Transactions of the Korean Society of Mechanical Engineers B (대한기계학회논문집B)

The Korean Society of Mechanical Engineers (대한기계학회)
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Biocompatibility Evaluation of Bent-Type Left Ventricular Assist Device During Long-Term Animal Experiment and Emergent Situation

장기 동물 실험 및 응급상황에서의 곡관형 좌심실보조장치의 생체적합성 평가

  • Kang, Seong Min (Dept. of Fusion System Engineering, Kangwon Nat'l Univ.) ;
  • Her, Keun (Cardiovascular and Thoracic Surgery, Soonchunhyang University Hospital) ;
  • Choi, Seong Wok (Dept. of Fusion System Engineering, Kangwon Nat'l Univ.)
  • 강성민 (강원대학교 융합시스템공학과) ;
  • 허균 (순천향대학병원 흉부외과) ;
  • 최성욱 (강원대학교 융합시스템공학과)
  • Received : 2014.03.28
  • Accepted : 2014.06.30
  • Published : 2014.09.01
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Abstract

Although medication is given to heart disease patients, conventional medication alone is not sufficient to treat heart disease. However, it has been reported that left ventricular assist device (LVAD) transplantation is an effective bridge to heart transplantation by assisting cardiac function. This study used long-term animal testing and emergency situations with a bovine model (Holstein) and canine model (Labrador-retriever) to evaluate the biocompatibility of LibraHeart-I (LH-1), which is a bent-tube type of LVAD that was developed in a previous study. In the long-term animal testing with the bovine model, the subjects survived for 49 days with no irregularities observed in their complete blood cell counts or the vital sign tests that were carried out during the test period. In short-term animal testing with the canine model, it was observed that blood did not remain inside the LH-I even without power support from an external drive source. In this study, the biocompatibility of the LH-I that was developed in a previous study was verified by the ejection performance during long-term animal testing and emergency situations.

심장 질환 환자에게 약물 치료를 시행하고 있으나, 통상의 약물 치료만으로는 심장질환을 치료하기에는 부족하다. 그러나 LVAD 를 이식한다면 심장기능을 보조하여 심장 이식까지의 가교 역할로서 효과가 있다고 보고되고 있다. 본 연구에서는 선행 연구로 개발된 곡관형 LVAD 인 LibraHeart-I(LH-1)을 이용하여, 대동물(Bovine model, Holstein)과 소동물(canine model, Labrador-retriever)을 대상으로 장기간 동물실험 및 응급상황에서의 생체적합성을 평가하고자 한다. 대동물을 대상으로 실시한 장기간의 동물 실험에서 49 일 생존하였으며, 실험기간 동안 실시한 혈액 검사 및 생징후에서 특이 소견을 관찰되지 않았다. 소동물을 대상으로 한 단기간의 동물 실험에서는 외부 구동부의 동력 지원 없이도 LH-I 내에 혈액이 머무르지 않는 것으로 관찰되었다. 본 연구에서는 장기간 동물실험 및 응급상황에서의 박출 성능을 통해 선행 연구로 개발된 LH-I의 생체적합성을 검증하였다.

Keywords

References

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