• Journal of the Society of Cosmetic Scientists of Korea
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• v.36 no.4
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• pp.315-321
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• 2010

In this study, we investigated the antibacterial activity and the skin moisturizing effect of cream contaning Cedrela sinensis A. Juss shoots extracts. MIC values of ethyl acetate fraction from Cedrela sinensis A. Juss shoots extracts on P. acnes and S. aureus were 0.13 %, 0.03% respectively and P. ovale and E. coli were 0.25 % equally. The results showed that the antibacterial activity of the ethyl acetate fraction on P. acnes and S. aureus were higher than the methyl paraben. The cream containing the ethyl acetate fraction from Cedrela sinensis A. Juss shoots extracts was formulated and its skin moisturizing effect was evaluated in a clinical trial. The skin hydration and transepidermal water loss (TEWL) were investigated after topical application of the cream. The skin hydrating effect of the cream containing Cedrela sinensis A. Juss shoots extract was 10 ~ 15 % higher than the placebo cream, and transepidermal water loss was decreased to 6.7 g/$m^2h$ in the subjects applied with cream containing the ethyl acetate fraction of Cedrela sinensis A. Juss shoots extracts. These results indicate that ethyl acetate fraction from Cedrela sinensis A. Juss shoots extracts could be applicable to new functional antibacterial cosmetics.

• Journal of the Korean Society of Food Science and Nutrition
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• v.22 no.5
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• pp.581-585
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• 1993

Five flavonoids isolated from the ethyl acetate fraction of Cedrela sinensis A. Juss. were identified by high performance liquid chromatography. Separation was achieved by reversed phase chromatography on ${\mu}-bondapak$ C18 column with isocratic elution method. The content of the major flavonoid, quercitrin was about 9.48%(w/w) and 37.06%(w/w) for the methanol extract and ethyl acetate fraction, respectively.

• Korean Journal of Pharmacognosy
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• v.27 no.3
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• pp.219-223
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• 1996

From the rachis of Cedrela sinensis A. Juss., methyl gallate, quercitrin, bis-(p-hydroxyphenyl)ether, adenosine, isoquercitrin, rutin, (+)-catechin and (-)-epicatechin were isolated and characterized by spectral data.

• YAKHAK HOEJI
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• v.37 no.3
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• pp.306-310
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• 1993

The leaves of Cedrela sinensis have been used for food at south area in Korea and oriental medicine for treating enteritis, dysentery and itch. Kaempferol, methyl gailate, quercetin, afzelin, quercitrin, isoquercitrin and rutin were isolated from the leaves of this plant and characterized by spectral data. These compounds are reported for the first time from this plant.

• The Korean Journal of Food And Nutrition
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• v.31 no.4
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• pp.464-470
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• 2018

All the parts of the Cedrela sinensis A. Juss., including the seeds, roots, and leaves, have been known to exert medicinal effects. The C. sinensis and its major compound, quercetin, were previously reported to exhibit the anti-inflammatory and anti-oxidative activities. However, the hepatoprotective effects of the C. sinensis leaves against the alcohol-induced oxidative stress in the HepG2 cells have not been studied. In this study, we investigated the antioxidant activities and analyzed the flavonoid contents of the C. sinensis-leaf extract (CE). The total flavonoid contents of the CE is 1,874.5 mg/100 g dry weight (DW), while the total quercetin 3-O-rhamnoside (quercitrin) contents, which was identified as the major flavonol in the CE, is 1,456.0 mg/100 g DW. In the ethanol-stimulated HepG2 cells, the CE effectively prevented the cytotoxic effect and increased the gene expression of the antioxidant enzymes, such as the heme oxygenase-1 (HO-1) and the glutathion peroxide (GPx). The level of the reactive oxygen species (ROS) production was significantly decreased in the CE-treated HepG2 cells. In conclusion, the C. sinensis extract suppressed the alcohol-induced oxidative stress in the HepG2 cells via the induced GPx and HO-1 gene expressions. It is expected the CE positive effects will likely be attributed to the flavonoids, like the quercetin, within the CE.

• Korean Journal of Pharmacognosy
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• v.41 no.4
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• pp.245-249
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• 2010

As part of ongoing study focused on the discovery of natural antioxidants from Korean plants by measuring the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging effect and superoxide quenching activity, methanol extract of Cedrela sinensis (Meliaceae) was found to show potent antioxidant activities. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of four phenolic compounds, (+)-catechin (1), (-)-epicatechin (2), catechin-($4{\alpha}{\rightarrow}8$)-catechin (3) and catechin-($4{\alpha}{\rightarrow}8$)-epicatechin (4). Their structures were elucidated by spectroscopic studies. These compounds showed the significant antioxidative effects on DPPH. In riboflavin originated superoxide quenching activity, four compounds exhibited the formation of the blue formazan in a dose dependant manner.

• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.4
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• pp.578-581
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• 1995

The seasonal variation of two flavonoid, quercitrin and afzelin, in the leaves of Cedrela sinensis A. Juss. from May until November was investigated by high performance liquid chromatography. Separation by reversed phase chromatography on ${\mu}-Bondapak\;C_{18}$ column was achieved by isocratic elution. The concentration of quercitrin was 5.81% (w/w) in May and high in July(8.89%, w/w), August(7.94%, w/w), and decreased from September to November. The content of another flavonoid, afzelin was 0.06% (w/w) in May and highest in June (0.12%, w/w), and was reduced from July.

• Korean journal of food and cookery science
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• v.11 no.3
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• pp.303-308
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• 1995

When we prepared the cooked namul, bugak and kimchi by the leaves of Cedrela sinensis, the changes of quercitrin which was isolated from the leaves of this plant in each preparations were analysed by HPLC. Separation by reversed phase chromatography on u-Bondapak C/Sub 18/ column was achieved by isocratic elution with THF-dioxane-MeOH-HOAc-5％ H/Sub 3/PO/Sub 4/-H/Sub 2/O (145: 125:50:20:2:658). When Kimchi was stored at 5$^{\circ}C$ for 20 days, the content of quercitrin in the methanol extract of Kimchi was 7.21％ and Kimchi at 20$^{\circ}C$ was reduced by 5.78％ (w/w). Contents of quercitrin in the leaves of Cedrela sinensis kimchi obsered to be gradually decreased during storage at 5$^{\circ}C$ and 20$^{\circ}C$. Contents of quercitrin of stored kimchi at 5$^{\circ}C$ was higher than that stored at 20$^{\circ}C$. The contents of quercitrin in Namul and Bugak were 13.06 and 5.03％ (w/w), respectively, which were lower than control.

• 한국약용작물학회:학술대회논문집
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• 2011.04a
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• pp.128-129
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• 2011

• 한국약용작물학회:학술대회논문집
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• 2008.05a
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• pp.154-155
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• 2008