• Communications of the Korean Mathematical Society
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• v.36 no.4
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• pp.817-827
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• 2021

In this paper, we prove that a diffeomorphism f on a normal almost contact 3-manifold M is a CRL-transformation if and only if M is an α-Sasakian manifold. Moreover, we show that a CR-loxodrome in an α-Sasakian 3-manifold is a pseudo-Hermitian magnetic curve with a strength $q={\tilde{r}}{\eta}({\gamma}^{\prime})=(r+{\alpha}-t){\eta}({\gamma}^{\prime})$ for constant 𝜂(𝛄'). A non-geodesic CR-loxodrome is a non-Legendre slant helix. Next, we prove that let M be an α-Sasakian 3-manifold such that (∇_YS)X = 0 for vector fields Y to be orthogonal to ξ, then the Ricci tensor 𝜌 satisfies 𝜌 = 2α²g. Moreover, using the CRL-transformation $\tilde{\nabla}^t$ we fine the pseudo-Hermitian curvature $\tilde{R}$, the pseudo-Ricci tensor $\tilde{\rho}$ and the torsion tensor field $\tilde{T}^t(\tilde{S}X,Y)$.

• The Korean Journal of Physiology and Pharmacology
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• v.9 no.2
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• pp.131-135
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• 2005

Potassium channels in human skin fibroblast have been studied as a possible site of Alzheimer disease pathogenesis. Fibroblasts in Alzheimer disease show alterations in signal transduction pathway such as changes in $Ca^{2+}$ homeostasis and/or $Ca^{2+}-activated$ kinases, phosphatidylinositol cascade, protein kinase C activity, cAMP levels and absence of specific $K^+$ channel. However, little is known so far about electrophysiological and pharmacological characteristics of large-conductance $Ca^{2+}$-activated $K^+$ ($BK_{Ca}$) channel in human fibroblast (CRL-1474). In the present study, we found Iberiotoxin- and TEA-sensitive outward rectifying oscillatory current with whole-cell recordings. Single channel analysis showed large conductance $K^{+}$ channels (106 pS of chord conductance at +40 mV in physiological $K^+$ gradient). The 106 pS channels were activated by membrane potential and $[Ca^{2+}]_i$, consistent with the known properties of $BK_{Ca}$ channels. $BK_{Ca}$ channels in CRL-1474 were positively regulated by adenylate cyclase activator ($10{\mu}M$ forskolin), 8-Br-cyclic AMP ($300{\mu}M$) or 8-Br-cyclic GMP ($300{\mu}M$). These results suggest that human skin fibroblasts (CR-1474) have typical $BK_{Ca}$ channel and this channel could be modulated by c-AMP and c-GMP. The electrophysiological characteristics of fibroblasts might be used as the diagnostic clues for Alzheimer disease.

• Molecules and Cells
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• v.43 no.11
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• pp.935-944
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• 2020

Aryl hydrocarbon receptor nuclear translocator (ARNT) plays an essential role in maintaining cellular homeostasis in response to environmental stress. Under conditions of hypoxia or xenobiotic exposure, ARNT regulates the subset of genes involved in adaptive responses, by forming heterodimers with hypoxia-inducible transcription factors (HIF1α and HIF2α) or aryl hydrocarbon receptor (AhR). Here, we have shown that ARNT interacts with DDB1 and CUL4-associated factor 15 (DCAF15), and the aryl sulfonamides, indisulam and E7820, induce its proteasomal degradation through Cullin-RING finger ligase 4 containing DCAF15 (CRL4^DCAF15) E3 ligase. Moreover, the two known neo-substrates of aryl sulfonamide, RNA-binding motif protein 39 (RBM39) and RNA-binding motif protein 23 (RBM23), are not required for ARNT degradation. In line with this finding, aryl sulfonamides inhibited the transcriptional activities of HIFs and AhR associated with ARNT. Our results collectively support novel regulatory roles of aryl sulfonamides in both hypoxic and xenobiotic responses.

• Journal of Animal Reproduction and Biotechnology
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• v.35 no.2
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• pp.177-182
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• 2020

The present study aimed to investigate the conceptus-related changes during early pregnancy in the Black Bengal breed of goat. A total of 22 gravid genitalia of the Black Bengal goats were collected from local slaughterhouses. The crown-rump lengths (CRL) of the conceptuses were determined to estimate the gestational age (GA). The length and diameter of uterine horn and amniotic sac were measured, and volume of amniotic and allantoic fluid formed by individual conceptus were recorded. The results reveal that the CRL is positively correlated with GA of the conceptus (R² = 0.89, p < 0.05); however, CRL was not influenced by number of conceptus. Both the left and the right uterine horn gradually increased in size with the advancement of pregnancy irrespective of conceptus number present in the horn. The size of the amniotic sac of conceptus gradually increased with the conceptus age but maintained spherical shape from 5 to 7 weeks of pregnancy. The amniotic fluid formed by individual conceptus rapidly increased from 5 weeks (3.4 ± 0.3 mL) to 7 weeks (21.0 ± 2.0 mL) and 9 weeks (111.5 ± 4.0 mL). The volume of allantoic fluid formed by individual conceptus was steadily increased until 7 weeks (60.0 ± 5.0 mL) and began to decline slowly thereafter (50.0 ± 5.0 mL at 9 weeks). Notably, there was no effect of conceptus number per pregnancy on individual amniotic and allantoic fluid volume. The cotyledons have first appeared on the allanto-chorionic surface from 4 to 5 weeks of pregnancy. The closed eye, nostril and hooves of the conceptus became visible at 7 weeks of pregnancy. The present study has shown the basic information on conceptus-related developmental changes during early pregnancy up to 9 weeks in Black Bengal goat.

• Proceedings of the Optical Society of Korea Conference
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• 2008.07a
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• pp.71-72
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• 2008

We review and report our analytical results in the technology front of optical industry in Japan as optical $recording^{1)}$, semiconductor $stepper^{2)}$, fiber communication, digital $camera^{4)}$ and $OCT^{5)}$ which are contributing to the improvement of people's higher quality of life and to the industrial economical growth from the aspects of the University, Industry and Government collaborations including international comparison to enhance the progress of sustainable global photonic innovation eco-systems. In the following part, some statistics of remarkable economical growth in east Asia and the global warming issue will be mentioned.

• Bulletin of the Korean Chemical Society
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• v.22 no.12
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• pp.1361-1365
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• 2001

Recombinant immunotoxins are hybrid cytotoxic proteins designed to selectively kill cancer cells. A divalent immunotoxins, [B3(FabH1)-PE38]2, was constructed by recombining Fab domain of B3 antibody as a cell-targeting domain and Pseudo monas exotoxin A (PE) as a cytotoxic domain. Monoclonal antibody, B3, is the murine antibody (IgG1k) directed against Lewis Y-related carbohydrate antigens, which are abundant on the surface of many carcinomas. Fab fragment of this antibody was used in this study with the modified hinge sequence where last two cysteines out of three were mutated to serine. PE is a 66 kDa bacterial toxin that kills eukaryotic cells by inhibiting protein synthesis with ADP ribosylation of ribosomal elongation factor 2 (EF2). Fc region of B3 antibody was substituted with the truncated form of PE (38 kDa, PE38) on DNA level. [B3(FabH1)-PE38]2 was formed by disulfide bond between cysteines in the modified hinge region of B3(FabH1)-PE38. Each polypeptide for recombinant immunotoxins was overexpressed in Escherichia coli and collected as inclusion bodies. Each inclusion body was solubilized and refolded, and cytotoxic effects were measured. Divalent immunotoxins, [B3(FabH1)-PE38]2, had ID50 values of about 10 ng/mL on A431 cell lines and about 4 ng/mL on CRL1739 cell lines. Control immunotoxins, B3(scFv)-PE40, had ID50 values of about 28 ng/mL on A431 cell lines and about 41 ng/mL on CRL1739 cell lines. Divalent immunotoxins, [B3(FabH1)-PE38]2, had higher cytotoxic effects than B3(scFv)-PE40 control immunotoxins.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.10 no.4
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• pp.113-127
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• 2000

It is an essential prior condition that information security of all sorts of administration-information on line for E-Government. Every country including United Slates has been constructing and managing Government PKI(Public Key Infrastructure) of information security of one\`s own authentication, confidentiality, integrity, non-repudiation in administration environment on line for information security base construction of E-Government. In this paper, we present an efficient GPKI(Government PKI) implementation suitable for Korea actual circumstance through study and analysis of superior case such as United State.

• Smart Media Journal
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• v.2 no.4
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• pp.9-19
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• 2013

This paper gives a review on three illumination issues of face tracking on smart phones: dark scenes, sudden lighting change and backlit effect. First, we propose a fast and robust face tracking method utilizing continuous adaptive mean shift algorithm (CAMSHIFT) and CbCr skin locus. Initially, the skin locus obtained from training video data. After that, a modified CAMSHIFT version based on the skin locus is accordingly provided. Second, we suggest an enhancement method to increase the chance of detecting faces, an important initialization step for face tracking, under dark illumination. The proposed method works comparably with traditional CAMSHIFT or particle filter, and outperforms these methods when dealing with our public video data with the three illumination issues mentioned above.

• Bulletin of the Korean Chemical Society
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• v.24 no.9
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• pp.1269-1275
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• 2003

The quaternary carbon-containing alcohols (1-6) were resolved enantioselectively by various lipases such as PFL (Pseudomonas fluorescens lipase), LAK (Pseudomonas fluorescens lipase), CRL (Candida rugosa lipase) and PCL (Pseudomonas cepacia lipase). The enzymatic resolution of racemic alcohol $({\pm})-2$ gave the excellent enantioselectivity in favor of (S)-2d in 99% ee, while those of the racemic alcohols (1, 3, 4, 5 and 6) gave the resolved alcohols with moderate to good enantioselectivity. Also, their absolute configurations were determined by chemical transformation to the known compounds.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.7 no.5
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• pp.879-886
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• 2006

In this paper, we proposed an advanced authentication structure for reducing the certificate acquisition time which is one of the factors that should be improved in a conventional wireless PKI. A conventional key exchange method simply performs the key exchange setup step based on discrete algebraic subjects. But the mutual-authentication procedure of wireless PKI for reducing authentication time uses an elliptical curve for a key exchange setup step. We simulated and compared the authentication structure proposed by Sufatrio, K. Lam[4] and the our authentication structure in terms of the authentication time. Simulation results show that the proposed method reduces the authentication time comparing to the conventional wireless PKI authentication method.