• Proceedings of the Korean Society of Applied Pharmacology
• /
• 2003.11a
• /
• pp.87-87
• /
• 2003

Taurine (2-aminoethanesulfonic acid, $^{+}NH_3CH_2CH_2{SO_3}^{-}$) is endogenous $\beta$-amino acid which is essential in fetal nutrition and development and is present in abundant quantities in several tissues of fetus. In utero, taurine deficiency causes abnormal development and abnormal function of brain, retina, kidney and myocardium. Thus, transfer of taurine into fetus is important during embryonic development. Taurine transporter (TauT) has 12 hydrophobic membrane -spanning domains, which is typical of the $Na^{+}$- and $Cl^{-}$-dependent transporter gene family. Among the various biosynthetic enzymes of taurine, cysteine sulfinic acid decarboxylase (CSD) is the rate-limiting enzyme for biosynthesis of taurine. However, the enzyme activities of taurine biosynthesis are limited in early stage of embryonic development. To analyze the expression period of TauT and CSD during embryonic development, we have investigated the gene expression of TauT and CSD using reverse transcriptase polymerase chain reaction (RT-PCR) in mouse and chicken embryos. RT-PCR anaylsis revealed that both TauT and CSD mRNAs were already expressed at Day-4.5 in mouse embryo. In chicken whole embryo, TauT and CSD mRNAs began to appear on developing times of 48 hrs and 12 hrs, respectively. TauT mRNA was detected in the organs of heart, brain and eye of the day-3 chicken embryo. Our data show that TauT and CSD mRNAs were expressed in early stage of embryonic development.

• Journal of the Institute of Electronics Engineers of Korea TC
• /
• v.46 no.5
• /
• pp.95-103
• /
• 2009

An efficient symbol time synchronization scheme for IEEE 802.11n MIMO-OFDM based WLAN systems using cyclic shift diversity (CSD) preamble is proposed. CSD is used to prevent unintentional beamforming when the same preamble signal is transmitted through transmit antennas. However, it is difficult to find a proper starting-point of the OFDM symbol with the conventional algorithms because of time offset by multi-peaks which are result from cross-correlation of received CSD preamble with a known short training symbol. In addition, the performance of symbol time sync. is affected by AGC and packet detection position. In this paper, an optimal symbol time synch. algorithm which is composed of the boundary detection scheme between LTS and OFDM symbols, the verification scheme for enhancement of boundary detection accuracy, and the SNR-varying threshold estimation scheme is proposed. Simulation result show that the proposed algorithm has performance gains of 4.3dB in SNR compared to the conventional algorithms at the rate of 1% sync. failure probability for $2{\times}2$ MIMO-OFDM system and 18dB at 0.1% when maximum frequency offset exists. It also can be applied to $4{\times}4$ MIMO-OFDM system without any modification. Hence, it is very suitable for MIMO-OFDM WLAN systems using CSD preamble.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.27 no.6C
• /
• pp.632-639
• /
• 2002

To reduce the area and power consumption in constant coefficient multiplications, the constant coefficient can be encoded using canonic signed digit(CSD) representation. When the partial product terms are added depending on the nonzero bit(1 or -1) positions in the CSD-encoded multiplier, all sign bits are properly extended before the addition takes place. In this paper, to reduce the overhead due to sign extension, a new method is proposed based on the fact that carry propagation in the sign extension part can be controlled such that a desired input bit can be propagated as a carry. Also, a fixed-width multiplier design method suitable for CSD multiplication is proposed. As an application, 43-tap filbert transformer for SSB/BPSK-DS/CDMA is implemented. It is shown that, about 16∼28% adders can be saved by the proposed method compared with the conventional methods.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.36 no.6
• /
• pp.532-540
• /
• 2008

Recently there are growing interests in calculating aerodynamic characteristics of aircraft configurations with structural deformation using the FSI(Fluid-Structure Interaction) system in which CFD(Computational Fluid Dynamics) and CSD(Computational Structure Dynamics) modules are coupled. In this paper the FSI system comprised of CAD, CFD, CSD, VSI(Volume Spline Interpolation) and grid deformation modules was constructed in order to investigate aerodynamic characteristics of the deformed shape. In the process VSI and grid generation modules are developed to combine CSD and CFD routines and to regenerate the aerodynamic grids for the deformed shape, respectively. For the CFD and CSD analysis, commercial programs FLUENT and NASTRAN were used. As a test model, DLR-F4 wing configuration was chosen and its aerodynamic characteristics were calculated by applying the static FSI system. It was shown that lift and drag coefficients of the wing at mach number 0.75 are reduced to 20.26% and 18.5%, respectively, owing to the structural deformation.

• Molecules and Cells
• /
• v.27 no.4
• /
• pp.423-428
• /
• 2009

Superoxide dismutases (SODs) constitute the first line of cellular defense against oxidative stress in plants. SODs generally occur in three different forms with Cu/Zn, Fe, or Mn as prosthetic metals. We cloned the full-length cDNA of the Thellungiella halophila Cu/Zn-SOD gene ThCSD using degenerate RT-PCR and rapid amplification of cDNA ends (RACE). Sequence analysis indicated that the ThCSD gene (GenBank accession number EF405867) had an open reading frame of 456 bp. The deduced 152-amino acid polypeptide had a predicted molecular weight of 15.1 kDa, an estimated pI of 5.4, and a putative Cu/Zn-binding site. Recombinant ThCSD protein was expressed in Escherichia coli and assayed for SOD enzymatic activity in a native polyacrylamide gel. The SOD activity of ThCSD was inactivated by potassium cyanide and hydrogen peroxide but not by sodium azide, confirming that ThCSD is a Cu/Zn-SOD. Northern blotting demonstrated that ThCSD is expressed in roots, stems, and leaves. ThCSD mRNA levels increased by about 30-fold when plants were treated with sodium chloride (NaCl), abscisic acid (ABA), and indole-acetic acid (IAA) and by about 50-fold when treated with UVB light. These results indicate that ThCSD is involved in physiological pathways activated by a variety of environmental conditions.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.29 no.1C
• /
• pp.119-128
• /
• 2004

In this paper, a low-power 8-point DCT structure is proposed using add and shift operations. Proposed structure adopts 4 cycles for complete 8-point DCT in order to minimize size of hardware and to enable high-speed processing. In the structure, hardware for the first cycle can be shared in the next 3 cycles since all columns in the DCT coefficient matrix are common except sign. Conventional DCT structures implemented with only add and shift operation use CSD(Canonic Signed Digit) form coefficients to reduce the number of adders. To reduce the number of adders further, we propose a new structure using common sub-expression sharing techniques. With this techniques, the proposed 8-point DCT structure achieves 19.5% adder reduction comparison to the conventional structure using only CSD coefficient form.

• Journal of Broadcast Engineering
• /
• v.16 no.1
• /
• pp.174-177
• /
• 2011

In this paper, we investigate a method for designing FIR filters with CSD coefficients. Firstly, the H/W complexity of a CSD FIR filter is estimated in terms of number of gates. Using the estimated complexity, an optimal filter that can meet the required performance with minimal H/W complexity can be designed. Next, based on the MILP problem solver called BonsaiG, we present a filter design program. From the two design examples, it is demonstrated that an optimal filter can be obtained by comparing the complexity of the candidate filters in terms of the gate counts, whose differences are estimated to be about 400-600 gates.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 2006.04a
• /
• pp.200-207
• /
• 2006

A new formal standardization methodology of the structural design document information is proposed in this paper. The standardization process is divided into three steps: pre-process of the collected sample document (CSD), construction of the document structure, and definition of the occurrence of each element in the document. During the pre-process, the detail document contents in the CSD are indexed with templates defined in this study, and the indexed CSD is translated into XML Schema (XSD) formal Afterwards the degree of confidences of all elements between the temporary standard document (TSD) and the translated CSD are calculated by using the XML schema matching algorithm; the TSD is then updated. This second step is repeated until all of the CSD are compared. In the final step, the common elements and unbounded elements are extracted by determining the occurrence of the temporary document elements, and the standardized document schema is exported in the XSD format. The case study dealing with the structural calculation documents show that the ,proposed methodology can be effectively used to build a XML -based information model of structural design documents.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.44 no.9
• /
• pp.48-53
• /
• 2007

Some digital signal processing applications, such as FFT, request multiplications with a group(or, groups) of a few predetermined coefficients. In this paper, based on the modified CSD algorithm, an efficient multiplier design method for predetermined coefficient groups is proposed. In the multiplier design for sine-cosine generator used in direct digital frequency synthesizer(DDFS), and in the multiplier design used in 128 point $radix-2^4$ FFT, it is shown that the area, power and delay time can be reduced up to 34%.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.16 no.4 s.109
• /
• pp.355-365
• /
• 2006

The coupled time-integration method with a staggered algorithm based on computational structural dynamics (CSD), finite element method (FEM) and computational fluid dynamics (CFD) has been developed in order to demonstrate physical vibration phenomena due to dynamic aeroelastic excitations. Virtual flutter tests for the spanwise curved ing model have been effectively conducted using the present advanced computational method with high speed parallel processing technique. In addition, the present system can simultaneously give a recorded data file to generate virtual animation for the flutter safety test. The results for virtual flutter test are compared with the experimental data of wind tunnel test. It is shown from the results that the effect of spanwise curvature have a tendency to decrease the flutter dynamic pressure for the same flight condition.