Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Antibaterial Activity and Skin Moisturizing Effect of Cedrela sinensis A. Juss Shoots Extracts

참죽나무 새순 추출물의 항균 활성과 피부 보습효과에 관한 연구

  • Kim, Sun-Young (Department of Fine Chemistry, Research Center for Development of Green Cosmetic, College of Nature and Life Science, Seoul National University of Science and Technology) ;
  • Lee, Min-Hye (Department of Fine Chemistry, Research Center for Development of Green Cosmetic, College of Nature and Life Science, Seoul National University of Science and Technology) ;
  • Jo, Na-Rae (Department of Fine Chemistry, Research Center for Development of Green Cosmetic, College of Nature and Life Science, Seoul National University of Science and Technology) ;
  • Park, Soo-Nam (Department of Fine Chemistry, Research Center for Development of Green Cosmetic, College of Nature and Life Science, Seoul National University of Science and Technology)
  • 김선영 (서울과학기술대학교 자연생명과학대학 정밀화학과, 그린코스메틱연구개발센터) ;
  • 이민혜 (서울과학기술대학교 자연생명과학대학 정밀화학과, 그린코스메틱연구개발센터) ;
  • 조나래 (서울과학기술대학교 자연생명과학대학 정밀화학과, 그린코스메틱연구개발센터) ;
  • 박수남 (서울과학기술대학교 자연생명과학대학 정밀화학과, 그린코스메틱연구개발센터)
  • Received : 2010.12.16
  • Accepted : 2010.12.23
  • Published : 2010.12.30
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Abstract

In this study, we investigated the antibacterial activity and the skin moisturizing effect of cream contaning Cedrela sinensis A. Juss shoots extracts. MIC values of ethyl acetate fraction from Cedrela sinensis A. Juss shoots extracts on P. acnes and S. aureus were 0.13 %, 0.03% respectively and P. ovale and E. coli were 0.25 % equally. The results showed that the antibacterial activity of the ethyl acetate fraction on P. acnes and S. aureus were higher than the methyl paraben. The cream containing the ethyl acetate fraction from Cedrela sinensis A. Juss shoots extracts was formulated and its skin moisturizing effect was evaluated in a clinical trial. The skin hydration and transepidermal water loss (TEWL) were investigated after topical application of the cream. The skin hydrating effect of the cream containing Cedrela sinensis A. Juss shoots extract was 10 ~ 15 % higher than the placebo cream, and transepidermal water loss was decreased to 6.7 g/$m^2h$ in the subjects applied with cream containing the ethyl acetate fraction of Cedrela sinensis A. Juss shoots extracts. These results indicate that ethyl acetate fraction from Cedrela sinensis A. Juss shoots extracts could be applicable to new functional antibacterial cosmetics.

본 연구에서는 피부 상재균에 대한 참죽나무 새순 추출물의 항균 작용과 참죽나무 새순 추출물을 함유하는 크림을 제조하여 인체 피부를 대상으로 보습 효능을 측정하였다. 참죽나무 새순 추출물의 네 가지 피부 상재균에 대한 MIC를 측정한 결과, P. acnes과 S. aureus에 대한 MIC는 각각 0.13 %, 0.03 %로 비교 물질인 methyl paraben보다 더 우수한 항균 활성을 나타내었고, P. ovale과 E. coli에 대한 MIC는 모두 0.25 %로 methyl paraben 보다 낮은 MIC를 나타내었다. 피부 보습 효능을 측정하기 위해, 참죽나무 새순 추출물의 ethyl acetate 분획을 0.25 % 함유하는 크림을 제조하고, 이를 14명의 피실험자의 피부에 도포한 후 피부 수분 보유랑과 경표피 수분 손실량을 각각 30 min, 60 min 간격으로 180 min 동안 측정하였다. 피부 수분 보유량은 placebo 크림에 비하여 참죽나무 새순 추출물 함유 크림이 10 ~ 15 % 정도 더 큰 수분 보유량 증가율을 나타내었다. 경표피 수분 손실량을 측정하였을 때, 무도포(control) 상태의 경표피 수분 손실량은 8.9 g/$m^2h$, 추출물 함유 크림은 6.7 g/$m^2h$으로, 추출물을 함유한 크림이 피부 표면의 수분 손실을 감소시킴을 알 수 있었다. 참죽나무 새순 추출물의 ethyl acetate 분획의 항균 활성과 피부 보습효과에 대한 결과로부터 화장품 원료로서의 가능성을 확인하였다.

Keywords

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