• Journal of Life Science
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• v.24 no.7
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• pp.798-803
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• 2014

Cathepsin D (CtsD), an aspartyl peptidase, is involved in apoptosis, resulting in the release of cytochrome C from mitochondria in cells. Here, we investigated microRNA regulation of CtsD expression in 3T3-L1 cells First, we observed the expression of CtsD in cells in response to doxorubicin (Dox). As expected, the level of CtsD mRNA was increased in 3T3-L1 cells exposed to Dox in a dose-dependent manner. Cellular viability of ectopically expressed CtsD cells was also decreased. Next, we used the miRanda program to search for particular microRNA targeting CtsD. MiR-145 was selected as a putative controller for CtsD because miR-145 had a high mirSVR score. In a reporter assay, the luciferase activity of cells containing the CtsD 3'-UTR region was decreased in cells transfected with miR-145 mimic compared to that of a control. The level of CtsD expression was down-regulated in preadipocytes ectopically expressing miR-145 and up-regulated by an miR-145 inhibitor. Cells also suppressed miR-145 expression when exposed to Dox. The miR-145 inhibitor reduced the cellular viability of 3T3-L1 cells. Taken together, these data suggest that miR-145 regulates CtsD-mediated cell death in adipocytes. These findings may have valuable implications concerning the molecular mechanism of CtsD-mediated cell death in obesity, suggesting that CtaD could be a useful therapeutic tool for the prevention and treatment of obesity by regulating fat cell numbers.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.10
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• pp.1537-1544
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• 2022

When designing chip, it considers design specification, timing problem, and clock synchronization on place & route (P&R) process. P&R process is complicated because of considering various factors. Chip uses clock tree synthesis (CTS) to reduce clock path delay. The purpose of this study is to examine shallow-CTS algorithm for checking clock tree synthesizable. Using open source Parser-Verilog, register transfer level (RTL) synthesizable Verilog file is parsed and it uses Pre-CTS and Post-CTS process that is included shallow-CTS. Based on longest clock path in the Pre-CTS and Post-CTS stages, the standard deviation before and after buffer insertion is compared and analyzed for the accuracy of CTS. In this paper, It is expected that the cost and time problem could be reduced by providing a pre-clock tree synthesis verification method at the RTL level without confirming the CTS result using the time-consuming licensed EDA tool.

• Annals of Clinical Neurophysiology
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• v.13 no.1
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• pp.31-37
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• 2011

Background: Carpal tunnel syndrome (CTS) and tarsal tunnel syndrome (TTS) are thought to share a similar pathophysiology, compression of the median and plantar nerve by the carpal tunnel and flexor retinaculum. A few reports introduced the relationship between idiopathic CTS and TTS without definite evidence of coexistence. The current study was designed to analyze the electrophysiologic characteristics of combined idiopathic CTS and TTS by comparing with each idiopathic CTS or TTS. Methods: We retrospectively collected patients with combined idiopathic CTS and TTS (CTS-TTS group) from June 2001 to February 2009. Patients with each idiopathic CTS or TTS were collected as controls. Electrophysiologic data of median and plantar nerves were compared between CTS-TTS group and controls. Results: CTS-TTS group was composed of 31 patients. Control group of each CTS or TTS were 50 CTS and 49 TTS patients. In comparison of median nerve conduction study between CTS-TTS group and CTS control group, decreased compound muscle action potential amplitude (p<0.001), decreased median sensory nerve action potential amplitude (p<0.001) and sensory nerve conduction velocity at finger stimulation (p=0.013) were prominent in CTS-TTS group. Decreased medial plantar sensory nerve action potential amplitude (p=0.034) was indicated when CTS-TTS groups and TTS control group were compared. Conclusions: If the electrophysiology study of patients with CTS or TTS was suggestive of severe degree of nerve injury, concerns about the possibility of combined CTS and TTS would be helpful.

• The Journal of the Korea Contents Association
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• v.13 no.11
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• pp.288-296
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• 2013

The purpose of this study were carpal tunnel syndrome in stroke patients according to the degree of spasticity in the median nerve cross-sectional area, nerve conduction velocity, and to evaluate differences in upper extremity function. The subjects of this study was in adult patients with stroke 42 patients from 21 patients CTS group and 21 patients Non-CTS group were selected. Measurement of median nerve-cross sectional area, nerve conduction velocity, GST, FMAS, CTS-FSS was measured. The study results were each group between the unaffected side and the affected side CTS and Non-CTS group in each grade between groups unaffected side(p<.001), and affected side(p<.001) median nerve-cross sectional area, median motor and sensory nerve onset latency, there was a statistically significant difference. CTS and Non-CTS group between groups in each grade GST(p<.05), FMAS(p<.05), CTS-FSS(p<.001), there was a statistically significant difference. In this study, the carpal tunnel pathokinesiology ever presented by the contents of upper extremity functional training in stroke patients is one of the information that you need to consider when presented.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.4
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• pp.643-653
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• 2012

In this paper, we consider a clock tree synthesis technique (CTS) based on buffer insertion method in the multiple clock domain. We propose some detail techniques about the preparing items and the practical method for implementing CTS. We also propose a post processing after CTS implementation. Until now, the buffer insertion-based CTS technique has been widely used, and this paper discusses especially it's practical technique to be applied in the commercial fields to develop ASIC and SoC. CTS is very dependent on the used tool. We use Astro of Synopsys and propose the empirical and theoretical information of the detail techniques for implementing CTS using this tool. We expect that the proposed technique becomes to be good guidelines to backend designers.

• Proceedings of the KIEE Conference
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• 2004.11c
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• pp.391-393
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• 2004

For performance and stability of a synchronized system, we need an efficient Clock Tree Synthesis(CTS) methodology to design clock distribution networks. In a system-on-a-chip(SOC) design environment, CTS effectively distributes clock signals from clock sources to synchronized points on layout design. In this paper, we suggest the pre-layout analysis of the clock network including gated clock, multiple clock, and test mode CTS optimization. This analysis can help to avoid design failure with potential CTS problems from logic designers and supply layout constraints so as to get an optimal clock distribution network. Our new design flow including pre-layout CTS analysis and structural violation checking also contributes to reduce design time significantly.

• Journal of the Korean Home Economics Association
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• v.36 no.2
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• pp.77-90
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• 1998

The purpose of this study is to examine the utility of the modified form of CTS2(the revised Conflict Tactic Scales) for use of children on university students fo Korea. To attain this purpose, we modified Straus's CTS2(the revised Conflict Tactic Scale) for use of children. It consist of negotiation subscale, physical assault subscale, psychological aggression subscale and injury subscale without sexual coercion subscale. The subjects consisted of 288 students from 19 to 24 of age. As results of analysis(correlation, factor analysis, Cronbach' α), reliability of subscales of CTS2 range from .83 to .98 and total reliability of CTS2 is .93 And there are evidences of construct validity(the convergent validity and discriminant validity) fo CTS2. we examine the prevalence of wife abuse behavior in our subjects' parents. There are the high prevalence of psychological aggression(75.7%) and physical assault(43.4%)

• IE interfaces
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• v.16 no.2
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• pp.195-200
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• 2003

In this paper, the selective use of RTS and CTS frames is considered to analyze the capacity of IEEE 802.11 WLAN (Wireless Local Area Network). The RTS and CTS frames are used to transmit the data frames longer than dot11RTSThreshold according to IEEE 802.11 specification. The analysis of the optimal RTS-CTS threshold is derived to maximize the capacity of IEEE 802.11 WLAN. And, numerical examples are also presented for IEEE 802.11 a and b WLANs.

• Korean Journal of Materials Research
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• v.30 no.2
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• pp.68-73
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• 2020

Due to its favorable optical properties, Cu₂SnS₃ (CTS) is a promising material for thin film solar cells. Doping, which modifies the absorber properties, is one way to improve the conversion efficiency of CTS solar cells. In this work, CTS solar cells with selenium doping were fabricated on a flexible substrate using sputtering method and the effect of doping on the properties of CTS solar cells was investigated. In XRD analysis, a shift in the CTS peaks can be observed due to the doped selenium. XRF analysis confirmed the different ratios of Cu/Sn and (S+Se)/(Cu+Sn) depending on the amount of selenium doping. Selenium doping can help to lower the chemical potential of sulfur. This effectively reduces the point defects of CTS thin films. Overall improved electrical properties were observed in the CTS solar cell with a small amount of selenium doping, and a notable conversion efficiency of 1.02 % was achieved in the CTS solar cell doped with 1 at% of selenium.

• Journal of the Korean Operations Research and Management Science Society
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• v.29 no.2
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• pp.97-116
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• 2004

Recently, e portion of on-line stock brokerage has been rapidly increased to be more than 50%, on the basis of contracted money. The usage of wCTS(Web Based Cyber Trading Systems) has now got into the steady state over the initial diffusion stage, which means wCTS has got more-than-half customer base in on-line service. Therefore, brokerage service providers have their competitive strategic focus on customer retention through the enhancement of customer loyalty. This study provides framework and survey results on explanation of wCTS user's loyalty, what and how factors affect wCTS user's loyalty. We adopt the results of early studies on information technology acceptance and diffusion such as TAM(Technology Acceptance Model) and IDT(Innovation Diffusion Theory). We also referred loyalty theory of marketing area and studios on CTS usage. We categorized explanation factors as three groups characteristics of users, characteristics of system, social environment. And we assumed that these three factors could affect the loyalty through two parameters : customer satisfaction and trust to the system. This study firstly shows that the ease of use and usefulness, the major factors of TAM. can also be applied to the loyalty of wCTS with resulting that the usefulness is more important than the ease of use In wCTS. Secondly, it shows that the innovative and risk-sensitive user has the lower degree of loyalty. Thirdly, it shows that the satisfaction and trust impact the loyalty simultaneously, the trust particularly impacts more strongly than the loyalty, due to the characteristics of monetary transaction in wCTS. This study provides meaningful results to the other on-line EC service fields as a first empirical research regarding the loyalty to wCTS which is a typical on-line EC service.