Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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Effect of Bone Marrow Aspirate with Autogenous Bone graft for Alveolar Cleft in a new Rabbit Model

가토의 치조열 모델에서 골수 흡인물이 자가뼈 이식술에 미치는 효과

  • Bae, Sung Gun (Department of Plastic and Reconstructive Surgery, Kyungpook National University) ;
  • Chung, Ho Yun (Department of Plastic and Reconstructive Surgery, Kyungpook National University) ;
  • Lee, Sang Yun (Department of Plastic and Reconstructive Surgery, Kyungpook National University) ;
  • Cho, Byoung Chae (Department of Plastic and Reconstructive Surgery, Kyungpook National University) ;
  • Yang, Jung Dug (Department of Plastic and Reconstructive Surgery, Kyungpook National University) ;
  • Park, Mee Young (Department of Neurology College of Medicine, Yeung Nam University)
  • 배성근 (경북대학교 의과대학 성형외과학교실) ;
  • 정호윤 (경북대학교 의과대학 성형외과학교실) ;
  • 이상윤 (경북대학교 의과대학 성형외과학교실) ;
  • 조병채 (경북대학교 의과대학 성형외과학교실) ;
  • 양정덕 (경북대학교 의과대학 성형외과학교실) ;
  • 박미영 (영남대학교 의과대학 신경과학교실)
  • Published : 2009.09.15
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Abstract

Purpose: Alveolar bone grafting has become an essential process in the treatmemt of alveolar cleft patient for stabilization of the maxillary arch, elimination of oronasal fistula, the reconstruction of the soft tissue nasal base support, and creation of bony support for tooth eruption for implant. The use of Autologous iliac cancellous bone is preferable because of the adequate quantity and high osteoinductive potential. However, even with iliac bone, insufficient osteoregeneration and absorption occur due to several factors such as the patient's age, cleft width, functional stress, and others. In order to increase osteoregeneration where the iliac bone is placed, the present study is associated with bone marrow aspirate (BMA). The experimental study evaluated the efficacy of osteoregeneration in normal cleft rabbits when alveolar bone grafting was performed with autologous iliac corticocancellous bone. Methods: Twenty - four New Zealand White rabbits were divided randomly into 2 groups (BMA, control). All animals underwent harvesting of corticocancellous bone graft from the right posterior iliac crest via standard surgical technique. $1m{\ell}$ of BMA were obtained by scraping the needle and aspirate with $10m{\ell}$ syringe from the contralateral iliac bone wall. The muco - periosteal flap on the palate was elevated. A mixture of Equal bone's volumes with BMA and saline as its control was inserted into the cleft. Animals were sacrificed at 2, 4, and 8 weeks and maxilla was harvested for dental peri - apical X-ray, bone matrix density (BMD),and histologic analysis. Result: BMD of regenerated bone to the cleft in the rabbits was higher than that of the control rabbits. X-ray, histologic analysis showed that increased osteoregeneration and low absorption rate were observed in the BMA group. Conclusion: Our experimental study showed BMA enhanced the osteoregeneration and survival rate of alveolar bone grafting. BMA is easy to extract & cost - time effective. So it can be an effective enhancers for bone grafting mixtures.

Keywords

Acknowledgement

Supported by : 경북대학교 병원

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