• The Korean Journal of Physiology and Pharmacology
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• 제22권4호
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• pp.379-389
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• 2018

A nucleobase adenine is a fundamental component of nucleic acids and adenine nucleotides. Various biological roles of adenine have been discovered. It is not produced from degradation of adenine nucleotides in mammals but produced mainly during polyamine synthesis by dividing cells. Anti-inflammatory roles of adenine have been supported in IgE-mediated allergic reactions, immunological functions of lymphocytes and dextran sodium sulfate-induced colitis. However adenine effects on Toll-like receptor 4 (TLR4)-mediated inflammation by lipopolysaccharide (LPS), a cell wall component of Gram negative bacteria, is not examined. Here we investigated anti-inflammatory roles of adenine in LPS-stimulated immune cells, including a macrophage cell line RAW264.7 and bone marrow derived mast cells (BMMCs) and peritoneal cells in mice. In RAW264.7 cells stimulated with LPS, adenine inhibited production of pro-inflammatory cytokines $TNF-{\alpha}$ and IL-6 and inflammatory lipid mediators, prostaglandin $E_2$ and leukotriene $B_4$. Adenine impeded signaling pathways eliciting production of these inflammatory mediators. It suppressed $I{\kappa}B$ phosphorylation, nuclear translocation of nuclear factor ${\kappa}B$ ($NF-{\kappa}B$), phosphorylation of Akt and mitogen activated protein kinases (MAPKs) JNK and ERK. Although adenine raised cellular AMP which could activate AMP-dependent protein kinase (AMPK), the enzyme activity was not enhanced. In BMMCs, adenine inhibited the LPS-induced production of $TNF-{\alpha}$, IL-6 and IL-13 and also hindered phosphorylation of $NF-{\kappa}B$ and Akt. In peritoneal cavity, adenine suppressed the LPS-induced production of $TNF-{\alpha}$ and IL-6 by peritoneal cells in mice. These results show that adenine attenuates the LPS-induced inflammatory reactions.

• 대한기계학회논문집
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• 제17권6호
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• pp.1465-1477
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• 1993

본 연구에서는 분말혼합체의 특성인 항복응력을 포함한 Generalized Newtonian Fluid의 구성 방정식을 도입하고 미끄럼현상을 고려한 신소재의 사출성형 충전과정 해석용 CAE(computer aided engineering)시스템을 개발하였다. 수치모사를 위한 수치해석방법으로는, 유한요소법(finite element method)과 유한차분법(finite difference method)을 함께 사용하였다. 유한요소법과 검사체적법(control volume technique) 을 병용하여 유동의 진행을 수치모사 하였으며, 유한차분법을 사용하여 온도분포를 계산하였다.

• 치과방사선
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• 제14권1호
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• pp.81-87
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• 1984

This study was performed to observe the secondary images and to analyse the relationships between the primary and secondary images in panoramic radiograph. Using the Moritta's Panex-EC panoramic x-ray machine and the human dry skull, the author analysed 17 radiographs which were selected from 65 radiographs of the dry skull that attached the radiopaque materials, and the attached regions of the radiopaque materials were the normal anatomical structures which were important and selected as a regions for the evaluation of the secondary images effectively. The results were as follows; 1. The cervical vertebrae showed three images. The midline image was the most distorted and less clear, and bilateral images were slightly superimposed over the posterior border of the mandibular ramus. 2. In mandible, the secondary image of the posterior border of the ramus was superimposed on the opposite ramus region, and this image was elongated from the anterior border of the ramus to the lateral side of the posterior border of the ramus. The secondary image of the condyle was observed on the upper area of the coronoid process, the sigmoid notch and the condyle in opposite side. 3. In maxilla, the posterior region of the hard palate showed the secondary image on the lower part of the nasal cavity and the medial wall of the maxillary sinus. 4. The primary images of the occipital condyle and the mastoid process appeared on the same region, and only the secondary image of the occipital condyle was observed symmetrically on the opposite side with similar shape to the primary one. 5. In the cranial base, the anatomical structures of the midsagittal portions like a inferior border of the frontal sinus, sella turcica, inferior borderr of the sphenoid sinus and inferior border of the posterior part of the occipital bone showed the simillar shape between the primary and secondary images symmetrically. 6. The petrous portion of the temporal bone showed the secondary image on the lateral side of the sella-turcica, and the secondary images of the posterior border of lesser wing, superior border of greater wing of the sphenoid bone and posterior border were observed on the anterior-superior and inferior region of the sella-turcica.

• 대한소아치과학회지
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• 제25권2호
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• pp.268-276
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• 1998

낭종은 환자의 연령, 낭종의 종류 및 위치에 따라 치료방법을 선택하는 것이 바람직하며, 환자의 연령이 어린 경우에는 조대술을 통하여 낭종에 이환된 치아를 가능한 보존시키는 것이 바람직한 것으로 생각된다. 낭종에 포함되었던 치아는 조대술로 낭종을 제거후에 생리적인 맹출이 이루어지는 것을 관찰할 수 있었으며 기능도 정상적으로 수행하는 것으로 판단된다. 그러나, 조대술을 이용하여 시술한 후에는 맹출된 치아에 병리조직이 잔존되어 재발의 가능성이 있으므로 주기적인 관찰이 요구될 것으로 생각된다.

• Tuberculosis and Respiratory Diseases
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• 제81권2호
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• pp.106-115
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• 2018

Chest tube insertion is a common procedure usually done for the purpose of draining accumulated air or fluid in the pleural cavity. Small-bore chest tubes (${\leq}14F$) are generally recommended as the first-line therapy for spontaneous pneumothorax in non-ventilated patients and pleural effusions in general, with the possible exception of hemothoraces and malignant effusions (for which an immediate pleurodesis is planned). Large-bore chest drains may be useful for very large air leaks, as well as post-ineffective trial with small-bore drains. Chest tube insertion should be guided by imaging, either bedside ultrasonography or, less commonly, computed tomography. The so-called trocar technique must be avoided. Instead, blunt dissection (for tubes >24F) or the Seldinger technique should be used. All chest tubes are connected to a drainage system device: flutter valve, underwater seal, electronic systems or, for indwelling pleural catheters (IPC), vacuum bottles. The classic, three-bottle drainage system requires either (external) wall suction or gravity ("water seal") drainage (the former not being routinely recommended unless the latter is not effective). The optimal timing for tube removal is still a matter of controversy; however, the use of digital drainage systems facilitates informed and prudent decision-making in that area. A drain-clamping test before tube withdrawal is generally not advocated. Pain, drain blockage and accidental dislodgment are common complications of small-bore drains; the most dreaded complications include organ injury, hemothorax, infections, and re-expansion pulmonary edema. IPC represent a first-line palliative therapy of malignant pleural effusions in many centers. The optimal frequency of drainage, for IPC, has not been formally agreed upon or otherwise officially established.

• Restorative Dentistry and Endodontics
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• 제1권1호
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• pp.26-32
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• 1975

After a vital pulpotomy in dogs' teeth, the responses of the remaining pulp tissue under hydroxides (calcium hydroxide, magnesium hydroxide, aluminium hydroxide and zinc hydroxide) were studied histologically. The class V cavities were prepared on the teeth and the pulp was amputated. Each hydroxide was placed over the amputated tissue and the cavity was sealed with zinc oxide eugenol cement. Animals were sacrificed after 3 days, 1, 2, and 3 weeks following the operation. The teeth were decalcified, sectioned and stained with hematoxylin and eosin. Microscopic examination reveals as follows; 1. Calcium hydroxide: Inflammatory change was seen in the superficial portion of the remaining pulp tissue at the 3rd day and 1st week. The incompleted calicified material began to be deposited from the canal wall at the 2nd week, and the advanced calcified material was seen at the 3rd week. 2. Magnesium hydroxide: Severe inflammatory change was seen in the superficial portion of the remaining pulp from the 3rd day and the 1st week samples. Inflammatory change was decreased at the 2nd week and the slight calcified material was deposited from the root canal at the 3rd week. 3. Aluminium hydroxide: Severe inflammatory changes were seen in the remaining pulp tissue, the blood vessel was dilated, and the odontoblasts were destroyed at the 3rd day and 1st week. The fibrous degeneration spread to the apex at the 2nd week. There was no evidence of newly formed odontoblasts or deposition of calcified material underneath aluminium hydroxide. 4. Zinc hydroxide: The micrscopic picture was destructive. A thick necrotic layer was found under the amputated surface at the 3rd day and 1st week. Granulation tissue formation as well as chronic inflammatory changes extended to the apical area in the pulp tissue. Also there were no sign of odontoblastic formation or calcified material at the 2nd and 3rd week.

• Advances in pediatric surgery
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• 제6권1호
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• pp.10-18
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• 2000

Multisystem organ failure resulting from gram negative bacterial sepsis is associated with high morbidity and mortality in surgical neonates. There are differences in the clinical characteristics of organ failure in neonates and adults. The purpose of this study is to identify the differences and determine the order of organ failure between baby rats and adult rats after induction of gram negative sepsis. Fifty baby rats less than 30-day-old and another 50 adult rats more than 2-month-old were divided into control group (G1) and experimental group (G2). The G1 consisted of 10 baby- and 10 adult-rats, and the G2 consisted of 40 babies and 40 adults. E. coli ($10^8/mL$ per 100g of body weight) were injected into the peritoneal cavity in G2 and same amount of saline was injected in G 1. Blood samples were obtained before injection, 24 hour, 48 hour, 72 hour and after death. WEC, platelet, $PaO_2$, $PaCO_2$, total bilirubin, BUN, creatinine, albumin and abdominal wall thickness were measured to evaluate the sequence of organ failure. The mortality was 55.0 % in G2-babies and 32.5 % in G2-adults. In baby rats, microvascular, hematologic and renal failure appeared within 24 hours after injection and pulmonary failure followed. Pulmonary, renal and liver failure developed within 24-48 hours in adult rats; however, microvascular failure did not appear until they were moribund. Thrombocytopenia, hypoalbuminemia, increased BUN and generalized edema was the earlist sign of sepsis in baby rats.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제14권1_2호
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• pp.160-168
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• 1992

저자는 31세 여자환자의 좌측하악부에서 매복된 제3대구치 주위의 함치성 낭종에서 기원한 Group 3a type의 다방성의 낭종성 법랑아세포종을 경험하여 병소에 포함된 치아 발거슬 및 enucleation/curettage로 현재까지 재발없이 치유되었기에 병리조직학적 소견을 중심으로 문헌고찰과 함께 보고하는 바이다.

• 대한전자공학회논문지TC
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• 제37권12호
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• pp.15-21
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• 2000

본 연구에서는 유전체슬랩으로 덮혀 있고 단락 종단된 평행평판 도파관의 좁은 슬릿을 통한 유전체슬랩 위의 도체스트립과의 전자기적인 결합을 평행평판 도파관에 TEM파가 입사되는 경우에 대하여 고려하였다. 슬릿의 전계와 도체스트립에 유기된 전류를 미지수로 하는 결합적분방정식을 유도하고 모멘트방법을 이용하여 풀었다. 그 결과로부터 슬릿의 폭이 매우 좁음에도 불구하고 도체스트립의 폭과 위치를 적절히 택하면 입사전력의 대부분이 도파관 외부로 결합될 수 있음을 관찰하였다. 또한 도체스트립과 도파관의 윗면이 캐비티를 구성하는 경우와 도체스트립이 기생소자 역할을 하는 경우에 있어서 관찰되는 두 가지 복사현상들 간의 차이점에 대하여 논의하였다.

• 대한세포병리학회지
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• 제4권1호
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• pp.74-76
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• 1993

저자들은 비교적 접할 기회가 흔치 않은 횡문근육종의 체액 세포학 3예를 경험하였기에 그 임상 소견과 함께 세포학적 소견을 간결히 기술하였다. 제 1예는 흉벽에 다형 횡문근육종이 있는 환자의 늑막 삼출액 소견으로서, 세포들은 느슨한 군집을 형성하거나 개별적으로 흩어져서 도말되었고 핵은 다형성이 심하였으며 다핵을 가지는 세포도 관찰되었고 과염색상을 보였다. 횡문근육종의 특이 소견인 가로무늬는 관찰되지 않았고 세포질은 미세 공포형이었다. 나머지 2예는 구강 원발성 및 원발 병소를 알수 없는 배형 횡문근육종으로서 이들의 늑막 삼출세포학적 소견은 서로 유사하였다. 군집을 형성하거나 개별적으로 흩어진 세포들은 작고 둥근 세포들로서 이들은 미미한 세포질과 과염색상의 핵을 가지고 있었으며 소 세포 암종에서 관찰되는 염주형 배열 또는 주물 현상은 인정되지 않았다. 육종의 체액 세포학은 원발 병소및 아형이 알려진 경우에 진단적이라고 여겨진다.