• Archives of Pharmacal Research
• /
• 제26권5호
• /
• pp.426-431
• /
• 2003

This study was carried out to investigate the addition of water-soluble isoflavone into milk by means of microencapsulation technique. The yield of microencapsulation, sensory attributes, and capsule stability of water-soluble isoflavone microcapsules in milk were measured. Coating materials used was polyglycerol monostearate (PGMS), and core material was water-soluble isoflavone. The encapsulation yield of water-soluble isoflavone with PGMS was 67.2% when the ratio of coating material to core material was 15 : 1. The rate of water-soluble isoflavone release from capsules was 18, 19, and 25% when stored at 4,20, and $30^{\circ}C$ for 12 days in milk, respectively. In sensory evaluation, beany flavor and color of microencapsuled water-soluble isoflavone added milk were significantly different from uncapsuled water-soluble isoflavone added milk, however, bitterness was not significantly different. In vitro study, micro-capsules of water-soluble isoflavone in simulated gastric fluid with the range of 3 to 6 pHs were released 3.0∼15.0%, however, the capsules in simulated intestinal fluid with pH 7 were released 95.7% for 40 min incubation time. In conclusion, this study provided that PGMS as coating materials was suitable for the microencapsulation of water-soluble isoflavone, and the capsule containing milk was almost not affected with sensory attribute.

• 한국작물학회지
• /
• 제51권4호
• /
• pp.269-273
• /
• 2006

Multiple linear regression analysis was conducted to interpretate the relationship between sesame grain yield and its components under early sowing cropping condition. The t test showed that stem length, number of capsules per plant, 1000 seeds weight and seed weight per plant gave significant contribution to sesame grain yield, therefore those variables were assumed to mostly influenced components to grain yield of sesame. In the stepwise regression analysis, the predicted equation for sesame grain yield per square meter (Y) was Y = -7.900 + 0.150X1 + 0.461X5 + 15.553X6 + 8.543X7. Meanwhile, F value showed that stem length, number of capsules per plant and seed weight per plant gave significant contribution to sesame grain yield, while 1000 seeds weight did not significantly show. Based on the results, it is reasonable to assume that high yield. potential of sesame under early sowing cropping condition would be obtained by selecting breeding lines with long stem length, number of capsules per plant, and seed weight per plant, which was different result at the late sowing cropping condition in which days to flowering and maturity were assumed to be more affected factors to the sesame grain yield.

• 한국수산과학회지
• /
• 제36권6호
• /
• pp.625-631
• /
• 2003

The aim of the present study was to investigate the ecological relationship between female body size (=shell length) and fecundity in a Korean population of protandric hermaphrodite, Crepidula onyx Sowerby, using 6 reproductive variables (the number of capsules per brood, capsule size, the number of embryos per capsule, total number of embryos per brood, egg size, and larval size). The investigation was based on 32 females, 107 egg capsules, 263 eggs, and 250 veliger larvae sampled in January 2000, from Yangpo, the southeastern coast of Korea. All foregoing reproductive variables, except larval size, were significantly correlated with the female body size (p<0.001$\~0.01$). There was a significant increase both in the number of capsules per brood and the number of embryos per capsule with female body size (p<0.001). Consequently, the fecundity of the female C. onyx increased with female body size to over 14.65 mm (the minimum size of egg brooding in the present study). This investigation, therefore, provides additional evidence that female fecundity of protandric hermaphrodites is positively correlated with female body size.

• 전자공학회논문지B
• /
• 제32B권11호
• /
• pp.1445-1454
• /
• 1995

In this study, we have developed a prototype of the automatic defects detection system for capsule inspection using the computer vision techniques. The subjects for inspection are empty hard capsules of various sizes which are made of gelatine. To inspect both sides of a capsule, 2-stage recognition is performed. Features we have used are various lengths of a capsule, area, linearity, symmetricity, head curvature and so on. Decision making is performed based on average value which is computed from 20 good capsules in training and permission bounds in factories. Most of time-consuming process for feature extraction is computed by hardware to meet the inspection speed of more than 20 capsules/sec. The main logic for control and arithmetic computation is implemented using EPLD for the sake of easy change of design and reduction in time for developement. As a result of experiment, defects on size or contour of binary images are detected over 95%. Because of dead zone in imaging system, detection ratio of defects on surface, such as bad joint, chip, speck, etc, is lower than the former case. In this case, detection ratio is 50-85%. Defects such as collet pinch and mashed cap/body seldom appear in binary image, and detection ratio is very low. So we have to process the gray-level image directly in partial region.

• Journal of Pharmaceutical Investigation
• /
• 제30권2호
• /
• pp.119-125
• /
• 2000

In an attempt to develop a non-aqueous liquid formulation of practically insoluble biphenyl dimethyl dicarboxylate (DDB), dissolution and permeation studies were performed. Various non-aqueous DDB solutions were formulated and filled into empty hard capsules. Dissolution rates of a new formulation were compared with those of commercially available DDB preparations using one and eight dose units. Dissolution rates after 2 hr of DDB tablets (DDB 25 mg), hard capsules (DDB 7.5 mg) and soft capsules (DDB 7.5 mg) on market and new formulation (DDB 7.5 mg) were 6.3, 15.0, 84.5 and 98.0%, respectively. Higher doses (8 units) resulted in a supersaturation within one hr of dissolution, and dissolved amounts were reduced markedly. Due to the saturation and precipitation, a directly proportional dose-dissolution relationship was not observed. The addition of copolyvidone and/or glycyrrhizic acid ammonium salt to DDB solution in polyethylene glycol 300 and 400 inhibited the formation of precipitates during dissolution and markedly enhanced the rabbit duodenal permeation of DDB. From the site-specific gastrointestinal permeation studies, it was found that permeation rates of DDB after mixing of non-aqueous DDB solutions with aqueous buffered solutions were faster in the order of $rectal\;<\;colonic\;{\risingdotseq}\;ileal\;{\risingdotseq}\;duodenal\;<\;jejunal\;<\;gastric$.

• International Journal of Air-Conditioning and Refrigeration
• /
• 제13권4호
• /
• pp.175-183
• /
• 2005

The present study has been conducted for manufacturing MPCM (microencapsulated phase change material) slurry with in-situ polymerization and proving their applicabilities for cooling system. The tetradecane as a core material of MPCM is coated with melamine. The produced capsules are observed by the optical microscope and SEM for superficial shapes and analysed their properties by DSC and particle size distribution by FA particle analyzer. It is found that narrow size distribution in 1 to $10{\mu}m$ is resulted in $5{\mu}m$ of average diameter and $9^{\circ}C$ melting temperature. The durability of MPCM capsules is tested with various types of pumps such as centrifugal, peristaltic, and mono. For the centrifugal and peristaltic pumps the breakage fraction of the capsules is resulted within $6\%$ during 10,000 cycles, while the mono is over $8\%$. The cooling system, which has adopted MPCM slurry as a medium for transporting cold thermal energy, is designed to investigate the performance of newly developed coolant. The discharging times of cold energy in circulating 10 and $20wt\%$ MPCM slurry are lasted to 105 and 285 minutes, respectively.

• 한국식품영양학회지
• /
• 제32권5호
• /
• pp.560-564
• /
• 2019

The purpose of this study was to analyze the effects of the pre-treatment method on the measurement of probiotic cell counts. The probiotic cell count was not significantly different in the pre-treatment method such as experimenters, diluted solution, medium, and homogenization duration. The mean value of probiotic cell count with capsule was $2.2{\times}10^{10}{\pm}9.5{\times}10^9CFU/g$. This probiotic cell count was converted into $2.8{\times}10^{10}{\pm}1.2{\times}10^{10}CFU/g$ based on the net weight. The mean value of probiotic cell count without capsules was $4.3{\times}10^{10}{\pm}1.8{\times}10^{10}CFU/g$. As a result of this comparison, probiotic cell count showed significant difference with and without capsules. Thus, it is suggested that the probiotic cell count is measured by removing the capsule in capsule probiotics.

• Journal of Microbiology and Biotechnology
• /
• 제30권12호
• /
• pp.1870-1875
• /
• 2020

Probiotics are often infused into functional foods or encapsulated in a supplement form to maintain a healthy balance between the gut microbiota and their host. Because there are milk-based functional foods such as yogurt and cheese on the market, it has been suggested that milk-based probiotics could be incorporated into skim milk proteins in a liquid capsule. Skim milk is mainly composed of casein and whey protein, which create a strong natural barrier and can be used to encapsulate probiotics. In this study, we compared the encapsulated probiotics prepared with milk-based concentrated cell mixtures using commercial probiotics. Probiotic capsules were emulsified with skim milk proteins using vegetable oil to form a double coating layer. The product was heat-stable when tested using a rheometer. The survival rate of the milk-based probiotic cells in the lower gastric environment with bile was significantly higher than commercial probiotics. Thus, milk-encapsulated probiotics exhibited greater efficacy in the host than other types of probiotics, suggesting that the former could be more viable with a longer shelf life under harsh conditions than other form of probiotics. Our findings suggested that, compared with other types of probiotics, milk-based probiotics may be a better choice for producers and consumers.

• 한국건축시공학회:학술대회논문집
• /
• 한국건축시공학회 2022년도 봄 학술논문 발표대회
• /
• pp.245-246
• /
• 2022

Recently, research on the self-healing of concrete using bacteria has been actively conducted. The self-healing method using bacteria has a low self-healing rate and the surrounding environment of the fracture site is very important. A previous study to solve this problem involves the manufacture of capsules using 3D printing. Fracture position control was an important topic in 3D printing-based capsules. In this study, to compensate for the shortcomings of existing studies, a capsule capable of selective destruction location control was produced using PDMS-based molds that are not restricted by the environment. Resin capsules were prepared for each part using several molds and a bonding surface was arranged. In order to verify this on the bonding surface, fracture strength and wave unit values were analyzed through a three-way compression experiment. It can be seen that as the curing time increases, the deviation between samples decreases. In addition, through experiments, it was confirmed that the junction surface and wave unit values coincide in all three directions. It can be used for self-healing research using various solutions.

• Journal of Pharmaceutical Investigation
• /
• 제39권3호
• /
• pp.207-216
• /
• 2009

Fluconazole is used as an orally administrated antifungal drug for the treatment of tinea corporis, candidiasis including skin mycotic pneumonia infections. The dosage of fluconazole varies with indication ranging from 50 mg/day to 400 mg/day. The fluconazole capsule 50 mg (3 capsules daily) is already available in Korean market. To improve the patient compliance, a fluconazole tablet 150 mg (once a day administration) was developed recently. The purpose of this study was to evaluate the bioequivalence of three doses of fluconazole capsule 50 mg (Diflucan 50 mg, Pfizer Korea Inc., as a reference drug) and a single dose of fluconazole tablet 150 mg (Plunazol 150 mg, Daewoong Pharm. Co., Korea) according to the guidelines of the Korea Food and Drug Administration (KFDA). The bioequivalence for three capsules of Diflucan 50 mg and a single tablet of Plunazol 150 mg was investigated in twenty-four healthy male volunteers under a randomized 2${\times}$2 crossover trial design. The average age of twenty-four volunteers was 24.78${\pm}$3.27 year-old, average height was 175.56${\pm}$5.45 cm and average weight was 67.24${\pm}$6.86 kg. After three capsules of Diflucan 50 mg or a single tablet of Plunazol 150 mg were orally administered, blood was taken at predetermined time intervals and the plasma concentrations of fluconazole in plasma were determined using LC-MS-MS. The 90% confidence intervals for the main parameters of statistical results after logarithmic transformation were AUCt 0.9272-1.0084 and Cmax 0.8423-0.9544 respectively, which are in the range of log 0.8 to log 1.25 and the statistical results of additional parameters (AUClast, t1/2 and MRT) were also in the 90% confidence interval that is in the range of log 0.8 to log 1.25. Therefore, the results of this study confirm the bioequivalence of three capsules of Diflucan 50 mg to one tablet of Plunazol 150 mg.