• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.8
• /
• pp.3333-3338
• /
• 2015

Background: This study was conducted to analyze positron emission tomography (PET) / computed tomography (CT) and magnetic resonance imaging (MRI) performance with oropharyngeal non-Hodgkin's lymphoma (ONHL).Materials and Methods: The complete image data of 30 ONHL cases were analyzed, all patients were performed PET / CT and MRI examination before the treatment, with the time interval of these two inspections not exceeding 14 days. The distribution, morphology, MRI signal characteristics, enhancement feature, standardized uptake value (SUV) max value and lymph node metastasis way of the lesions were analyzed. Results: Among the 30 cases, 23 cases were derived from the B-cell (76.7%), 5 cases were derived from the peripheral T cells (16.7%) and 2 cases were derived from the NK/T cells (6.7%). 19 cases exhibited the palatine tonsil involvement (63.3%). As for the lesion appearance, 10 cases appeared as mass, 8 cases were the diffused type and 12 cases were the mixed type. 25 cases exhibited the SUVmax value of PET / CT primary lesions as 11 or more (83.3%). MRI showed that all patients exhibited various degrees of parapharyngeal side-compressed narrowing, but MRI still exhibited the high-signal fat, and the oropharyngeal mucosa was intact. 25 cases were associated with the neck lymph node metastasis, among who 22 cases had no necrosis in the metastatic lymph nodes, while the rest 3 cases exhibited the central necrosis in the metastatic lymph nodes. Conclusions: PET / CT and MRI have important value in diagnosing and determining the lesion extent of ONHL.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.3
• /
• pp.1255-1258
• /
• 2015

Background: Locally advanced head and neck cancer is generally incurable and has a short survival rate. This study aimed to evaluate symptom relief, disease response, and acute toxicity after palliative hypo-fractionated radiotherapy and long-term survival in affected patients. Materials and Methods: Between January 2011 to December 2011, 80 patients who were histopathologically diagnosed as having stage III or stage IV head and neck squamous cell carcinoma based on Eastern Cooperative Oncology Group (ECOG) performance status 1-3, were offered palliative radiotherapy (20 Gy/5Fr/5 Days). Later these patients were evaluated on 30th day after completion of treatment for disease response based on World Health Organisation (WHO) criteria and palliation of symptoms using symptomatic response grading and acute toxicities by the Radiation Therapy Oncology Group (RTOG). Many patients were given post radiation therapy (RT) palliative chemotherapy for appropriate palliative care and a few patients were selected for further curative RT. The overall survival was also evaluated among this group of patients with last follow up date of 1st May, 2014. Results: The most common presenting complaint was pain followed by dysphagia. Most patients (60-70%) had appreciable relief in their presenting symptoms. A good response was observed in the majority following palliative RT; a few patients had progressive disease and some had stable and regressed disease. None of the patients experienced radiation toxicity that required hospital admission. Almost all showed grade one and two acute skin and mucosal toxicity one month after completion of treatment. The mean survival days for patients given only hypofractionated palliative RT was 307 days, those with post palliative RT and palliative chemotherapy was 390 days and patients who went on to receive further palliative RT and curative RT dose had significantly overall survival of 582 days. Conclusions: Advanced head and neck cancer should be identified for suitable palliative hypofractionated radiotherapy to achieve acceptable symptom relief in a great proportion of patients and should be followed by palliative chemotherapy or curative RT in suitable cases for long-term symptom-free survival.

• Journal of the Korean Applied Science and Technology
• /
• v.30 no.2
• /
• pp.362-370
• /
• 2013

The coconut shell based activated carbon was applied for EDLC (electric double layer capacitor) electrode with the post treatments. The electrochemical properties were evaluated with a coin cell using the activated carbon as electrode. The initial gravimetric and volumetric capacitance of the coconut shell based activated carbon electrode s were 66 F/g and 39 F/cc, and these values decreased to 54 F/g and 32 F/cc after 100 cycles, respectively showing 82% of charge-discharge efficiency. The properties of CV graph with the commercial activated carbon electrodes showed the serious polarization as the result of additional reaction between electrolyte and impurities of the electrode materials. In order to remove impurities efficiently, the commercial activated carbon was treated by alkali and acid solutions consecutively, and then heat treated to control the pore size distribution and the content of surface functional groups. The surface functional groups decreased with the increased heat temperature and the specific capacitance increased with the decreased surface functional groups. The initial capacitance of coconut shell based activated carbon elec trode which was treated with NaOH and HNO3, and then heat treated at $800^{\circ}C$ was 44 F/cc, and the value turned out to be 42 F/cc after 100 cycles, showing over 95% of charge-discharge efficiency.

• Clinical and Experimental Pediatrics
• /
• v.58 no.3
• /
• pp.96-101
• /
• 2015

Purpose: Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD. Methods: We enrolled 91 children with AD and 32 control subjects without history or symptoms of allergic diseases. Blood was drawn to evaluate complete blood cell count, total eosinophil count (TEC), and total IgE, specific IgE to common allergens, 25(OH)D, and IL-31 levels. Serum 25(OH)D and IL-31 levels were measured using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. The scoring atopic dermatitis (SCORAD) index was used to evaluate the severity of AD. Results: The mean 25(OH)D level was significantly lower in the AD group than in the control group; 25(OH)D decreased greatly in the moderate and severe AD groups compared with the mild AD group. Children with atopic sensitization showed significantly lower 25(OH)D levels than nonatopic children. However, serum IL-31 levels were not related to AD group, SCORAD index, or 25(OH)D levels. The SCORAD index was inversely correlated with serum 25(OH)D level and positively correlated with TECs and total IgE levels. Children with moderate and severe AD had significantly higher TECs than children with mild AD. Conclusion: Vitamin D is related to the severity of AD independently of IL-31.

• Asian-Australasian Journal of Animal Sciences
• /
• v.31 no.1
• /
• pp.63-70
• /
• 2018

Objective: The aim of the study was to isolate gossypol-degrading bacteria and to assess its potential for gossypol degradation. Methods: Rumen liquid was collected from fistulated cows grazing the experimental pasture. Approximately 1 mL of the rumen liquid was spread onto basal medium plates containing 2 g/L gossypol as the only source of carbon and was then cultured at $39^{\circ}C$ to isolate gossypol-degrading bacteria. The isolated colonies were cultured for 6 h and then their size and shape observed by microscope and scanning electron microscope. The 16S rRNA gene of isolated colonies was sequenced and aligned using National Center for Biotechnology Information-Basic Local Alignment Search Tool. The various fermentation conditions, initial pH, incubation temperature, inoculum level and fermentationperiod were analyzed in cottonseed meal (CSM). The crude protein (CP), total gossypol (TG), and free gossypol (FG) were determined in CSM after fermentation with isolated strain at $39^{\circ}C$ for 72 h. Results: Screening results showed that a single bacterial isolate, named Rumen Bacillus Subtilis (RBS), could use gossypol as a carbon source. The bacterium was identified by 16S rDNA sequencing as being 98% homologous to the sequence of Bacillus subtilis strain GH38. The optimum fermentation conditions were found to be 72 h, $39^{\circ}C$, pH 6.5, moisture 50%, inoculum level $10^7cell/g$. In the optimum fermentation conditions, the FG and TG content in fermented CSM decreased 78.86% and 49% relative to the control. The content of CP and the essential amino acids of the fermented CSM increased respectively, compared with the control. Conclusion: The isolation of a gossypol-degrading bacterium from the cow rumen is of great importance for gossypol biodegradation and may be a valuable potential source for gossypol-degradation of CSM.

• Membrane Journal
• /
• v.30 no.5
• /
• pp.307-318
• /
• 2020

Conventional perfluorinated sulfonic acid membrane, Nafion is widely used for vanadium redox flow battery (VRFB). It is desired to prevent vanadium ion permeation through a membrane to retain the capacity, and to keep the cell efficiency of a VRFB. Highly proton conductive and chemically stable Nafion membranes, however, suffer from high vanadium permeation, which induce the reduction in charge and discharge capacity by side reactions of vanadium ions. In this study, to resolve the issue, silica nanoparticles, which are functionalized with 3-aminopropyl group (fS) are introduced to enhance the long-term performance of a VRFB by lowering vanadium permeation. It is expected that amine groups on silica nanoparticles are converted to positive ammonium ion, which could deteriorate positively charged vanadium ions' crossover by Gibbs-Donnan effect. There is reduction in proton conductivity may due to acid-base complexation between fS and Nafion side chains, but ion selectivity of proton to vanadium ion is enhanced by introducing fS to Nafion membranes. With the composite membranes of Nafion and fS, VRFBs maintain their discharge capacity up to 80% at a high current density of 150 mA/㎠ during 200 cycles.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.15 no.3
• /
• pp.1548-1556
• /
• 2014

The study was conducted to analyze the effect of Playing Exercise Program on body composition and physical fitness on mentally handicapped. The subjects participated research were 12 male and 7 female who were mentally handicapped. P.E.P. was applied once a week for 120 minutes in total for 10 weeks. Pre-Post test for body composition (weight, body fat percentage, body fat mass, muscle mass, cell mass) and Physical Fitness (muscular endurance, strength; hand strength, back strength, flexibility; trunk flexion forward) were conducted to analyze the effects. For obtaining the statistics, SPSS 18.0 was used and mean and standard deviation were calculated. T-test was performed to differentiate performance ability and to compare the effect of P.E.P. on body composition and physical fitness for 10 weeks and the statistical level of significance was set to p<.05. The result obtained showed significant difference for only muscle mass in body composition variable. Moreover when analyzing physical fitness variable, there were significant differences in back strength, grasping left and right hand, trunk flexion forward and muscular endurance. Therefore, it can be concluded that the P.E.P. was effective for mentally handicapped. And the program can be utilized as effective energy consumption program and can contribute to preventing adult diseases.

• Microbiology and Biotechnology Letters
• /
• v.17 no.3
• /
• pp.263-268
• /
• 1989

To maximize the performance of recombinant cell fermentation process through optimizing environmental conditions, the production of invertase from recombinant Saccharomyces cerebisiae Containing SUC2 gene was studied as a model. The recombinant cells showed biphasic growth on glucose. Since the promoter of the SUC2 is regulated by the concentration of glucose in the medium, expression of invertase by recombinant yeast began when the glucose concentration decreased in a range of 0.25-0.4 g/L during the batch culture. Plasmid segregation occured frequently during glucose fermentation, and infrequently during ethanol oxidation. A rapid appearance of invertase activity with glucose was observed under nonaerated condition, and the maximum specific invertase activity was about 1.5 times as high as under aerobic condition, In fed batch culture, when n low level of glucose was continuously supplied to the tormentor after the time of glucose depletion during growth phase, specific and total invertase activity increased about 1.7 and 2.9 fold, respectively, in a batch culture.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.38 no.4
• /
• pp.443-449
• /
• 2014

To check the characteristics of nuclear fuels during an irradiation test, the nuclear fuel rod needs to be disassembled from the test rig located in the pool of the research reactor. Then, the disassembled fuel rod is delivered to the hot cell for intermediate examination. A fuel rod that passes the intermediate examination is delivered to the reactor pool to be reassembled into the test rig. The irradiation test is resumed with the reassembled test rig. Because nuclear fuel rods irradiated by neutrons are highly radioactive, all the disassembly and reassembly processes should be carried out in the pool of the research reactor to prevent operators being exposed to radiation. In particular, because a test rig is 5.4-m long and the reactor pool of HANARO is 6-m deep, special tools need to be developed for performing the disassembly and reassembly processes. In this study, a new assembly design of nuclear fuel rods for intermediate examination is introduced. Furthermore, tools for treating the irradiated fuel rod assembly are introduced, and their performance is verified by an out pile test.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.38 no.9
• /
• pp.739-745
• /
• 2014

Although medication is given to heart disease patients, conventional medication alone is not sufficient to treat heart disease. However, it has been reported that left ventricular assist device (LVAD) transplantation is an effective bridge to heart transplantation by assisting cardiac function. This study used long-term animal testing and emergency situations with a bovine model (Holstein) and canine model (Labrador-retriever) to evaluate the biocompatibility of LibraHeart-I (LH-1), which is a bent-tube type of LVAD that was developed in a previous study. In the long-term animal testing with the bovine model, the subjects survived for 49 days with no irregularities observed in their complete blood cell counts or the vital sign tests that were carried out during the test period. In short-term animal testing with the canine model, it was observed that blood did not remain inside the LH-I even without power support from an external drive source. In this study, the biocompatibility of the LH-I that was developed in a previous study was verified by the ejection performance during long-term animal testing and emergency situations.