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Fever  

Lee, Taek Jin (Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital)
Kim, Dong Soo (Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital)
Publication Information
Clinical and Experimental Pediatrics / v.50, no.2, 2007 , pp. 121-126 More about this Journal
Abstract
Fever has been recognized as a cardinal feature of disease since antiquity, but only recently has the pathophysiology of fever come to be understood. It became clear that the ultimate cause of fever is not a bacterial product (a so-called exogenous pyrogen) but a product of host inflammatory cells (i.e., an endogenous pyrogen). Many studies have demonstrated that mononuclear phagocytes are the principal source of endogenous pyrogen and that a variety of mononuclear cell products can mediate the febrile response. Cytokines are also important as mediators of the acute-phase response to infection and inflammation.
Keywords
Fever;
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