• Journal of Life Science
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• v.29 no.9
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• pp.964-971
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• 2019

Hepatic lipid accumulation and insulin resistance increases in patients with non-alcoholic fatty liver disease. Piperine is a major compound found in black pepper (Piper nigrum) and long pepper (P. longum). Piperine has been used in fine chemical for its anti-cancer, anti-obesity, anti-diabetic, anti-inflammatory and anti-oxidant properties. However, the signaling-based mechanism of piperine and its role as an inhibitor of lipogenesis and insulin resistance in human hepatocyte cells remains ill-defined. In the present study, we explored the effects of piperine on lipid accumulation and insulin resistance, and explored the potential underlying molecular mechanisms in palmitate-treated HepG2 cells. Piperine treatment resulted in a significant reduction of triglyceride content. Furthermore, piperine treatment decreased palmitate-treated intracellular lipid deposition by inhibiting the lipogenic target genes, sterol-regulatory-element-binding protein 1c (SREBP-1c) and fatty acid synthase (FAS); whereas the expression of carnitine palmitoyl transferase (CPT-1) and phosphorylation of acetyl coenzyme A carboxylase (ACC) gene involved in fatty acid oxidation was increased. Moreover, piperine also inhibited the phosphorylation of insulin receptor substrate (IRS)-1 (Ser307). Piperine treatment modulated palmitate-treated lipid accumulation and insulin resistance in HepG2 cells with concomitant reduction of lipogenic target genes, such as SREBP-1 and FAS, and induction of CPT-1-ACC and phosphorylation of IRS-1 (Tyr632)-Akt pathways. Therefore, piperine represents a promising treatment for the prevention of lipid accumulation and insulin resistance.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.24 no.4
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• pp.220-227
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• 2013

Objectives : This study aims to investigate the clinical characteristics and neuropsychological profiles of children with attention-deficit hyperactivity disorder (ADHD) and their siblings. Methods : Eighteen children (age $8.2{\pm}1.7$ years, 12 boys) with ADHD and their 18 siblings (age $7.8{\pm}1.6$ years, 8 boys) completed Continuous Performance (CPT), Stroop, Children's Trail Making, Rey-Kim Memory, and Kim's Frontal Executive Function tasks. The parents of these subjects underwent the Attention-Deficit/Hyperactivity Disorder Rating Scale (ARS), 10-item Parent General Behavior Inventory (P-GBI), and the Social Responsiveness Scale (SRS). Paired t-tests were used. Results : The inattention (p=.020), and hyperactivity-impulsivity (p=.001), scores of the ARS and the P-GBI score (p=.004) were significantly higher in children with ADHD than in their siblings. Deficits in social communication and motivation on SRS were higher in children with ADHD than in their siblings (p=.017 and p=.011, respectively). Z-scores of omission and commission errors as well as response time variability on visual CPT and omission errors on auditory CPT were in clinically significant range, and z-score of omission errors on auditory CPT was in borderline range in siblings. Omission (p=.018) and commission errors on Visual CPT (p=.007) were significantly higher in children with ADHD compared to their siblings. Recognition efficiency on Kim's Frontal Executive Function Task was lower in children with ADHD compared to their siblings, but in normal range in both groups. Stroop interference and figure fluency on Kims Frontal Executive Function Task were in borderline range in ADHD group, and figure fluency was in borderline range in siblings. Conclusion : Our results support a preliminary evidence for mild degree of attention deficit in ADHD siblings. Further studies are needed to examine the cognitive functions of siblings with ADHD in larger samples.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.3335-3341
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• 2014

Background: Severe toxicity is commonly observed in cancer patients receiving irinotecan (CPT-11) UDPglucuronosyltransferase1A1 (UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38 but the relationship between UGT1A1 and severe toxicity remains unclear. Our study aimed to assess this point to guide clinical use of CPT-11. Materials and Methods: 89 cancer patients with advanced disease received CPT-11-based chemotherapy for at least two cycles. Toxicity, including GI and hematologic toxicity was recorded in detail and UGT1A1 variants were genotyped. Regression analysis was used to analyse relationships between these variables and tumor response. Results: The prevalence of grade III-IV diarrhea was 10.1%, this being more common in patients with the TA 6/7 genotype (5 of 22 patients, 22.7%) (p<0.05). The prevalence of grade III-IV neutropenia was 13.4%and also highest in patients with the TA 6/7 genotype (4 of 22 patients; 18.2%) but without significance (p>0.05). The retreatment total bilirubin levels were significantly higher in TA6/7 patients (mean, $12.75{\mu}mol/L$) with compared to TA6/6 (mean, $9.92{\mu}mol/L$) with p<0.05. Conclusions: Our study support the conclusion that patients with a $UGT1A1^*28$ allele (s) will suffer an increased risk of severe irinotecan-induced diarrhea, whether with mid-or low-dosage. However, the $UGT1A1^*28$ allele (s) did not increase severe neutropenia. Higher serum total bilirubin is an indication that patients UGT1A1 genotype is not wild-type, with significance for clinic usage of CPT-11.

• Journal of the Korean Geotechnical Society
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• v.26 no.11
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• pp.47-61
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• 2010

To predict the settlement rate of a ground area that incorporates vertical drains, it is desirable to conduct various kinds of advanced field and laboratory tests for hydraulic properties. However, it is urgently needed to appropriately evaluate the hydraulic properties using the results of conventional soil tests which are extensively used for local practice. To achieve this purpose, a number of CPT dissipation test, laboratory permeability and consolidation tests were performed at five sites in the floodplain of the Nakdong River delta, and the test data were comprehensively analyzed. As a result, it is found that the coefficients of horizontal consolidation ($C_{h,NC}$) and permeability ($k_{h,OC}$) of the clay agreed well with those of the CPT-based methods proposed by Baligh and Levadoux (1986). The values of $C_{h,NC}$ and $k_{h,OC}$ were in the range of $0.4{\sim}3.0\;cm^2/sec$ and $0.40{\sim}2.50\;cm^2/sec$, each of which slightly increases or decreases with depth, respectively. It was also inferred that these trends seem to reflect the depositional environments of the clay.

• International Journal of Quality Innovation
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• v.5 no.2
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• pp.63-69
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• 2004

This is an R&D project on design optimization of the inner shield of the Omega color picture tube at Samsung SDI in Korea. This was an R&D project which basically used the IDOV (Identify, Design, Optimize, Validate) process for Six Sigma implementation. Most Six Sgima projects use the process of DMAIC (Define, Measure, Analyze, Improve, Control). However, this project introduces a new cycle, RDIDOV (Recognize, Define, and IDOV). Here CPT means Color Picture Tube. Sam sung SDI is one of the two companies which began Six Sigma in Korea. This case study shows a good example how an R&D Six Sigma project can be usefully employed in manufacturing companies using a new process cycle.

• Proceedings of the Korean Geotechical Society Conference
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• 2008.10a
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• pp.713-720
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• 2008

본 연구는 낙동강 하구 대심도 연약지반에 항타관입된 PHC 말뚝에 대하여 SPT 지지력 공식으로 부터 계산된 선단지지력 값과 PDA 시험에서 얻어진 선단지지력 측정값을 비교하였다. 또한, SPT N값이 50이 넘는 경우에 대하여는 N값과 롯드 관입깊이의 선형관계를 가정하여 30cm 관입깊이에 해당하는 N값을 적용한 경우와 CPT $q_c$와의 상관성을 이용하여 $q_c$값으로부터 N값을 산정한 경우의 2가지 분석을 수행하였다. 그 결과, 본 연구에서 적용한 SPT 지지력 공식 모두 측정된 선단지지력 값과 차이가 났으며, SPT 지지력 공식은 대심도 연약지반에 항타 근입된 말뚝에 대하여 실제적인 설계를 수행할 때 신뢰하기 어려운 것으로 나타났다. 또한, N>50인 경우에 대하여 N값과 롯드 관입깊이의 선형관계를 적용하는 것은 지지력을 매우 과대평가하는 것으로 나타났다.

• Journal of the Korean Geotechnical Society
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• v.29 no.1
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• pp.71-80
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• 2013

Before and after the test constructions, and after an 11-month hiatus from the pilot pile installations, the in-situ tests (CPT, SPT) were carried out at the ground adjacent to the noise- and vibration-free screw concrete piles installed by 2 kinds of construction methods (i.e., the toe-jetting shoe type, the pre-digging type). In the toe-jetting shoe type construction methods, after construction, the soil strength within 3.5D (where, D = pile diameter) from the pile center decreased greatly by about 46% of the original ground and, after an 11-month hiatus, a strength recovery adjacent to the piles appeared about 71% of the original ground. In the pre-digging type construction methods, a strength recovery adjacent to the piles appeared 100% of the strength of the original ground.

• The Journal of Korean Physical Therapy
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• v.23 no.2
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• pp.53-59
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• 2011

Purpose: This study was designed to compare the effects of transcutaneous electrical nerve stimulation (TENS) and silver spike point (SSP) therapy on current perception threshold (CPT) and mechanical pain threshold (MPT). Methods: Forty-five healthy adult male and female subjects were studied. Fourteen of them were males and twenty-one were females. Subject were randomly assigned to receive; (1) TENS (80/120 Hz alternating frequency), (2) SSP (3 Hz), or (3) no treatment (control group). Electric stimulation was applied over LI4 and LI11 on acupuncture points of the left forearm for 30 minutes. CPT and MPT were recorded before and after electrical stimulation. The data were analyzed using linear mixed models, with group treated as a between subject factor and time a within-subject factor. Results: At 30 minutes after cessation of electrical stimulation the CPT of C fibers and A${\delta}$fibers was reduced in the TENS group that of C fibers was reduced in the SSP group (p<0.05). After cessation of electrical stimulation, the MPT of C fibers and A${\delta}$fibers increased in the TENS group, and that of A${\delta}$fibers increased in the SSP group (p<0.05). Conclusion: After TENS and SSP stimulation, MPT of C fibers and A${\delta}$fibers were selectively increased. In particular, the TENS group showed increases in both C and A${\delta}$fibers, while the SSP group showed increases only in A${\delta}$fibers.

• The Journal of Korean Medicine
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• v.16 no.2 s.30
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• pp.365-385
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• 1995

In order to prove the antitumor effect of Wekyungtang(WKT) that was originated in Bigeubchunkeumyobang(備急千金要方), Wekyungtang with Houttuyniae Herba(WKT-I) and Wekyungtang with Oldenlandiae diffusae Herba(WKT-II) experimentally, the studies were done, We evaluated the cytotoxic activity against B16- Fo as well as the synergistic effects with anticancer drugs such as cyclophophamide (CPM), cisplatin(CPT) and 5-fluorouracil (5-FU) in vitro and measured body weight, survival time, hematological changes, changes of tissues in G57BL／6 implanted with B16-Fo. The results were obtained as follows: 1. In vitro cytotoxic effect against B16-Fo was shown in all groups as compared with control group, but the concentrations showing inhibitory growth rate below 55% of control was recognized in all concentrations of Wekyungtang(WKT) against B16-Fo and also concentration of $10^4$g／ml above in all group with cyclophophamide (CPM), concentration of $10^3$g／ml in Wekyungtang(WKT-l) with cisplatin(CPT) in synergistic effect, 2. In vivo body and tumor weight were significantly suppressed in all groups as compared with control group 3. The number of platelet, WBC, RBC were significantly increased in all groups, platelet aggregation was significantly increased in WKT-I and WKT-II as compared with control group. 4. In changes of tissues heavy infiltration oh cancer was shown in portal vein, pulmonary tissue, vein, peribronchiole, aveoli, while WKT-I was effective in antihepatic metastasis and WKT-II in pulmonary matastasis. From above results it was concluded that wekyungtang(WKT), wekyungtang with Houttuyniae Herba(WKT-I) and wekyungtang with Oldenlandiae diffusae Herba(WKT -II) had antitumor effect, and also wekyungtang combined with Houttuyniae Herba or Oldenlandiae diffusae Herba were more effective than wekyungtang only and also cyclophophamide (CPM), cisplatin(CPT) showed the more synergistic effect which suggests the necessity of continuous study on the mechanism of antitumor action of Houttuyniae Herba or Oldenlandiae diffusae Herba.

• Geotechnical Engineering
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• v.2 no.3
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• pp.37-50
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• 1986

The uncertainties encountered in the stability analysis for the foundation of offshore structures on clay are formulated in probabilistic terms and used to evaluate the reliability of the foundation design. The major sources of uncertainty are: soil properties, f.ave loads, and methods of analysis. The major part of the uncertainty in safety factor is contributed by the uncertainty in the undrained shear strength. All sources of uncertainties that affect the shear strength of clay are modeled and systematically analyzed. The in situ undrained shear strengths are evaluated by laboratory tests and cone penetration tests. The undrained shear strengths from the laboratory test and CPT, respectively at Statfjord B site in the North Sea, are used as an example in risk analysis. Using the CPT alone, the failure probability on sliding of gravity platform at Statfjord B is much larger than the failure probability using the laboratory undrained shear strengths. The major uncertainty of using the CPT as the estimate of th2 undrained shear strength of clay results from the correlation between the cone resistance and the undrained shear strength.