Diabetes is an Important Risk Factor for Metastasis in Non-Muscle-Invasive Bladder Cancer

  • Ozer, Kutan (Urology, Ataturk Training and Research Hospital, Katip Celebi University) ;
  • Horsanali, Mustafa Ozan (Urology, Ataturk Training and Research Hospital, Katip Celebi University) ;
  • Gorgel, Sacit Nuri (Urology, Ataturk Training and Research Hospital, Katip Celebi University) ;
  • Ozbek, Emin (Urology, Istanbul Training and Research Hospital)
  • Published : 2016.02.05


Background: Epidemiological evidence indicates that individuals with diabetes mellitus (DM) may have a modestly increased risk of bladder cancer. In the present study, we aimed to show any association between DM and risk of metastasis in patients with non-muscle-invasive bladder cancer (NMIBC). Materials and Methods: We retrospectively analyzed 698 patients between January 2007 and December 2014 who were diagnosed with and underwent transurethral resection of bladder tumors (TUR-BT). Comparisons of means was conducted by independent samples t test, and relations between categorical variables were investigated by non-parametric chi-square test. A p value of 0.05 was accepted as statistically significant in comparisons. Results: We analyzed 418 patients with non muscle invasive bladder cancer. 123 of whom were diabetic and 295 non-diabetic. In diabetic patients, 13 were N1 stage and 11 M1 stage. When compared with non diabetic patients that was statistically significant (p<0.001). TNM stages were more advanced in diabetic patients (p<0.001), but concurrent CIS (p=0.1) and squamous metaplasia did not significantly differ between diabetic and non-diabetic cases (p=1). Conclusions: Diabetic patients with non-muscle-invasive bladder cancer may suffer metastases earlier than expected although they are non invasive. Therefore such patients must be followed-up carefully and early cystectomy decision may be necessary. Further prospective studies with more patients are needed to confirm these findings.



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