• Proceedings of the PSK Conference
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• 2001.10a
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• pp.237.2-237.2
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• 2001

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.3
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• pp.317-325
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• 2017

Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in parallel with worldwide epidemic of obesity. Reactive oxygen species (ROS) contributes to the development and progression of NAFLD. Peroxisomes play an important role in fatty acid oxidation and ROS homeostasis, and catalase is an antioxidant exclusively expressed in peroxisome. The present study examined the role of endogenous catalase in early stage of NAFLD. 8-week-old male catalase knock-out (CKO) and age-matched C57BL/6J wild type (WT) mice were fed either a normal diet (ND: 18% of total calories from fat) or a high fat diet (HFD: 60% of total calories from fat) for 2 weeks. CKO mice gained body weight faster than WT mice at early period of HFD feeding. Plasma triglyceride and ALT, fasting plasma insulin, as well as liver lipid accumulation, inflammation (F4/80 staining), and oxidative stress (8-oxo-dG staining and nitrotyrosine level) were significantly increased in CKO but not in WT mice at 2 weeks of HFD feeding. While phosphorylation of Akt (Ser473) and $PGC1{\alpha}$ mRNA expression were decreased in both CKO and WT mice at HFD feeding, $GSK3{\beta}$ phosphorylation and Cox4-il mRNA expression in the liver were decreased only in CKO-HF mice. Taken together, the present data demonstrated that endogenous catalase exerted beneficial effects in protecting liver injury including lipid accumulation and inflammation through maintaining liver redox balance from the early stage of HFD-induced metabolic stress.

• 소프트웨어세계
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• s.4
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• pp.143-145
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• 1999

• Geotechnical Engineering
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• v.12 no.6
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• pp.115-126
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• 1996

The purpose of 1,his study is to analyze the compression and strength charactefistics of the decomposed -weathered soil originating from biotite gneiss or fine grained gneiss sampled from Poidong, Seoul : to figure out the behavioural characteristics of the decomposed -weathered soil in accordance with mineral composition and origin by comparing experimental results of residual soils. originating from granites and sampled from Bulam, Andong and Kimchun area. A series of CIU, CID CKoV, CKoD tests were car lied out. Although weathered soils have different origin and mineral composition, the slope of the NCL A was similar. It was also shown that plastic strain ratio was about 85% mainly due to the particle crushing effect during compression. The Poidong soil showed strain softening phenomenon unlike the Kimchun and Andong soils. this implies that the behavioural characteristics are affected by the origin and the mineral composition of the soil particles. Moreover, it was found that the angle of the shear resistance$(\phi')$ was dependent on the mineral composition. On the oher hand, measured Af values of decomposed weathered soils were more than one regardless of the origin and the mineral composition.

• Journal of the Korean Society for information Management
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• v.21 no.1
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• pp.209-230
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• 2004

This study examines the concept of knowledge and knowledge management. Then. it analyzes some factors for successful knowledge management in terms of trust. communication channels, decision making participation, innovativeness, shared value. and CKO support. The suggestions of the study ran be used to establish knowledge management in organizations.

• Knowledge Management Research
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• v.7 no.1
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• pp.81-96
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• 2006

The purpose of this study is to survey what strategy BACHE, a bathtub manufacturing company, chooses to implement knowledge management. Generally speaking, the success factors of this case company is follow-up management. The first factor is to use linguistic metaphors for employees to understand difficult knowledge management terms easily. The second one is that CEO tries to set and lead pro-knowledge management corporate culture. The third one is based on the CKO's competence to read business circumstances and apply the theory of knowledge management to the workplace. The fourth one has something to do with a way of knowledge creation, for example, a suggestion system and QC circle. The fifth one depends upon CKO's mission to share knowledge invented from his own company's with the rivals and large companies which order bathtubs so that overall bathtub industry can upgrade knowledge management.

• Information Systems Review
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• v.2 no.1
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• pp.1-11
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• 2000

• The Journal of Bigdata
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• v.4 no.1
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• pp.11-27
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• 2019

There is gradually being a decrease in earnings rate of the container terminals because of worsened business environment. To enhance global competitiveness of terminal, operators of the container terminal have been attempting to deal with problems of operations through analyzing overall the terminal operations. For improving operations of the container terminal, the operators try to efforts about analyzing and utilizing data from the database which collects and stores data generated during terminal operation in real time. In this paper, we have analyzed the characteristics of operating processes and defined the event log data to generate container processes and CKO processes using stored data in TOS (terminal operating system). And we have explained how imperfect event logs creating non-normal processes are refined effectively by analyzing the container and CKO processes. We also have proposed the framework to refine the event logs easily and fast. To validate the proposed framework we have implemented it using python2.7 and tested it using the data collected from real container terminal as input data. In consequence we could have verified that the non-normal processes in the terminal operations are greatly improved.

• Biomolecules & Therapeutics
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• v.27 no.2
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• pp.134-144
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• 2019

The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased with the incidence of obesity; however, the underlying mechanisms are unknown. In this study, high-resolution metabolomics (HRM) along with transcriptomics were applied on animal models to draw a mechanistic insight of NAFLD. Wild type (WT) and catalase knockout (CKO) mice were fed with normal fat diet (NFD) or high fat diet (HFD) to identify the changes in metabolic and transcriptomic profiles caused by catalase gene deletion in correspondence with HFD. Integrated omics analysis revealed that cholic acid and $3{\beta}$, $7{\alpha}$-dihydroxy-5-cholestenoate along with cyp7b1 gene involved in primary bile acid biosynthesis were strongly affected by HFD. The analysis also showed that CKO significantly changed all-trans-5,6-epoxy-retinoic acid or all-trans-4-hydroxy-retinoic acid and all-trans-4-oxo-retinoic acid along with cyp3a41b gene in retinol metabolism, and ${\alpha}/{\gamma}$-linolenic acid, eicosapentaenoic acid and thromboxane A2 along with ptgs1 and tbxas1 genes in linolenic acid metabolism. Our results suggest that dysregulated primary bile acid biosynthesis may contribute to liver steatohepatitis, while up-regulated retinol metabolism and linolenic acid metabolism may have contributed to oxidative stress and inflammatory phenomena in our NAFLD model created using CKO mice fed with HFD.

• Proceedings of the SAREK Conference
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• 2003.07a
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• pp.135-135
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• 2003