• Title/Summary/Keyword: CLIP domain

Search Result 10, Processing Time 0.033 seconds

CLIP-domain serine proteases in Drosophila innate immunity

  • Jang, In-Hwan;Nam, Hyuck-Jin;Lee, Won-Jae
    • BMB Reports
    • /
    • v.41 no.2
    • /
    • pp.102-107
    • /
    • 2008
  • Extracellular proteases play an important role in a wide range of host physiological events, such as food digestion, extracellular matrix degradation, coagulation and immunity. Among the large extracellular protease family, serine proteases that contain a "paper clip"-like domain and are therefore referred to as CLIP-domain serine protease (clip-SP), have been found to be involved in unique biological processes, such as immunity and development. Despite the increasing amount of biochemical information available regarding the structure and function of clip-SPs, their in vivo physiological significance is not well known due to a lack of genetic studies. Recently, Drosophila has been shown to be a powerful genetic model system for the dissection of biological functions of the clip-SPs at the organism level. Here, the current knowledge regarding Drosophila clip-SPs has been summarized and future research directions to evaluate the role that clip-SPs play in Drosophila immunity are discussed.

Interaction of CLIP-170, a Regulator of Microtubule Plus End Dynamics, with Kinesin 1 via KIF5s (미세소관의 plus end dynamics를 조절하는 CLIP-170과 kinesin 1의 KIF5s를 통한 결합)

  • Jang, Won Hee;Jeong, Young Joo;Lee, Won Hee;Kim, Mooseong;Kim, Sang-Jin;Urm, Sang-Hwa;Seog, Dae-Hyun
    • Journal of Life Science
    • /
    • v.27 no.6
    • /
    • pp.673-679
    • /
    • 2017
  • Microtubules are long rods in the cytoplasm of cells that plays a role in cell motility and intracellular transport. Microtubule-based transport by motor proteins is essential in intracellular transport. Kinesin 1 is a molecular motor protein that mediates the intracellular transport of various membranous vesicles, mRNAs, and proteins along microtubules. It is comprised of two heavy chains (KHCs, also called KIF5s) and two light chains (KLCs). KIF5s bear a motor domain in their amino (N)-terminal regions and interact with various cargoes through the cargo-binding domain in their carboxyl (C)-terminal regions. To identify proteins interacting with KIF5B, yeast two-hybrid screening was performed, and a specific interaction with the cytoplasmic linker protein 170 (CLIP-170), a plus end microtubule-binding protein, was found. The coiled-coil domain of CLIP-170 is essential for interactions with KIF5B in the yeast two-hybrid assay. CLIP-170 bound to the cargo-binding domain of KIF5B. Also, other KIF5s, KIF5A and KIF5C, interacted with CLIP-170 in the yeast two-hybrid assay. In addition, glutathione S-transferase (GST) pull-downs showed that KIF5s specifically interacted with CLIP-170. An antibody to KIF5B specifically co-immunoprecipitated CLIP-170 associated with KIF5B from mouse brain extracts. These results suggest that kinesin 1 motor protein may transport CLIP-170 in cells.

Transforming Text into Video: A Proposed Methodology for Video Production Using the VQGAN-CLIP Image Generative AI Model

  • SukChang Lee
    • International Journal of Advanced Culture Technology
    • /
    • v.11 no.3
    • /
    • pp.225-230
    • /
    • 2023
  • With the development of AI technology, there is a growing discussion about Text-to-Image Generative AI. We presented a Generative AI video production method and delineated a methodology for the production of personalized AI-generated videos with the objective of broadening the landscape of the video domain. And we meticulously examined the procedural steps involved in AI-driven video production and directly implemented a video creation approach utilizing the VQGAN-CLIP model. The outcomes produced by the VQGAN-CLIP model exhibited a relatively moderate resolution and frame rate, and predominantly manifested as abstract images. Such characteristics indicated potential applicability in OTT-based video content or the realm of visual arts. It is anticipated that AI-driven video production techniques will see heightened utilization in forthcoming endeavors.

A Study on Tether Cables Used for Deep Submergence Vehicles (심해 잠수정용 테더 케이블에 관한 연구)

  • H. Shin;D.S. Kim
    • Journal of the Society of Naval Architects of Korea
    • /
    • v.32 no.2
    • /
    • pp.56-67
    • /
    • 1995
  • In this paper, a ship-cable-vehicle system's static configuration is shown obtained by solving cable nonlinear statics. Eigenfrequencies of the cable were calculated by the frequency domain analysis application of the linearized cable dynamic equations. Also extreme tensions in a slack-and-snapping long vertical cable were calculated by the clip-ping-off model.

  • PDF

Development of Expert Process Planning System for Injection Mold (사출금형의 공정설계 전문가시스템의 개발)

  • 조규갑;임주택;노형민
    • Transactions of the Korean Society of Mechanical Engineers
    • /
    • v.16 no.12
    • /
    • pp.2252-2260
    • /
    • 1992
  • This paper deals with development of expert process planning system which automatically generates process plan for manufacturing parts of injection mold. The specific domain of study is two-plate injection mold without support plate. Decision making rules for selection of machining processes machine tools, cutting tools and for determination of sequence of machining operations are acquired by interview of skilled process planner. The developed expert process planning system is programmed by using expert system shell CLIPS on the IBM PC/AT. The proposed system works well to real problems.

Terahertz Time-Domain Spectroscopy and Imaging using Compact Fiber-coupled Terahertz Modules (초소형의 광섬유 결합형 테라헤르츠 모듈을 이용한 시간영역에서의 분광 및 이미징)

  • Yoon, Young-Jong;Kim, Namje;Ryu, Han-Cheol;Moon, Kiwon;Shin, Jun-Hwan;Han, Sang-Pil;Park, Kyung Hyun
    • Korean Journal of Optics and Photonics
    • /
    • v.25 no.2
    • /
    • pp.72-77
    • /
    • 2014
  • We have demonstrated a terahertz (THz) time-domain spectroscopy and imaging system using compact fiber-coupled THz modules. Using this THz spectroscopy system we have measured the absorption spectrum of water vapor in free space over 3 THz, as well as the refractive indices of various substrates such as Si, $Al_2O_3$, and GaAs using the transfer-function method. Through the THz imaging system we have observed a high-quality THz image of a medical knife and metal clip sample, with a resolution of $192{\times}89$ pixels using a step size of 250 ${\mu}m$.

Assessment of Masks Used by Healthcare Workers: Development and Validation of a Mask Qualitative Assessment Tool (MQAT)

  • Gharibi, Vahid;Cousins, Rosanna;Mokarami, Hamidreza;Jahangiri, Mehdi;Keshavarz, Mohammad A.;Shirmohammadi-Bahadoran, Mohammad M.
    • Safety and Health at Work
    • /
    • v.13 no.3
    • /
    • pp.364-371
    • /
    • 2022
  • Background: Respiratory masks can provide healthcare workers with protection from biological hazards when they have good performance. There is a direct relationship between the visual specifications of a mask and its efficacy; thus, the aim of this study was to develop tools for qualitative assessment of the performance of masks used by healthcare workers. Methods: A mixed-methods design was used to develop a qualitative assessment tool for medical face masks (MFM) and particle filtering half masks (PFHM). The development of domains and items was undertaken using observation and interviews, the opinions of an expert panel, and a review of texts and international standards. The second phase evaluated the psychometric properties of tools. Finally, the validated Mask Qualitative Assessment Tools (MQAT) were used to assess six samples from 10 brands of the two types of masks. Results: MQAT-MFM and MQAT-PHFM shared 42 items across seven domains: "cleanliness," "design," "marking, labeling and packaging," "mask layers," "mask strap," "materials and construction," and "nose clip." MQAT-MFM included one additional item. MQAT-PHFM included another nine items associated with an eighth "Practical Performance" domain, and the valve version had another additional "Exhalation Valve" domain and six items. The evaluation indicated 80% compliance for MFM and 71% compliance for PFHM. "Marking, labeling and packaging" and "Layers" were associated with the least compliance in both types of masks and should be checked carefully for defining mask quality. Conclusion: MQAT can be used for immediate screening and initial assessment of MFM and PHFM through appearance, simple tools, and visual inspection.

Content-based Music Information Retrieval using Pitch Histogram (Pitch 히스토그램을 이용한 내용기반 음악 정보 검색)

  • 박만수;박철의;김회린;강경옥
    • Journal of Broadcast Engineering
    • /
    • v.9 no.1
    • /
    • pp.2-7
    • /
    • 2004
  • In this paper, we proposed the content-based music information retrieval technique using some MPEG-7 low-level descriptors. Especially, pitch information and timbral features can be applied in music genre classification, music retrieval, or QBH(Query By Humming) because these can be modeling the stochasticpattern or timbral information of music signal. In this work, we restricted the music domain as O.S.T of movie or soap opera to apply broadcasting system. That is, the user can retrievalthe information of the unknown music using only an audio clip with a few seconds extracted from video content when background music sound greeted user's ear. We proposed the audio feature set organized by MPEG-7 descriptors and distance function by vector distance or ratio computation. Thus, we observed that the feature set organized by pitch information is superior to timbral spectral feature set and IFCR(Intra-Feature Component Ratio) is better than ED(Euclidean Distance) as a vector distance function. To evaluate music recognition, k-NN is used as a classifier

Fashion-show Animation Generation using a Single Image to 3D Human Reconstruction Technique (이미지에서 3차원 인물복원 기법을 사용한 패션쇼 애니메이션 생성기법)

  • Ahn, Heejune;Minar, Matiur Rahman
    • Journal of Korea Society of Industrial Information Systems
    • /
    • v.24 no.5
    • /
    • pp.17-25
    • /
    • 2019
  • In this paper, we introduce the technology to convert a single human image into a fashion show animation video clip. The technology can help the customers confirm the dynamic fitting result when combined with the virtual try on technique as well as the interesting experience to a normal person of being a fashion model. We developed an extended technique of full human 2D to 3D inverse modeling based on SMPLify human body inverse modeling technique, and a rigged model animation method. The 3D shape deformation of the full human from the body model was performed by 2 part deformation in the image domain and reconstruction using the estimated depth information. The quality of resultant animation videos are made to be publically available for evaluation. We consider it is a promising approach for commercial application when supplemented with the post - processing technology such as image segmentation technique, mapping technique and restoration technique of obscured area.