• Advances in pediatric surgery
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• 제17권2호
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• pp.179-187
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• 2011

Experimental tracheal ligation (TL) has been shown to reverse the pulmonary hypoplasia associated with congenital diaphragmatic hernia (CDH) and to normalize gas exchange. The purpose of this study was to determine whether the TL would correct the surfactant deficiency present in the fetal rabbit model of CDH by using lamellar body count. Lamellar bodies are synthesized and secreted by the type II pneumocytes of fetal lung. The phospholipids present in these bodies constitute the major component of pulmonary surfactant. Twenty-one pregnant New Zealand rabbits underwent hysterotomy and fetal surgery on gestational day 24. Two fetuses of each pregnant rabbit were operated. In the fetus of one end of bicornuate uterus, left DH was created by excision of fetal diaphragm through open thoracotomy (DH Group). In the fetus of the other end of bicornuate uterus, left DH and TL were created (TL Group). The fetuses were delivered by Cesarean section on gestational day 31. Fourteen in control group, 12 in the DH group and 13 in TL group were born alive. En bloc excision of lungs, bronchi and trachea was done in all newborn rabbits. A five Fr catheter was inserted through trachea and repeated irrigations with 10 cc normal saline were done. The irrigated fluid was centrifuged at $280{\times}g$ for 5 minutes and the lamellar bodies were counted with the upper level fluid in platelet channel of electronic cell counter. The average lamellar body counts were $37.1{\pm}14.2{\times}10^3/{\mu}L$ in control group, $11.5{\pm}4.4 {\times}10^3/{\mu}L$ in DH group, and $6.5{\pm}0.9{\times}10^3/{\mu}L$ in TL group. Lamellar body count in DH group was lower than in control group and did not increase after TL. This study shows TL has no therapeutic effect on decreased surfactant level of CDH and the pregnant rabbit is appropriate for the animal model of CDH.

• 사물인터넷융복합논문지
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• 제9권6호
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• pp.1-9
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• 2023

최근 MS Office 파일 내에 악성 스크립트 등이 은닉된 멀웨어 파일이 발견되고 있다. 이에 본 논문에서는 머신러닝 기법을 적용하여 악성 디지털 파일을 자동으로 검출할 수 있는 시스템을 설계 및 구현하였다. MS Office 파일 내 OLE VBA 매크로 기능을 악용하여 악성 스크립트를 검출하거나, OOXML 구조 분석을 통해 CDH/LFH/ECDH 내부 필드 값에 악성 스크립트를 탐지하고, OOXML 구조에서 참조되지 않는 비정상적인 CDH/LFH 정보를 추가한 경우 이를 검출할 수 있는 메커니즘을 제시하였다. 그리고 VirusTotal 악성 스크립트 판별 기능을 이용하여 MS Office 파일에 대한 악의적 손상 여부 자동 판별하는 기능을 이용하여 머신러닝 기반 통합 소프트웨어를 설계 및 구현하였다. 실험 결과 파일 손상 여부를 자동 판별할 수 있으며 최적의 머신러닝 모델을 이용하여 임의의 MS Office 파일에 대해 향상된 검출 성능을 제공하는 것을 확인하였다.

• 전기학회논문지
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• 제64권8호
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• pp.1137-1144
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• 2015

Accurate and robust load forecasting model is very important in power system operation. In case of short-term electric load forecasting, its result is offered as an standard to decide a price of electricity and also can be used shaving peak. For this reason, various models have been developed to improve forecasting accuracy. In order to achieve accurate forecasting result for summer season, this paper proposes a forecasting model using corrected effective temperature based on Heat Index and CDH data as inputs. To do so, we establish polynomial that expressing relationship among CDH, load, temperature. After that, we estimate parameters that is multiplied to each of the terms using PSO algorithm. The forecasting results are compared to Holt-Winters and Artificial Neural Network. Proposing method shows more accurate by 1.018%, 0.269%, 0.132% than comparison groups, respectively.

• Genomics & Informatics
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• 제9권3호
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• pp.102-113
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• 2011

C-terminal SRC kinase (CSK) is a ubiquitously expressed, cytosolic enzyme that phosphorylates and inactivates several SRC family protein tyrosine kinases. Recent genomewide association studies have implicated CSK in the regulation of blood pressure. The current study aim is to determine the blood pressure association of the genes regulated by CSK down-regulation. The CSK mRNA expression was downregulated in vascular smooth muscle cells using small interfering RNA (siRNA). CSK mRNA levels fell by 90% in cells that were treated with CSK siRNA; the RNA from these cells was examined by microarray using the Illumina HumanRef-8 v3 platform, which comprises 24,526 reference mRNA probes. On treatment with CSK siRNA, 19 genes were downregulated by more than 2-fold and 13 genes were upregulated by more than 2-fold. Three (CANX, SLC30A7, and HMOX1) of them revealed more than 3 fold differential expression. Interestingly, the HMOX1 SNPs were associated with diastolic blood pressure in the 7551 Koreans using Korea Association REsource data, and the result was supported by the other reports that HMOX1 linked to blood vessel maintenance. Among the remaining 29 differentially expressed genes, seven (SSBP1, CDH2, YWHAE, ME2, PFTK1, G3BP2, and TUFT1) revealed association with both systolic and diastolic blood pressures. The CDH2 gene was linked to blood pressures. Conclusively, we identified 32 differentially expressed genes which were regulated by CSK reduction, and two (HOMX1 and CDH2) of them might influence the blood pressure regulation through CSK pathway.

• 대한약침학회지
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• 제13권4호
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• pp.109-118
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• 2010

Objectives : This pilot study is designed to reveal the effect of Carthami-semen acupuncture treatment on chronic daily headache. Methods : 1. All the voluntary subjects were diagnosed as CDH. 2. Carthami-semen acupuncture is applied 2 times a week for 4 weeks. 3. The patients were assessed by Headache impairment test score(HIT), Short Form 36 (SF-36) Health Survey, and Headache Free Days(HFD) before and after 4 weeks treatment, and two weeks the treatment finished. Results : The result were as follows ; 1. HIT score decreased from $65.3{\pm}5.5$ to $53.1{\pm}9.4$, and furthermore declined to $49.5{\pm}8.0$ after 2 weeks the treatment finished. 2. HFD increased from 19.1% to 31.5% during the treatment time. Moreover it showed continuous effectiveness after 2 weeks the treatment finished. 3. SF-36 showed significant improvement on all of the QOL items. Conclusions : This pilot study suggests that Carthami-semen acupuncture treatment has an effect on the CDH patients.

• 대한치과의사협회지
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• 제40권7호통권398호
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• pp.512-515
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• 2002

• International Journal of Oral Biology
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• 제31권2호
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• pp.27-32
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• 2006

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline mutations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast cancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma(SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign epithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

• Current Research on Agriculture and Life Sciences
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• 제5권
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• pp.68-74
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• 1987

A. calcoaceticus C10은 CL 배지에서 ${\varepsilon}$-caprolactone 및 succinate에 의해 생육에 아무 영향도 받지 않았으나 adipate와 xylose에 의해서 균의 생육도가 증가하였다. 특히 이 균이 탄소원으로 이용할 수 없는 포도당에 의해서도 생육도가 증가하였으며 6시간 배양 후 0.2%의 포도당을 첨가한 경우에는 16시간 후 CL 배지에서 생육한 것보다 약 2배의 생육도를 냐타내었다. A. calcoacelicus C10이 생산하는 cyclohexanol dehydrogenase(CDH)는 ${\varepsilon}$-caprolactone, succinate, xylose 및 포도당에 의해 이화물 억제를 받지 않았으나 사이클로헥사놀 대사경로의 최종생산물인 adipate에 의하여 생합성 억제를 받았다. CL 배지에 0.1%의 adipate를 첨가한 배지에서는 CDH가 다소 유도되었으나 0.2%의 adipate를 첨가한 배지에서는 CDH가 거의 유도되지 않아 0.5%의 adipate를 첨가한 것과 비슷한 억제효과를 나타내었다.

• Advances in pediatric surgery
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• 제7권1호
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• pp.21-25
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• 2001

Congenital diaphragmatic hernia (CDH) in the past was considered a surgical emergency requiring immediate operation. Several groups now advocate preoperative stabilization and delayed surgery. The treatment strategy for CDH in this institution is delayed surgery after preoperative stabilization. The aim of this study was to evaluate the results of delayed surgery. A retrospective review of 16 neonates with CDH was performed. Surfactant. conventional mechanical ventilation. high frequency oscillation. and nitric oxide were utilized for preoperative stabilization as necessary. The difference in outcome between two groups differentiated by the duration of the preoperative stabilization periods with mechanical ventilation (${\leq}$ 8 hours and > 8 hours) was determined. Chi-square test was used to analyze the data. There were 7 right-sided hernias and 9 left. The average duration of stabilization was 32.4 hours. Hepatic herniation through the defect was found in 6 cases and all died. The most common postoperative complication was pneumothorax. The mortality rate of the right side hernia was higher than the left (85.7% vs. 33.3%. p=0.036). Mortality rate of the group (N=8) whose preoperative stabilization period was 8 hours or less was better than that (N=6) whose preoperative stabilization period was more than 8 hours (25.0% vs. 83.3%. p=0.031). The overall mortality rate was 56.3%. The better prognosis was noticed in left side hernia. no liver herniation, or shorter preoperative stabilization period.

• 정보보호학회논문지
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• 제15권1호
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• pp.41-55
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• 2005

그룹키 통의 프로토콜은 일련의 그룹을 형성하는 다수의 통신 참여자들이 공개된 통신망을 통해 안전하고 효율적인 방법으로 그룹의 세션키를 설정하기 위한 목적으로 설계된다. 본 논문에서는 유료 방송 시스템과 같은 그룹중심의 응용이나 서비스에 적합한 ID 기반의 2 라운드의 그룹키 동의 프로토콜을 제안하고, 이의 안전성을 CDH 가정과 BDDH 가정에 기반하여 랜덤 오라클 모델에서 증명한다. 제안하는 프로토콜은 Nam이 제안한 3 라운드 그룹키 동의 프로토콜을 기초로 설계된 것으로, 개인식별정보에 기반한 암호 시스템을 사용하여 키 관리 절차를 보다 간단히 하였으며, 새로운 인증 메카니즘을 사용하여 키 전송 메시지들의 길이를 줄이고 결합적 단순성을 제공하였다. 또한 제안하는 프로토콜은 전송되는 메시지들에 대한 인증을 묶음(batch) 기법을 사용하여 검증하도록 설계하여 효율성을 더욱 개선 시 켰다.