• Biomolecules & Therapeutics
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• v.24 no.2
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• pp.109-114
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• 2016

In Drosophila, rhomboid proteases are active cardinal regulators of epidermal growth factor receptor (EGFR) signaling pathway. iRhom1 and iRhom2, which are inactive homologs of rhomboid intramembrane serine proteases, are lacking essential catalytic residues. These are necessary for maturation and trafficking of tumor necrosis factor-alpha (TNF-${\alpha}$) converting enzyme (TACE) from endoplasmic reticulum (ER) to plasma membrane through Golgi, and associated with the fates of various ligands for EGFR. Recent studies have clarified that the activation or downregulation of EGFR signaling pathways by alteration of iRhoms are connected to several human diseases including tylosis with esophageal cancer (TOC) which is the autosomal dominant syndrom, breast cancer, and Alzheimer's disease. Thus, this review focuses on our understanding of iRhoms and the involved mechanisms in the cellular processes.

• Journal for History of Mathematics
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• v.12 no.1
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• pp.32-44
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• 1999

This paper is a sequel to [8]. Development of modern logic was initiated by Boole and Morgan. Boolean logic is one of their completed works. Cantor created the set theory along with cardinal and ordinal numbers. His theory on infinite sets brought about a remarkable development on modern mathematical theory, but generated many paradoxes (e.g. Russell Paradox) that in turn motivated mathematicians to solve them. Further, mathematicians attempted to construct sound foundations for Mathematics. As a result three important schools of thought were formed in relation to fundamentals of mathematics for the resolution of paradoxes of set theory, namely logicism developed by Russell and Whitehead, intuitionism lead by Brouwer and formalism contended by Hilbert and Bernays. In this paper, we examine the logic for intuitionism which is originated by Brouwer in 1908 and study Heyting algebra.

• Korean Journal of Child Studies
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• v.21 no.1
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• pp.215-234
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• 2000

This study analyzed the aims, contents, and methods of early education in Sohak(小學) a textbook for childhood education in the choson Dynasty. The analysis was based on the 6th Korean National Kindergarten Curriculum(in process) and the theories of education in Sohak. Sohak consists of Establishing the Education Process(入敎), Clarifying the Cardinal Human Relationships(明倫), Reverencing for the Self(敬身), Examining Antiquity(稽古), Admirable Sayings(嘉言), and Exemplary Deeds(善行). The aim of education in Sohak was to preserve Sheng(性), i.e. human nature inherited from heaven. The contents of education in Sohak was divided into 6 groups: distinction by age and sex, health, basic life habits, private life, family life, and group life. Methods of education in Sohak was the consolidation of knowledge and conduct, education of self control, learning of exploration, learning of constructive models, learning of keep the stages and telling stories of the sayings of the saints.

• BMB Reports
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• v.49 no.9
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• pp.474-487
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• 2016

Itch is one of the most distressing sensations that substantially impair quality of life. It is a cardinal symptom of many skin diseases and is also caused by a variety of systemic disorders. Unfortunately, currently available itch medications are ineffective in many chronic itch conditions, and they often cause undesirable side effects. To develop novel therapeutic strategies, it is essential to identify primary afferent neurons that selectively respond to itch mediators as well as the central nervous system components that process the sensation of itch and initiate behavioral responses. This review summarizes recent progress in the study of itch, focusing on itch-selective receptors, signaling molecules, neuronal pathways from the primary sensory neurons to the brain, and potential decoding mechanisms based on which itch is distinguished from pain.

• Clinical and Experimental Pediatrics
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• v.50 no.2
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• pp.121-126
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• 2007

Fever has been recognized as a cardinal feature of disease since antiquity, but only recently has the pathophysiology of fever come to be understood. It became clear that the ultimate cause of fever is not a bacterial product (a so-called exogenous pyrogen) but a product of host inflammatory cells (i.e., an endogenous pyrogen). Many studies have demonstrated that mononuclear phagocytes are the principal source of endogenous pyrogen and that a variety of mononuclear cell products can mediate the febrile response. Cytokines are also important as mediators of the acute-phase response to infection and inflammation.

• Korean Journal Plant Pathology
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• v.14 no.6
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• pp.735-737
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• 1998

A severely wilting of strawberry caused by a Phytophthora sp. has occurred houses after planting in vinyl-houses field at Ssanglim and Anlim areas Kyungbuk in Korea from October in 1997. Phytophthora sp. isolated from diseased tissues of the crown of strawberry. Browning rot of inner crown and root resulted in wilt and eventual death of the plant. The causal fungus was identified as Phytophthora cactorum. Sporangia were ovoid, conspicuously papillate, caducous and measured 30.0~56.6$\times$23.8~35.2 (av. 39.3~29.9) ${\mu}{\textrm}{m}$. Sexuality of the fungus was homothallic. Oogonia were sperical and 23.3~32.3 (av. 29.0) ${\mu}{\textrm}{m}$ in size. Most ahteridia were paragynous and measured av. 10.2~12.2 ${\mu}{\textrm}{m}$. Cardinal temperature for growth at minimum, optium, maximum were recorded at 7, 20~25, and 32$^{\circ}C$, respectively. The fungus show strong pathogenicity to strawberry. This is the first report of strawberry caused by Phytophthora cactorum in Korea.

• Journal of Chest Surgery
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• v.16 no.4
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• pp.533-538
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• 1983

The author made a clinical study of IIO cases of empyema thoracis who were diagnosed and treated at department of chest surgery, chosun university hospital, during the period of December 1979 through June 1983. 1. In age and sex distribution, 45 cases [41%] was under the age of 15 years, 65 cases [59%] was above the age of 15 years. The ratio of male to female was 2.6:1. 2. The predisposing factors were pneumonia 45 cases [41%] and pulmonary tuberculosis 40 cases [36.5%]. 3. The cardinal symptoms were dyspnea, chest pain, fever, cough in order. 4. Etiologic organisms were confirmed in 69% which requested in 87 cases. Staphylococcal infection were 19 cases, Streptococcal infection were 13 cases, pneumococcal infection were 11 cases. 5. In treatment of empyema, thoracentesis 4 cases, closed thoracotomy 50 cases, open drainage 29 cases, decortication 14 cases and thoracoplasty 13 cases. In children, only thoracentesis and closed thoracotomy was favorable result in treatment. 6. 103 cases were discharged with recovery and improvement but 7 cases were early discharged by their economic or personal condition without improved.

• The Mathematical Education
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• v.3 no.10
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• pp.7-20
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• 1965

One of the prerequisites for the improvement of the teaching of mathematics in our country is an improved curriculum-one which takes account of the increasing use of mathematics in science and technology and in other areas of knowledge and at the same time one which reflects recent advances in mathematics itself. In the new curriculum of mathematics, we have found the problems to teach the concept of sets at secondary level. The idea of a set is the most fundamental one in mathematics. So, this thesis contains the studies of the systematic analysis of sets in dealing with the traditional textbook. The scope of the work is limited to the fundamental ideas, and so it merely touches on the topics of the Concpets, Operations, Cardinal Numbers, Application of Logic, one-to-one Correspondence, Probability and so on. It provides only the essentials, definitions, proofs and some example which are already known and understood in their traditional context. It also presents at the appropriate stages the concepts required (illustrated by examples) in a much clearer fashion than classical teaching does. To compete a study of the sets covered in the textbook of each year, greater detail is needed at the appropriate level.

• The Korean Journal of Pain
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• v.12 no.1
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• pp.157-161
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• 1999

We report a patient with spontaneous intracranial hypotension. In addition to the cardinal feature of a postural headache and a low CSF pressure, the patient also had subdural hematoma demonstrated by brain MRI. Radionuclide cisternography revealed a CSF leakage in the intracranium. CSF leakage from spinal meningeal defects may be the most common cause of this syndrome. The headache is a consequence of the low CSF pressure producing displacement of pain-sensitive structures. Methods of treatment are identical to those for post-dural puncture headaches. We experienced a patient with spontaneous intracranial hypotension developed in the intracranium who was successfully managed with a cervical blood patch.

• Journal for History of Mathematics
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• v.30 no.5
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• pp.289-304
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• 2017

The interdisciplinary study explores the discussion of actual infinity between Georg Cantor and Roman Catholic Church. Regarding the actual infinity, we first trace the theological background of Cantor by interpreting his correspondence and major works including ${\ddot{U}}ber$ die verschiedenen Standpunkte in bezug auf das aktuelle Unendliche(1885) and Mitteilungen zur Lehre vom Transfiniten (1887), and then investigate his argumentation for two points at issue: (1) pantheism and (2) inconsistency of the necessity with freedom of God. In terms of mathematics and theology, Cantor defined the actual infinity(aphorismenon) as characterized by (1) the transfinite infinity(Transfinitum) and (2) the absolute infinity(Absolutum). Transfinitum is conceptualized here in mathematical terms as a multipliable actual infinity, whereas Absolutum is not as a multipliable actual infinity. The results imply that Cantor's own concept of Transfinitum and Absolutum is adequate for Roman Catholic theology as well as mathematics including the reflection principle.