• 한국지구과학회지
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• 제37권7호
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• pp.420-433
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• 2016

본 연구의 목적은 2011년 4월 22일부터 10월 22일까지 우리나라에서 강수가 있는 총 75일 동안 COMS 위성의 적외 채널 $10.8{\mu}m$ 휘도 온도(IR), 적외 채널 $10.8{\mu}m$와 수증기 채널 $6.7{\mu}m$의 휘도 온도차(IR-WV), 정규화 된 가시반사도(VIS)와 기상 레이더의 강우강도를 이용하여 2-D와 3-D 대류운의 강우강도 (CRR) 조견표를 향상시키는 것이다. 특별히 한국형 2-D와 3-D CRR 조견표를 검증하기 위해 2011년 강수가 있는 24일 동안의 기상 레이더 강우강도 자료가 사용된다. 2-D와 3-D CRR 조견표는 각 채널의 등급 범주별 강우 총수와 비강우 총수의 행렬을 이용하여 구한 강우 확률에 평균 누적강우강도와 최대 강우강도를 각각 곱함으로써 2-D (IR, IR-WV)와 3-D (IR, IR-WV, VIS) 조견표의 기본과 최대 행렬을 얻을 수 있다. 최종적으로 새로운 2-D와 3-D의 CRR 조견표는 경험적으로 기본과 최대 강우강도 행렬의 회귀 분석으로 얻어진다. 그 결과 새로운 CRR 조견표는 기존보다 낮은 IR 휘도 온도, 낮은 IR-WV 휘도 온도차일 때에도 비교적 많은 강우 현상을 나타내며, $10mm\;h^{-1}$ 이상의 강우강도 영역이 확대되어 나타난다. 정확도와 범주별 통계가 주어진 기간 동안 발생했던 CRR 자료에 대해 계산된다. 새로운 2-D와 3-D CRR 조견표의 평균 오차, 평균절대 오차, 제곱근평균 오차가 기존 조견표보다 작게 나타나며, 예측 거짓경고비율은 감소하고, 탐지확률은 증가하며, 임계성공지수는 개선된다. 태풍과 뇌우와 같은 기상 이변에서의 강한 호우를 고려하기 위해서 습윤 보정 계수를 교정한다. 이 인자는 수치모델이나 COMS에서 복원한 지면에서 500 hPa까지 평균한 총가강수량과 상대습도의 곱 (PW RH)으로 정의된다. 이 연구에서는 PW RH에 근거하여 IR 운정 휘도 온도가 210 K 이하일 때, 상대습도가 40% 이상일 때 1에서 2사이를 경험적으로 정한다. 새로운 2-D와 3-D CRR 조견표를 적용한 결과 평균 오차, 평균 절대 오차, 제곱근 평균 오차가 줄어든다.

• 한국수자원학회논문집
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• 제49권5호
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• pp.399-410
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• 2016

유속계수는 상수도 설계, 운영, 유지관리 등의 과정에서 항상 현장 실정이 고려된 값이 사용되어야 한다. 본 연구는 광역상수도 정밀안전진단 과정에서의 174개 실측자료를 바탕으로 유속계수와 주요 인자 간의 관계를 통계적 기법을 활용하여 분석하였다. 이들 관계를 분석하기 위해서 교차분석, 일원배치 분산분석, 상관분석 등을 수행하였으며, 그 결과 유속계수와 사용년수 및 관경이 높은 상관관계를 나타내고 여러 범주형 자료 형태 영향인자 중에 내부도장재가 상대적으로 유속계수에 많은 영향을 주는 것으로 검토되었다. 반면 다중회귀분석의 결과에서는 사용년수, 관경 및 수종이 중요한 영향인자인 것으로 검토되었다. 군집분석 결과, 유속계수는 기본적으로 사용년수 약 20년, 관경 1500mm를 기준으로 분류되는 경향이 있었으며, 유속계수는 전반적으로 사용년수에 많은 영향은 받으나 대구경 관에서는 상대적으로 사용년수보다 관경에 많은 영향을 받는 것으로 검토되었다. 마지막으로 본 연구에서는 회귀분석과 군집분석을 사용하여 유속계수 산정식들을 제안하였으며, 이러한 추정식들은 추후 광역상수도의 유속계수 결정 및 사용 시에 판단기준이 될 수 있을 것으로 판단된다.

• 대한가정학회지
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• 제46권7호
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• pp.47-58
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• 2008

Using the Toddler Temperament Scale(Saslow, 1993), the temperament stability of 239 toddlers from the ages of 18 and 30-months was analyzed longitudinally. TTS was composed of five sub-scales; Activity, Approach-Withdrawal, Adaptability, Intensity, and Mood. Significant correlations were established when stabilities of the temperamental sub-scales from 18- to 24-months, 24- to 30-months and 18- to 30-months were examined. For example, in relation to 'Approach-Withdrawal' factor, which was the most stable across infancy, infants who showed higher scores in 18 months of age also showed higher scores in 24- and 30-months of age. In addition, the stability of temperament in the categorical status of each infant was analyzed. Infants were divided into three groups at each age: 'Easy', 'slow-to-warm up', or 'difficult' according to their relative status within each age group. It was found that 54% of infants stayed in the same temperament group from 18 to 24 months, and so did 78% of infants from 24 to 30 months. In particular, 'easy' group illustrated the highest stability among the groups; 71.2% of infants stayed in the same temperament group between 18 and 24 months of age, while 85.9% of infants did so between 24 and 30 months of age. In conclusion, the results of this study indicate high temperament stability during the studied age bracket, while also confirming the fact that stability, in general, increases with age.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3903-3909
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• 2016

Purpose: To evaluate the expression of Her2/neu and Ki-67 in benign and malignant gallbladder lesions, and to establish correlations with clinico-pathologic parameters. Materials and Methods: A retrospective analysis was conducted on formalin fixed paraffin embedded (FFPE) benign (n=25) and malignant gallbladder (n=25) tissue samples. Hematoxylin and eosin stained slides of each case were reviewed for: type of malignancy (whether adenocarcinoma, squamous cell carcinoma, or any other type), grade (well, moderate, and poor), depth of invasion, pre-neoplastic changes in adjacent mucosal epithelium like metaplasia and dysplasia. Immunohistochemistry for Her 2 neu and Ki-67 was performed and data analysis was conducted using SPSS 17 software. Chi-square test was used to compare categorical/dichotomous variables. P value of ${\leq}0.05$ was considered significant. Results: The difference of Her 2 neu expression and Ki67 index between benign and malignant groups was found to be statistically significant. Her2/neu positivity did not have any significant correlation with various clinicopathological parameters other than liver involvement. 5 cases of gallbladder cancer showed both Her2/neu and Ki67 positivity. Ten cases were Ki67 positive but Her2/neu negative while one case was Her2/neu positive but Ki67 negative. Conclusions: The present study demonstrated overexpression of Her2/neu and Ki67 in gallbladder cancer. A trend of decreasing Her2/neu expression with increasing grade of tumor was observed. Furthermore, greater Ki67 positivity was found in cases with lymph node metastasis and distant metastasis. Future studies with a larger number of patients will be required to precisely define the correlation of Her2/neu expression and Ki67 positivity with clinicopathological parameters. The results however are encouraging and suggest evaluation of Her2/neu as a candidate for targeted therapy.

• 한국융합학회논문지
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• 제7권5호
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• pp.145-153
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• 2016

이 연구는 메타분석을 활용하여 현재 다양한 영역에서 실시되고 있는 수용전념치료 프로그램의 효과에 대해 종합적으로 평가하였다. 메타분석은 통계적인 방법을 활용하여 개입의 크기와 방향을 제시한다. 이를 통해 개입에 대한 종합적 분석이 가능하다. 논문의 선정기준을 통해 총 43편의 연구물을 분석 대상으로 선정하였다. 선정된 33편의 연구물에서 183개의 효과크기를 종합하여 전체효과크기, 하위집단별 효과크기, 메타회귀분석 결과를 제시하였다. 그 결과 수용전념치료 프로그램의 전체 효과크기는 0.704로 나타났다. 이는 중간 이상의 효과크기를 의미한다. 수용전념치료의 효과 영역에 따라 효과크기를 비교한 결과, 정의적 영역, 인지적 영역, 행동적 영역 순으로 효과크기를 나타냈다. 참가자의 특성에 따른 효과크기를 비교한 결과 첫째, 성별에 따른 분석결과, 혼성 집단, 여성 집단, 남성 집단 순으로 효과크기를 나타냈다. 둘째 연령에 따른 분석 결과 일반성인, 대학생(대학원생), 청소년 순이었다. 이러한 연구 결과를 바탕으로 후속연구와 향후 프로그램 운영에 대한 시사점을 논의하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.105-108
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• 2016

Background: Epidemiological evidence indicates that individuals with diabetes mellitus (DM) may have a modestly increased risk of bladder cancer. In the present study, we aimed to show any association between DM and risk of metastasis in patients with non-muscle-invasive bladder cancer (NMIBC). Materials and Methods: We retrospectively analyzed 698 patients between January 2007 and December 2014 who were diagnosed with and underwent transurethral resection of bladder tumors (TUR-BT). Comparisons of means was conducted by independent samples t test, and relations between categorical variables were investigated by non-parametric chi-square test. A p value of 0.05 was accepted as statistically significant in comparisons. Results: We analyzed 418 patients with non muscle invasive bladder cancer. 123 of whom were diabetic and 295 non-diabetic. In diabetic patients, 13 were N1 stage and 11 M1 stage. When compared with non diabetic patients that was statistically significant (p<0.001). TNM stages were more advanced in diabetic patients (p<0.001), but concurrent CIS (p=0.1) and squamous metaplasia did not significantly differ between diabetic and non-diabetic cases (p=1). Conclusions: Diabetic patients with non-muscle-invasive bladder cancer may suffer metastases earlier than expected although they are non invasive. Therefore such patients must be followed-up carefully and early cystectomy decision may be necessary. Further prospective studies with more patients are needed to confirm these findings.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.807-812
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• 2014

Background: The clinical course of the neoplasm may vary due to both patient and tumor cell characteristics. Aim: The aim of this study was to research the influence of certain clinical and pathological features on the prognosis of early stage breast cancer. Materials and Methods: This study included 117 women that were treated and followed-up in between the years 2001-2011. The demographic, clinical and histopathological features of the cases were reviewed retrospectively. Statistical analysis: In categorical comparisons between groups, cross-tab statistics were provided and significance levels were estimated using chi-square test. Cox regression analysis, Pearson and Spearman correlation tests, and the Kaplan-Meier test were also used. Results: With an average of 35-months follow-up, the mean disease-free survival of patients was 91 months and the mean overall survival time was 132 months. In the whole study group, the disease-free survival rates were 88, 84, 83 and 52%, while the overall survival rates 95, 94, 83, and 83% within the first, third, fifth and tenth years, respectively. The disease-free and overall survival rates were decreased with increasing tumor grades, though this was not statistically significant. The presence of lymphovascular invasion, positive staining with Ki67 and postmenopausal status were associated with shorter disease-free and overall survival times. In multivariate analysis, only age and Her2/neu receptor status influenced the prognosis significantly. Conclusions: In parallel to clinical, histopathological, and immunohistochemical prognostic features in breast cancer, in this study positive Her2/neu receptor status, a previously accepted poor prognostic factor, was found to have positive influence after trastuzumab treatment.

• 산업경영시스템학회지
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• 제41권2호
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• pp.133-140
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• 2018

In this study, a correlation between execution of quality management activities and their results was verified by applying the Malcolm Baldrige model (hereafter referred to as the MB model) as a quality management performance measurement indicator for small and medium enterprises (SMEs) in South Korea. To achieve this goal, we need to determine whether the categorical requirements in the MB model are recognized consistently in SMEs, as a prerequisite. To this end, factor analysis was conducted for measurement variables in each category, which revealed that the process indicator was made up of six factors and the outcome indicator was made up of five factors, like those configured in the MB model. This result can be interpreted to mean that the requirements in each category of the MB model were well produced and recognized consistently throughout SMEs in South Korea. In addition, the analysis of causality between the process indicator (quality management activities) and the outcome indicator (management results) showed high causality between them. Although the quality management levels of SMEs in South Korea are inferior to those of conglomerates or other national quality award-winning companies, this study is significant in that the causality between quality management activities and results was verified, since this study targeted SMEs in South Korea as the target of investigation. Thus, it is empirically proven that the MB model can contribute to improved management results for SMEs in Korea.

• 한국임상약학회지
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• 제29권2호
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• pp.79-88
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• 2019

Backgrounds: Inflammatory bowel disease (IBD) including ulcerative colitis (UC) and Crohn's disease (CD) increased prevalence and economic burden. Objectives: This study aimed to investigate drug use pattern in IBD patients in a real world. Methods: National Health Insurance claim data from 2010 to 2014 were used in this population-based study. All IBD patients diagnosed during study period were enrolled. IBD medications included 5-aminosalicylic acid (ASA), glucocorticoid, immunomodulator and anti-tumor necrosis factor-${\alpha}$ agent(anti TNF-${\alpha}$). Growth rate of IBD prevalence, prescribed drug classes, duration of drug therapy and medication cost were analyzed. Number and percentage of patients for categorical variables, and mean and median for continuous variables were presented. Results: Total numbers of patients were 131,158 and 57,286 during 5 years, and their annual growth rate were 3.2 and 5.7% for UC and CD. UC and CD were prevalent in the 40-50 (41.2%) and 20-30 age groups (36.0%). About 60% of IBD patients was prescribed any of medications. 5-ASA was the most frequently prescribed, followed by corticosteroid and immunomodulator. Anti TNF-${\alpha}$ use was the lowest, but 5 times higher than UC in CD. Combination therapies with different class of drugs were in 29% for UC and 62% for CD. Mean prescription days per patient per year were 306 and 378, and the median medication cost per patient per year was KRW 420,000 (USD 383) and KRW 830,000 (USD755), for UC and CD, respectively. Conclusions: Increasing prevalence of IBD requires further studies to contribute to achieve better clinical outcomes of drug therapy.

• Journal of Korean Neurosurgical Society
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• 제62권5호
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• pp.603-609
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• 2019

Objective : The purpose of this retrospective study was to determine which of the proximal adjacent segment disease (ASD) and distal ASD was more prevalent and what parameters is more related to ASD in proximal levels and distal levels after more than 2 levels fusions. Methods : The medical records were reviewed retrospectively for 856 cases. A total of 66 cases of ASD were enrolled. On preop magnetic resonance imaging, disc degeneration was measured at the upper and lower parts of surgically treated levels and confirmed by the commonly used Pfirrmann grade. Segmental flexibility in sagittal plane was embodied in segment range of motion (ROM) obtained through flexion and extension X-ray before surgery. Coronal angle was recorded as methods Cobb's angle including fusion levels preoperatively. For the comparison of categorical variables between two independent groups, the chi-square test and Fisher exact test were performed. Results : Proximal ASD and distal ASD were 37/856 (4.32%) and 29/856 (3.39%), respectively. The incidence of proximal ASD was relatively high but insignificant differences. In comparison between ASD group and non ASD group, proximal Pfirmman was higher in proximal ASD and distal Pfirmman was higher in distal ASD group (p=0.005, p<0.008, respectively). However, in the ROM, proximal ROM was higher in proximal ASD, but distal ROM was not different between the two groups (p<0.0001, p=0.995, respectively). Coronal angle was not quite different in both groups (p=0.846). Conclusion : In spite of higher frequency in ASD in proximal level in spinal fusion, it is not clear that incidence of ASD in proximal level is not higher than that of distal ASD group in more than 2 level thoracolumbar fusions. Not only Pfirrmann grade but also proximal segmental ROM is risk factor for predicting the occurrence of ASD in patients more than 2 level of thoracolumbar spine fusion operation excluding L5S1.