• Journal of Gastric Cancer
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• 제6권4호
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• pp.221-226
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• 2006

목적: 암 환자의 골수에서 발견되는 cytokeratin 양성세포와 암의 재발과의 상관관계에 대해서는 알려진 바가 많지 않다. 이에 위암환자의 골수에서 발견되는 cytokeratin 양성세포가 위암 환자의 재발과 생존율을 예측할 수 있는지 알아보고자 하였다. 대상 및 방법: 1998년 6월부터 2000년 7월까지 경북대학교병원 외과에서 원발성 위암으로 수술받은 환자 419명을 대상으로 하였다. 수술 직전 장골능선에서 골수를 흡인하여 단핵구를 분리하고 항 cytokeratin 항체를 이용하여 면역세포화학적 염색을 하였다. 결과: Cytokeratin 양성세포는 219예(52.4%)에서 발견되었고, 위암의 침윤깊이(P=0.021), 병기(P=0.026)에 따라서 통계학적으로 유의한 차이가 있었으나, 암의 위치, 육안형, 림프절전이, 원격전이, 분화도에 따라서는 유의한 차이가 없었다. 골수의 cytokeratin 양성세포 유무에 따른 5년 생존율은 유의한 차이가 없었고(P=0.248), 재발여부, 재발부위도 유의한 차이가 없었다. 결론: 위암 환자의 골수에서 cytokeratin 양성세포 유무는 예후인자로 사용되기 어렵고 재발양상을 예측하기도 어렵다.

• 해양환경안전학회지
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• 제25권7호
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• pp.920-926
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• 2019

본 연구에서는 해양수산부 연안침식 실태조사에서 운영 중인 해운대 해수욕장 비디오 모니터링 시스템을 이용하여 연안정비 사업 실시 이후의 백사장 면적변화를 분석하였다. 해운대 해수욕장은 연안정비사업을 통한 대규모 양빈이후 계절변동 특성과 함께 해빈 안정화 과정을 거치면서 잘 유지되었으나, 최근 2년간 복수의 태풍 내습에 의하여 해운대 해수욕장의 계절변동특성 및 해빈안정화 양상은 균형을 상실하였으며, 급격한 침식이 발생하였다. 특히, 2018년 태풍 솔릭, 콩레이에 의해 침식된 백사장은 계절변동에 의한 겨울철 해빈면적을 회복하지 못하였으며, 2019년에 내습한 다수의 태풍들로 인하여 해빈면적이 전년 대비 9.5 %(12,607 ㎡) 감소하였다. 해운대 해빈 전면에서 관측된 파랑자료와 해빈면적자료를 분석한 결과, 계절에 따른 입사파향에 따라 백사장의 서측, 중앙부, 동측의 침퇴적 경향이 뚜렷이 나타났다. 향후에는 계절변동특성의 둔화와 지속적인 침식경향이 나타나는 원인을 파악하기 위해 잠제 시설물의 마루높이, 기능유지 여부 및 잠제 외부로의 모래유출추적 등 보다 정밀한 모니터링이 필요하다.

• 대한치과보철학회지
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• 제32권4호
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• pp.484-514
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• 1994

Cantilever bridge is widely used by mny clinicians, but its worst mechanical character, so called Class I lever system, makes dentists hesitate to restore the missing tooth with it. Therefore it is important to study stress of the cantilever bridge. In this study, two models of cantilever bridges that restores the missing mandibular second molar with two abutment teeth were constructed. One model was a type of cantilever bridge supported by a normal alveolar bone, the other one was supported by an alveolar bone resorbed to its 1/3 of root length. Maximum bite force(550N) and funtional maximum bite force(300N) were vertically applied to the distal end of the pontic, distal 1/3, and distal half of the pontic. And each force was also applied to centric occlusal contacts as a distributed force. Total 16 loading cases were compared and analyzed with 3-dimensional finite element method. The results were as follows: 1. The stress was concentrated on the joint of the pontic and the retainer, grooves, and distal cervical margin of the posterior retainer. 2. In case of maximum bite force(550N) at the end of the pontic, the risk of fracture at the joint of the pontic and the retainer was high. 3. In case of distributed force in centric occlusion and functional maximum bite force(300N), the stresses were less than the yield strength of the type VI gold for any loading cases. 4. In case of alveolar bone resorption, the occlusal force to the cantilever pontic caused more stress on the root apex and less stress on the alveolar crest region of the distal surface of the posterior abutment. 5. In case of alveolar bone resorption, the displacement was larger than that of normal alveolar bone in all loading cases.

• Applied Microscopy
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• 제28권2호
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• pp.139-158
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• 1998

The development of the superior cervical ganglion was studied by electron microscopic method in human fetuses ranging from 40 mm to 260 mm of crown-rump length (10 to 30 weeks of gestational age). At 40 mm fetus, the superior cervical ganglion was composed of clusters of undifferentiated cell, primitive neuroblast, primitive supporting cell, and unmyelinated fibers. At 70mm fetus, the neuroblasts and their processes were ensheated by the bodies or processes of satellite cells. The cytoplasm of the neuroblast contained rough endoplasmic reticulum, mitochondria, Golgi complex, Nissl bodies and dense-cored vesicles. As the neuroblasts grew and differentiated dense-cored vesicles moved away from perikaryal cytoplasm into developing processes. Synaptic contacts between the cholinergic axon and dendrites of postganglionic neuron and a few axosomatic synapses were first observed at 70 mm fetus. At 90 mm fetus the superior cervical ganglion consisted of neuroblasts, satellite cells, granule-containing cells, and unmyelinated nerve fibers. The ganglion cells increased somewhat in numbers and size by 150 mm fetus. Further differentiation resulted in the formation of young ganglion cells, whose cytoplasm was densely filled with cell organelles. During next prenatal stage up to 260 mm fetus, the cytoplasm of the ganglion cells contained except for large pigment granules, all intracytoplasmic structures which were also found in mature superior cervical ganglion. A great number of synaptic contact zones between the cholinergic preganglionic axon and the dendrites of the postganglionic neuron were observed and a few axosomatic synapses were also observed. Two morphological types of the granule-containing cells in the superior cervical ganglion were first identified at 90 mm fetus. Type I granule-containing cell occurred in solitary, whereas type II tended to appeared in clusters near the blood capillaries. Synaptic contacts were first found on the solitary granule-containing cell at 150 mm fetus. Synaptic contacts between the soma of type I granule-containing cells and preganglionic axon termials were observed. In addition, synaptic junctions between the processes of the granule- containing cells and dendrites of postganglionic neuron were also observed from 150 mm fetus onward. In conclusion, superior cervical ganglion cells and granule-containing cells arise from a common undifferentiated cell precursor of neural crest . The granule-containg cells exhibit a local modulatory feedback system in the superior cervical ganglion and nay serve as interneurons between the preganglionic and postganglionic cells.

• 한국해안해양공학회지
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• 제19권1호
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• pp.81-96
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• 2007

단조해안에서의 비선형 천수거동을 가장 강건한 파랑모형인 Navier Stokes 식에 기초하여 수치모의 하였다. 이와 더불어 SUPERTANK LABORATORY DATA COLLECTION PROJECT(Krauss et al., 1992)에서 취득한 자료를 활용하여 Reynolds 응력에 대한 구배모형의 한계를 검증하였다. 취득한 쇄파대 유동계의 자기상관함수는 상당한 특성길이를 지니며 이러한 결과는 구배모형이 큰 오류를 야기할 수 있다는 사실을 시사한다. 이러한 인식에 기초하여 파랑모형은 Large Eddy Simulation(LES), Smooth Particle Hydrodynamics(SPH), Gaussian kernel function을 사용하여 수치 적분하였다. 잔차응력은 Lagrangian Dynamic Smagronski 모형(Meneveau et al.,1996)을 활용하여 모의하였으며 모의 기간 중 유체 알갱이간의 이격거리는 관성부영역의 특성길이보다 작게 유지되도록 노력하였다. 천수과정에서 진행되는 동조 비동조 고차 조화성분으로 전이된 파랑에너지로 인해 상당히 예리하고 왜도된 파형, 파형의 마루로부터 시작되는 물입자 자유낙하, 착수로 인한 커다란 물보라의 형성, 물보라 형성층의 해변으로의 이행, wave finger(Narayanaswamy와 Darlymple, 2002) 등이 비교적 정확히 재현되는 등 상당히 고무적인 결과를 얻었다.

• 한국해안·해양공학회논문집
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• 제32권1호
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• pp.55-68
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• 2020

너울이 우세한 온화한 해양환경에서 출현하는 beach cusp에서의 경계층 streaming 수리특성을 살펴보기 위해 edge waves의 천수 과정을 수치 모의하였다. Beach cusp을 유지하는 것으로 알려진 synchronous edge waves는 같은 주기와 파고를 지니는 두 개의 Cnoidal wave가 전면해역에서 비스듬히 조우 되도록 조파하여 재현하였다. Beach cusp의 진폭 A_B과 파장 L_B은 맹방 해변에서 수행된 관측결과를 토대로 각각 1.25 m, 18 m로 선정하였다. 모의결과 천수 각 단계에서 예외 없이 경계층 streaming을 관측할 수 있었으며 최대 경계층 streaming은 사주 정점에서 발생하였다. 주기가 가장 짧은 RUN 1의 경우 그 세기는 약 0.32 m/s 내외에 분포하며 이러한 수치는 free stream 유속 u_∞ 진폭의 두 배에 달하는 것으로 wave Reynolds 응력에 기반한 Longuet-Higgins(1957)의 해석 해와는 상당한 차이를 보였다. 수치 모의과정에서 온화한 해양환경에서 해빈이 복원되는 과정을 특정할 수 있었으며 이 과정을 정리하면 다음과 같다: 너울로 구성된 파랑 무리에서 성분 파랑 간의 공진성 상호작용으로 생성된 외 중력파가 쇄파선 인근에 도달하는 경우 중력으로 인한 가속이 더해진 Phase II 파랑 궤도 운동으로 수면 가까이 상승한 많은 모래가 쇄파 시 발생하는 파 마루로부터 시작된 up-rush에 의해 전 빈 정점 가까이 이동하며 이 과정에서 발생하는 침투로 인해 퇴적되는 것으로 모의 되었다.

• Archives of Plastic Surgery
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• 제36권5호
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• pp.531-537
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• 2009

Purpose: Alveolar bone grafting has become an essential process in the treatmemt of alveolar cleft patient for stabilization of the maxillary arch, elimination of oronasal fistula, the reconstruction of the soft tissue nasal base support, and creation of bony support for tooth eruption for implant. The use of Autologous iliac cancellous bone is preferable because of the adequate quantity and high osteoinductive potential. However, even with iliac bone, insufficient osteoregeneration and absorption occur due to several factors such as the patient's age, cleft width, functional stress, and others. In order to increase osteoregeneration where the iliac bone is placed, the present study is associated with bone marrow aspirate (BMA). The experimental study evaluated the efficacy of osteoregeneration in normal cleft rabbits when alveolar bone grafting was performed with autologous iliac corticocancellous bone. Methods: Twenty - four New Zealand White rabbits were divided randomly into 2 groups (BMA, control). All animals underwent harvesting of corticocancellous bone graft from the right posterior iliac crest via standard surgical technique. $1m{\ell}$ of BMA were obtained by scraping the needle and aspirate with $10m{\ell}$ syringe from the contralateral iliac bone wall. The muco - periosteal flap on the palate was elevated. A mixture of Equal bone's volumes with BMA and saline as its control was inserted into the cleft. Animals were sacrificed at 2, 4, and 8 weeks and maxilla was harvested for dental peri - apical X-ray, bone matrix density (BMD),and histologic analysis. Result: BMD of regenerated bone to the cleft in the rabbits was higher than that of the control rabbits. X-ray, histologic analysis showed that increased osteoregeneration and low absorption rate were observed in the BMA group. Conclusion: Our experimental study showed BMA enhanced the osteoregeneration and survival rate of alveolar bone grafting. BMA is easy to extract & cost - time effective. So it can be an effective enhancers for bone grafting mixtures.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제42권
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• pp.32.1-32.4
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• 2020

Background: Le Fort I osteotomy is a highly effective treatment for skeletal jaw deformities and is commonly performed. High Le Fort I osteotomy is a modified surgical procedure performed for improving the depression of the cheeks by setting the osteotomy higher than the conventional Le Fort I osteotomy. Developments in three-dimensional (3D) technology have popularized the use of 3D printers in various institutions, especially in orthognathic surgeries. In this study, we report a safe and inexpensive method of performing a high Le Fort I osteotomy using a novel 3D device and piezosurgery, which prevent tooth root injury without disturbing the operation field for patients with a short midface and long tooth roots. Results: A 17-year-old woman presented with facial asymmetry, mandibular protrusion, a short midface, and long tooth roots. We planned high Le Fort I osteotomy and bilateral sagittal split ramus osteotomy. Prevention of damage to the roots of the teeth and the infraorbital nerve and accurate determination of the posterior osteotomy line were crucial for clinical success. Le Fort I osteotomy using 3D devices has been reported previously but were particularly large in size for this case. Additionally, setting the fixing screw of the device was difficult, because of the risk of damage to the roots of the teeth. Therefore, a different surgical technique, other than the conventional Le Fort I osteotomy and 3D device, was required. The left and right parts of the 3D device were fabricated separately, to prevent any interference in the surgical field. Further, the 3D device was designed to accurately cover the bone surface from the piriform aperture to the infra-zygomatic crest with two fixation points (the anterior nasal spine and the piriform aperture), which ensured stabilization of the 3D device. The device is thin and does not interfere with the surgical field. Safe and accurate surgical performance is possible using this device and piezosurgery. The roots of the teeth and the infraorbital nerve were unharmed during the surgery. Conclusions: This device is considerably smaller than conventional devices and is a simple, low-cost, and efficient method for performing accurate high Le Fort I osteotomy.

• Journal of Periodontal and Implant Science
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• 제49권3호
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• pp.171-184
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• 2019

Purpose: To evaluate the effects of intra-alveolar socket grafting, subepithelial connective tissue grafts, and individualized abutments on peri-implant hard and soft tissue outcomes following immediate implant placement. Methods: This randomized experimental study employed 5 mongrel dogs, with 4 sites per dog (total of 20 sites). The mesial roots of P3 and P4 were extracted in each hemimandible and immediate dental implants were placed. Each site was randomly assigned to 1 of 4 different treatment groups: standardized healing abutment (control group), alloplastic bone substitute material (BSS) + standardized healing abutment (SA group), BSS + individualized healing abutment (IA group), and BSS + individualized healing abutment + a subepithelial connective tissue graft (IAG group). Clinical, histological, and profilometric analyses were performed. The intergroup differences were calculated using the Bonferroni test, setting statistical significance at P<0.05. Results: Clinically, the control and SA groups demonstrated a coronal shift in the buccal height of the mucosa ($0.88{\pm}0.48mm$ and $0.37{\pm}1.1mm$, respectively). The IA and IAG groups exhibited an apical shift of the mucosa ($-0.7{\pm}1.15mm$ and $-1.1{\pm}0.96mm$, respectively). Histologically, the SA and control groups demonstrated marginal mucosa heights of $4.1{\pm}0.28mm$ and $4.0{\pm}0.53mm$ relative to the implant shoulder, respectively. The IA and IAG groups, in contrast, only showed a height of 2.6mm. In addition, the height of the mucosa in relation to the most coronal buccal bone crest or bone substitute particles was not significantly different among the groups. Volumetrically, the IA group ($-0.73{\pm}0.46mm$) lost less volume on the buccal side than the control ($-0.93{\pm}0.44mm$), SA ($-0.97{\pm}0.73mm$), and IAG ($-0.88{\pm}0.45mm$) groups. Conclusions: The control group demonstrated the most favorable change of height of the margo mucosae and the largest dimensions of the peri-implant soft tissues. However, the addition of a bone substitute material and an individualized healing abutment resulted in slightly better preservation of the peri-implant soft tissue contour.

• 대한치과보철학회지
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• 제57권3호
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• pp.304-311
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• 2019

치아가 발거된 치조제는 수직, 수평적인 골흡수가 점진적으로 일어나게 되며 흡수의 양상은 수평적으로 서로 다르게 나타난다. 이로 인해 상대적으로 하악궁이 상악궁에 비해 확장되는 경향을 보이며, 상악과 하악 치조제 간의 위치관계에 따라 적합한 인공치 배열 방법을 선택하여 의치의 안정을 도모해야 한다. 본 증례는 77세 남자환자로 기존에 사용하던 상악 총의치, 하악 국소의치의 재제작을 희망하였다. 상악과 하악 치조골의 흡수정도에서 차이를 보여 치조제 간의 위치관계에 대한 정확한 평가가 필요하였고, 이를 위해 치과용 CAD 소프트웨어를 활용했다. 교합기에 부착된 주모형과 교합제를 스캔하여 디지털 스캔 데이터로 변환하고, CAD 소프트웨어 상에서 치조정간선의 법칙에 따라 상악과 하악 치조제간의 위치관계를 평가하여 우측 구치부를 편측 교차교합으로 배열하였다. 보철물 완성 후 주기적인 검진을 거친 결과 의치는 적절한 유지, 안정, 지지를 얻었고 환자 또한 심미적, 기능적으로 만족하였다. 본 증례에서는 상악의 완전 무치악, 하악의 부분 무치악 환자에서 치조제간의 위치관계에 대한 정확한 평가를 위해 디지털 기술을 활용하였으며, 이를 통해 보철치료의 임상 및 기공과정을 보다 효율적으로 진행할 수 있었기에 이를 보고하고자 한다.