an eccentric load can be produced the three global behaviors of flexure, torsion, and distortion. But it is very difficult to evaluate each influences of major behaviors numerically. If we can decompose an eccentric load P into flexural, torsional, and distortional forces, we can execute quantitative analysis each influences of major behaviors. Decomposition of Applied Load for Thin-walled Rectangular multi-cell box girders is researched by Park, Nam-Hoi(Development of a multicell Box Beam Element Including Distortional Degrees of Freedom, 2003). But researches about thin-walled trapezoidal multi-cell section is insufficient. So, this paper deals with decomposition process and independent analysis method of multi-cell box girders include trapezoidal section.

• Proceedings of the KSR Conference
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• 2005.11a
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• pp.229-234
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• 2005

Thin-walled multicell box girders subjected to an eccentric load can he produced the three global behaviors of flexure, torsion, and distortion. Specially in railway bridges subjected to much eccentric load, it is quite important to evaluate influences of torsion and distortion. But it is very difficult to evaluate each influences of major behaviors numerically. If we can decompose an eccentric load P into flexural, torsional, and distortional forces. we can execute quantitative analysis each influences of major behaviors. Decomposition of Applied Load for Thin-walled Rectangular multi-cell box girders is reserched by Park, Nam- Hoi(Development of a multicell Box Beam Element Including Distortional Degrees of Freedom, 2003). But researches about trapezoidal multi-cell section is insufficient. So, this paper deals with multi-cell trapezoidal box girders. An expanded method, which is based on the force decomposition method for a single cell box girder given by Nakai and Yoo, is developed herein to decompose eccentric load Pinto flexural, torsional, and distortional forces. Derive formulas by decomposition of eccentric load is verified by 3D shell-modelling numerical analysis.

• BMB Reports
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• v.51 no.3
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• pp.157-162
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• 2018

Angiogenesis is a complex, multistep process involving dynamic changes in endothelial cell (EC) shapes and behaviors, especially in specialized cell types such as tip cells (with active filopodial extensions), stalk cells (with less motility) and phalanx cells (with stable junction connections). The Hippo-Yes-associated protein (YAP)/ transcription activator with PDZ binding motif (TAZ) signaling plays a critical role in development, regeneration and organ size by regulating cell-cell contact and actin cytoskeleton dynamics. Recently, with the finding that YAP is expressed in the front edge of the developing retinal vessels, Hippo-YAP/TAZ signaling has emerged as a new pathway for blood vessel development. Intriguingly, the LATS1/2-mediated angiomotin (AMOT) family and YAP/TAZ activities contribute to EC shapes and behaviors by spatiotemporally modulating actin cytoskeleton dynamics and EC junction stability. Herein, we summarize the recent understanding of the role of Hippo-YAP/TAZ signaling in the processes of EC sprouting and junction maturation in angiogenesis.

• Korean Institute of Interior Design Journal
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• v.20 no.5
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• pp.23-33
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• 2011

Starting with 21st Century, the role of the design has been widened and designers began to regard the psychological and behavioral factors as main design considerations. These factors are the core elements especially in designing interactive space. This research proposed the user-centered design methodology for interactive space. It developed Programming Process for Supporting Interactive Behaviors. To compose the process, this research analyzed the influential factors on the interactivity and the results were applied on the process. This newly proposed Programming Process contains four basic stages which are 'Opportunity Identification Cell', 'Intersubject Cell', 'Interaction & Interface Cell', and 'Programming Solution Cell'. More detailed tasks are also specified for each stage. This research asserts that the design process for Interactive space should differ from the past design processes in the fact that it puts much more attention on systemizing the psychological and behavioral elements than before. Therefore the design process for Interactive space should be reinforced with the data related to these psychological and behavioral understandings. The Programming Process of this paper is an attempt to enlarge the roles of these data in designing interactive space, and thus it is an attempt to accommodate the contemporary user-centered design paradigm.

• 한국전산유체공학회:학술대회논문집
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• 2002.10a
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• pp.103-108
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• 2002

The M-AUSMPW+ scheme that can capture shock waves exactly with monotonic characteristics is modifided from AUSMPW+ by analyzing the cause of oscillation in shock regions. Firstly shock-capturing characteristics of general FVS including the AUSM-type schemes are investigated in detail, according to the difference between a cell-interface and a sonic transition position. The cause of oscillation is the improper numerical dissipation that could not represent the real Physics. The M-AUSMPW+ could capture shocks exactly without oscillatory behaviors in considering the sonic transition position and an cell-interface position.

• Bulletin of the Korean Chemical Society
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• v.24 no.4
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• pp.437-440
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• 2003

In a mediator-aided microbial fuel cell, the choice of a proper mediator is one of the most important factors for the development of a better fuel cell system as it transfers electrons from bacteria to the electrode. The electrochemical behaviors within the lipid layer of two representative mediators, thionin and safranine O both of which exhibit reversible electron transfer reactions, were compared with the fuel cell efficiency. Thionin was found to be much more effective than safranine O though it has lower negative formal potential. Cyclic voltammetric and fluorescence spectroscopic analyses indicated that both mediators easily penetrated the lipid layer to pick up the electrons produced inside bacteria. While thionin could pass through the lipid layer, the gradual accumulation of safranine O was observed within the layer. This restricted dynamic behavior of safranine O led to the poor fuel cell operation despite its good negative formal potential.

• KSBB Journal
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• v.4 no.3
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• pp.271-275
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• 1989

Batch growth of plant cell suspension cultures of Thalictrum rugosum was studied to clarify the kinetic behaviors. It was found that the product formation was growth associated. The specific growth rate was $0.20-0.25\;day\;^{-1}$/TEX> at the growth phase and the FW/DCW ratio was an interesting parameter which represented the status of the cells or the status of sugar concentration. The cell yield was 0.36 g cells/g sugar. The maximum berberine level was 139 mg/L of which 120 mg/L was intracellular. In terms of the specific content of berberine, the product was 1.10% of dry cell weight. At the growth phase, the relationship between the specific growth rate and sugar concentration was described well by Monod kinetics.